+F Repair protein KO
#
DNA Repair and Recombination Proteins - Theileria parva
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D TP01_0582 RNA helicase K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E TP02_0373 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E TP01_0968 8-oxoguanine DNA-glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E TP03_0162 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E TP02_0334 apurinic/apyrimidinic endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F TP01_0899 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F TP02_0469 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F TP04_0813 DNA polymerase epsilon, catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F TP04_0814 DNA polymerase epsilon, catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F TP02_0276 hypothetical protein K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
E TP03_0445 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E TP02_0600 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E TP02_0912 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E TP03_0549 DNA ligase I K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E TP01_0091 hypothetical protein K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F TP01_0871 DNA repair protein Rad23 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F TP04_0669 hypothetical protein K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F TP01_0243 hypothetical protein K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F TP03_0185 DNA-directed RNA polymerase II largest subunit K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F TP04_0340 DNA-directed RNA polymerase II subunit K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F TP01_0029 DNA-directed RNA polymerase II K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F TP02_0359 DNA-directed RNA polymerase II subunit Rpb4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F TP04_0911 DNA-directed RNA polymerase II K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F TP04_0461 hypothetical protein K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F TP01_0225 DNA-directed RNA polymerase II subunit Rpb7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F TP01_0233 RNA polymerase subunit K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F TP02_0205 DNA-directed RNA polymerase II subunit K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F TP02_0237 DNA-directed RNA polymerase subunit N K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F TP03_0027 DNA-directed RNA polymerase II K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F TP03_0016 transcription activator K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F TP04_0669 hypothetical protein K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F TP01_0243 hypothetical protein K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F TP04_0027 ATP-dependant helicase K10841 ERCC6; DNA excision repair protein ERCC-6
F TP03_0547 hypothetical protein K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E TP02_0144 DNA helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E TP01_0155 DNA repair protein Rad3 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E TP03_0481 hypothetical protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E TP04_0823 hypothetical protein K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E TP01_0989 hypothetical protein K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E TP03_0115 hypothetical protein K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E TP01_0781 cyclin-dependent kinase K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E TP04_0577 cyclin K06634 CCNH; cyclin H
E TP02_0520 hypothetical protein K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E TP02_0095 replication factor A protein K07466 RFA1; replication factor A1
E TP02_0022 hypothetical protein K10739 RFA2; replication factor A2
D Other NER factors
E TP01_0997 hypothetical protein K10849 ERCC1; DNA excision repair protein ERCC-1
E TP03_0395 DNA repair endonuclease K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E TP04_0530 DNA repair protein Rad2 K10846 ERCC5; DNA excision repair protein ERCC-5
E TP03_0549 DNA ligase I K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E TP01_0952 hypothetical protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E TP01_0456 DNA mismatch repair protein MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E TP01_0185 DNA repair protein K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E TP01_0756 DNA mismatch repair protein MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E TP03_0491 DNA mismatch repair protein PMS1 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E TP01_0899 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E TP02_0469 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E TP02_0095 replication factor A protein K07466 RFA1; replication factor A1
E TP02_0022 hypothetical protein K10739 RFA2; replication factor A2
D RFC (replication factor C)
E TP03_0565 replication factor C large subunit K10754 RFC1; replication factor C subunit 1
E TP01_0978 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E TP03_0432 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E TP04_0380 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E TP01_1062 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E TP03_0445 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E TP02_0600 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E TP04_0147 exonuclease I K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E TP03_0549 DNA ligase I K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E TP04_0621 DNA repair exonuclease K10865 MRE11; double-strand break repair protein MRE11
E TP02_0154 RAD50 DNA repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E TP04_0621 DNA repair exonuclease K10865 MRE11; double-strand break repair protein MRE11
E TP02_0154 RAD50 DNA repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E TP04_0230 DNA repair protein Rad51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E TP04_0230 DNA repair protein Rad51 K04482 RAD51; DNA repair protein RAD51
E TP04_0453 hypothetical protein K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E TP01_0805 DNA repair protein Rad54 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E TP02_0509 DNA helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E TP02_0509 DNA helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E TP03_0692 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E TP02_0095 replication factor A protein K07466 RFA1; replication factor A1
E TP02_0022 hypothetical protein K10739 RFA2; replication factor A2
D Protein phosphatase 4
E TP02_0042 serine/threonine protein phosphatase K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E TP02_0594 hypothetical protein K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E TP03_0573 hypothetical protein K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E TP04_0500 hypothetical protein K22803 SMC5; structural maintenance of chromosomes protein 5
E TP01_0122 hypothetical protein K22804 SMC6; structural maintenance of chromosomes protein 6
D Other HR factors
E TP03_0382 hypothetical protein K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E TP04_0298 hypothetical protein K10881 SHFM1; 26 proteasome complex subunit DSS1
E TP02_0917 AAA family ATPase K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
E TP04_0621 DNA repair exonuclease K10865 MRE11; double-strand break repair protein MRE11
E TP02_0154 RAD50 DNA repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E TP02_0509 DNA helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E TP03_0692 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E TP04_0230 DNA repair protein Rad51 K04482 RAD51; DNA repair protein RAD51
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E TP03_0275 hypothetical protein K23314 WRAP53; telomerase Cajal body protein 1
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D TP02_0924 hypothetical protein K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D TP02_0288 ubiquitin-protein ligase K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D TP03_0025 ubiquitin-conjugating enzyme K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D TP01_0508 ubiquitin-protein ligase K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D TP03_0445 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D TP02_0600 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
D TP01_0978 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D TP03_0432 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D TP04_0380 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D TP01_1062 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
D TP03_0559 hypothetical protein K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D TP02_0787 hypothetical protein K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D TP02_0607 hypothetical protein K06630 YWHAE; 14-3-3 protein epsilon
D TP03_0351 vacuolar sorting protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D TP01_0040 hypothetical protein K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D TP03_0215 hypothetical protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D TP01_1059 hypothetical protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D TP02_0698 hypothetical protein K12861 BCAS2; pre-mRNA-splicing factor SPF27
D TP04_0666 hypothetical protein K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D TP01_0381 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D TP03_0528 ribonucleotide-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D TP01_0725 ribonucleotide-diphosphate reductase small subunit K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D TP01_1196 ribonucleotide-diphosphate reductase small subunit K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E TP02_0373 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E TP03_0162 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F TP05_0028 RNA polymerase beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F TP05_0029 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F TP05_0043 DNA-directed RNA polymerase subunit beta'' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F TP05_0042 DNA-directed RNA polymerase subunit beta'' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F TP03_0199 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F TP01_0126 DNA-directed RNA polymerase, subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F TP02_0771 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F TP01_1125 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
F TP04_0501 hypothetical protein K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D TP01_0381 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024