+E Replication protein KO
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DNA Replication Proteins - Thamnophis sirtalis (common garter snake)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 106543345 ORC1; origin recognition complex subunit 1 isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 106541799 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 106550481 ORC3; origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 106545604 ORC4; origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 106550268 ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 106554988 ORC6; LOW QUALITY PROTEIN: origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 106555247 CDC6; cell division control protein 6 homolog isoform X1 K02213 CDC6; cell division control protein 6
D 106546667 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 106539223 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 106554043 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 106541189 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 106540055 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 106555552 MCM7; DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 106545909 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 106549539 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 106555427 CCNE1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 106551743 CCNE2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 106539726 CDK2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 106541254 CDC7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 106553832 DBF4; protein DBF4 homolog A K06629 DBF4; protein DBF4
C GINS complex
D 106555241 GINS1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 106554088 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 106544940 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
C Other initiation factors
D 106541273 TOPBP1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 106554874 DNA topoisomerase 2-binding protein 1-A-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 106552471 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 106549395 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 106544537 MCM9; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 106554161 MCM10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 106542663 protein FAM111A-like K24274 FAM111A; protein FAM111A
D 106554798 CINP; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 106553060 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 106539424 POLA1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 106545320 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
C DNA polymerase epsilon complex
D 106545953 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 106548828 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 106548020 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 106547697 POLD2; LOW QUALITY PROTEIN: DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 106539418 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 106538832 DNA polymerase subunit gamma-1-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 106549679 POLG; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 106549378 POLG2; LOW QUALITY PROTEIN: DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 106543379 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 106539525 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 106539658 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 106554393 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 106544357 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106550464 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 106537762 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 106539267 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 106556606 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 106554771 RNASEH2A; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
C Other elongation factors
D 106556638 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 106542767 DNA2; LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 106539929 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 106541395 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 106540053 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 106550060 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 106548897 ATAD5; ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
D 106543079 GMNN; geminin K10749 GMNN; geminin
D 106546059 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 106551525 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 106538994 CCNB3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 106549230 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 106538615 POT1; protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 106538608 TERF1; telomeric repeat-binding factor 1 isoform X1 K11110 TERF1; telomeric repeat-binding factor 1
E 106555903 TERF2; telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 106541813 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 106552258 uncharacterized protein LOC106552258 isoform X1 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 106552674 CCDC79; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
D CST complex (animals)
E 106548473 OBFC1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 106552231 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 106539513 telomerase-binding protein EST1A-like K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 106551872 SMG5; protein SMG5 K11125 SMG5; protein SMG5
D 106543681 telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 106541199 telomerase protein component 1-like K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 106554026 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 106545408 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 106546095 NOP10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 106544212 DKC1; H/ACA ribonucleoprotein complex subunit 4 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 106543681 telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 106555543 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 106552716 SNRPD1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 106552354 SNRPD2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 106551285 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 106557113 SNRPE; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 106552109 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 106542622 SNRPG; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 106544357 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106550464 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 106537762 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 106539267 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 106554130 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
D 106547556 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 106545520 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 106545720 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 106539815 WRN; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 106556993 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 106554042 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 106537486 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 106551595 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 106546946 PARP3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106541205 poly [ADP-ribose] polymerase 1-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106541441 PARP4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106546264 TNKS2; tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 106551406 TNKS; tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 106553227 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 106552849 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 106546309 uncharacterized protein C19orf43 homolog K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 106539808 RIF1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 106545154 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 106543433 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 106539816 PURG; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 106542802 SDE2; protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
B DNA Topoisomerases
C 106545344 TOP1; DNA topoisomerase 1 isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 106555167 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 106554533 DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 106552919 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 106547265 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 106556606 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 106556606 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 106542767 DNA2; LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 106539929 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 106550060 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022