+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces sp. 769

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS E GZL_00792 NysA K16382 amphA; polyene macrolide polyketide synthase, loading module E GZL_00791 NysB K16383 amphB; polyene macrolide polyketide synthase, A-type KR domains E GZL_00790 NysC K16384 amphC; polyene macrolide polyketide synthase E GZL_00801 NysI K16385 amphI; polyene macrolide polyketide synthase, KS-AT-KR-ACP domains E GZL_00800 NysJ K16386 amphJ; polyene macrolide polyketide synthase E GZL_00799 NysK K16387 amphK; polyene macrolide polyketide synthase D Pimaricinolide synthase E GZL_09212 ScnS0 K16391 pimS0; pimaricinolide synthase, loading module E GZL_09210 ScnS1 K19203 pimS1; pimaricinolide synthase PimS1 E GZL_09207 ScnS2 K19204 pimS2; pimaricinolide synthase PimS2 E GZL_09208 PimS3 protein K19205 pimS3; pimaricinolide synthase PimS3 E GZL_09209 type I modular polyketide synthase K19206 pimS4; pimaricinolide synthase PimS4 D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E GZL_07659 Beta-ketoacyl synthase K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E GZL_07660 Beta-ketoacyl synthase K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E GZL_07661 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E GZL_07662 Polyketide cyclase K14670 whiEVI; aromatase E GZL_07663 Polyketide synthesis cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E GZL_p00214 type II PKS ketoacyl synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E GZL_p00215 keto-acyl synthase beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E GZL_p00216 acyl carrier protein-like protein K05553 actI3; minimal PKS acyl carrier protein E GZL_p00217 hypothetical protein K12420 actIII; ketoreductase [EC:1.1.1.-] E GZL_p00218 cyclase-like protein K05554 actVII; aromatase [EC:4.2.1.-] E GZL_06846 polyketide cyclase K05555 actIV; cyclase [EC:4.-.-.-] E GZL_p00211 second ring cyclase (CYC) K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E GZL_p00214 type II PKS ketoacyl synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E GZL_p00215 keto-acyl synthase beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E GZL_p00216 acyl carrier protein-like protein K05553 actI3; minimal PKS acyl carrier protein E GZL_p00217 hypothetical protein K12420 actIII; ketoreductase [EC:1.1.1.-] D Decaketide PKS E GZL_p00214 type II PKS ketoacyl synthase K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E GZL_p00215 keto-acyl synthase beta K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E GZL_p00216 acyl carrier protein-like protein K05553 actI3; minimal PKS acyl carrier protein E GZL_p00217 hypothetical protein K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D GZL_02842 Type III PKS C putative chalcone synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D GZL_00058 hypothetical protein K05375 mbtH; MbtH protein D GZL_02924 putative MbtH-like protein K05375 mbtH; MbtH protein D GZL_07295 MbtH-like protein K05375 mbtH; MbtH protein D GZL_08294 MbtH domain protein K05375 mbtH; MbtH protein D GZL_09355 hypothetical protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D GZL_00805 NysF K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] D GZL_02748 phosphopantetheinyl transferase K02362 entD; enterobactin synthetase component D / holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7] D GZL_08593 2 C3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D GZL_p00203 3-hydroxypicolinic acid:AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D GZL_07306 siderophore 2 C3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72] C Bacillibactin synthetase D GZL_08593 2 C3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D GZL_p00203 3-hydroxypicolinic acid:AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase D GZL_p00202 pyochelin synthetase F K12240 pchF; L-cysteine---[L-cysteinyl-carrier protein] ligase PchF [EC:6.2.1.69] C Mycobactin synthetase C Vibriobactin synthetase D GZL_08593 2 C3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D GZL_p00203 3-hydroxypicolinic acid:AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D GZL_08593 2 C3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D GZL_p00203 3-hydroxypicolinic acid:AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D GZL_08593 2 C3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] D GZL_p00203 3-hydroxypicolinic acid:AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase B Ketoreductase C GZL_01083 hypothetical protein K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-] C GZL_08371 3-hydroxyacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-] C GZL_p00221 ketoreductase K14633 gra6; ketoreductase RED2 [EC:1.1.1.-] B Oxygenase C GZL_03700 cytochrome P-450 K15991 tylHI; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase [EC:1.14.15.34] C GZL_00796 NysN K16389 amphN; cytochrome P450 monooxygenase C GZL_09214 ScnG K16389 amphN; cytochrome P450 monooxygenase C GZL_00798 NysL K16390 amphL; cytochrome P450 monooxygenase C GZL_05877 cytochrome P450 monooxygenase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C GZL_08215 cytochrome P450 hydroxylase K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C GZL_00966 epoxide hydrolase K21159 sgcF; epoxide hydrolase C GZL_07923 epoxide hydrolase K21159 sgcF; epoxide hydrolase C GZL_07658 Cupin 2 conserved barrel domain protein K14673 whiEII; putative monooxygenase C GZL_00510 monooxygenase FAD-binding protein K14672 whiEVIII; putative polyketide hydroxylase C GZL_00512 hypothetical protein K14672 whiEVIII; putative polyketide hydroxylase C GZL_01672 polyketide hydroxylase K14672 whiEVIII; putative polyketide hydroxylase C GZL_07656 tetracenomycin polyketide synthesis hydroxylase TcmG K14672 whiEVIII; putative polyketide hydroxylase B Methylase C GZL_07664 O-methyltransferase family 2 K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase C GZL_00794 NysDI K16388 amphDI; polyene glycosyltransferase C GZL_09216 putative glucosyl transferase K16388 amphDI; polyene glycosyltransferase B Halogenase C GZL_07290 hypothetical protein K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] B beta-Branched incorporating proteins C GZL_06864 polyketide beta-ketoacyl:acyl carrier protein synthase K00646 pksF; malonyl-[acp] decarboxylase [EC:4.1.1.124] C GZL_06863 acyl carrier protein K15337 acpK; polyketide biosynthesis acyl carrier protein C GZL_06865 hypothetical protein K15311 pksG; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22] C GZL_06866 enoyl-CoA hydratase K15312 pksH; 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase [EC:4.2.1.181] C GZL_06867 enoyl-CoA hydratase K15313 pksI; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125] B Others C GZL_02226 NADH-FMN oxidoreductase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] C GZL_02917 NADH-FMN oxidoreductase K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36] # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase C GZL_07987 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase C GZL_08684 putative aminotransferase K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C GZL_08687 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46] C GZL_08686 (S)-2-hydroxy-acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025