+E Replication protein KO
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DNA Replication Proteins - Temnothorax longispinosus
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 139808967 Orc1; (RefSeq) origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 139812723 Orc2; (RefSeq) origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 139820177 Orc3; (RefSeq) origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 139823058 Orc4; (RefSeq) origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 139809329 Orc5; (RefSeq) origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 139813976 Dup; (RefSeq) uncharacterized protein Dup K10727 CDT1; chromatin licensing and DNA replication factor 1
D 139821833 uncharacterized protein K02213 CDC6; cell division control protein 6
D 139824852 Mcm2; (RefSeq) DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 139822501 Mcm3; (RefSeq) DNA replication licensing factor Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 139820809 Dpa; (RefSeq) DNA replication licensing factor MCM4 isoform X1 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 139811800 DNA replication licensing factor Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 139813740 Mcm6; (RefSeq) DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 139813904 Mcm7; (RefSeq) DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 139819580 Cyca; (RefSeq) cyclin-A1 K06627 CCNA; cyclin-A
D 139820722 Cyce; (RefSeq) G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 139813798 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 139812214 cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 139810992 DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 139809878 Psf2; (RefSeq) probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 139818579 Psf3; (RefSeq) DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 139812646 Sld5; (RefSeq) DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 139818694 Mus101; (RefSeq) DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 139821926 Recq4; (RefSeq) ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 139810257 Cdc45; (RefSeq) cell division control protein 45 homolog isoform X1 K06628 CDC45; cell division control protein 45
D 139808371 DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 139812888 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 139812579 Mcm10; (RefSeq) protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 139813763 mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 139814252 cyclin-dependent kinase 2-interacting protein-like K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 139810645 Dnapol-alpha180; (RefSeq) DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 139822593 Dnapol-alpha73; (RefSeq) DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 139814230 Dnapol-alpha50; (RefSeq) DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 139808890 DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
D 139815668 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 139815967 uncharacterized protein K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 139811539 Dnapol-epsilon255; (RefSeq) DNA polymerase epsilon catalytic subunit 1 isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 139811011 Dnapol-epsilon58; (RefSeq) DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 139821124 Chrac-14; (RefSeq) DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 139811157 Pole4; (RefSeq) DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 139814419 Dnapol-delta; (RefSeq) DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 139813672 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
D 139822144 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 139819940 uncharacterized protein isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 139818427 Tam; (RefSeq) DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 139822303 Dnapol-gamma35; (RefSeq) DNA polymerase subunit gamma-2 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 139808454 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 139812792 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 139813598 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 139821269 Rpa-70; (RefSeq) replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 139809337 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 139825312 uncharacterized protein K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 139820121 Gnf1; (RefSeq) replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 139819707 Rfc4; (RefSeq) replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 139821464 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 139808894 Rfc3; (RefSeq) replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 139822643 Rfc38; (RefSeq) replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 139820130 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 139816864 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 139813138 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 139817693 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 139812449 Pcna; (RefSeq) proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 139817039 Dna2; (RefSeq) DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 139819649 Fen1; (RefSeq) flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 139815796 Tos; (RefSeq) exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 139817368 Dnalig1; (RefSeq) DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 139823114 Elg1; (RefSeq) uncharacterized protein Elg1 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 139818798 Dnmt1a; (RefSeq) DNA methyltransferase 1a K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 139823946 DNA (cytosine-5)-methyltransferase 3B-like K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 139809671 uncharacterized protein K10749 GMNN; geminin
D 139809971 uncharacterized protein isoform X1 K10749 GMNN; geminin
D 139824953 uncharacterized protein K10749 GMNN; geminin
D 139821497 Cycb3; (RefSeq) G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 139823535 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3-like K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 139821389 Cdk1; (RefSeq) cyclin-dependent kinase 1 isoform X1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 139824530 telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 139819350 Smg5; (RefSeq) nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 139820509 Tert; (RefSeq) telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 139818889 Gar1; (RefSeq) uncharacterized protein Gar1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 139808630 Nhp2; (RefSeq) H/ACA ribonucleoprotein complex subunit 2-like protein isoform X1 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 139808223 Nop10; (RefSeq) H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 139813975 Nop60b; (RefSeq) H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 139820509 Tert; (RefSeq) telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 139808035 Smb; (RefSeq) small ribonucleoprotein particle protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 139820759 Smd1; (RefSeq) probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 139809958 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 139811224 Smd3; (RefSeq) small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 139812036 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 139810872 Smf; (RefSeq) small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 139809106 Snrpg; (RefSeq) small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 139819707 Rfc4; (RefSeq) replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 139821464 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 139808894 Rfc3; (RefSeq) replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 139822643 Rfc38; (RefSeq) replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 139820485 Mre11; (RefSeq) double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
C Other termination factors
D 139822517 Tefu; (RefSeq) serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 139814043 Blm; (RefSeq) uncharacterized protein Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 139818683 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 139815163 Mei-9; (RefSeq) DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 139811541 Parp1; (RefSeq) poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 139811542 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 139808036 Tnks; (RefSeq) poly [ADP-ribose] polymerase tankyrase isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 139821058 uncharacterized protein K11135 PINX1; Pin2-interacting protein X1
D 139810383 Rtel1; (RefSeq) regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 139813288 Pif1; (RefSeq) ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 139813917 Pur-alpha; (RefSeq) transcriptional regulator protein Pur-beta isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 139815957 Wdr79; (RefSeq) telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 139822163 splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 139820067 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 139821648 Top1; (RefSeq) DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 139819718 Top2; (RefSeq) DNA topoisomerase 2 isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 139817453 Top3beta; (RefSeq) DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 139823101 Top3alpha; (RefSeq) DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 139819207 Mtssb; (RefSeq) single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 139820130 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 139820130 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 139817039 Dna2; (RefSeq) DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 139819649 Fen1; (RefSeq) flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 139817368 Dnalig1; (RefSeq) DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025