+E Replication protein KO
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DNA Replication Proteins - Tarenaya hassleriana (spider flower)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 104799099 origin of replication complex subunit 1B-like K02603 ORC1; origin recognition complex subunit 1
D 104806568 origin of replication complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 104809222 LOW QUALITY PROTEIN: origin of replication complex subunit 2-like K02604 ORC2; origin recognition complex subunit 2
D 104821161 origin of replication complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 104805050 origin of replication complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 104825846 origin of replication complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 104822117 origin of replication complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 104800876 CDT1-like protein a, chloroplastic K10727 CDT1; chromatin licensing and DNA replication factor 1
D 104826211 CDT1-like protein a, chloroplastic K10727 CDT1; chromatin licensing and DNA replication factor 1
D 104825264 CDT1-like protein b K10727 CDT1; chromatin licensing and DNA replication factor 1
D 104800725 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 104816080 cell division control protein 6 homolog B-like K02213 CDC6; cell division control protein 6
D 104801409 DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 104806124 DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 104819624 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 104808931 DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 104811945 DNA replication licensing factor MCM6 isoform X1 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 104801305 DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 104799792 putative cyclin-A3-1 isoform X1 K06627 CCNA; cyclin-A
D 104800218 cyclin-A1-2 isoform X1 K06627 CCNA; cyclin-A
D 104806825 cyclin-A1-1 K06627 CCNA; cyclin-A
D 104808211 cyclin-A2-4-like isoform X1 K06627 CCNA; cyclin-A
D 104808251 cyclin-A1-1-like isoform X1 K06627 CCNA; cyclin-A
D 104812477 cyclin-A2-4-like isoform X1 K06627 CCNA; cyclin-A
D 104820502 putative cyclin-A3-1 isoform X1 K06627 CCNA; cyclin-A
D 104825754 putative cyclin-A3-1 K06627 CCNA; cyclin-A
D 104815036 cyclin-A2-2 K06627 CCNA; cyclin-A
D 104813571 cyclin-A2-4-like K06627 CCNA; cyclin-A
D 104814180 putative cyclin-A3-1 isoform X1 K06627 CCNA; cyclin-A
D 104818174 cyclin-dependent kinase A-1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 104825029 cell division control protein 2 homolog A-like isoform X1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 104807924 uncharacterized protein LOC104807924 isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 104812498 probable DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 104827330 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 104824313 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 104827096 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 104800232 DNA topoisomerase 2-binding protein 1-A-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 104810225 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 104815922 BRCT domain-containing protein At4g02110-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 104813680 DNA topoisomerase 2-binding protein 1-A isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 104825943 BRCT domain-containing protein At4g02110 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 104820520 ATP-dependent DNA helicase Q-like 5 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 104808789 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 104816318 probable DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 104819509 probable DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 104807811 protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 104827210 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 104807895 DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 104809335 DNA primase small subunit isoform X1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 104807138 probable DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 104825491 probable DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 104826411 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 104810934 DNA polymerase epsilon subunit B K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 104826426 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 104815749 DNA polymerase epsilon subunit C K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 104818425 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 104824475 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
D 104808089 uncharacterized protein LOC104808089 K03504 POLD3; DNA polymerase delta subunit 3
D 104820303 uncharacterized protein LOC104820303 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
D 104804633 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
D 104806192 replication protein A 70 kDa DNA-binding subunit E-like isoform X1 K07466 RFA1; replication factor A1
D 104826582 replication protein A 70 kDa DNA-binding subunit A isoform X1 K07466 RFA1; replication factor A1
D 104819400 replication protein A 70 kDa DNA-binding subunit B-like K07466 RFA1; replication factor A1
D 104802929 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
D 104803594 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
D 104805250 replication protein A 14 kDa subunit B-like isoform X1 K10740 RPA3; replication factor A3
D 104804847 replication protein A 14 kDa subunit B K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 104810945 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 104800216 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 104809417 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104800207 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 104824562 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 104824207 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 104811993 ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 104824253 uncharacterized protein C12B10.15c K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 104815801 proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
D 104826301 proliferating cell nuclear antigen 2-like K04802 PCNA; proliferating cell nuclear antigen
D 104808236 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 104818763 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 104812654 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 104813917 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 104818327 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 104800577 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 104800189 uncharacterized protein LOC104800189 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 104798456 DNA (cytosine-5)-methyltransferase CMT2 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 104809536 putative DNA (cytosine-5)-methyltransferase CMT1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 104820805 DNA (cytosine-5)-methyltransferase 1-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 104815273 DNA (cytosine-5)-methyltransferase CMT3 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 104823726 DNA (cytosine-5)-methyltransferase 1-like isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 104802799 uncharacterized protein LOC104802799 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 104805940 cyclin-SDS K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104816953 cyclin-B1-4-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104800470 cyclin-B1-4 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104809782 cyclin-B2-4-like isoform X2 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104811466 cyclin-B2-4-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104808136 putative cyclin-B3-1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104809968 cyclin-B1-3-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104816598 cyclin-B1-3 isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104819723 cyclin-B2-1-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 104804291 cyclin-B2-1-like isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
E 104800748 CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 104805904 CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 104827206 LOW QUALITY PROTEIN: telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 104802867 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 104827273 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 104818364 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 104813898 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 104804047 H/ACA ribonucleoprotein complex subunit 3-like protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 104814520 H/ACA ribonucleoprotein complex subunit 3-like protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 104803283 LOW QUALITY PROTEIN: H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 104816817 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 104824422 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 104827206 LOW QUALITY PROTEIN: telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 104806243 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 104812077 small nuclear ribonucleoprotein-associated protein B'-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 104801227 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 104822445 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 104819017 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 104802174 small nuclear ribonucleoprotein Sm D2-like isoform X1 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 104817495 small nuclear ribonucleoprotein Sm D2-like K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 104809773 small nuclear ribonucleoprotein SmD3b K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 104811465 small nuclear ribonucleoprotein SmD3b-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 104803931 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 104803508 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 104803938 probable small nuclear ribonucleoprotein F isoform X1 K11098 SNRPF; small nuclear ribonucleoprotein F
E 104803496 probable small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 104826821 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 104823127 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 104800216 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 104809417 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104800207 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 104824562 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 104813315 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 104826172 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 104820929 nijmegen breakage syndrome 1 protein K10867 NBN; nibrin
C Other termination factors
D 104818218 serine/threonine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 104809610 ATP-dependent DNA helicase Q-like 4A isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 104819729 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 104807928 DNA repair endonuclease UVH1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 104800882 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 104801277 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 104799546 poly [ADP-ribose] polymerase 3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 104817794 G patch domain-containing protein 4 K11135 PINX1; Pin2-interacting protein X1
D 104812517 regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 104818196 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 104810308 transcription factor Pur-alpha 1 isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 104806275 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 104801375 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 104817053 protein SDE2 homolog isoform X1 K25059 SDE2; replication stress response regulator SDE2
D 104817828 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 104817691 DNA topoisomerase 1 alpha K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 104811639 DNA topoisomerase 1 alpha K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 104820131 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 104800954 DNA topoisomerase 3-beta isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 104818422 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 104803364 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
D 104821851 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
D Other elongation factors
E 104817879 DNA polymerase I A, chloroplastic/mitochondrial K02335 polA; DNA polymerase I [EC:2.7.7.7]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
D RFC (replication factor C)
D Other elongation factors
E 104808236 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 104818763 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 104800577 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
C 104826959 DNA gyrase subunit A, chloroplastic/mitochondrial isoform X1 K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C 104816412 DNA gyrase subunit B, chloroplastic isoform X1 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C 104826889 DNA gyrase subunit B, mitochondrial-like isoform X1 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C 104816912 DNA topoisomerase 6 subunit B isoform X1 K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022