+D Protein KO
#
Membrane Trafficking - Trypanosoma brucei gambiense
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
D TbgDal_X16880 calcium-dependent lipid binding protein,putative K28063 ESYT; extended synaptotagmin
C Septins
C DOC-2 proteins
C Acrosomal exocytosis proteins
C Phospholipases
D TbgDal_XI6720 phosphoinositide-specific phospholipase C,putative K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Kinases and associated proteins
D TbgDal_IV1500 phosphatidylinositol 4-phosphate 5-kinase alpha,putative K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D TbgDal_IV1630 nucleoside diphosphate kinase, putative K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D TbgDal_IX6720 nucleoside diphosphate kinase, putative K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D TbgDal_XI18090 nucleoside diphosphate kinase, putative K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
C Others
D TbgDal_IX9000 hypothetical protein, conserved K23531 CABP1_2_4_5; calcium-binding protein 1/2/4/5
B Small GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D TbgDal_IX6700 EF hand containing protein K02183 CALM; calmodulin
D TbgDal_XI10980 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_XI14480 calmodulin, putative, (fragment) K02183 CALM; calmodulin
D TbgDal_XI14490 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_XI14500 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_XI14510 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_XI14520 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_XI4210 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_XI9050 calmodulin, putative K02183 CALM; calmodulin
D TbgDal_IX660 syntaxin binding protein 1, putative K15292 STXBP1; syntaxin-binding protein 1
D TbgDal_IX9310 trypanin-related protein, putative K19942 GAS8; dynein regulatory complex subunit 4
D TbgDal_IX3000 inositol/phosphatidylinositol phosphatase,putative K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D TbgDal_V1520 peroxisome targeting signal 1 receptor, putative K13342 PEX5; peroxin-5
D TbgDal_X14030 hypothetical protein, conserved K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D TbgDal_IV460 geranylgeranyl transferase type II beta subunit,putative K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
C Rho GTPases
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
C Exocyst complex assembly proteins
B Others
C Exomer complex
C Others
D TbgDal_IX5610 hypothetical protein, conserved K19995 SCAMP; secretory carrier-associated membrane protein
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D TbgDal_X12150 hypothetical protein, conserved K08486 STX1B_2_3; syntaxin 1B/2/3
D TbgDal_XI9830 syntaxin, putative K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
C Stx-TGN / EE
D TbgDal_IX8030 syntaxin, putative K08489 STX16; syntaxin 16
D TbgDal_X14430 syntaxin, putative K08489 STX16; syntaxin 16
C Stx-cisGolgi
D TbgDal_X16590 syntaxin 5, putative K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
B SNAP-25[N] (Qb)
C Vti1
D TbgDal_VIII3655 hypothetical protein, conserved K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D TbgDal_XI11530 GOLGI SNAP receptor complex member, putative K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D TbgDal_X18940 SNARE protein, putative K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
B SNAP-25[C] (Qc)
C STX6
D TbgDal_X2830 hypothetical protein, conserved K08499 TLG1; member of the syntaxin family of t-SNAREs
C STX8
C STX10
C Bet1
D TbgDal_III4020 Golgi vesicular membrane trafficking protein,putative K08504 BET1; blocked early in transport 1
D TbgDal_XI20 hypothetical protein, conserved K08504 BET1; blocked early in transport 1
C Sft1
C Syp7
D TbgDal_IX2020 syntaxin, putative K08506 SYP7; syntaxin of plants SYP7
D TbgDal_X17850 syntaxin, putative K08506 SYP7; syntaxin of plants SYP7
D TbgDal_X2220 syntaxin, putative K08506 SYP7; syntaxin of plants SYP7
C Use1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D TbgDal_II3150 synaptobrevin, putative K08515 VAMP7; vesicle-associated membrane protein 7
D TbgDal_V4970 synaptobrevin, putative K08515 VAMP7; vesicle-associated membrane protein 7
D TbgDal_X820 synaptobrevin, putative K08515 VAMP7; vesicle-associated membrane protein 7
C Ykt6
D TbgDal_IX8790 vesicle-associated membrane protein, putative K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D TbgDal_X15000 hypothetical protein, conserved K08517 SEC22; vesicle transport protein SEC22
D TbgDal_X18420 SLY2 homolog, putative K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D TbgDal_IX660 syntaxin binding protein 1, putative K15292 STXBP1; syntaxin-binding protein 1
D TbgDal_IX470 sec1 family transport protein, putative K19998 SCFD1; sec1 family domain-containing protein 1
C Palmitoyltransferases
D TbgDal_VIII3170 hypothetical protein, conserved K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
C Others
D TbgDal_I790 N-ethylmaleimide sensitive factor (NsF) K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D TbgDal_I1890 soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative K15296 NAPA; alpha-soluble NSF attachment protein
D TbgDal_XI18020 hypothetical protein, conserved K15296 NAPA; alpha-soluble NSF attachment protein
D TbgDal_X7000 Transitional endoplasmic reticulum ATPase,putative K13525 VCP; transitional endoplasmic reticulum ATPase
D TbgDal_VII2520 hypothetical protein, conserved K14012 NSFL1C; UBX domain-containing protein 1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D TbgDal_X7400 clathrin heavy chain, putative K04646 CLTC; clathrin heavy chain
C Dynamin
D TbgDal_III5280 dynamin, putative K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D TbgDal_III5320 dynamin, putative K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
C Other core components
D TbgDal_XI650 epsin, putative K12471 EPN; epsin
D TbgDal_VII640 heat shock 70 kDa protein, putative K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D TbgDal_XI12620 heat shock protein 70, putative K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D TbgDal_XI12660 heat shock protein 70, (fragment) K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D TbgDal_IV1500 phosphatidylinositol 4-phosphate 5-kinase alpha,putative K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D TbgDal_IX3000 inositol/phosphatidylinositol phosphatase,putative K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
C Kinases
D TbgDal_V2270 protein kinase, putative K08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
D TbgDal_VII4590 serine/threonine-protein kinase, putative K08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
C Ubiquitin E3 ligases
C Others
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D TbgDal_III5280 dynamin, putative K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D TbgDal_III5320 dynamin, putative K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
D TbgDal_IX4160 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_IX8590 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_IX8610 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
C RhoA-dependent endocytosis
D TbgDal_III5280 dynamin, putative K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D TbgDal_III5320 dynamin, putative K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D TbgDal_IV3390 myosin IB heavy chain, putative K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
C Kinases
D TbgDal_I1120 phosphatidylinositol 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_VIII6270 PI3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
C Phospholipase C
D TbgDal_XI6720 phosphoinositide-specific phospholipase C,putative K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
C F-BAR proteins
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D TbgDal_X12220 hypothetical protein, conserved K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D TbgDal_IX3000 inositol/phosphatidylinositol phosphatase,putative K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D TbgDal_I1120 phosphatidylinositol 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_VIII6270 PI3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_XI10280 protein kinase, putative K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D TbgDal_X8280 vacuolar protein sorting-associated protein 45,putative K12479 VPS45; vacuolar protein sorting-associated protein 45
D TbgDal_VII3680 hypothetical protein, conserved K20027 ZDHHC1_11; palmitoyltransferase ZDHHC1/11 [EC:2.3.1.225]
B Arf GTPases and associated proteins
C Arf GTPases
D TbgDal_IX4160 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_IX8590 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_IX8610 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf associated proteins
D TbgDal_XI10260 ADP-ribosylation factor GTPase activating protein, putative K12486 SMAP; stromal membrane-associated protein
D TbgDal_IX1190 hypothetical protein, conserved K23538 ELMOD; ELMO domain-containing protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D TbgDal_III4410 phosphatidylinositol 4-kinase alpha, putative K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D TbgDal_I2040 hypothetical protein, conserved K21842 EFR3; protein EFR3
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D TbgDal_IX6510 GTP-binding protein, putative K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D TbgDal_X2750 vacuolar protein sorting-associated protein 35,putative K18468 VPS35; vacuolar protein sorting-associated protein 35
D TbgDal_XI16000 vacuolar sorting protein, putative K18467 VPS29; vacuolar protein sorting-associated protein 29
D TbgDal_XI11240 vacuolar sorting-associated protein-like,putative K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
C FERRY complex
D TbgDal_IX2310 GTPase activating protein, putative K17544 TBCK; TBC domain-containing protein kinase-like protein
C Rab associated proteins
D TbgDal_I1120 phosphatidylinositol 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_VIII6270 PI3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_XI7950 proteasome alpha 7 subunit, putative K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D TbgDal_V3840 hypothetical protein, conserved K18469 TBC1D5; TBC1 domain family member 5
D TbgDal_X14030 hypothetical protein, conserved K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D TbgDal_IV460 geranylgeranyl transferase type II beta subunit,putative K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
B Arf GTPases and associated proteins
C Arf GTPases
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D TbgDal_V3280 hypothetical protein, conserved K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
C ESCRT-I complex
D TbgDal_XI12030 vacuolar sorting-associated protein-like,putative K12184 VPS28; ESCRT-I complex subunit VPS28
C ESCRT-II complex
D TbgDal_IV2840 hypothetical protein, conserved K12188 SNF8; ESCRT-II complex subunit VPS22
D TbgDal_X18890 T. brucei spp.-specific protein K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D TbgDal_IX6010 hypothetical protein, conserved K12197 CHMP1; charged multivesicular body protein 1
D TbgDal_XI3400 vesicular protein trafficking mediator, putative K12197 CHMP1; charged multivesicular body protein 1
D TbgDal_XI2310 hypothetical protein, conserved K12191 CHMP2A; charged multivesicular body protein 2A
D TbgDal_XI11230 SNF7-like protein, putative K12193 VPS24; charged multivesicular body protein 3
D TbgDal_XI10810 hypothetical protein, conserved K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D TbgDal_X4790 SNF-7-like protein, putative K12198 CHMP5; charged multivesicular body protein 5
D TbgDal_VIII5390 hypothetical protein, conserved K12195 CHMP6; charged multivesicular body protein 6
D TbgDal_III3440 katanin, putative K12196 VPS4; vacuolar protein-sorting-associated protein 4
D TbgDal_IV1230 vacuolar transport protein 4A, putative K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D TbgDal_VII8400 hypothetical protein, conserved K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D TbgDal_XI2530 hypothetical protein, conserved K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D TbgDal_XI12350 hypothetical protein, conserved K20178 VPS8; vacuolar protein sorting-associated protein 8
D TbgDal_VIII7460 hypothetical protein, conserved K20179 VPS11; vacuolar protein sorting-associated protein 11
D TbgDal_X15710 S. cerevisiae Vps16 homolog, putative K20180 VPS16; vacuolar protein sorting-associated protein 16
D TbgDal_XI1230 hypothetical protein, conserved K20181 VPS18; vacuolar protein sorting-associated protein 18
D TbgDal_III2260 vacuolar sorting protein, putative K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D TbgDal_VIII7460 hypothetical protein, conserved K20179 VPS11; vacuolar protein sorting-associated protein 11
D TbgDal_X15710 S. cerevisiae Vps16 homolog, putative K20180 VPS16; vacuolar protein sorting-associated protein 16
D TbgDal_XI1230 hypothetical protein, conserved K20181 VPS18; vacuolar protein sorting-associated protein 18
D TbgDal_III2260 vacuolar sorting protein, putative K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D TbgDal_I3280 hypothetical protein, conserved K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D TbgDal_VI2540 vacuolar assembly protein vps41, putative K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
C RAVE complex
D TbgDal_XI6910 Cyclin A/CDK2-associated protein K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D TbgDal_V5040 adaptor complex protein (AP) 3 delta subunit 1,putative K12396 AP3D; AP-3 complex subunit delta
D TbgDal_XI11940 adaptin AP-3 complex beta3 subunit, putative K12397 AP3B; AP-3 complex subunit beta
D TbgDal_IV1940 adaptor complex AP-3 medium subunit, putative K12398 AP3M; AP-3 complex subunit mu
D TbgDal_VIII6860 clathrin assembly sigma-adaptin protein 3,putative K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Lysosomal membrane proteins
D TbgDal_XI8340 hypothetical protein, conserved K28023 MFSD1; MFS transporter, Pht family, lysosomal dipeptide transporter
D TbgDal_III1140 hypothetical protein, conserved K14617 LMBRD1; LMBR1 domain-containing protein 1
C Others
D TbgDal_X3350 hypothetical protein, conserved K20195 MON1; vacuolar fusion protein MON1
D TbgDal_X2720 ubiquitin-conjugating enzyme variant Kua homologue, putative K20656 TMEM189; plasmanylethanolamine desaturase [EC:1.14.19.77]
D TbgDal_IV770 hypothetical protein, conserved K24260 WDR11; WD repeat-containing protein 11
D TbgDal_III1875 hypothetical protein, unlikely K28212 LEPROT; OB-RGRP/VPS55 family protein
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
C Rab4 associated proteins
C Rab11 associated proteins
D TbgDal_X16570 protein transport protein Sec13, putative K14004 SEC13; protein transport protein SEC13
D TbgDal_II2640 hypothetical protein, conserved K23539 UNC119; protein unc-119
C Other Rab GTPase associated proteins
D TbgDal_IX3000 inositol/phosphatidylinositol phosphatase,putative K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D TbgDal_X12220 hypothetical protein, conserved K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D TbgDal_XI9360 RAD51 protein, putative K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D TbgDal_X2580 hypothetical protein, conserved K20296 ANG2; vacuolar protein sorting-associated protein 51
D TbgDal_VII1580 hypothetical protein, conserved K20298 VPS52; vacuolar protein sorting-associated protein 52
D TbgDal_X18980 hypothetical protein, conserved K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D TbgDal_XI2570 hypothetical protein, conserved K18464 RTSC; WASH complex subunit strumpellin
D TbgDal_XI6670 hypothetical protein, conserved K18465 MRT43; WASH complex subunit 7
C Retriever complex
D TbgDal_XI16000 vacuolar sorting protein, putative K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
D TbgDal_V2320 hypothetical protein, conserved K23289 EIPR1; EARP and GARP complex-interacting protein 1
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D TbgDal_X15860 dynein light chain 2B, cytoplasmic, putative K10419 DYNLRB; dynein light chain roadblock-type
D TbgDal_IX3000 inositol/phosphatidylinositol phosphatase,putative K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D TbgDal_VIII5560 hypothetical protein, conserved K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D TbgDal_IX4160 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_IX8590 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_IX8610 ADP-ribosylation factor, putative K07937 ARF1_2; ADP-ribosylation factor 1/2
D TbgDal_VII7200 ADP-ribosylation factor, putative K07942 ARL1; ADP-ribosylation factor-like protein 1
C Arf GTPase associated proteins
D TbgDal_XI16200 ADP-ribosylation factor GTPase activating protein 1, putative K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D TbgDal_IX9620 ADP-ribosylation factor GTPase activating protein, putative K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D TbgDal_XI10260 ADP-ribosylation factor GTPase activating protein, putative K12486 SMAP; stromal membrane-associated protein
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D TbgDal_XI11870 hypothetical protein, conserved K20289 COG2; conserved oligomeric Golgi complex subunit 2
D TbgDal_X7530 hypothetical protein, conserved K20290 COG3; conserved oligomeric Golgi complex subunit 3
D TbgDal_VII8590 hypothetical protein, conserved K20291 COG4; conserved oligomeric Golgi complex subunit 4
D TbgDal_XI19010 hypothetical protein, conserved K20292 COG5; conserved oligomeric Golgi complex subunit 5
D TbgDal_X3490 hypothetical protein, conserved K20293 COG6; conserved oligomeric Golgi complex subunit 6
D TbgDal_VII300 hypothetical protein, conserved K20294 COG7; conserved oligomeric Golgi complex subunit 7
D TbgDal_XI12520 oligomeric golgi complex component 8, putative K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D TbgDal_X2580 hypothetical protein, conserved K20296 ANG2; vacuolar protein sorting-associated protein 51
D TbgDal_VII1580 hypothetical protein, conserved K20298 VPS52; vacuolar protein sorting-associated protein 52
D TbgDal_X18980 hypothetical protein, conserved K20299 VPS53; vacuolar protein sorting-associated protein 53
D TbgDal_X10430 hypothetical protein, conserved K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D TbgDal_IX7910 hypothetical protein, conserved K20300 TRAPPC1; trafficking protein particle complex subunit 1
D TbgDal_VIII5900 hypothetical protein, conserved K20301 TRAPPC2; trafficking protein particle complex subunit 2
D TbgDal_VIII4830 TRAPP, putative K20302 TRAPPC3; trafficking protein particle complex subunit 3
D TbgDal_XI17860 hypothetical protein, conserved K20303 TRAPPC4; trafficking protein particle complex subunit 4
D TbgDal_IX7370 transport protein particle (TRAPP) subunit,putative K20280 TRAPPC5; trafficking protein particle complex subunit 5
D TbgDal_VIII7090 hypothetical protein, conserved K20304 TRAPPC6; trafficking protein particle complex subunit 6
D TbgDal_III1430 hypothetical protein, conserved K20305 TRAPPC8; trafficking protein particle complex subunit 8
B Others
C AP-1 complex
D TbgDal_IV540 AP-1 adapter complex gamma subunit, putative K12391 AP1G1; AP-1 complex subunit gamma-1
D TbgDal_X9830 beta-adaptin, fragment, putative K12392 AP1B1; AP-1 complex subunit beta-1
D TbgDal_VII3510 Mu-adaptin 1, putative K12393 AP1M; AP-1 complex subunit mu
D TbgDal_III4390 clathrin coat assembly protein ap19, putative K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D TbgDal_V5040 adaptor complex protein (AP) 3 delta subunit 1,putative K12396 AP3D; AP-3 complex subunit delta
D TbgDal_XI11940 adaptin AP-3 complex beta3 subunit, putative K12397 AP3B; AP-3 complex subunit beta
D TbgDal_IV1940 adaptor complex AP-3 medium subunit, putative K12398 AP3M; AP-3 complex subunit mu
D TbgDal_VIII6860 clathrin assembly sigma-adaptin protein 3,putative K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
D TbgDal_VI2750 AP-1/4 adapter complex gamma/epsilon subunit,putative K12400 AP4E1; AP-4 complex subunit epsilon-1
D TbgDal_VIII7270 adaptor complex AP-4 medium subunit, putative K12402 AP4M1; AP-4 complex subunit mu-1
D TbgDal_X16660 clathrin assembly sigma-adaptin protein complex 4, putative K12403 AP4S1; AP-4 complex subunit sigma-1
C GGA
C Aftiphilin/p200/gamma-synergin complex
C Others
D TbgDal_III4410 phosphatidylinositol 4-kinase alpha, putative K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D TbgDal_IV1500 phosphatidylinositol 4-phosphate 5-kinase alpha,putative K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D TbgDal_III4620 hypothetical protein, conserved K20318 SYS1; protein SYS1
D TbgDal_V2190 hypothetical protein, unlikely K20318 SYS1; protein SYS1
D TbgDal_XI18780 hypothetical protein, conserved K26680 DOP1; protein dopey
D TbgDal_VIII7050 hypothetical protein, conserved K27894 HID1; protein HID1
D TbgDal_II2480 hypothetical protein, conserved K26752 TVP23; golgi apparatus membrane protein TVP23
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D TbgDal_V6040 ADP-ribosylation factor, putative K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D TbgDal_X16570 protein transport protein Sec13, putative K14004 SEC13; protein transport protein SEC13
D TbgDal_XI6960 protein transport protein sec31, putative K14005 SEC31; protein transport protein SEC31
D TbgDal_X9490 protein transport protein Sec23A, putative K14006 SEC23; protein transport protein SEC23
D TbgDal_III950 protein transport protein Sec24C, putative K14007 SEC24; protein transport protein SEC24
C TRAPP complex I
D TbgDal_IX7910 hypothetical protein, conserved K20300 TRAPPC1; trafficking protein particle complex subunit 1
D TbgDal_VIII5900 hypothetical protein, conserved K20301 TRAPPC2; trafficking protein particle complex subunit 2
D TbgDal_VIII4830 TRAPP, putative K20302 TRAPPC3; trafficking protein particle complex subunit 3
D TbgDal_XI17860 hypothetical protein, conserved K20303 TRAPPC4; trafficking protein particle complex subunit 4
D TbgDal_IX7370 transport protein particle (TRAPP) subunit,putative K20280 TRAPPC5; trafficking protein particle complex subunit 5
D TbgDal_VIII7090 hypothetical protein, conserved K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D TbgDal_XI17110 cytosolic coat protein, putative K20347 TMED2; p24 family protein beta-1
D TbgDal_IX9350 COP-coated vesicle membrane protein gp25L precursor, putative K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D TbgDal_IV2410 thioredoxin, putative K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
D TbgDal_VII1260 protein disulfide isomerase, putative K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
C Rab associated proteins
D TbgDal_X14680 RAB-interacting protein, putative K20359 RABAC1; PRA1 family protein 1
D TbgDal_X14700 RAB-interacting protein, putative K20359 RABAC1; PRA1 family protein 1
D TbgDal_I1980 GTPase activating protein of Rab-like GTPase,putative K20372 TBC1D20; TBC1 domain family member 20
D TbgDal_VI2600 GTPase activating protein, conserved, putative K20360 TBC1D22; TBC1 domain family member 2
D TbgDal_I1140 hypothetical protein, conserved K20362 YIF1; protein transport protein YIF1
D TbgDal_IX8290 hypothetical protein, conserved K22939 IER3IP1; immediate early response 3-interacting protein 1
C ER-Golgi intermediate compartment (ERGIC) proteins
D TbgDal_XI4790 lectin, putative K10080 LMAN1; lectin, mannose-binding 1
D TbgDal_IV5290 hypothetical protein, conserved K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D TbgDal_VIII7570 hypothetical protein, conserved K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D TbgDal_VIII180 T. brucei spp.-specific protein K20368 CNIH; protein cornichon
D TbgDal_XI11670 hypothetical protein, conserved K20368 CNIH; protein cornichon
D TbgDal_XI18370 hypothetical protein, conserved K20368 CNIH; protein cornichon
D TbgDal_XI8650 glucose-regulated protein 78, putative K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D TbgDal_XI8690 glucose-regulated protein 78, putative K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D TbgDal_IV190 coatomer alpha subunit, putative K05236 COPA; coatomer subunit alpha
D TbgDal_I1540 coatomer beta subunit, putative K17301 COPB1; coatomer subunit beta
D TbgDal_II4230 beta prime COP protein K17302 COPB2; coatomer subunit beta'
D TbgDal_XI13350 coatomer gamma subunit, putative K17267 COPG; coatomer subunit gamma
D TbgDal_VIII5160 coatomer delta subunit, putative K20471 COPD; coatomer subunit delta
D TbgDal_XI16710 coatomer epsilon subunit, putative K17268 COPE; coatomer subunit epsilon
D TbgDal_X5290 coatomer zeta subunit, putative K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
C Golgi to ER traffic proteins (GET)
C Rab GTPases
C Rab associated proteins
D TbgDal_XI15670 hypothetical protein, conserved K20476 RIC1; RAB6A-GEF complex partner protein 1
D TbgDal_XI9300 ER lumen retaining receptor protein, putative K10949 KDELR; ER lumen protein retaining receptor
D TbgDal_VI2600 GTPase activating protein, conserved, putative K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
C FXYD proteins
C YIPF proteins
D TbgDal_VI1200 hypothetical protein, conserved K22940 YIPF1_2; protein YIPF1/2
D TbgDal_IX750 membrane protein YIP1, putative K20363 YIPF5_7; protein YIPF5/7
C ER membrane protein complex
D TbgDal_VII7230 hypothetical protein, conserved K23563 EMC2; ER membrane protein complex subunit 2
D TbgDal_X5790 hypothetical protein, conserved K23564 EMC3; ER membrane protein complex subunit 3
D TbgDal_VI2360 hypothetical protein, conserved K23565 EMC4; ER membrane protein complex subunit 4
D TbgDal_IV2290 hypothetical protein, conserved K23566 MMGT1; membrane magnesium transporter 1
D TbgDal_XI19200 hypothetical protein, conserved K23567 EMC6; ER membrane protein complex subunit 6
D TbgDal_VII1250 hypothetical protein, conserved K23568 EMC7; ER membrane protein complex subunit 7
D TbgDal_VIII1180 hypothetical protein, conserved K23569 EMC8_9; ER membrane protein complex subunit 8/9
C SEC61 complex
D TbgDal_XI7030 SEC61-like (pretranslocation process) protein,putative K10956 SEC61A; protein transport protein SEC61 subunit alpha
D TbgDal_III640 protein transport protein sec61 gamma subunit,putative K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
D TbgDal_VII2440 hypothetical protein, conserved K13249 SSR1; translocon-associated protein subunit alpha
C Multi-pass translocon (MPT) complex
D TbgDal_VII850 hypothetical protein, conserved K26499 NCLN; BOS complex subunit NCLN
C Post-GPI attachment to proteins factors (PGAP)
D TbgDal_III2660 hypothetical protein, conserved K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
C Others
D TbgDal_IX470 sec1 family transport protein, putative K19998 SCFD1; sec1 family domain-containing protein 1
D TbgDal_III2490 hypothetical protein, conserved K21848 ARV1; lipid intermediate transporter
D TbgDal_X17650 hypothetical protein, conserved K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
C Atg1 complex
C PI3K complex
D TbgDal_I1120 phosphatidylinositol 3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_VIII6270 PI3-kinase, putative K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D TbgDal_XI10280 protein kinase, putative K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
C ATG9 transmembrane protein
D TbgDal_XI1050 hypothetical protein, conserved K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D TbgDal_III4560 hypothetical protein, conserved K17908 WIPI1_2; autophagy-related protein 18
C Atg12 conjugation proteins
C Atg8 conjugation proteins
D TbgDal_VII3640 microtubule-associated protein 1A/1B, light chain 3, putative K08341 GABARAP; GABA(A) receptor-associated protein
D TbgDal_VII6870 microtubule-associated protein 1A/1B, light chain 3, putative K08341 GABARAP; GABA(A) receptor-associated protein
D TbgDal_VII6890 microtubule-associated protein 1A/1B, light chain 3, putative K08341 GABARAP; GABA(A) receptor-associated protein
D TbgDal_XI18290 peptidase, putative K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D TbgDal_II410 autophagocytosis associated protein, putative K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D TbgDal_III3570 aspartyl aminopeptidase, putative K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
C Other Cvt associated proteins
B Mitophagy
C Cargo receptors
C Scaffold proteins
C PINK1-Parkin associated proteins
D TbgDal_IX5860 hypothetical protein, conserved K19513 CLEC16A; protein CLEC16A
C Other mitophagy associated proteins
D TbgDal_X2400 hexokinase, putative K00844 HK; hexokinase [EC:2.7.1.1]
D TbgDal_X2420 hexokinase, putative K00844 HK; hexokinase [EC:2.7.1.1]
D TbgDal_VI2460 cysteine peptidase, Clan CA, family C19,putative K11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]
B Pexophagy
C Selective cargos
D TbgDal_X150 peroxin 14, putative K13343 PEX14; peroxin-14
C Cargo receptors
C Other pexophagy associated proteins
B Aggrephagy
C Cargo receptors
C Scaffold proteins
C Other aggrephagy associated proteins
D TbgDal_X7000 Transitional endoplasmic reticulum ATPase,putative K13525 VCP; transitional endoplasmic reticulum ATPase
B Xenophagy
C Cargo receptors
C Other xenophagy associated proteins
B ER-phagy
C ER-phagy recepters
C Other ER-phagy associated proteins
D TbgDal_X4200 hypothetical protein, conserved K23344 DDRGK1; DDRGK domain-containing protein 1
D TbgDal_X9880 hypothetical protein, conserved K22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]
C ER stress-related proteins
D TbgDal_XI8650 glucose-regulated protein 78, putative K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D TbgDal_XI8690 glucose-regulated protein 78, putative K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
D TbgDal_III2970 elongation initiation factor 2 alpha subunit,putative K03237 EIF2S1; translation initiation factor 2 subunit 1
B Chaperone mediated autophagy (CMA)
C Selective cargos
D TbgDal_X6830 fructose-bisphosphate aldolase, glycosomal putative K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
D TbgDal_X4560 aspartate aminotransferase, putative K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D TbgDal_IX5650 glyceraldehyde-3-phosphate dehydrogenase,putative K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TbgDal_VI4080 glyceraldehyde 3-phosphate dehydrogenase,glycosomal K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TbgDal_VI4110 glyceraldehyde 3-phosphate dehydrogenase,glycosomal K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TbgDal_X8410 glyceraldehyde 3-phosphate dehydrogenase,cytosolic, putative K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TbgDal_X16510 pyruvate kinase 1, putative K00873 PK; pyruvate kinase [EC:2.7.1.40]
D TbgDal_X16520 pyruvate kinase 1, putative K00873 PK; pyruvate kinase [EC:2.7.1.40]
D TbgDal_X6030 ubiquitin-like protein DSK2, putative K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D TbgDal_VII640 heat shock 70 kDa protein, putative K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D TbgDal_XI12620 heat shock protein 70, putative K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D TbgDal_XI12660 heat shock protein 70, (fragment) K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D TbgDal_X13260 Heat shock protein 83, putative K04079 HSP90A; molecular chaperone HtpG
D TbgDal_X13270 Heat shock protein 83, putative K04079 HSP90A; molecular chaperone HtpG
D TbgDal_X13280 heat shock protein K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
D TbgDal_III6040 Hsc70-interacting protein (Hip), putative K09560 ST13; suppressor of tumorigenicity protein 13
C Other CMA associated proteins
D TbgDal_X2530 elongation factor 1-alpha, putative K03231 EEF1A; elongation factor 1-alpha
D TbgDal_X2550 elongation factor 1-alpha, putative K03231 EEF1A; elongation factor 1-alpha
D TbgDal_X1360 serine carboxypeptidase III precursor, putative K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D TbgDal_X1380 serine carboxypeptidase III precursor, putative K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D TbgDal_X1400 serine carboxypeptidase III precursor, putative K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D TbgDal_X1410 serine carboxypeptidase III precursor, putative K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
C mTORC1 complex
D TbgDal_IV150 phosphatidylinositol 3-kinase tor, putative K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D TbgDal_IV590 hypothetical protein, conserved K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D TbgDal_X10260 phosphatidylinositol 3 kinase, putative K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
C mTORC2 complex
D TbgDal_IV150 phosphatidylinositol 3-kinase tor, putative K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D TbgDal_IV590 hypothetical protein, conserved K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D TbgDal_X10260 phosphatidylinositol 3 kinase, putative K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D TbgDal_VIII2950 hypothetical protein, conserved K08267 RICTOR; rapamycin-insensitive companion of mTOR
C SEACIT/GATOR1 complex
C SEACAT/GATOR2 complex
D TbgDal_X16570 protein transport protein Sec13, putative K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
C Rab associated proteins
C Others
D TbgDal_III5030 protein kinase, putative K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
D TbgDal_III990 serine/threonine-protein phosphatase, putative K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D TbgDal_VIII5420 amino acid transporter, putative K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D TbgDal_X7020 amino acid tansporter, putative K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D TbgDal_VI4630 hypothetical protein, conserved K24928 TTC5; tetratricopeptide repeat protein 5
#
AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
C Nox associated proteins
B Actin-binding proteins
C Myosins
D TbgDal_IV3390 myosin IB heavy chain, putative K10356 MYO1; myosin I
C Arp2/3 complex
D TbgDal_X15950 ARP2/3 complex subunit, putative K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D TbgDal_VIII4170 ARP2/3 complex subunit, putative K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D TbgDal_X5570 ARP2/3 complex subunit, putative K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D TbgDal_II1330 ARP2/3 complex subunit, putative K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D TbgDal_X12850 ARP2/3 complex 16kDa subunit, putative K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D TbgDal_X19350 actin-like protein 2, putative, (fragment) K17260 ACTR2; actin-related protein 2
D TbgDal_X19390 actin-like protein 2, putative K17260 ACTR2; actin-related protein 2
D TbgDal_IX2830 actin related protein 3, putative K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
C Others
D TbgDal_XI15400 profilin, putative K05759 PFN; profilin
D TbgDal_III5840 cofilin/actin depolymerizing factor, putative K05765 CFL; cofilin
B Mucins
C Membrane bound mucins
C Secretory mucins
B MARVEL domain-containing proteins
B Specific organelles associated proteins
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
C Rho guanine nucleotide exchange factors (GEFs)
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: September 19, 2025