+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Thermotomaculum hydrothermale</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
C    RFC (replication factor C)
C    RNase H
D      TTHT_1515 rnhA; ribonuclease HI	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
C    Other elongation factors
B  DNA Replication Termination Factors
C    DNA methylation enzymes
D      TTHT_0287 dcm; DNA (cytosine-5)-methyltransferase 1	K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      TTHT_0767 DNA-binding protein HU-beta	K03530 hupB; DNA-binding protein HU-beta 
D      TTHT_0948 DNA-binding protein HU-beta	K03530 hupB; DNA-binding protein HU-beta 
D      TTHT_1100 DNA-binding protein HU-beta	K03530 hupB; DNA-binding protein HU-beta 
D      TTHT_0001 dnaA; chromosomal replication initiator protein	K02313 dnaA; chromosomal replication initiator protein 
D      TTHT_0909 dnaB; replicative DNA helicase	K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] 
D      TTHT_0725 dnaC; DNA replication protein DnaC	K02315 dnaC; DNA replication protein DnaC 
D      TTHT_1516 DNA primase	K02316 dnaG; DNA primase [EC:2.7.7.101] 
D      TTHT_1782 DNA primase	K02316 dnaG; DNA primase [EC:2.7.7.101] 
D      TTHT_1879 ssb; single-strand DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
C    Initiation factors (archaeal)
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
E        TTHT_2024 dnaE; dnaE DNA polymerase III subunit alpha	K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] 
E        TTHT_2055 dnaN; DNA polymerase III subunit beta	K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] 
E        TTHT_1607 hypothetical protein	K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] 
E        TTHT_1102 dnaX; DNA polymerase III subunit gamma/tau	K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 
D      RNase H
E        TTHT_1515 rnhA; ribonuclease HI	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
E        TTHT_0996 rnhB; ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      Other elongation factors
E        TTHT_1563 polA; DNA polymerase I	K02335 polA; DNA polymerase I [EC:2.7.7.7] 
E        TTHT_1993 conserved hypothetical protein	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
C    Elongation factors (archaeal)
D      B-family DNA polymerases
D      D-family DNA polymerases
D      RNase H
E        TTHT_1515 rnhA; ribonuclease HI	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
E        TTHT_0996 rnhB; ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      RFC (replication factor C)
D      Other elongation factors
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
C    Prevention of re-replication factors
B  DNA Topoisomerases
C    TTHT_2058 gyrA; DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
C    TTHT_2057 gyrB; DNA gyrase subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
C    TTHT_0628 topA; DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
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#Last updated: July 3, 2025