+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Synechococcus sp. NIES-970</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
C    NIES970_29790 cas; putative CRISPR-associated protein	K15342 cas1; CRISP-associated protein Cas1 
C    NIES970_29800 cas2; CRISPR-associated protein	K09951 cas2; CRISPR-associated protein Cas2 
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
D      NIES970_29710 cas3; CRISPR-associated helicase	K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4] 
C    Subtype I-A factors
D      NIES970_29730 CRISPR-associated regulatory protein, DevR family	K19075 cst2; CRISPR-associated protein Cst2 
D      NIES970_29760 hypothetical protein	K19089 cas5a_b_c; CRISPR-associated protein Cas5a/b/c 
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
C    Subtype II-A factors
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
C    Subtype III-A factors
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
C    NIES970_30100 type 1 restriction-modification system specificity subunit	K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] 
C    NIES970_30090 type I N6 DNA Methyltransferase	K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 
B  Type II R-M system
C    Restriction endonucleases
C    DNA methyltransferases
D      NIES970_25350 dam; adenine-specific DNA methylase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
D      NIES970_00720 site-specific DNA-methyltransferase	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
B  Type III R-M system
B  Type IV R-M system
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A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
D      NIES970_15530 hypothetical protein	K26986 mazE6; antitoxin MazE6 
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
C    YafQ-dinJ
C    YoeB-YefM
D      NIES970_11990 addiction module toxin, Txe/YoeB family	K19158 yoeB; toxin YoeB [EC:3.1.-.-] 
D      NIES970_12000 putative antitoxin of toxin-antitoxin stability system	K19159 yefM; antitoxin YefM 
C    HipA-HipB
C    HicA-HicB
C    YafO-YafN
C    PspC-PspB
C    CcdB-CcdA
C    ParE-ParD
C    Doc-Phd
D      NIES970_05130 hypothetical protein	K07341 doc; death on curing protein 
D      NIES970_15520 death-on-curing protein	K07341 doc; death on curing protein 
C    HigB-HigA
D      NIES970_29930 hypothetical protein	K07334 higB-1; toxin HigB-1 
D      NIES970_29600 hypothetical protein	K21498 higA-1; antitoxin HigA-1 
D      NIES970_29920 hypothetical protein	K21498 higA-1; antitoxin HigA-1 
C    MqsR-MqsA
C    VapC-VapB
D      NIES970_25740 PilT protein domain protein	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      NIES970_28500 hypothetical protein	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      NIES970_29630 PilT domain-containing protein	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      NIES970_29750 PIN domain protein	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      NIES970_25730 hypothetical protein	K28280 vapB22; antitoxin VapB22 
D      NIES970_29640 hypothetical protein	K28280 vapB22; antitoxin VapB22 
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
D      NIES970_29120 plasmid stabilization protein	K07062 fitB; toxin FitB [EC:3.1.-.-] 
C    BC_0920-BC_0921
C    SpoIISA-SpoIISB
C    Tse6-Tsi6
C    Type II TA system related factors
D      NIES970_26550 ftsZ; cell division protein FtsZ	K03531 ftsZ; cell division protein FtsZ 
D      NIES970_22480 cell shape determining protein, MreB/Mrl family subfamily	K03569 mreB; rod shape-determining protein MreB and related proteins 
D      NIES970_15380 gltX; glutamyl-tRNA synthetase	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
C    CptA-CptB
C    AbiEii-AbiEi
B  Type V TA system
C    GhoT-GhoS
C    Other GhoT/OrtT toxin family protein
B  Type VI TA system
C    SocB-SocA
B  Type VII TA system
C    Hha-TomB
C    TglT-TakA
C    HepT-MntA
B  Type VIII TA system
C    SdsR-RyeA
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A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    NIES970_08290 nifS_1; cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
C    NIES970_08470 nifS_2; cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
C    NIES970_11340 nifS_3; cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: May 19, 2025