+F Repair protein KO
#
DNA Repair and Recombination Proteins - Trichogramma pretiosum
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106648357 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 106649281 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106657129 putative uncharacterized protein DDB_G0291608 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111694519 alpha-protein kinase 1-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 106652073 uncharacterized protein LOC106652073 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106660367 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 106649967 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 106656075 uncharacterized protein LOC106656075 isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 106656258 DNA-(apurinic or apyrimidinic site) lyase-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 106654197 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 106649419 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
F 106656752 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
F 106660287 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 106660210 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 106656273 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 106648964 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 106659183 chromatin accessibility complex protein 1 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
F 106650539 nuclear transcription factor Y subunit C-2 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 106649266 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106657342 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 106654303 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 106656130 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 106657373 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 106655220 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 106655360 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 106652645 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106653862 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 106658062 uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 106653170 high mobility group protein DSP1-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 106658341 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 106650973 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 106659035 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 106652040 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 106651625 cullin-4B isoform X2 K10609 CUL4; cullin 4
F 106651824 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 106648582 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 106654973 DNA-directed RNA polymerase II subunit RPB1-like isoform X2 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 106653996 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 106654007 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 106658585 DNA-directed RNA polymerase II subunit RPB2-like K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 106656124 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 106652636 DNA-directed RNA polymerase II 16 kDa polypeptide isoform X2 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 106656123 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 106648434 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 106648282 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 106656232 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 106657572 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 106654738 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 106660508 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 106654919 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 106652040 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 106651625 cullin-4B isoform X2 K10609 CUL4; cullin 4
F 106651824 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 106655760 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 106658685 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 106650487 DNA excision repair protein haywire K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 106655087 TFIIH basal transcription factor complex helicase XPD subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 106659822 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 106651092 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 106649214 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 106653100 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 106659682 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 106660519 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 106658756 cyclin-H K06634 CCNH; cyclin H
E 106658852 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 106651807 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106657015 replication protein A 32 kDa subunit-A-like K10739 RFA2; replication factor A2
E 106657355 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 106652092 uncharacterized protein LOC106652092 K10740 RPA3; replication factor A3
D Other NER factors
E 106654789 DNA repair protein complementing XP-A cells homolog isoform X2 K10847 XPA; DNA-repair protein complementing XP-A cells
E 106651520 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 106660063 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 106649982 DNA repair protein complementing XP-G cells-like K10846 ERCC5; DNA excision repair protein ERCC-5
E 106654303 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 106651833 cullin-3 K03869 CUL3; cullin 3
E 106653030 cullin-5 isoform X2 K10612 CUL5; cullin 5
E 106659581 elongin-C K03872 ELOC; elongin-C
E 106659565 elongin-B K03873 ELOB; elongin-B
E 106657874 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 106657259 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 106650580 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 106648520 DNA mismatch repair protein Msh6-like K08737 MSH6; DNA mismatch repair protein MSH6
E 106653882 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 106658157 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 106658597 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 106659518 mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 106654197 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 106649419 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
E 106656752 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
E 106660287 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 106651807 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106657015 replication protein A 32 kDa subunit-A-like K10739 RFA2; replication factor A2
E 106657355 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 106652092 uncharacterized protein LOC106652092 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 106655183 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 106654833 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 106656068 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 106654888 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 106655330 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 106649266 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106658026 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 106653170 high mobility group protein DSP1-like isoform X1 K10802 HMGB1; high mobility group protein B1
E 106654303 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 106650845 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 106660585 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 106656062 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106655964 ankyrin repeat domain-containing protein 11-like K10683 BARD1; BRCA1-associated RING domain protein 1
E 106656140 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 106656062 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106648779 BRISC complex subunit FAM175B-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 106651588 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 106651499 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 106649369 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 106656062 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106659769 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 106659082 DNA topoisomerase 2-binding protein 1 isoform X2 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 106656062 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106659452 DNA endonuclease RBBP8-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 106650845 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 106660585 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 106656062 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106657181 uncharacterized protein LOC106657181 isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 106653848 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 106653848 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106650472 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 106651011 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 106648364 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 106655017 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 106660503 DNA repair and recombination protein rhm52-like isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 106648381 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 106659333 uncharacterized protein LOC106659333 isoform X2 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 106649385 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 106650544 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 106660362 Bloom syndrome protein homolog isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657150 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657985 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657679 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 106660362 Bloom syndrome protein homolog isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657150 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657985 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106653054 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106654227 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106652237 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 106651807 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106657015 replication protein A 32 kDa subunit-A-like K10739 RFA2; replication factor A2
E 106657355 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 106652092 uncharacterized protein LOC106652092 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 106656906 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 106652122 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 106660537 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 106652300 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 106656727 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 106651915 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 106658700 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 106659806 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 106652706 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 106649994 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 106649830 non-structural maintenance of chromosomes element 4 homolog A isoform X2 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 106658457 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 106651551 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 106656931 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 106651507 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 106657909 uncharacterized protein LOC106657909 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 106653088 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 106648095 uncharacterized protein LOC106648095 isoform X2 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 106660259 flap endonuclease GEN-like K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 106653329 LOW QUALITY PROTEIN: flap endonuclease GEN-like K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 106654614 spatacsin K19026 SPG11; spatacsin
E 106652327 uncharacterized protein LOC106652327 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 106658924 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 106649015 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 106654186 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 106649573 uncharacterized protein LOC106649573 K23112 BRAT1; BRCA1-associated ATM activator 1
E 106649829 protein C21orf2 homolog K23456 CFAP410; cilla- and flagella-associated protein
E 111693379 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 106657382 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 106656903 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 106658455 biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 106659001 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 106648593 X-ray repair cross-complementing protein 6-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 106648677 X-ray repair cross-complementing protein 5-like isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 106651357 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 106657798 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
E 106653179 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 106650845 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 106660585 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 106656557 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 106651877 uncharacterized protein LOC106651877 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
D Other NHEJ factors
E 106652645 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106653862 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 106659138 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 106655423 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 106648448 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 106660362 Bloom syndrome protein homolog isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657150 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106657985 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106653054 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106654227 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106652237 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 106658746 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 106656062 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 106657181 uncharacterized protein LOC106657181 isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 106659769 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 106650498 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 106653848 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106650472 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 106648216 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 106656933 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 106654897 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 106652869 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 106655103 reticulocyte-binding protein 2 homolog a-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 106652946 E3 ubiquitin-protein ligase RNF168-like isoform X1 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 106655573 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 106648079 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 106660104 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
E 106656844 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 106658624 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 106657617 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 106658381 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 106658618 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 106656305 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106650929 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 106658176 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 106649642 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 106649266 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 106650807 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 106650172 uncharacterized protein LOC106650172 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 106656647 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 106656044 checkpoint protein HUS1-like K10903 HUS1; HUS1 checkpoint protein
D 106659951 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 106653513 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 106654833 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 106656068 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106654888 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 106655330 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 106659951 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 106657598 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 106651829 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 106653876 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 106649389 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 106658393 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 106650884 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 106655114 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 106650125 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 106657380 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 106654953 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 106657061 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 106649768 serine/threonine-protein kinase Chk2-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 106651124 M-phase inducer phosphatase-like isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 106653741 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 106654137 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 106653551 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 106656880 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 106651085 titin homolog isoform X4 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 106654256 plastin-1 K17336 PLS3; plastin-3
D 106653518 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 106659143 formin-J-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 106659376 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106649664 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 106657650 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 106653259 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 106655464 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 106648283 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 106649579 uncharacterized protein LOC106649579 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 106655074 uncharacterized protein LOC106655074 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 106650559 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 106649388 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 106650182 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 106656732 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 106652543 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 106651096 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 106656576 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 106648337 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 106651435 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 106660205 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 106659627 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106649281 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106660367 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 106652073 uncharacterized protein LOC106652073 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 106654192 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 106654192 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 106651435 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024