+F Repair protein KO
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DNA Repair and Recombination Proteins - Theileria orientalis
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D TOT_010000554 DEAD-box helicase K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E TOT_020000368 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E TOT_010000919 7,8 dihydro-8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E TOT_030000687 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E TOT_020000317 apurinic/apyrimidinic endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F TOT_010000846 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F TOT_020000458 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F TOT_040000115 DNA polymerase epsilon catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F TOT_020000250 uncharacterized protein K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F TOT_040000568 uncharacterized protein K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E TOT_020000588 proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
E TOT_030000409 proliferating cell nuclear antigen 1 K04802 PCNA; proliferating cell nuclear antigen
E TOT_020000938 5'-3' exonuclease K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E TOT_030000340 DNA ligase 1 precursor K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E TOT_010000083 uncharacterized protein K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F TOT_010000332 uncharacterized protein K10838 XPC; xeroderma pigmentosum group C-complementing protein
F TOT_010001303 DNA repair protein K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F TOT_040000249 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F TOT_030000207 uncharacterized protein K10609 CUL4; cullin 4
F TOT_010000226 uncharacterized protein K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F TOT_030000665 DNA-directed RNA polymerase K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F TOT_040000532 DNA-directed RNA polymerase K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F TOT_010000024 DNA-directed RNA polymerase II K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F TOT_020000349 RNA polymerase subunit RPB4-like protein K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F TOT_040000029 DNA-directed RNA polymerase K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F TOT_040000454 RNA polymerase common subunit K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F TOT_010001224 DNA-directed RNA polymerase II K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F TOT_010000217 DNA-directed RNA polymerases I, II, and III subunit K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F TOT_020000191 DNA-directed RNA polymerase 2 subunit K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F TOT_020000219 DNA-directed RNA polymerase subunit RPB10 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F TOT_030000851 DNA-directed RNA polymerase II K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F TOT_040000249 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F TOT_030000207 uncharacterized protein K10609 CUL4; cullin 4
F TOT_010000226 uncharacterized protein K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F TOT_040000984 uncharacterized protein K10841 ERCC6; DNA excision repair protein ERCC-6
F TOT_030000338 uncharacterized protein K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E TOT_020000133 DNA repair helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E TOT_010000142 DNA excision-repair helicase K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E TOT_030000370 uncharacterized protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E TOT_040000918 uncharacterized protein K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E TOT_010000940 transcription factor IIH subunit K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E TOT_030000738 uncharacterized protein K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E TOT_010000735 cyclin-dependent kinase CRK3 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E TOT_040000348 cyclin K06634 CCNH; cyclin H
E TOT_020000510 CDK-activating kinase assembly factor K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E TOT_020000080 replication factor-A protein 1 K07466 RFA1; replication factor A1
E TOT_020000017 uncharacterized protein K10739 RFA2; replication factor A2
D Other NER factors
E TOT_010000947 DNA repair protein K10849 ERCC1; DNA excision repair protein ERCC-1
E TOT_030000456 uncharacterized protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E TOT_040000390 uncharacterized protein K10846 ERCC5; DNA excision repair protein ERCC-5
E TOT_030000340 DNA ligase 1 precursor K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E TOT_010000901 conserved hypothetical protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
E TOT_030000134 uncharacterized protein K24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E TOT_010000401 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E TOT_010001218 uncharacterized protein K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E TOT_010000710 uncharacterized protein K08734 MLH1; DNA mismatch repair protein MLH1
E TOT_030000360 DNA mismatch repair protein K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E TOT_010000846 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E TOT_020000458 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E TOT_020000080 replication factor-A protein 1 K07466 RFA1; replication factor A1
E TOT_020000017 uncharacterized protein K10739 RFA2; replication factor A2
D RFC (replication factor C)
E TOT_030000263 uncharacterized protein K10754 RFC1; replication factor C subunit 1
E TOT_010001330 replication factor C subunit K10755 RFC2_4; replication factor C subunit 2/4
E TOT_030000422 replication factor K10755 RFC2_4; replication factor C subunit 2/4
E TOT_010001347 replication factor C subunit K10756 RFC3_5; replication factor C subunit 3/5
E TOT_040000569 replication factor C subunit K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E TOT_020000588 proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
E TOT_030000409 proliferating cell nuclear antigen 1 K04802 PCNA; proliferating cell nuclear antigen
E TOT_040000754 uncharacterized protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E TOT_030000340 DNA ligase 1 precursor K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E TOT_040000311 uncharacterized protein K10865 MRE11; double-strand break repair protein MRE11
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E TOT_040000311 uncharacterized protein K10865 MRE11; double-strand break repair protein MRE11
D BRCA complex
E TOT_040000669 DNA repair protein Rad51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E TOT_040000669 DNA repair protein Rad51 K04482 RAD51; DNA repair protein RAD51
E TOT_040000462 uncharacterized protein K10869 RAD51L1; RAD51-like protein 1
D Rad52 family proteins
D Rad54 family proteins
E TOT_010000761 recombinational repair protein K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
E TOT_030000183 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E TOT_020000080 replication factor-A protein 1 K07466 RFA1; replication factor A1
E TOT_020000017 uncharacterized protein K10739 RFA2; replication factor A2
D Protein phosphatase 4
E TOT_020000028 serine/threonine protein phosphatase pp-X isozyme 1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E TOT_020000582 conserved hypothetical protein K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E TOT_030000253 uncharacterized protein K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E TOT_040000417 chromosome maintenance protein K22803 SMC5; structural maintenance of chromosomes protein 5
E TOT_010000112 uncharacterized protein K22804 SMC6; structural maintenance of chromosomes protein 6
D Other HR factors
E TOT_030000468 MUS81 endonuclease homolog K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E TOT_040000602 uncharacterized protein K10881 SHFM1; 26 proteasome complex subunit DSS1
E TOT_020000941 26S protease subunit K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E TOT_010000621 minichromosome maintenance protein K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E TOT_040000407 DNA replication protein K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
E TOT_040000311 uncharacterized protein K10865 MRE11; double-strand break repair protein MRE11
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E TOT_030000183 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E TOT_040000669 DNA repair protein Rad51 K04482 RAD51; DNA repair protein RAD51
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E TOT_030000572 uncharacterized protein K23314 WRAP53; telomerase Cajal body protein 1
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D TOT_030000520 ubiquitin carrier protein K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D TOT_020000267 ubiquitin carrier protein K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D TOT_010000453 ubiquitin carrier protein K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D TOT_020000588 proliferating cell nuclear antigen 2 K04802 PCNA; proliferating cell nuclear antigen
D TOT_030000409 proliferating cell nuclear antigen 1 K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
D TOT_010001330 replication factor C subunit K10755 RFC2_4; replication factor C subunit 2/4
D TOT_030000422 replication factor K10755 RFC2_4; replication factor C subunit 2/4
D TOT_010001347 replication factor C subunit K10756 RFC3_5; replication factor C subunit 3/5
D TOT_040000569 replication factor C subunit K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
D TOT_030000351 uncharacterized protein K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D TOT_020000774 uncharacterized protein K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D TOT_020000598 14-3-3 protein K06630 YWHAE; 14-3-3 protein epsilon
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D TOT_010000034 conserved hypothetical protein K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D TOT_030000634 uncharacterized protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D TOT_010001002 CDC5-like K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D TOT_020000687 conserved hypothetical protein K12861 BCAS2; pre-mRNA-splicing factor SPF27
D TOT_040000244 PRL1 protein K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D TOT_010000342 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D TOT_030000324 ribonucleoside-diphosphate reductase large chain K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D TOT_010000684 ribonucleotide reductase R2 subunit/ribonucleoside-diphosphate reductase small chain K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D TOT_010001136 ribonucleoside reductase K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E TOT_020000368 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E TOT_030000687 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F TOT_010000115 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F TOT_030000653 DNA-directed RNA polymerase D subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E TOT_020000872 uncharacterized protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F TOT_020000795 uncharacterized protein K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F TOT_010001355 DNA topoisomerase 2 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D TOT_020000872 uncharacterized protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D TOT_010000342 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 5, 2025