+F Repair protein KO
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DNA Repair and Recombination Proteins - Streptococcus thermophilus JIM 8232
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D STH8232_1747 ogt; putative methylated-DNA--protein-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E STH8232_1246 uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E STH8232_2022 hypothetical protein K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E STH8232_1428 nth; endonuclease III, DNA repair K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D STH8232_1719 putative A3CMM1 UDP-glucose 4-epimerase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0790 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0226 mutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0876 mutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_1326 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0530 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_1542 putative mutT/NudX family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_2104 dut; deoxyuridine 5-triphosphate nucleotidohydrolase (DUTPase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D STH8232_1747 ogt; putative methylated-DNA--protein-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E STH8232_1246 uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E STH8232_2022 hypothetical protein K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E STH8232_0075 3-methyladenine DNA glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E STH8232_0812 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E STH8232_1428 nth; endonuclease III, DNA repair K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E STH8232_1777 exoA; 3-exo-deoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E STH8232_1432 recJ; single strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E STH8232_1782 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E STH8232_2030 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E STH8232_2013 excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E STH8232_1720 hypothetical protein K03702 uvrB; excinuclease ABC subunit B
E STH8232_1528 excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
E STH8232_1187 pcrA; ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E STH8232_0688 uvrD, superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E STH8232_2030 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E STH8232_1782 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F STH8232_2151 rpoB; DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (Transcriptase subunit beta) (RNA polymerase subunit beta) K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F STH8232_2150 rpoC; DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (Transcriptase subunit beta) (RNA polymerase subunit beta) K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F STH8232_2208 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F STH8232_0223 rpoE; DNA-directed RNA polymerase delta subunit K03048 rpoE; DNA-directed RNA polymerase subunit delta
F STH8232_1656 DNA-directed RNA polymerase omega chain(RNAP omega;subunit) K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F STH8232_0006 transcription repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E STH8232_0068 mismatch repair ATPase (MutS family) K03555 mutS; DNA mismatch repair protein MutS
E STH8232_2031 mutS2; DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E STH8232_0072 mutL; DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E STH8232_1423 exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E STH8232_1422 xseB; exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E STH8232_1403 dnaE; DNA polymeraDNA polymerase III alphase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E STH8232_0104 polC; DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E STH8232_0002 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E STH8232_0912 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E STH8232_0602 dnaH; DNA polymerase III delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E STH8232_1844 dnaQ; DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E STH8232_1372 folC2; folylpolyglutamate synthase / dihydrofolate synthase K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E STH8232_1782 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E STH8232_1187 pcrA; ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E STH8232_0688 uvrD, superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E STH8232_2127 ssbA; single strand binding protein K03111 ssb; single-strand DNA-binding protein
E STH8232_2018 ssbB; single strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E STH8232_2036 recD; exodeoxyribonuclease V K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E STH8232_0077 recA; protein RecA K03553 recA; recombination protein RecA
E STH8232_0074 ruvA; holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
E STH8232_2236 ruvB; holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E STH8232_1655 priA; primosomal replication factor Y K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E STH8232_1618 sbcC; ATP-dependent dsDNA exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E STH8232_1619 sbcD; ATP-dependent dsDNA exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E STH8232_0077 recA; protein RecA K03553 recA; recombination protein RecA
E STH8232_2102 radA; DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E STH8232_2325 recF; DNA repair and genetic recombination protein K03629 recF; DNA replication and repair protein RecF
E STH8232_1990 recG; ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E STH8232_1432 recJ; single strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E STH8232_0045 recO; DNA repair protein recO (Recombination protein O) K03584 recO; DNA repair protein RecO (recombination protein O)
E STH8232_0805 recR; recombination protein recR K06187 recR; recombination protein RecR
E STH8232_1418 recN; DNA repair and genetic recombination protein K03631 recN; DNA repair protein RecN (Recombination protein N)
E STH8232_0325 recU; recombination protein U K03700 recU; recombination protein U
E STH8232_0074 ruvA; holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
E STH8232_2236 ruvB; holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D AddAB pathway proteins
E STH8232_1976 rexA; ATP-dependent exonuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E STH8232_1977 rexB; ATP-dependent exonuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E STH8232_1159 cas1-2; CRISPR-associated protein cas1 K15342 cas1; CRISP-associated protein Cas1
E STH8232_0854 hypothetical protein K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E STH8232_1618 sbcC; ATP-dependent dsDNA exonuclease K03546 sbcC; DNA repair protein SbcC/Rad50
E STH8232_1619 sbcD; ATP-dependent dsDNA exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F STH8232_1503 hypothetical protein K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F STH8232_1741 hypothetical protein K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F STH8232_1100 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F STH8232_1414 hstH; histone-like DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F STH8232_1432 recJ; single strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F STH8232_0045 recO; DNA repair protein recO (Recombination protein O) K03584 recO; DNA repair protein RecO (recombination protein O)
F STH8232_0805 recR; recombination protein recR K06187 recR; recombination protein RecR
F STH8232_1782 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F STH8232_2013 excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F STH8232_1720 hypothetical protein K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D STH8232_1907 hypothetical protein K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D STH8232_1585 umuC1; soS responce UmuC protein K03502 umuC; DNA polymerase V
D STH8232_1066 umuC-MucB-like protein K03502 umuC; DNA polymerase V
C Other SOS response factors
D STH8232_0077 recA; protein RecA K03553 recA; recombination protein RecA
D STH8232_1095 umuD; UV resistance protein UmuD K01356 lexA; repressor LexA [EC:3.4.21.88]
D STH8232_1418 recN; DNA repair and genetic recombination protein K03631 recN; DNA repair protein RecN (Recombination protein N)
D STH8232_2127 ssbA; single strand binding protein K03111 ssb; single-strand DNA-binding protein
D STH8232_2018 ssbB; single strand binding protein K03111 ssb; single-strand DNA-binding protein
D STH8232_0484 recX; regulatory protein recX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D STH8232_1009 dinG; ATP-dependent DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D STH8232_1719 putative A3CMM1 UDP-glucose 4-epimerase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0790 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0226 mutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0876 mutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_1326 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_0530 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_1542 putative mutT/NudX family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D STH8232_2104 dut; deoxyuridine 5-triphosphate nucleotidohydrolase (DUTPase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D STH8232_1495 nrdE; ribonucleotide reductase alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D STH8232_1496 nrdF; ribonucleotide diphosphate reductase beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D STH8232_0940 hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024