+F Repair protein KO
#
DNA Repair and Recombination Proteins - Thrips palmi (melon thrips)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 117651068 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 117652276 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 117639471 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 117653304 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 117651747 LOW QUALITY PROTEIN: uncharacterized protein LOC117651747 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 117645891 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 117647572 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 117639579 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 117639756 uncharacterized protein LOC117639756 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 117649253 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 117646544 endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 117649720 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 117643804 DNA-(apurinic or apyrimidinic site) lyase-like isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 117651584 DNA-(apurinic or apyrimidinic site) lyase 2-like isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 117649312 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 117642089 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F 117643378 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 117643807 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 117653530 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 117654405 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 117650344 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 117653868 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 117654026 flap endonuclease 1-like isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 117650481 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 117651505 uncharacterized protein LOC117651505 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 117641908 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 117642202 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 117646498 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 117643430 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 117651313 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 117639979 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 117643076 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 117644403 high mobility group-T protein-like K10802 HMGB1; high mobility group protein B1
E 117641793 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 117649712 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 117646991 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 117653850 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 117639298 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 117650468 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 117654212 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 117645996 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 117639823 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 117641986 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 117641987 DNA-directed RNA polymerases I, II, and III subunit RPABC1-like K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 117653806 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 117652311 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 117643439 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 117641151 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 117653298 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117651825 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 117652674 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 117639298 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 117650468 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 117651914 DNA excision repair protein ERCC-8-like K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 117649843 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 117645080 UV-stimulated scaffold protein A-like isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 117645349 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 117649036 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 117641517 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 117648530 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 117646515 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 117651327 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 117648318 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 117646995 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 117639095 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 117651673 LOW QUALITY PROTEIN: cyclin-H K06634 CCNH; cyclin H
E 117647984 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 117642127 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D Other NER factors
E 117645254 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 117646884 DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 117640464 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 117647603 DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 117647084 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 117639277 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 117652193 cullin-5 K10612 CUL5; cullin 5
E 117648246 elongin-C isoform X1 K03872 ELOC; elongin-C
E 117647772 elongin-B-like isoform X1 K03873 ELOB; elongin-B
E 117651127 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 117652691 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 117645283 DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 117640836 DNA mismatch repair protein Msh6-like K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 117647054 PMS1 protein homolog 1-like isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 117642406 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 117650565 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 117643663 DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 117649312 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 117642089 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E 117642127 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D RFC (replication factor C)
E 117647246 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 117651844 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 117640107 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 117644305 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 117650344 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 117649645 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 117644403 high mobility group-T protein-like K10802 HMGB1; high mobility group protein B1
E 117641268 WD repeat-containing protein 76-like isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 117643931 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 117642472 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117653682 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 117651359 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646703 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117649229 BRCA1-associated RING domain protein 1-like isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 117651359 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646703 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117639358 uncharacterized protein LOC117639358 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 117647558 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
D BRCA1-B complex
E 117651359 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646703 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D BRCA1-C complex
E 117651359 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646703 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646394 uncharacterized protein LOC117646394 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 117643931 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 117642472 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117653682 nibrin K10867 NBN; nibrin
D BRCA complex
E 117651359 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646703 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117653059 LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 117640422 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 117640422 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 117652205 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 117644169 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 117641811 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 117649230 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 117642793 DNA repair and recombination protein radC-like isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 117653694 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 117646615 uncharacterized protein LOC117646615 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 117650853 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 117646663 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 117638957 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 117644429 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117653931 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 117649064 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 117644429 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117646125 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117645271 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117647064 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 117642146 uncharacterized protein LOC117642146 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 117642127 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D Protein phosphatase 4
E 117639429 serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 117640332 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 117642234 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 117650263 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 117649028 LOW QUALITY PROTEIN: uncharacterized protein LOC117649028 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 117640850 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 117642180 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 117654360 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 117652535 E3 SUMO-protein ligase MMS21-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 117641046 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 117648319 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 117641515 EP300-interacting inhibitor of differentiation 3 isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 117641277 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 117641701 exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 117646028 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117639529 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 117642590 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 117640674 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 117647556 spatacsin K19026 SPG11; spatacsin
E 117643458 uncharacterized protein LOC117643458 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 117651104 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 117645979 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117651866 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 117650729 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 117650916 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 117654155 uncharacterized protein LOC117654155 K22806 SPIDR; DNA repair-scaffolding protein
E 117650022 uncharacterized protein LOC117650022 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 117646395 trithorax group protein osa isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 117642878 zinc finger SWIM domain-containing protein 7-like isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 117642869 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 117652449 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 117644874 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 117643127 uncharacterized protein LOC117643127 isoform X1 K27803 HROB; homologous recombination OB-fold protein
E 117644013 DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 117653446 DNA helicase MCM9-like K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 117654531 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 117649184 X-ray repair cross-complementing protein 5 isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 117647601 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 117643931 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 117642472 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 117643673 uncharacterized protein LOC117643673 K10886 XRCC4; DNA-repair protein XRCC4
E 117648397 non-homologous end-joining factor 1-like K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 117641793 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 117650481 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 117651313 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 117639979 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 117644486 protein artemis-like K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 117652796 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 117641614 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 117650447 uncharacterized protein LOC117650447 K10896 FANCM; fanconi anemia group M protein
E 117650635 Fanconi anemia core complex-associated protein 24-like K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 117646614 centromere protein S-like K11511 APITD1; centromere protein S
E 117648610 centromere protein X-like K15360 STRA13; centromere protein X
E 117642080 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 117644429 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117646125 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117645271 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117647064 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 117642146 uncharacterized protein LOC117642146 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 117642518 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 117641139 Fanconi anemia group I protein homolog K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 117651359 breast cancer type 1 susceptibility protein homolog K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117646703 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117653059 LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
D Other FA pathway factors
E 117652629 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 117639812 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 117640422 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 117652205 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 117649957 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 117646819 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 117640916 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 117639942 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 117645065 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 117654407 E3 ubiquitin-protein ligase BRE1-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 117645391 ERC protein 2-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 117643400 E3 ubiquitin-protein ligase rnf168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 117649357 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2-like K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 117642419 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 117649667 papilin-like isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 117639311 gastrulation defective protein 1 homolog isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 117641268 WD repeat-containing protein 76-like isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 117651556 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 117639983 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 117653461 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 117652853 uncharacterized protein LOC117652853 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 117646091 DNA polymerase nu-like K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 117640898 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 117654400 E3 ubiquitin-protein ligase RAD18-like isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 117651321 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 117650289 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 117650344 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 117654039 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 117642224 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 117641682 cell cycle checkpoint protein RAD1-like isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 117649958 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 117651844 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 117640107 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 117644305 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 117641682 cell cycle checkpoint protein RAD1-like isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 117650020 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 117647220 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 117643862 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 117639947 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 117641844 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 117640627 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 117645148 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 117650015 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 117652334 LOW QUALITY PROTEIN: serine/threonine-protein kinase atr-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 117648170 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 117644168 cellular tumor antigen p53-like K04451 TP53; tumor protein p53
D 117654046 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 117646761 myosin light chain kinase A-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 117647209 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 117644908 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 117646847 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 117652846 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117642906 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 117641048 protein sickie-like K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 117641561 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 117639974 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 117644438 mediator of DNA damage checkpoint protein 1-like isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 117651739 plastin-2 K17336 PLS3; plastin-3
D 117640532 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 117651999 KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117640142 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 117649255 vacuolar protein sorting-associated protein 4-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 117650705 abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 117654043 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 117647411 LOW QUALITY PROTEIN: DNA polymerase theta-like K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 117639591 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 117647342 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 117653498 uncharacterized protein LOC117653498 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 117650849 DNA cross-link repair 1A protein-like K15340 DCLRE1A; DNA cross-link repair 1A protein
D 117643117 uncharacterized protein LOC117643117 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 117651338 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 117644816 DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 117651677 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 117647657 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 117641864 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 117652644 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 117645815 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 117652329 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 117645989 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 117653244 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 117651068 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 117639471 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 117653304 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 117647572 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 117645891 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 117639579 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 117649720 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 117651130 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 117651130 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 117645989 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024