+E Replication protein KO
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DNA Replication Proteins - Triplophysa dalaica
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 130424383 orc1; origin recognition complex subunit 1 isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 130410025 orc2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 130437253 orc3; origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 130424513 orc4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 130421500 orc5; origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 130423763 orc6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 130427971 cdt1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 130410496 cdc6; cell division control protein 6 homolog isoform X1 K02213 CDC6; cell division control protein 6
D 130430020 mcm2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 130434296 mcm3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 130434455 mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 130413270 mcm4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 130426799 mcm5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 130424731 mcm6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 130417844 mcm6l; MCM6 minichromosome maintenance deficient 6, like isoform X1 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 130437787 mcm7; DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 130411929 ccna1; cyclin-A1 K06627 CCNA; cyclin-A
D 130438368 ccna2; cyclin-A2 K06627 CCNA; cyclin-A
D 130424956 ccne1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 130433025 ccne2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 130415704 G1/S-specific cyclin-E2-like K06626 CCNE; G1/S-specific cyclin-E1
D 130427402 cdk2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 130418410 cdc7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 130432768 dbf4; protein DBF4 homolog A K06629 DBF4; protein DBF4
C GINS complex
D 130431977 gins1; DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 130435189 gins2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 130414194 gins3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 130440212 gins4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 130413663 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 130415968 recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 130440406 cdc45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 130437121 mcm8; DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 130433857 mcm9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 130420946 mcm10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 130420910 DNA helicase B-like K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 130421179 helb; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 130419466 serine protease FAM111A-like K24274 FAM111A; protein FAM111A
D 130419494 serine protease FAM111A-like isoform X1 K24274 FAM111A; protein FAM111A
D 130419621 serine protease FAM111A-like K24274 FAM111A; protein FAM111A
D 130419391 serine protease FAM111A-like K24274 FAM111A; protein FAM111A
D 130437030 cinp; cyclin-dependent kinase 2-interacting protein isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 130432849 mtbp; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 130414619 ticrr; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 130413670 pola1; LOW QUALITY PROTEIN: DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 130440171 pola2; DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 130408816 prim1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 130431645 prim2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 130420005 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 130436596 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 130420072 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 130409923 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 130425721 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 130406899 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 130407952 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D 130410489 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 130414221 polg; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 130425340 polg2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 130429195 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 130432512 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
C RFC (replication factor C)
D 130414098 rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 130408009 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 130410207 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 130412008 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 130419035 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 130434312 rnaseh1; ribonuclease H1 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 130409771 rnaseh2a; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 130427681 rnaseh2b; ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 130438298 rnaseh2c; ribonuclease H2 subunit C isoform X1 K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 130412134 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 130431774 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 130413113 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 130417960 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 130417961 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 130437329 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 130430559 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 130418483 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 130426552 atad5a; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 130426599 dnmt1; DNA (cytosine-5)-methyltransferase 1 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 130437075 dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 130434042 dnmt3aa; DNA (cytosine-5-)-methyltransferase 3 alpha a isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 130408786 dnmt3bb.1; DNA (cytosine-5)-methyltransferase 3B isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 130440242 dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 130412268 mcidas; multicilin K26119 MCIDAS; multicilin
D 130435592 G2/mitotic-specific cyclin-B1-like isoform X1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 130419371 ccnb1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 130423376 ccnb2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 130407435 G2/mitotic-specific cyclin-B3-like K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 130427318 ccnb3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 130437370 cdk1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 130414545 pot1; LOW QUALITY PROTEIN: protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 130413709 terf1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 130420889 terfa; telomeric repeat binding factor a isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 130416071 tinf2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 130430163 terf2ip; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 130430081 acd; adrenocortical dysplasia protein homolog K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 130436019 terb1; telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 130427111 terb2; telomere repeats-binding bouquet formation protein 2 isoform X1 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 130431062 membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 130408870 ctc1; CST complex subunit CTC1 isoform X1 K23311 CTC1; CST complex subunit CTC1
E 130436033 stn1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 130424411 ten1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 130411409 smg6; LOW QUALITY PROTEIN: telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 130432873 smg5; nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 130415884 tert; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 130417502 tep1; telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 130438143 gar1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 130408387 nhp2; H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 130408338 dkc1; H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 130415884 tert; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 130424736 snrpb; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 130415265 snrpd1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 130435611 snrpd2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 130408090 snrpd3l; small nuclear ribonucleoprotein D3 polypeptide, like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 130439879 snrpd3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 130410632 snrpe; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 130420918 snrpf; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 130409510 snrpg; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 130408009 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 130410207 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 130412008 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 130419035 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 130429164 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 130408149 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 130433121 nbn; nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 130428577 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 130411363 wrn; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 130435363 blm; recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 130440155 prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 130438990 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 130434927 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 130424205 parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 130417992 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 130427649 parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 130407836 tnksa; poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 130418886 tnksb; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 130434786 pinx1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 130410716 rtel1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 130412898 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 130425997 trir; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 130427600 rif1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 130417967 pif1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 130438244 purab; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 130407428 puraa; purine-rich element binding protein Aa K21772 PURA; transcriptional activator protein Pur-alpha
D 130437938 wrap53; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
D 130429404 sde2; splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 130424781 rtf2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 130413400 top1mt; DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 130409903 top1a; DNA topoisomerase I, like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 130435621 zgc:173742; DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 130415331 top2b; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 130439358 top2a; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 130419855 top3b; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 130426730 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 130421163 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 130434312 rnaseh1; ribonuclease H1 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 130434312 rnaseh1; ribonuclease H1 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 130431774 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 130413113 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 130417960 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 130417961 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 130418483 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022