+E Replication protein KO
#
DNA Replication Proteins - Takifugu rubripes (torafugu)
%
!
AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 101075554 orc1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 101078119 orc2; origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 101075356 orc3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 101067690 orc4; origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 101063376 orc5; origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 101071855 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 115246432 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 101074758 cdc6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 101063252 mcm2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 101065085 mcm3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 101064276 mcm4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 101069963 mcm5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 101071397 mcm6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 105417405 mcm7; DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 101065451 ccna2; cyclin-A2 K06627 CCNA; cyclin-A
D 101073573 ccna1; cyclin-A1 isoform X1 K06627 CCNA; cyclin-A
D 101063185 G1/S-specific cyclin-E1-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 101065632 G1/S-specific cyclin-E1-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 101070487 G1/S-specific cyclin-E1-like K06626 CCNE; G1/S-specific cyclin-E1
D 101070855 ccne2; G1/S-specific cyclin-E2 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 105419021 G1/S-specific cyclin-E1-like K06626 CCNE; G1/S-specific cyclin-E1
D 115251941 G1/S-specific cyclin-E1-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 115252159 G1/S-specific cyclin-E1-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 115252218 G1/S-specific cyclin-E1-like K06626 CCNE; G1/S-specific cyclin-E1
D 101062041 cdk2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 105418139 cdc7; cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 101065886 dbf4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 105419995 uncharacterized protein LOC105419995 K06629 DBF4; protein DBF4
C GINS complex
D 101063167 gins1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 101061357 gins2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 101061601 gins3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 101069861 gins4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 101069985 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 101061277 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 101064879 cdc45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 101070044 mcm8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 101068427 mcm9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 101069855 mcm10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 101070419 mcmbp; mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 101074173 cinp; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 101062241 mtbp; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 101068238 ticrr; treslin isoform X1 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 101069062 pola1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 101063892 pola2; DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 101077321 prim1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 101072988 prim2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 101077972 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 101078592 pole2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 101066885 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 101067055 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 101069965 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 101079028 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 101080005 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 101071291 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 101072474 polg; DNA polymerase subunit gamma-1 isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 105419918 polg2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 101072637 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 101074412 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 101072512 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 101078394 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
D 101068248 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 101066281 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 101063782 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 101067299 rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 101064880 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 101077142 LOW QUALITY PROTEIN: replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 115252627 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 115252628 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 101062638 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 101065614 rnaseh2a; ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 101066094 rnaseh2b; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 101075025 rnaseh2c; ribonuclease H2 subunit C isoform X1 K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 101076907 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 101072400 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 101066655 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 101070845 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 101070255 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 101079442 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 101065037 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 101063054 atad5; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 101063571 dnmt1; DNA (cytosine-5)-methyltransferase 1 isoform X2 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 101063003 DNA (cytosine-5)-methyltransferase 3A-like isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 101077240 DNA (cytosine-5)-methyltransferase 3A-like isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 101061553 uncharacterized protein LOC101061553 isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 101065802 uncharacterized protein LOC101065802 isoform X2 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 101066026 DNA (cytosine-5)-methyltransferase 3B-like isoform X2 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 101065302 geminin K10749 GMNN; geminin
D 115251763 geminin-like K10749 GMNN; geminin
D 101077677 mcidas; multicilin K26119 MCIDAS; multicilin
D 101074701 ccnb1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 115250234 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 101074416 G2/mitotic-specific cyclin-B2-like isoform X1 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 101076205 G2/mitotic-specific cyclin-B2-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 101073216 ccnb3; G2/mitotic-specific cyclin-B3 isoform X2 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 101064374 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 115248355 cyclin-dependent kinase 1-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 101071663 pot1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 101076047 terf1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 101065323 telomeric repeat-binding factor 2 isoform X2 K11111 TERF2; telomeric repeat-binding factor 2
E 101073111 tinf2; TERF1-interacting nuclear factor 2 isoform X2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 101080073 terf2ip; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 105419012 acd; adrenocortical dysplasia protein homolog K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 101062759 terb1; telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 105417282 terb2; telomere repeats-binding bouquet formation protein 2 isoform X1 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 105418745 membrane-anchored junction protein isoform X2 K25751 MAJIN; membrane-anchored junction protein
E 115250619 membrane-anchored junction protein-like isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 101071482 CST complex subunit CTC1-like K23311 CTC1; CST complex subunit CTC1
E 105418912 CST complex subunit CTC1-like K23311 CTC1; CST complex subunit CTC1
E 101063679 stn1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 101065619 ten1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 101071970 smg6; telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 101065130 smg5; protein SMG5 K11125 SMG5; protein SMG5
D 101064919 tert; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 105418220 tep1; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 101079836 gar1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 101075612 nhp2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 101073954 H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 115247953 H/ACA ribonucleoprotein complex subunit DKC1-like isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 101064919 tert; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 101068957 snrpb; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 101071894 snrpd1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 101076582 snrpd2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 101073110 snrpd3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 101067277 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 101067496 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 101074074 snrpf; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 101069413 snrpg; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 101063782 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 101067299 rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 101064880 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 101077142 LOW QUALITY PROTEIN: replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 115252627 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 115252628 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 101074351 mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 101070531 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 101064980 nbn; nibrin K10867 NBN; nibrin
C Other termination factors
D 101079070 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 101078538 blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 101073073 prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 101067597 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 101080146 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 101073563 parp2; poly [ADP-ribose] polymerase 2 isoform X1 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
D 101061340 poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 101070151 poly [ADP-ribose] polymerase tankyrase-1 isoform X2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 101064123 pinx1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 101077470 rtel1; regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 101068671 telo2; telomere length regulation protein TEL2 homolog isoform X2 K11137 TELO2; telomere length regulation protein
D 101075141 trir; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 101074104 rif1; telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 101079328 pif1; ATP-dependent DNA helicase PIF1 isoform X2 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 101074066 transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 101075532 transcriptional activator protein Pur-alpha-like K21772 PURA; transcriptional activator protein Pur-alpha
D 101064400 purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 101065293 wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 101067950 sde2; replication stress response regulator SDE2 isoform X2 K25059 SDE2; replication stress response regulator SDE2
D 101070546 rtf2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 101063343 top1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 101069232 DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 101073826 DNA topoisomerase I, mitochondrial-like isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 101075432 top2a; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 101075827 DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 115246518 DNA topoisomerase 2-beta-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 101062659 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 101078908 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 115246427 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 101078486 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 101062638 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 101062638 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 101072400 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 101066655 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101070845 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101065037 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025