+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces sp. CNQ-509

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E AA958_14850 polyketide cyclase K14670 whiEVI; aromatase C C7-C14 cyclized polyketide type D Octaketide PKS E AA958_14835 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_30255 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_14840 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_30260 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_14845 tetracenomycin C polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E AA958_30265 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E AA958_30270 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E AA958_08855 hypothetical protein K05554 actVII; aromatase [EC:4.2.1.-] E AA958_30275 cyclase K05554 actVII; aromatase [EC:4.2.1.-] E AA958_04520 hypothetical protein K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E AA958_14835 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_30255 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_14840 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_30260 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_14845 tetracenomycin C polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E AA958_30265 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E AA958_30270 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] E AA958_30250 polyketide synthase K15926 jadI; cyclase D Decaketide PKS E AA958_14835 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_30255 beta-ACP synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_14840 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_30260 beta-ketoacyl synthase K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E AA958_14845 tetracenomycin C polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E AA958_30265 actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E AA958_30270 ketoacyl reductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D AA958_31865 stilbene synthase K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D AA958_24285 polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D AA958_24385 polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D AA958_32450 stilbene synthase K16167 bpsA; alkylresorcinol/alkylpyrone synthase D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D AA958_29280 hypothetical protein K05375 mbtH; MbtH protein D AA958_31895 protein mbtH K05375 mbtH; MbtH protein D AA958_32755 protein mbtH K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase C Bacillibactin synthetase C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase C Myxochelin synthetase C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C AA958_20030 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C AA958_31875 enoyl-CoA hydratase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C AA958_14830 cupin K14673 whiEII; putative monooxygenase C AA958_24370 hypothetical protein K14672 whiEVIII; putative polyketide hydroxylase B Methylase C AA958_32445 membrane protein K16168 bpsB; methyltransferase B Glycosyltransferase B Halogenase B beta-Branched incorporating proteins B Others C AA958_21095 hypothetical protein K14628 actVI2; enoyl reductase C AA958_32660 polyketide synthase K15968 tcmI; tetracenomycin F2 cyclase [EC:4.2.1.154] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase B Aminotransferase C AA958_31860 GntR family transcriptional regulator K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C AA958_31850 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C AA958_31845 2-hydroxy-acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C AA958_31870 enoyl-CoA hydratase K16425 dpgB; isomerase DpgB C AA958_31875 enoyl-CoA hydratase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025