+D Protein KO
#
Membrane Trafficking - Toxoplasma gondii
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
C Septins
C DOC-2 proteins
C Acrosomal exocytosis proteins
C Phospholipases
C Kinases and associated proteins
D 7897831 nucleoside diphosphate kinase, putative K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
C Others
B Small GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D 7894828 CAM2; calmodulin CAM2 K02183 CALM; calmodulin
D 7899483 calmodulin, putative K02183 CALM; calmodulin
D 7901452 calmodulin, putative K02183 CALM; calmodulin
D 7893982 PF2 arrest specific protein 8/11, putative K19942 GAS8; dynein regulatory complex subunit 4
D 7898540 hypothetical protein K19942 GAS8; dynein regulatory complex subunit 4
C Rho GTPases
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
C Exocyst complex assembly proteins
B Others
C Exomer complex
C ER-PM contacts associated proteins
C Others
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
C Stx-Endo
C Stx-TGN / EE
D 7895959 SNARE domain-containing protein K08489 STX16; syntaxin 16
C Stx-cisGolgi
D 7897613 syntaxin 5, putative K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
B SNAP-25[N] (Qb)
C Vti1
C NPSN
C Gos1 (Gos28)
C Bos1 / Membrin
C Sec20
B SNAP-25[C] (Qc)
C STX6
D 7895180 syntaxin 6, n-terminal protein K08500 SYP6; syntaxin of plants SYP6
C STX8
C STX10
C Bet1
D 7894412 hypothetical protein K08504 BET1; blocked early in transport 1
C Sft1
C Syp7
C Use1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D 7899832 vesicle-associated membrane protein, putative K08515 VAMP7; vesicle-associated membrane protein 7
C Ykt6
D 7895777 prenylated protein, putative K08516 YKT6; synaptobrevin homolog YKT6
D 7897040 SNARE protein K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D 7894536 synaptobrevin family protein K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
C Palmitoyltransferases
D 7901541 DHHC zinc finger domain-containing protein K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
C Others
D 7901210 N-ethylmaleimide-sensitive fusion protein, putative K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D 7895045 CDC48CY; cell division protein CDC48CY K13525 VCP; transitional endoplasmic reticulum ATPase
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D 7896454 clathrin heavy chain, putative K04646 CLTC; clathrin heavy chain
C Dynamin
D 7893800 DRPA; dynamin-related protein DRPA K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D 29769796 AP-2 complex subunit sigma-1, putative K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D 7895357 HSP70; heat shock protein HSP70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
C GPCR adaptor proteins
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
C Kinases
C Ubiquitin E3 ligases
C Others
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D 7893800 DRPA; dynamin-related protein DRPA K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
C Arf6-dependent endocytosis
C RhoA-dependent endocytosis
D 7893800 DRPA; dynamin-related protein DRPA K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D 7894864 myosin D K10356 MYO1; myosin I
D 7900154 myosin A K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
C Kinases
C Phospholipase C
C Sorting nexins
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
C F-BAR proteins
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
C Rab associated proteins
D 7893465 Sec1 family protein K12479 VPS45; vacuolar protein sorting-associated protein 45
B Arf GTPases and associated proteins
C Arf GTPases
C Arf associated proteins
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
C FTS/Hook/FHIP (FHF) complex
C FERRY complex
C Rab associated proteins
D 7895514 proteasome subunit alpha type 7, putative K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
B Arf GTPases and associated proteins
C Arf GTPases
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
C ESCRT-I complex
C ESCRT-II complex
C ESCRT-III complex
C ESCRT associated proteins
B Tethering complex
C CORVET complex
D 7895221 vacuolar protein sorting 16, putative K20180 VPS16; vacuolar protein sorting-associated protein 16
C Hops complex
D 7895221 vacuolar protein sorting 16, putative K20180 VPS16; vacuolar protein sorting-associated protein 16
B Acidification regulators
C Rabconnectin-3 complex
C RAVE complex
D 7896261 suppressor of kinetochore protein 1, putative K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D 7897080 adaptor-related protein complex 3, sigma 2 subunit K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Lysosomal membrane proteins
C Others
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
C Rab4 associated proteins
C Rab11 associated proteins
C Other Rab GTPase associated proteins
D 7900581 sarcalumenin/eps15 family protein K12483 EHD1; EH domain-containing protein 1
D 7893468 DNA repair protein RAD51, putative K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D 7898828 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
C WASH complex
C Retriever complex
D 29769287 vacuolar protein sorting 29, putative K18467 VPS29; vacuolar protein sorting-associated protein 29
C CCC complex
C Others
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
C Retromer subcomplex
D 7894912 vacuolar sorting protein 35, putative K18468 VPS35; vacuolar protein sorting-associated protein 35
D 29769287 vacuolar protein sorting 29, putative K18467 VPS29; vacuolar protein sorting-associated protein 29
D 7897250 vacuolar protein sorting-associated protein 26, putative K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C Rab associated proteins
B Arf GTPases and associated proteins
C Arf GTPases
D 7895498 ADP-ribosylation factor family protein 1, putative K07942 ARL1; ADP-ribosylation factor-like protein 1
C Arf GTPase associated proteins
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
C GARP complex
D 7898828 Vps52 / Sac2 family protein K20298 VPS52; vacuolar protein sorting-associated protein 52
C TRAPP complex II
D 7895684 mbp-1 interacting protein-2a family protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D 7895753 Sedlin, N-terminal region protein, putative K20301 TRAPPC2; trafficking protein particle complex subunit 2
D 7895779 Bet3 transport protein, putative K20302 TRAPPC3; trafficking protein particle complex subunit 3
D 7899975 sybindin family protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D 7894576 transport protein particle component, Bet3 domain-containing protein K20280 TRAPPC5; trafficking protein particle complex subunit 5
D 7898829 hypothetical protein K20310 TRAPPC13; trafficking protein particle complex subunit 13
B Others
C AP-1 complex
D 7901148 beta adaptin protein, putative K12392 AP1B1; AP-1 complex subunit beta-1
D 7897780 mu1 adaptin K12393 AP1M; AP-1 complex subunit mu
D 7897004 clathrin assembly protein AP19, putative K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D 7897080 adaptor-related protein complex 3, sigma 2 subunit K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
D 7896616 coatomer protein complex, gamma sub-unit, putative K12402 AP4M1; AP-4 complex subunit mu-1
D 7897684 clathrin adaptor complex small chain family protein K12403 AP4S1; AP-4 complex subunit sigma-1
C GGA
C Aftiphilin/p200/gamma-synergin complex
C Others
D 7897795 sortilin, putative K28985 PEP1; vacuolar protein sorting/targeting protein 10
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D 7900768 small GTP-binding protein sar1, putative K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D 7896540 Sec23/Sec24 trunk domain-containing protein K14006 SEC23; protein transport protein SEC23
C TRAPP complex I
D 7895684 mbp-1 interacting protein-2a family protein K20301 TRAPPC2; trafficking protein particle complex subunit 2
D 7895753 Sedlin, N-terminal region protein, putative K20301 TRAPPC2; trafficking protein particle complex subunit 2
D 7895779 Bet3 transport protein, putative K20302 TRAPPC3; trafficking protein particle complex subunit 3
D 7899975 sybindin family protein K20303 TRAPPC4; trafficking protein particle complex subunit 4
D 7894576 transport protein particle component, Bet3 domain-containing protein K20280 TRAPPC5; trafficking protein particle complex subunit 5
C p24 family proteins
D 7894732 transmembrane protein K20346 TMED4_9_11; p24 family protein alpha
D 7897783 hypothetical protein K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D 7901012 protein disulfide isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
C Rab GTPases
C Rab associated proteins
C ER-Golgi intermediate compartment (ERGIC) proteins
D 7896014 chaperonin protein BiP K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]
D 29769609 RER1 protein, putative K29081 RER1; Rer1 family protein
B Retrieval pathways
C Coat protein complex I (COP-I)
D 7893910 coatomer protein complex, subunit alpha, putative K05236 COPA; coatomer subunit alpha
D 7900919 beta-COP K17301 COPB1; coatomer subunit beta
D 7895334 coatomer gamma 2-subunit protein, putative K17267 COPG; coatomer subunit gamma
D 7895266 adaptor complexes medium subunit family protein K20471 COPD; coatomer subunit delta
D 7899760 clathrin adaptor complex small chain subfamily protein K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
C Golgi to ER traffic proteins (GET)
D 7898910 arsenite-activated ATPase family protein K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
C Rab GTPases
C Rab associated proteins
D 29769495 endoplasmic reticulum lumen protein retaining receptor (ERD2) family protein K10949 KDELR; ER lumen protein retaining receptor
D 7894192 ER-retrevial receptor Ter1p, putative K10949 KDELR; ER lumen protein retaining receptor
D 7896661 endoplasmic reticulum retention receptor K10949 KDELR; ER lumen protein retaining receptor
B Others
C Oxysterol-binding proteins
C FXYD proteins
C YIPF proteins
C ER membrane protein complex
D 7894360 membrane protein, putative K23564 EMC3; ER membrane protein complex subunit 3
C SEC61 complex
D 7894544 preprotein translocase Sec61, putative K10956 SEC61A; protein transport protein SEC61 subunit alpha
C TRAP complex
C Multi-pass translocon (MPT) complex
C Post-GPI attachment to proteins factors (PGAP)
C Others
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
C Atg1 complex
C PI3K complex
C ATG9 transmembrane protein
C Atg18-Atg2 complex
C Atg12 conjugation proteins
C Atg8 conjugation proteins
D 7900047 autophagy-related protein 8 atg8, putative K08341 GABARAP; GABA(A) receptor-associated protein
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D 7901480 aspartyl aminopeptidase K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
C Other Cvt associated proteins
B Mitophagy
C Cargo receptors
C Scaffold proteins
C PINK1-Parkin associated proteins
C Other mitophagy associated proteins
D 7893817 hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
B Pexophagy
C Selective cargos
C Cargo receptors
C Other pexophagy associated proteins
B Aggrephagy
C Cargo receptors
C Scaffold proteins
C Other aggrephagy associated proteins
D 7895045 CDC48CY; cell division protein CDC48CY K13525 VCP; transitional endoplasmic reticulum ATPase
B Xenophagy
C Cargo receptors
C Other xenophagy associated proteins
B ER-phagy
C ER-phagy recepters
D 7900017 translocation protein sec62, putative K12275 SEC62; translocation protein SEC62
C Other ER-phagy associated proteins
C ER stress-related proteins
D 7896014 chaperonin protein BiP K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]
D 7898318 heat shock protein 90, putative K09487 HSP90B; heat shock protein 90kDa beta
D 7896028 eukaryotic initiation factor-2, alpha subunit K03237 EIF2S1; translation initiation factor 2 subunit 1
B Chaperone mediated autophagy (CMA)
C Selective cargos
D 7900118 fructose-1,6-bisphosphate aldolase K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
D 7900119 fructose-bisphosphate aldolase, putative K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
D 7901097 PYKI; pyruvate kinase PyK1 K00873 PK; pyruvate kinase [EC:2.7.1.40]
D 7896366 ubiquitin family protein K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D 7895357 HSP70; heat shock protein HSP70 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D 7896433 HSP90; heat shock protein HSP90 K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
D 7900576 HIP; Hsp70 interacting protein HIP K09560 ST13; suppressor of tumorigenicity protein 13
C Other CMA associated proteins
D 7894068 elongation factor 1-alpha (EF-1-ALPHA), putative K03231 EEF1A; elongation factor 1-alpha
D 7898184 elongation factor 1-alpha (EF-1-ALPHA), putative K03231 EEF1A; elongation factor 1-alpha
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
C mTORC1 complex
C mTORC2 complex
C SEACIT/GATOR1 complex
C SEACAT/GATOR2 complex
C KICSTOR complex
C Rab GTPases
C Rab associated proteins
C Others
D 7896355 serine/threonine-protein phosphatase PP2A catalytic subunit K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
#
AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
C Nox associated proteins
B Actin-binding proteins
C Myosins
D 7894864 myosin D K10356 MYO1; myosin I
D 7900154 myosin A K10356 MYO1; myosin I
C Arp2/3 complex
C Nucleation-promoting factors (NPFs)
C Others
D 7893682 ADF; actin depolymerizing factor ADF K05765 CFL; cofilin
B Mucins
C Membrane bound mucins
C Secretory mucins
B MARVEL domain-containing proteins
B Specific organelles associated proteins
C Melanosome
C Auto phagosome
C Lipid droplets
D 7895735 Rab18/RabC-family small GTPase K07910 RAB18; Ras-related protein Rab-18
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
C Rho guanine nucleotide exchange factors (GEFs)
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 6, 2026