+F Repair protein KO
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DNA Repair and Recombination Proteins - Theobroma cacao (cacao)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 18597349 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 18604822 DExH-box ATP-dependent RNA helicase DExH14 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 18606365 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 18609902 uracil-DNA glycosylase, mitochondrial K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 18599136 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 18612559 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 18601228 methyl-CpG-binding domain protein 4-like protein K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 18592379 N-glycosylase/DNA lyase OGG1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 18603837 putative DNA glycosylase At3g47830 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 18602548 endonuclease III homolog 1, chloroplastic K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 18610767 DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 18593583 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 18599104 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 18594334 uncharacterized LOC18594334 K03504 POLD3; DNA polymerase delta subunit 3
F 18599638 uncharacterized LOC18599638 K03505 POLD4; DNA polymerase delta subunit 4
F 18599640 uncharacterized LOC18599640 K03505 POLD4; DNA polymerase delta subunit 4
F 18599641 uncharacterized LOC18599641 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 18590361 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 18604482 DNA polymerase epsilon subunit B K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 18590310 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 18590558 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 18600652 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 18590967 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 18595862 DNA-repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
D Other BER factors
E 18597091 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 18597500 transcription factor bHLH140 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 18594227 polynucleotide 3'-phosphatase ZDP K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 18609378 DNA polymerase beta K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 18613182 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 18590339 poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 18613577 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 18601846 DNA repair protein RAD4 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 18610499 ubiquitin receptor RAD23c K10839 RAD23; UV excision repair protein RAD23
F 18602065 ubiquitin receptor RAD23d K10839 RAD23; UV excision repair protein RAD23
F 18596343 ubiquitin receptor RAD23b K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 18588272 RING-box protein 1a K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 18596492 cullin-4 K10609 CUL4; cullin 4
F 18607075 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 18590503 protein DAMAGED DNA-BINDING 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
F 18588292 uncharacterized LOC18588292 K15082 RAD7; DNA repair protein RAD7
F 18588153 uncharacterized LOC18588153 K15082 RAD7; DNA repair protein RAD7
F 18610587 DNA repair protein RAD16 K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 18610701 DNA-directed RNA polymerase II subunit 1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 18596855 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 18607988 DNA-directed RNA polymerases II, IV and V subunit 3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 18611686 DNA-directed RNA polymerase II subunit 4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 18597364 DNA-directed RNA polymerases IV and V subunit 4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 18588559 DNA-directed RNA polymerases II and IV subunit 5A K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 18589470 DNA-directed RNA polymerases II and IV subunit 5A K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 18598796 DNA-directed RNA polymerase V subunit 5A K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 18587326 DNA-directed RNA polymerases IV and V subunit 5B K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 18605508 DNA-directed RNA polymerases II, IV and V subunit 6A K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 18590613 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 18594588 DNA-directed RNA polymerases II, IV and V subunit 8B K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 18586467 DNA-directed RNA polymerases II, IV and V subunit 8B K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 18603623 DNA-directed RNA polymerases II, IV and V subunit 9A K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 18609497 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 18591123 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 18614612 DNA-directed RNA polymerases II, IV and V subunit 11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 18595592 DNA-directed RNA polymerases II, IV and V subunit 12 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 18588272 RING-box protein 1a K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 18596492 cullin-4 K10609 CUL4; cullin 4
F 18607075 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 18591975 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 18613116 protein CHROMATIN REMODELING 8 K10841 ERCC6; DNA excision repair protein ERCC-6
F 18613971 UV-stimulated scaffold protein A homolog K23720 UVSSA; UV-stimulated scaffold protein A
F 18596767 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 18594094 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 18606560 DNA repair helicase XPB1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 18613370 DNA repair helicase XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 18590160 probable RNA polymerase II transcription factor B subunit 1-1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 18590083 GTF2H2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 18592319 RNA polymerase II transcription factor B subunit 4 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 18596870 RNA polymerase II transcription factor B subunit 2 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 108660422 RNA polymerase II transcription factor B subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 18604245 cyclin-dependent kinase D-3 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 18600447 cyclin-H1-1 K06634 CCNH; cyclin H
E 18611514 uncharacterized LOC18611514 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 18606891 replication protein A 70 kDa DNA-binding subunit E K07466 RFA1; replication factor A1
E 18588315 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 18604843 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
E 18587613 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
E 18589297 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
E 18598253 replication protein A 14 kDa subunit B K10740 RPA3; replication factor A3
D Other NER factors
E 18600419 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 18606146 DNA repair endonuclease UVH1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 18600725 DNA repair protein UVH3 K10846 ERCC5; DNA excision repair protein ERCC-5
E 18590967 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 18596022 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 18610438 cullin-3A K03869 CUL3; cullin 3
E 18590608 transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E 18589014 uncharacterized LOC18589014 K03873 ELOB; elongin-B
E 18612117 uncharacterized LOC18612117 K15077 ELA1; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 18604054 DNA mismatch repair protein MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E 18605549 DNA mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
E 18588626 DNA mismatch repair protein MSH7 K08737 MSH6; DNA mismatch repair protein MSH6
E 18613685 DNA mismatch repair protein MSH6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 18593050 MLH1; DNA mismatch repair protein MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E 18613541 DNA mismatch repair protein PMS1 K10858 PMS2; DNA mismatch repair protein PMS2
E 18610643 DNA mismatch repair protein MLH3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 18593583 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 18599104 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 18594334 uncharacterized LOC18594334 K03504 POLD3; DNA polymerase delta subunit 3
E 18599638 uncharacterized LOC18599638 K03505 POLD4; DNA polymerase delta subunit 4
E 18599640 uncharacterized LOC18599640 K03505 POLD4; DNA polymerase delta subunit 4
E 18599641 uncharacterized LOC18599641 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 18606891 replication protein A 70 kDa DNA-binding subunit E K07466 RFA1; replication factor A1
E 18588315 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 18604843 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
E 18587613 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
E 18589297 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
E 18598253 replication protein A 14 kDa subunit B K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 18586892 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 18606466 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 18592388 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 18599796 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 18610901 uncharacterized LOC18610901 K10756 RFC3_5; replication factor C subunit 3/5
E 18606894 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 18592371 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 18590558 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 18604252 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 18596590 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 18590967 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 18587898 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 18593815 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 18602645 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 18601219 nijmegen breakage syndrome 1 protein K10867 NBN; nibrin
D BRCA1-core complex
E 18613088 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
E 18607067 protein BREAST CANCER SUSCEPTIBILITY 1 homolog K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 18588035 uncharacterized LOC18588035 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 18591561 BRCA1-A complex subunit BRE K12173 BRE; BRCA1-A complex subunit BRE
E 18595762 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 18591724 Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 18613673 BRCT domain-containing protein At4g02110 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 18592412 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 18593815 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 18602645 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 18601219 nijmegen breakage syndrome 1 protein K10867 NBN; nibrin
D BRCA complex
E 18597460 protein BREAST CANCER SUSCEPTIBILITY 2 homolog B K08775 BRCA2; breast cancer 2 susceptibility protein
E 18588206 DNA repair protein RAD51 homolog K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 18588206 DNA repair protein RAD51 homolog K04482 RAD51; DNA repair protein RAD51
E 18590829 DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 18614322 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 18590764 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 18610073 DNA repair protein XRCC2 homolog K10879 XRCC2; DNA-repair protein XRCC2
E 18589261 DNA repair protein XRCC3 homolog K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 18592767 uncharacterized LOC18592767 K26556 RAD52-1; DNA repair RAD52-like protein 1, mitochondrial
E 18612868 uncharacterized LOC18612868 K26558 RAD52-2; DNA repair RAD52-like protein 2, chloroplastic
D Rad54 family proteins
E 18607922 protein CHROMATIN REMODELING 25 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 18607728 protein CHROMATIN REMODELING 35 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 18592904 SNF2 domain-containing protein CLASSY 3 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 18585788 SNF2 domain-containing protein CLASSY 1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E 18600553 ATP-dependent DNA helicase Q-like 1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 18606963 mediator of RNA polymerase II transcription subunit 34 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 18600464 ATP-dependent DNA helicase Q-like SIM K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 18607822 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 18610689 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 18609700 ATP-dependent DNA helicase Q-like 5 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 18607822 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 18610689 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 18611919 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 18602598 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 18605144 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 18590426 uncharacterized LOC18590426 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 18606891 replication protein A 70 kDa DNA-binding subunit E K07466 RFA1; replication factor A1
E 18588315 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
E 18604843 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
E 18587613 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
E 18589297 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
E 18598253 replication protein A 14 kDa subunit B K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 18593416 serine/threonine-protein phosphatase PP-X isozyme 2 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 18603798 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 18603618 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
E 18609906 uncharacterized LOC18609906 K19022 AP5B1; AP-5 complex subunit beta-1
E 18603376 AP-5 complex subunit mu K19023 AP5M1; AP-5 complex subunit mu-1
E 18593603 AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 18599560 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 18605339 structural maintenance of chromosomes protein 6A K22804 SMC6; structural maintenance of chromosomes protein 6
E 18590844 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 18594079 E3 SUMO-protein ligase MMS21 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 18599096 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 18589697 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 18611715 crossover junction endonuclease EME1B K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 18585749 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 18603882 protein DELETION OF SUV3 SUPPRESSOR 1(I) K10881 SHFM1; 26 proteasome complex subunit DSS1
E 18591071 uncharacterized LOC18591071 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 18586108 structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 18614227 flap endonuclease GEN-like 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 18605548 flap endonuclease GEN-like 2 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 18611704 uncharacterized LOC18611704 K19026 SPG11; spatacsin
E 18587909 uncharacterized LOC18587909 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 18611204 protein MRG1 K11339 MORF4L1; mortality factor 4-like protein 1
E 18592048 protein MRG2 K11339 MORF4L1; mortality factor 4-like protein 1
E 18600746 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 18609440 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 18587289 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 18601000 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 18608052 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 18602647 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
E 18593311 DNA-dependent metalloprotease WSS1 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E 18610477 single-stranded DNA-binding protein WHY1, chloroplastic K26559 WHY1; single-stranded DNA-binding protein WHY1
E 18592762 single-stranded DNA-bindig protein WHY2, mitochondrial K26561 WHY2; single-stranded DNA-binding protein WHY2
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 18594301 ATP-dependent DNA helicase 2 subunit KU70 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 18614298 ATP-dependent DNA helicase 2 subunit KU80 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 18593815 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 18602645 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 18589404 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 18603137 DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 18609378 DNA polymerase beta K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 18597500 transcription factor bHLH140 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 18597170 uncharacterized LOC18597170 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 18605777 uncharacterized LOC18605777 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
C FA (Fanconi anemia) pathway
D FA core complex
E 18611356 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 18592978 uncharacterized LOC18592978 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 18605201 MHF histone-fold complex subunit 1 K11511 APITD1; centromere protein S
E 18605001 centromere protein X K15360 STRA13; centromere protein X
E 18588608 probable ubiquitin-conjugating enzyme E2 37 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 18607822 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 18610689 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 18611919 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 18602598 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 18605144 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 18590426 uncharacterized LOC18590426 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 18612304 Fanconi anemia group D2 protein homolog K10891 FANCD2; fanconi anemia group D2 protein
E 18603531 Fanconi anemia group I protein homolog K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 18597460 protein BREAST CANCER SUSCEPTIBILITY 2 homolog B K08775 BRCA2; breast cancer 2 susceptibility protein
E 18591724 Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 18602562 fanconi-associated nuclease 1 homolog K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 18588206 DNA repair protein RAD51 homolog K04482 RAD51; DNA repair protein RAD51
E 18614322 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 18605042 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 18600271 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 18608428 phytochrome-associated serine/threonine-protein phosphatase K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 18590884 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 18595035 serine/threonine-protein phosphatase 6 regulatory subunit 2 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
D Others
E 18596953 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 18613047 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 18587898 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 18607006 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 18608091 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 18608025 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 18600364 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 18610470 ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 18604625 ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 18599807 ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 18590411 putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 2 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D 18603170 putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 3 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D 18598591 putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 18609862 ubiquitin-conjugating enzyme E2 variant 1A K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 18598359 ubiquitin-conjugating enzyme E2 variant 1D K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 18594172 ubiquitin-conjugating enzyme E2 36 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 18590558 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
D 18600470 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 18595322 uncharacterized LOC18595322 K10903 HUS1; HUS1 checkpoint protein
D 18606791 uncharacterized LOC18606791 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 18610737 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 18606466 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 18592388 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 18599796 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 18610901 uncharacterized LOC18610901 K10756 RFC3_5; replication factor C subunit 3/5
D 18606894 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 18592371 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 18606791 uncharacterized LOC18606791 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 18605676 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 18610060 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 18605042 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 18594747 uncharacterized LOC18594747 K20403 TTI1; TELO2-interacting protein 1
D 18585954 uncharacterized protein At2g39910 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 18588893 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 18586339 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 18607481 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 18603913 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 18612046 14-3-3-like protein B K06630 YWHAE; 14-3-3 protein epsilon
D 18608255 14-3-3 protein 6 K06630 YWHAE; 14-3-3 protein epsilon
D 18589754 14-3-3-like protein A K06630 YWHAE; 14-3-3 protein epsilon
D 18596695 14-3-3-like protein D K06630 YWHAE; 14-3-3 protein epsilon
D 18592147 14-3-3 protein 7 K06630 YWHAE; 14-3-3 protein epsilon
D 18591785 14-3-3-like protein B K06630 YWHAE; 14-3-3 protein epsilon
D 18592122 14-3-3-like protein K06630 YWHAE; 14-3-3 protein epsilon
D 18613510 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 18603416 uncharacterized LOC18603416 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 18589787 serine/threonine-protein kinase Nek6 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 18599034 serine/threonine-protein kinase Nek6 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 18600227 serine/threonine-protein kinase Nek2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 18613291 serine/threonine-protein kinase Nek2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 18590227 serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 18598467 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 18590343 protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 18613987 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 18591496 protein DECREASED SIZE EXCLUSION LIMIT 1 K24770 DSE1; protein decreased size exclusion limit 1
B Other factors with a suspected DNA repair function
C DNA polymerases
D 18587916 helicase and polymerase-containing protein TEBICHI K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 18608165 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 18605643 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 18611859 protein artemis K15340 DCLRE1A; DNA cross-link repair 1A protein
D 18601164 DNA cross-link repair protein SNM1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 18588176 DNA cross-link repair protein SNM1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 18608578 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 18590093 exonuclease V, chloroplastic K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 18587567 endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 18604779 DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 18596931 endonuclease 1 K05986 NUCS; nuclease S1 [EC:3.1.30.1]
D 18596932 endonuclease 4 K05986 NUCS; nuclease S1 [EC:3.1.30.1]
D 18609213 endonuclease 2 K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
D 18608731 switch 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 18603299 pre-mRNA-processing factor 19 homolog 1 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 18600076 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 18595237 pre-mRNA-splicing factor SPF27 homolog K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 18603521 protein pleiotropic regulatory locus 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 18610563 nudix hydrolase 1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 18591367 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 18611720 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 18602878 ribonucleoside-diphosphate reductase small chain A K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 18601017 ribonucleoside-diphosphate reductase small chain K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 18606365 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 18609902 uracil-DNA glycosylase, mitochondrial K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 18610919 DNA-3-methyladenine glycosylase 1 K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E 18591392 probable DNA-3-methyladenine glycosylase 2 K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E 18599136 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 18612559 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 18587847 uncharacterized LOC18587847 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 18610162 DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 18606983 uncharacterized LOC18606983 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 18594976 probable GMP synthase [glutamine-hydrolyzing] K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 18595431 probable GMP synthase [glutamine-hydrolyzing] K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 18591344 probable GMP synthase [glutamine-hydrolyzing] K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E 18595327 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E 18603837 putative DNA glycosylase At3g47830 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E 18602548 endonuclease III homolog 1, chloroplastic K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 18598841 DNA-(apurinic or apyrimidinic site) lyase, chloroplastic K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
D DNA ligase
D DNA polymerase I
E 18593578 DNA polymerase I B, chloroplastic/mitochondrial K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E 18593578 DNA polymerase I B, chloroplastic/mitochondrial K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F 9978095 rpoB; RNA polymerase beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F 9978093 rpoC2; RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F 9978094 rpoC1; RNA polymerase beta K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F 9978151 rpoA; RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 18596867 endonuclease MutS2 K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 18604042 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E 18588379 DNA repair protein recA homolog 3, mitochondrial K03553 recA; recombination protein RecA
E 18594624 DNA repair protein recA homolog 1, chloroplastic K03553 recA; recombination protein RecA
D RecFOR pathway proteins
E 18588379 DNA repair protein recA homolog 3, mitochondrial K03553 recA; recombination protein RecA
E 18594624 DNA repair protein recA homolog 1, chloroplastic K03553 recA; recombination protein RecA
E 18596043 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E 18609773 ATP-dependent DNA helicase homolog RECG, chloroplastic K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F 18586967 DNA gyrase subunit A, chloroplastic/mitochondrial K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F 18598680 DNA gyrase subunit B, chloroplastic/mitochondrial K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 18588379 DNA repair protein recA homolog 3, mitochondrial K03553 recA; recombination protein RecA
D 18594624 DNA repair protein recA homolog 1, chloroplastic K03553 recA; recombination protein RecA
D 18604042 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 18610563 nudix hydrolase 1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 18591367 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024