+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Streptomyces violaceusniger
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E Strvi_2543 Beta-ketoacyl synthase K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
E Strvi_2542 Beta-ketoacyl synthase K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
E Strvi_2541 phosphopantetheine-binding protein K14669 whiEV; minimal PKS acyl carrier protein
E Strvi_2540 cyclase/dehydrase K14670 whiEVI; aromatase
E Strvi_2539 Polyketide synthesis cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E Strvi_4077 beta-lactamase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
D Decaketide PKS
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D Strvi_5198 MbtH domain protein K05375 mbtH; MbtH protein
D Strvi_8793 MbtH domain protein K05375 mbtH; MbtH protein
D Strvi_7975 MbtH domain protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D Strvi_8298 amino acid adenylation domain protein K02364 entF; L-serine---[L-seryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.72]
C Bacillibactin synthetase
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
C Myxochelin synthetase
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
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APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
B Oxygenase
C Strvi_5392 FAD-binding monooxygenase K16022 rif19; flavoprotein hydroxylase
C Strvi_5921 FAD-binding monooxygenase K16022 rif19; flavoprotein hydroxylase
C Strvi_7659 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C Strvi_2196 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C Strvi_1428 Epoxide hydrolase domain protein K21159 sgcF; epoxide hydrolase
C Strvi_6005 Epoxide hydrolase domain protein K21159 sgcF; epoxide hydrolase
C Strvi_6316 Epoxide hydrolase domain protein K21159 sgcF; epoxide hydrolase
C Strvi_6384 Epoxide hydrolase domain protein K21159 sgcF; epoxide hydrolase
C Strvi_8156 FAD-binding monooxygenase K14253 oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
C Strvi_2544 Cupin 2 conserved barrel domain protein K14673 whiEII; putative monooxygenase
C Strvi_2546 FAD-binding monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C Strvi_6777 O-methyltransferase family 3 K16028 asm17; O-methyltransferase
C Strvi_5877 O-methyltransferase family 3 K16028 asm17; O-methyltransferase
C Strvi_2536 O-methyltransferase family 2 K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C Strvi_6781 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein K16024 asm13; methoxymalonate biosynthesis protein
C Strvi_5876 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein K16024 asm13; methoxymalonate biosynthesis protein
C Strvi_5875 hypothetical protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein
C Strvi_6780 hypothetical protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein
C Strvi_4990 methoxymalonate biosynthesis protein K16025 asm14; methoxymalonate biosynthesis acyl carrier protein
C Strvi_5874 acyl-CoA dehydrogenase domain-containing protein K16026 asm15; methoxymalonate biosynthesis protein
C Strvi_6779 acyl-CoA dehydrogenase domain-containing protein K16026 asm15; methoxymalonate biosynthesis protein
C Strvi_5873 FkbH like protein K16027 asm16; methoxymalonate biosynthesis protein
C Strvi_6778 FkbH like protein K16027 asm16; methoxymalonate biosynthesis protein
C Strvi_5872 Carbamoyltransferase K16035 asm21; 7-O-carbamoyltransferase [EC:2.1.3.-]
C Strvi_5920 N-acetyltransferase K15466 rifF; amide synthase
C Strvi_5385 N-acetyltransferase K15466 rifF; amide synthase
C Strvi_8777 FMN-binding flavin reductase domain protein K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
B Aminotransferase
C Strvi_8790 FMN-dependent alpha-hydroxy acid dehydrogenase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
B Others
C Strvi_7696 aminotransferase class V K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]
C Strvi_8789 4-hydroxyphenylpyruvate dioxygenase K16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]
C Strvi_8790 FMN-dependent alpha-hydroxy acid dehydrogenase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C Strvi_5274 FMN-dependent alpha-hydroxy acid dehydrogenase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C Strvi_7609 aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024