+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Treponema pallidum subsp. pallidum SS14</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
C    RFC (replication factor C)
C    RNase H
D      TPASS_0353 rnhA; ribonuclease H	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
C    Other elongation factors
B  DNA Replication Termination Factors
C    DNA methylation enzymes
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      TPASS_0251 DNA-binding protein II	K04764 ihfA; integration host factor subunit alpha 
D      TPASS_0001 dnaA; chromosomal replication initiation protein DnaA	K02313 dnaA; chromosomal replication initiator protein 
D      TPASS_0058 dnaB; replicative DNA helicase DnaB	K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] 
D      TPASS_0492 dnaG; DNA primase	K02316 dnaG; DNA primase [EC:2.7.7.101] 
D      TPASS_0062 ssb; single-strand DNA binding protein Ssb	K03111 ssb; single-strand DNA-binding protein 
D      TPASS_0310 hypothetical protein	K03111 ssb; single-strand DNA-binding protein 
C    Initiation factors (archaeal)
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
E        TPASS_0669 dnaE; DNA polymerase III, subunit alpha	K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] 
E        TPASS_0002 dnaN; DNA-directed DNA polymerase beta subunit	K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] 
E        TPASS_0588 hypothetical protein	K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] 
E        TPASS_0643 dnaQ; DNA polymerase III, subunit epsilon	K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] 
E        TPASS_0521 possible DNA polymerase III, gamma and tau subunits	K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 
E        TPASS_1005 dnaZX; DNA polymerase III, subunits gamma and tau	K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 
D      RNase H
E        TPASS_0353 rnhA; ribonuclease H	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      Other elongation factors
E        TPASS_0634 lig; DNA ligase	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
C    Elongation factors (archaeal)
D      B-family DNA polymerases
D      D-family DNA polymerases
D      RNase H
E        TPASS_0353 rnhA; ribonuclease H	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
D      RFC (replication factor C)
D      Other elongation factors
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
D      TPASS_0810 dam; DNA adenine methyltransferase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
C    Prevention of re-replication factors
B  DNA Topoisomerases
C    TPASS_0005 gyrA; DNA topoisomerase (ATP-hydrolyzing) subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
C    TPASS_1006 gyrB; DNA gyrase, subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
C    TPASS_0394 topA; DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
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#Last updated: August 27, 2025