+F Repair protein KO
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DNA Repair and Recombination Proteins - Thioalkalivibrio nitratireducens
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D TVNIR_3420 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D TVNIR_2392 phr_[H]; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E TVNIR_3589 mutY_[H]; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E TVNIR_2386 nth_[H]; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D TVNIR_2593 mutT_[H]; Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) / Thiamin-phosphate pyrophosphorylase-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TVNIR_2817 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TVNIR_3286 nudG_[H]; Putative 7,8-Dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TVNIR_0393 dut_[H]; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D TVNIR_3420 Methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D TVNIR_2392 phr_[H]; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E TVNIR_1377 Uracil-DNA glycosylase, family 5 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E TVNIR_3219 Uracil-DNA glycosylase, family 4 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E TVNIR_1123 yfjP_[H]; HhH-GPD base excision DNA repair family protein; Probable 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E TVNIR_3589 mutY_[H]; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E TVNIR_0101 mutM_[H]; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E TVNIR_2386 nth_[H]; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E TVNIR_3820 xthA_[H]; Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E TVNIR_3759 exoA_[H]; Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E TVNIR_2722 recJ_[H]; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E TVNIR_1421 ligA_[H]; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E TVNIR_3740 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E TVNIR_2548 uvrA_[H]; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E TVNIR_1610 uvrB_[H]; Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E TVNIR_1378 uvrC_[H]; Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E TVNIR_3785 uvrD_[H]; ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E TVNIR_3740 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E TVNIR_1421 ligA_[H]; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F TVNIR_2581 rpoB_[H]; DNA-directed RNA polymerase beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F TVNIR_2580 rpoC_[H]; DNA-directed RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F TVNIR_2550 rpoA_[H]; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F TVNIR_3699 rpoZ_[H]; DNA-directed RNA polymerase omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F TVNIR_1824 mfd_[H]; Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E TVNIR_1451 mutS_[H]; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E TVNIR_2779 mutL_[H]; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E TVNIR_3088 xseA_[H]; Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E TVNIR_3433 exodeoxyribonuclease VII, small subunit - like protein K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E TVNIR_1893 dnaE_[H]; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E TVNIR_3812 dnaN_[H]; DNA polymerase III beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E TVNIR_3203 holC_[H]; DNA polymerase III chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E TVNIR_2522 holA_[H]; DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E TVNIR_1588 holB_[H]; DNA polymerase III delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E TVNIR_3099 DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E TVNIR_2723 DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E TVNIR_0809 dnaX_[H]; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E TVNIR_1421 ligA_[H]; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E TVNIR_3785 uvrD_[H]; ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E TVNIR_2545 ssb_[H]; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E TVNIR_2102 Putative single stranded DNA-binding protein of prophage K03111 ssb; single-strand DNA-binding protein
E TVNIR_0042 phage DNA methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E TVNIR_2442 D12 class N6 adenine-specific DNA methyltransferase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E TVNIR_1736 phage DNA methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E TVNIR_0137 recB_[H]; Exodeoxyribonuclease V beta chain K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E TVNIR_0136 recC_[H]; Exodeoxyribonuclease V gamma chain K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E TVNIR_0138 recD_[H]; Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E TVNIR_1453 recA_[H]; RecA protein K03553 recA; recombination protein RecA
E TVNIR_3375 ruvA_[H]; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E TVNIR_3374 ruvB_[H]; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E TVNIR_3376 ruvC_[H]; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E TVNIR_3553 priA_[H]; Helicase PriA essential for oriC/DnaA-independent DNA replication K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E TVNIR_1453 recA_[H]; RecA protein K03553 recA; recombination protein RecA
E TVNIR_3428 radA_[H]; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E TVNIR_3813 recF_[H]; DNA recombination and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E TVNIR_3702 recG_[H]; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E TVNIR_1856 ATP-dependent DNA helicase-like protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E TVNIR_1854 ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E TVNIR_2722 recJ_[H]; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E TVNIR_0830 recO_[H]; DNA recombination and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E TVNIR_0811 recR_[H]; Recombination protein RecR K06187 recR; recombination protein RecR
E TVNIR_3155 recN_[H]; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E TVNIR_1789 rdgC_[H]; DNA recombination-dependent growth factor C K03554 rdgC; recombination associated protein RdgC
E TVNIR_3375 ruvA_[H]; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E TVNIR_3374 ruvB_[H]; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E TVNIR_3376 ruvC_[H]; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E TVNIR_2451 ygbT_[C]; CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
E TVNIR_1486 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E TVNIR_1178 yjgR_[H]; ATPase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F TVNIR_1814 gyrA_[H]; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F TVNIR_3816 gyrB_[H]; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F TVNIR_0413 topA_[H]; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F TVNIR_2769 hupB_[H]; DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F TVNIR_2722 recJ_[H]; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F TVNIR_0830 recO_[H]; DNA recombination and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F TVNIR_0811 recR_[H]; Recombination protein RecR K06187 recR; recombination protein RecR
F TVNIR_1421 ligA_[H]; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F TVNIR_0469 fis_[C]; DNA-binding protein Fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F TVNIR_2214 ihfA_[H]; Integration host factor alpha subunit K04764 ihfA; integration host factor subunit alpha
F TVNIR_1805 ihfB_[H]; Integration host factor beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F TVNIR_3210 recQ_[H]; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F TVNIR_2548 uvrA_[H]; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F TVNIR_1610 uvrB_[H]; Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D TVNIR_2228 dinB_[H]; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D TVNIR_2715 ymfK_[C]; putative phage repressor K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D TVNIR_1453 recA_[H]; RecA protein K03553 recA; recombination protein RecA
D TVNIR_1878 lexA_[H]; SOS-response repressor and protease LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D TVNIR_3155 recN_[H]; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D TVNIR_1879 recA_[C]; SOS cell division inhibitor SulA K14160 imuA; protein ImuA
D TVNIR_1880 imuB_[H]; DNA polymerase IV-like protein ImuB K14161 imuB; protein ImuB
D TVNIR_2937 dnaE2_[H]; DNA polymerase III alpha subunit K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D TVNIR_2545 ssb_[H]; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D TVNIR_2102 Putative single stranded DNA-binding protein of prophage K03111 ssb; single-strand DNA-binding protein
D TVNIR_1454 recX_[H]; Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D TVNIR_0464 rep_[H]; ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D TVNIR_2965 yoaA_[H]; DinG family ATP-dependent helicase YoaA K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D TVNIR_2593 mutT_[H]; Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) / Thiamin-phosphate pyrophosphorylase-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TVNIR_2817 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TVNIR_3286 nudG_[H]; Putative 7,8-Dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TVNIR_0393 dut_[H]; Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D TVNIR_2334 nrdA_[H]; Ribonucleotide reductase of class Ia (aerobic), alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D TVNIR_3568 nrdEB_[H]; Ribonucleotide reductase of class II (coenzyme B12-dependent) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D TVNIR_2333 nrdB_[H]; Ribonucleotide reductase of class Ia (aerobic), beta subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024