+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Saccharothrix syringae
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
E EKG83_23210 type I polyketide synthase K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
E EKG83_13740 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E EKG83_28335 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
D Chivosazol hybrid PKS-NRPS
E EKG83_13740 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E EKG83_28335 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
E EKG83_13740 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E EKG83_28335 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
D Difficidin PKS
E EKG83_13740 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E EKG83_28335 PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
D EKG83_13185 type I polyketide synthase K15314 sgcE; enediyne polyketide synthase
D EKG83_27920 type I polyketide synthase K15314 sgcE; enediyne polyketide synthase
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
C C7-C14 cyclized polyketide type
D Octaketide PKS
E EKG83_32220 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_16320 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_32215 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_16315 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_32210 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E EKG83_16310 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E EKG83_32190 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E EKG83_16370 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E EKG83_32185 cyclase K05554 actVII; aromatase [EC:4.2.1.-]
E EKG83_16305 cyclase K05554 actVII; aromatase [EC:4.2.1.-]
E EKG83_16300 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E EKG83_32220 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_16320 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_32215 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_16315 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_32210 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E EKG83_16310 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E EKG83_32190 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E EKG83_16370 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E EKG83_32225 TcmI family type II polyketide cyclase K15926 jadI; cyclase
D Decaketide PKS
E EKG83_32220 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_16320 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_32215 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_16315 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E EKG83_32210 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E EKG83_16310 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E EKG83_32190 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
E EKG83_16370 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-]
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D EKG83_13095 type III polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
D EKG83_25495 hybrid non-ribosomal peptide synthetase/type I polyketide synthase K15395 ftdB; hybrid polyketide synthase / nonribosomal peptide synthetase FtdB
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D EKG83_28815 MbtH family protein K05375 mbtH; MbtH protein
D EKG83_30445 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein
D EKG83_30680 MbtH family protein K05375 mbtH; MbtH protein
D EKG83_33240 MbtH family protein K05375 mbtH; MbtH protein
D EKG83_33820 MbtH family NRPS accessory protein K05375 mbtH; MbtH protein
D EKG83_25890 MbtH family protein K05375 mbtH; MbtH protein
D EKG83_22845 MbtH family protein K05375 mbtH; MbtH protein
D EKG83_19020 MbtH family protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D EKG83_32795 isochorismatase family protein K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D EKG83_32800 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D EKG83_25955 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D EKG83_32795 isochorismatase family protein K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D EKG83_32800 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D EKG83_25955 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D EKG83_32795 isochorismatase family protein K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D EKG83_32800 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D EKG83_25955 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D EKG83_32800 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D EKG83_25955 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D EKG83_32795 isochorismatase family protein K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D EKG83_32795 isochorismatase family protein K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D EKG83_32800 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D EKG83_25955 (2,3-dihydroxybenzoyl)adenylate synthase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
C EKG83_13190 acyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase
C EKG83_27915 acyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
B Oxygenase
C EKG83_16920 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C EKG83_22955 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C EKG83_30320 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C EKG83_12300 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C EKG83_15635 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C EKG83_21925 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C EKG83_21225 2,4-dichlorophenol 6-monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
C EKG83_41855 FAD-binding protein K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C EKG83_24505 SAM-dependent methyltransferase K16028 asm17; O-methyltransferase
C EKG83_31050 methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
C EKG83_21075 methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
B Glycosyltransferase
B Halogenase
C EKG83_28905 FAD-dependent oxidoreductase K14257 ctcP; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
B beta-Branched incorporating proteins
B Others
C EKG83_24510 3-hydroxyacyl-CoA dehydrogenase family protein K16024 asm13; methoxymalonate biosynthesis protein
C EKG83_24515 acyl carrier protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein
C EKG83_24520 acyl-CoA dehydrogenase family protein K16026 asm15; methoxymalonate biosynthesis protein
C EKG83_24525 HAD-IIIC family phosphatase K16027 asm16; methoxymalonate biosynthesis protein
C EKG83_16295 flavin reductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
C EKG83_30880 flavin reductase K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
C EKG83_13170 DUF1702 family protein K21161 sgcE3; enediyne biosynthesis protein E3
C EKG83_27960 DUF1702 family protein K21161 sgcE3; enediyne biosynthesis protein E3
C EKG83_13175 VCBS repeat-containing protein K21162 sgcE4; enediyne biosynthesis protein E4
C EKG83_28010 CRTAC1 family protein K21162 sgcE4; enediyne biosynthesis protein E4
C EKG83_28035 CRTAC1 family protein K21162 sgcE4; enediyne biosynthesis protein E4
C EKG83_13105 CRTAC1 family protein K21162 sgcE4; enediyne biosynthesis protein E4
C EKG83_13165 CRTAC1 family protein K21162 sgcE4; enediyne biosynthesis protein E4
C EKG83_28005 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5
C EKG83_28040 enediyne biosynthesis protein K21163 sgcE5; enediyne biosynthesis protein E5
C EKG83_27965 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7
C EKG83_29620 flavin reductase K21185 sgcE6; flavin reductase
C EKG83_25685 flavin reductase K21185 sgcE6; flavin reductase
C EKG83_27910 flavin reductase K21185 sgcE6; flavin reductase
C EKG83_27995 flavin reductase K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
C EKG83_30910 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
C EKG83_16745 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
C EKG83_29585 PLP-dependent aminotransferase family protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
C EKG83_30970 PLP-dependent aminotransferase family protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]
B Others
C EKG83_29580 hppD; 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]
C EKG83_30955 hppD; 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]
C EKG83_30070 alpha-hydroxy-acid oxidizing protein K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C EKG83_30930 alpha-hydroxy-acid oxidizing protein K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C EKG83_36570 aspartate/glutamate racemase family protein K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024