+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces sp. PBH53

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS E QR97_14580 AMP-dependent synthetase K15670 rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74] E QR97_14585 beta-ketoacyl synthase K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E QR97_26065 hypothetical protein K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E QR97_34415 hypothetical protein K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E QR97_34410 polyketide synthase K15673 rifE; rifamycin polyketide synthase modules 9 and 10 D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E QR97_02920 beta-ACP synthase K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E QR97_02915 polyketide beta-ketoacyl synthase K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E QR97_02910 Curamycin polyketide synthase acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E QR97_02905 polyketide cyclase K14670 whiEVI; aromatase E QR97_02900 polyketide synthase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E QR97_20400 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_38780 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_20405 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_38785 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_20410 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E QR97_28995 hypothetical protein K05553 actI3; minimal PKS acyl carrier protein E QR97_38685 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E QR97_20455 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E QR97_38690 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E QR97_20430 beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-] E QR97_38800 beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E QR97_20400 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_38780 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_20405 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_38785 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_20410 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E QR97_28995 hypothetical protein K05553 actI3; minimal PKS acyl carrier protein E QR97_38685 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E QR97_20455 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E QR97_38690 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] D Decaketide PKS E QR97_20400 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_38780 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_20405 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_38785 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E QR97_20410 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E QR97_28995 hypothetical protein K05553 actI3; minimal PKS acyl carrier protein E QR97_38685 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E QR97_20455 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E QR97_38690 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D QR97_20280 polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D QR97_02525 antibiotic synthesis protein MbtH K05375 mbtH; MbtH protein D QR97_23445 protein mbtH K05375 mbtH; MbtH protein D QR97_26080 protein mbtH K05375 mbtH; MbtH protein D QR97_28975 hypothetical protein K05375 mbtH; MbtH protein D QR97_36980 antibiotic synthesis protein MbtH K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D QR97_13570 4'-phosphopantetheinyl transferase K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] C Bacillibactin synthetase C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase C Myxochelin synthetase C Petrobacin synthetase C Syringomycin synthetase D QR97_36975 alanine-phosphoribitol ligase K16126 syrB1; L-threonine---[L-threonyl-carrier protein] ligase [EC:6.2.1.70] C Vanchrobactin synthetase C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C QR97_26140 3-(3-hydroxyphenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase C QR97_37450 hypothetical protein K14630 actVA5; two-component flavin-dependent monooxygenase [EC:1.14.14.-] C QR97_36490 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C QR97_38055 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C QR97_38665 antibiotic biosynthesis monooxygenase K15941 snoaB; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-] C QR97_02925 protein in whiE locus K14673 whiEII; putative monooxygenase C QR97_02935 monooxygenase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C QR97_02895 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] C QR97_38770 hypothetical protein K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase B Halogenase C QR97_34400 tryptophan halogenase K16033 asm12; FADH2-dependent halogenase C QR97_36970 chemotaxis protein CheX K15650 cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase B beta-Branched incorporating proteins B Others C QR97_26060 hypothetical protein K15466 rifF; amide synthase C QR97_34405 3-amino-5-hydroxybenzoic acid synthase K15466 rifF; amide synthase C QR97_20360 hypothetical protein K14626 actVIA; actinorhodin biosynthesis protein ActVIA C QR97_20440 hypothetical protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-] C QR97_23405 oxidase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase C QR97_37095 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase B Others C QR97_07570 ornithine carbamoyltransferase K16105 vioL; carbamoyltransferase ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025