+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Varroa destructor (honeybee mite)</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      111243174 methylated-DNA--protein-cysteine methyltransferase-like	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      111250915 activating signal cointegrator 1 complex subunit 3-like	K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] 
C    BER (base exicision repair)
D      DNA glycosylases
E        111252021 DNA-3-methyladenine glycosylase-like	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        111252444 N-glycosylase/DNA lyase-like	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        111254763 DNA-(apurinic or apyrimidinic site) lyase-like	K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2] 
E        111247140 DNA-(apurinic or apyrimidinic site) lyase 2-like isoform X1	K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2] 
D      Long Patch-BER factors
E        DNA polymerase delta complex
F          111246717 DNA polymerase delta catalytic subunit-like	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
F          111245067 DNA polymerase delta subunit 2-like	K02328 POLD2; DNA polymerase delta subunit 2 
E        DNA polymerase epsilon complex
F          111247908 DNA polymerase epsilon catalytic subunit A-like isoform X1	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
F          111248617 DNA polymerase epsilon subunit 2-like	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
F          111250902 DNA polymerase epsilon subunit 3-like	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
F          111244081 DNA polymerase epsilon subunit 4-like	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
E        111255538 proliferating cell nuclear antigen-like	K04802 PCNA; proliferating cell nuclear antigen 
E        111244619 flap endonuclease 1-like	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        111246951 DNA ligase 1-like	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      Short Patch-BER factors
E        111247037 uncharacterized protein LOC111247037 isoform X1	K10803 XRCC1; DNA-repair protein XRCC1 
E        111250629 DNA ligase 3-like isoform X1	K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] 
D      Other BER factors
E        111251840 tyrosyl-DNA phosphodiesterase 1-like	K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] 
E        111246377 ubiquitin carboxyl-terminal hydrolase 36-like	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        111250126 uncharacterized protein F21D5.5-like	K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] 
E        111247446 high mobility group protein DSP1-like	K10802 HMGB1; high mobility group protein B1 
E        111244392 poly [ADP-ribose] polymerase-like isoform X1	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
E        111247461 poly [ADP-ribose] polymerase 2-like	K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
F          111251555 uncharacterized protein LOC111251555	K10838 XPC; xeroderma pigmentosum group C-complementing protein 
F          111245192 UV excision repair protein RAD23 homolog B-like isoform X1	K10839 RAD23; UV excision repair protein RAD23 
F          111252624 caltractin-like	K10840 CETN2; centrin-2 
E        Cul4-DDB2 complex
F          111249014 E3 ubiquitin-protein ligase RBX1-like isoform X1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          111249852 cullin-4B-like	K10609 CUL4; cullin 4 
F          111253465 DNA damage-binding protein 1-like	K10610 DDB1; DNA damage-binding protein 1 
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
F          111245786 DNA-directed RNA polymerase II subunit RPB1-like isoform X1	K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] 
F          111251866 DNA-directed RNA polymerase II subunit RPB2	K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] 
F          111248343 DNA-directed RNA polymerase II subunit RPB3-like	K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 
F          111251448 DNA-directed RNA polymerase II subunit RPB4-like	K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 
F          111245903 DNA-directed RNA polymerases I, II, and III subunit RPABC1-like	K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 
F          111248899 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like	K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 
F          111249818 DNA-directed RNA polymerase II subunit RPB7-like isoform X1	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
F          111244117 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like	K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 
F          111242935 DNA-directed RNA polymerase II subunit RPB9-like	K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 
E        Cul4-CSA complex
F          111249014 E3 ubiquitin-protein ligase RBX1-like isoform X1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          111249852 cullin-4B-like	K10609 CUL4; cullin 4 
F          111253465 DNA damage-binding protein 1-like	K10610 DDB1; DNA damage-binding protein 1 
F          111250287 DNA excision repair protein ERCC-8-like	K10570 ERCC8; DNA excision repair protein ERCC-8 
E        Other TCR factor
F          111247899 DNA excision repair protein ERCC-6-like isoform X1	K10841 ERCC6; DNA excision repair protein ERCC-6 
F          111253869 UV-stimulated scaffold protein A-like isoform X1	K23720 UVSSA; UV-stimulated scaffold protein A 
F          111244201 transcription elongation factor 1 homolog	K25829 ELOF1; transcription elongation factor 1 
D      TFIIH complex
E        111250740 DNA excision repair protein haywire-like isoform X1	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        111247020 TFIIH basal transcription factor complex helicase XPD subunit-like	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        111245203 general transcription factor IIH subunit 1-like	K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 
E        111245370 general transcription factor IIH subunit 2-like	K03142 TFIIH2; transcription initiation factor TFIIH subunit 2 
E        111254349 uncharacterized protein LOC111254349	K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 
E        111253841 general transcription factor IIH subunit 4-like isoform X1	K03144 TFIIH4; transcription initiation factor TFIIH subunit 4 
E        111245941 cyclin-dependent kinase 7-like isoform X1	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        111246573 cyclin-H-like	K06634 CCNH; cyclin H 
E        111250808 CDK-activating kinase assembly factor MAT1-like	K10842 MNAT1; CDK-activating kinase assembly factor MAT1 
D      RPA (replication factor A)
E        111250051 replication protein A 70 kDa DNA-binding subunit-like	K07466 RFA1; replication factor A1 
E        111247201 replication protein A 32 kDa subunit-A-like isoform X1	K10739 RFA2; replication factor A2 
E        111249204 uncharacterized protein LOC111249204 isoform X1	K10740 RPA3; replication factor A3 
D      Other NER factors
E        111243205 DNA repair protein complementing XP-A cells-like	K10847 XPA; DNA-repair protein complementing XP-A cells 
E        111244662 DNA excision repair protein ERCC-1-like	K10849 ERCC1; DNA excision repair protein ERCC-1 
E        111244182 DNA repair endonuclease XPF-like isoform X1	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
E        111245177 DNA repair protein complementing XP-G cells homolog isoform X1	K10846 ERCC5; DNA excision repair protein ERCC-5 
E        111246951 DNA ligase 1-like	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
E        111254929 MMS19 nucleotide excision repair protein homolog isoform X1	K15075 MET18; DNA repair/transcription protein MET18/MMS19 
E        111244360 cullin-3-like isoform X1	K03869 CUL3; cullin 3 
E        111246528 cullin-5-like isoform X1	K10612 CUL5; cullin 5 
E        111245574 elongin-C	K03872 ELOC; elongin-C 
E        111249138 elongin-B-like	K03873 ELOB; elongin-B 
E        111246685 transcription elongation factor B polypeptide 3-like isoform X1	K15076 ELOA; elongin-A 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        111246541 DNA mismatch repair protein Msh2-like isoform X1	K08735 MSH2; DNA mismatch repair protein MSH2 
E        111250617 DNA mismatch repair protein Msh6-like isoform X1	K08737 MSH6; DNA mismatch repair protein MSH6 
D      MutL homologs
E        111250917 DNA mismatch repair protein MLH1-like isoform X1	K08734 MLH1; DNA mismatch repair protein MLH1 
E        111251877 mismatch repair endonuclease PMS2-like	K10858 PMS2; DNA mismatch repair protein PMS2 
E        111251132 uncharacterized protein LOC111251132 isoform X1	K08739 MLH3; DNA mismatch repair protein MLH3 
D      DNA polymerase delta complex
E        111246717 DNA polymerase delta catalytic subunit-like	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
E        111245067 DNA polymerase delta subunit 2-like	K02328 POLD2; DNA polymerase delta subunit 2 
D      RPA (replication factor A)
E        111250051 replication protein A 70 kDa DNA-binding subunit-like	K07466 RFA1; replication factor A1 
E        111247201 replication protein A 32 kDa subunit-A-like isoform X1	K10739 RFA2; replication factor A2 
E        111249204 uncharacterized protein LOC111249204 isoform X1	K10740 RPA3; replication factor A3 
D      RFC (replication factor C)
E        111250094 replication factor C subunit 1-like isoform X1	K10754 RFC1; replication factor C subunit 1 
E        111246822 replication factor C subunit 4-like	K10755 RFC2_4; replication factor C subunit 2/4 
E        111255325 replication factor C subunit 2-like	K10755 RFC2_4; replication factor C subunit 2/4 
E        111253224 replication factor C subunit 5-like	K10756 RFC3_5; replication factor C subunit 3/5 
E        111249725 replication factor C subunit 3-like isoform X1	K10756 RFC3_5; replication factor C subunit 3/5 
D      Other MMR factors
E        111255538 proliferating cell nuclear antigen-like	K04802 PCNA; proliferating cell nuclear antigen 
E        111248633 exonuclease 1-like	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
E        111247446 high mobility group protein DSP1-like	K10802 HMGB1; high mobility group protein B1 
E        111246951 DNA ligase 1-like	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
E        111252636 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like	K10865 MRE11; double-strand break repair protein MRE11 
E        111253034 double-strand break repair protein MRE11-like	K10865 MRE11; double-strand break repair protein MRE11 
E        111252827 DNA repair protein RAD50-like isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      BRCA1-core complex
E        111252775 BRCA1-associated RING domain protein 1-like	K10683 BARD1; BRCA1-associated RING domain protein 1 
D      BRCA1-A complex
E        111250714 BRISC complex subunit Abraxas 2-like	K20774 FAM175A; BRCA1-A complex subunit Abraxas 
E        111248318 BRISC and BRCA1-A complex member 2-like	K12173 BRE; BRCA1-A complex subunit BRE 
E        111254657 lys-63-specific deubiquitinase BRCC36-like isoform X1	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
D      BRCA1-B complex
E        111252443 Fanconi anemia group J protein-like isoform X1	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        111255387 DNA topoisomerase 2-binding protein 1-like isoform X1	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      BRCA1-C complex
E        111252636 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like	K10865 MRE11; double-strand break repair protein MRE11 
E        111253034 double-strand break repair protein MRE11-like	K10865 MRE11; double-strand break repair protein MRE11 
E        111252827 DNA repair protein RAD50-like isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      BRCA complex
E        111250972 DNA repair protein RAD51 homolog A-like isoform X1	K04482 RAD51; DNA repair protein RAD51 
D      RecA family proteins
E        111250972 DNA repair protein RAD51 homolog A-like isoform X1	K04482 RAD51; DNA repair protein RAD51 
E        111247370 DNA repair protein RAD51 homolog 4-like	K10871 RAD51L3; RAD51-like protein 3 
E        111244333 DNA repair protein XRCC2-like isoform X1	K10879 XRCC2; DNA-repair protein XRCC2 
E        111244274 DNA repair protein XRCC3-like	K10880 XRCC3; DNA-repair protein XRCC3 
D      Rad52 family proteins
D      Rad54 family proteins
E        111246919 DNA repair and recombination protein RAD54-like	K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] 
E        111244615 helicase ARIP4-like isoform X1	K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] 
D      RecQ family DNA helicases
E        111246400 putative ATP-dependent DNA helicase Q1	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        111250461 putative ATP-dependent DNA helicase Q1	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        111253894 Werner syndrome ATP-dependent helicase-like	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
E        111255405 Bloom syndrome protein homolog isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        111251853 uncharacterized protein LOC111251853 isoform X1	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
E        111251294 ATP-dependent DNA helicase Q5-like isoform X1	K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] 
D      Bloom's syndrome complex (BTR)
E        111255405 Bloom syndrome protein homolog isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        111252460 DNA topoisomerase 3-alpha-like isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        111254219 DNA topoisomerase 3-beta-1-like	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
D      RPA (replication factor A)
E        111250051 replication protein A 70 kDa DNA-binding subunit-like	K07466 RFA1; replication factor A1 
E        111247201 replication protein A 32 kDa subunit-A-like isoform X1	K10739 RFA2; replication factor A2 
E        111249204 uncharacterized protein LOC111249204 isoform X1	K10740 RPA3; replication factor A3 
D      Protein phosphatase 4
E        111253107 serine/threonine-protein phosphatase 4 catalytic subunit isoform X1	K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] 
E        111246344 serine/threonine-protein phosphatase 4 catalytic subunit-like	K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] 
E        111243380 uncharacterized protein LOC111243380 isoform X1	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        111247834 serine/threonine-protein phosphatase 4 regulatory subunit 2-like	K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 
E        111250762 serine/threonine-protein phosphatase 4 regulatory subunit 3-like	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
D      AP-5 complex
D      SMC5-SMC6 complex
E        111246624 structural maintenance of chromosomes protein 5-like isoform X1	K22803 SMC5; structural maintenance of chromosomes protein 5 
E        111245264 structural maintenance of chromosomes protein 6-like	K22804 SMC6; structural maintenance of chromosomes protein 6 
E        111249237 uncharacterized protein LOC111249237	K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] 
E        111248417 uncharacterized protein LOC111248417 isoform X1	K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] 
E        111248454 uncharacterized protein LOC111248454	K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] 
E        111245868 non-structural maintenance of chromosomes element 3 homolog	K22823 NSMCE3; non-structural maintenance of chromosomes element 3 
E        111251982 EP300-interacting inhibitor of differentiation 3-like isoform X1	K22825 NSMCE4; non-structural maintenance of chromosomes element 4 
D      Other HR factors
E        111253041 uncharacterized protein LOC111253041 isoform X1	K10883 EME2; crossover junction endonuclease EME2 
E        111243736 exonuclease 3'-5' domain-containing protein 2-like	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        111245006 exonuclease 3'-5' domain-containing protein 2-like	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        111254230 LOW QUALITY PROTEIN: exonuclease 3'-5' domain-containing protein 2-like	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        111246936 uncharacterized protein LOC111246936 isoform X1	K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-] 
E        111251004 26S proteasome complex subunit SEM1-like	K10881 SHFM1; 26 proteasome complex subunit DSS1 
E        111250492 structure-specific endonuclease subunit slx1-like isoform X1	K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] 
E        111253769 uncharacterized protein LOC111253769 isoform X1	K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) 
E        111252024 spatacsin-like isoform X1	K19026 SPG11; spatacsin 
E        111248137 uncharacterized protein LOC111248137	K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 
E        111243479 mortality factor 4-like protein 1 isoform X1	K11339 MORF4L1; mortality factor 4-like protein 1 
E        111252347 mortality factor 4-like protein 1	K11339 MORF4L1; mortality factor 4-like protein 1 
E        111249285 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1	K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] 
E        111253810 fidgetin-like protein 1	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        111245826 tonsoku-like protein	K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 
E        111244450 PCNA-interacting partner-like	K27412 PARPBP; PCNA-interacting partner 
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
E        111249260 ATP-dependent DNA helicase 2 subunit 1-like isoform X1	K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 
E        111250759 uncharacterized protein LOC111250759 isoform X1	K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 
D      MRX complex
E        111252636 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like	K10865 MRE11; double-strand break repair protein MRE11 
E        111253034 double-strand break repair protein MRE11-like	K10865 MRE11; double-strand break repair protein MRE11 
E        111252827 DNA repair protein RAD50-like isoform X1	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      DNA Ligase 4 complex
D      X-family DNA polymerases
D      Other NHEJ factors
E        111246377 ubiquitin carboxyl-terminal hydrolase 36-like	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        111247895 protein artemis-like isoform X1	K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-] 
E        111244639 tyrosyl-DNA phosphodiesterase 2-like isoform X1	K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] 
C    FA (Fanconi anemia) pathway
D      FA core complex
E        111248323 uncharacterized protein LOC111248323 isoform X1	K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
D      FA core complex binding factors
E        111253162 protein hairy-like	K06054 HES1; hairy and enhancer of split 1 
E        111247382 centromere protein S-like isoform X1	K11511 APITD1; centromere protein S 
E        111244852 centromere protein X-like	K15360 STRA13; centromere protein X 
E        111244211 ubiquitin-conjugating enzyme E2 T-like	K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] 
D      Bloom's syndrome complex (BTR)
E        111255405 Bloom syndrome protein homolog isoform X1	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        111252460 DNA topoisomerase 3-alpha-like isoform X1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        111254219 DNA topoisomerase 3-beta-1-like	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
D      FANCD2-I complex
E        111248267 Fanconi anemia group D2 protein-like isoform X1	K10891 FANCD2; fanconi anemia group D2 protein 
E        111255094 uncharacterized protein LOC111255094 isoform X1	K10895 FANCI; fanconi anemia group I protein 
D      Downstream FA components
E        111252443 Fanconi anemia group J protein-like isoform X1	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
D      Other FA pathway factors
E        111253145 fanconi-associated nuclease 1-like	K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] 
E        111250972 DNA repair protein RAD51 homolog A-like isoform X1	K04482 RAD51; DNA repair protein RAD51 
E        111251216 telomere length regulation protein TEL2 homolog	K11137 TELO2; telomere length regulation protein 
E        111247202 WD repeat-containing protein 48-like	K15361 WDR48; WD repeat-containing protein 48 
C    Other DSBR factors
D      Protein phosphatase 6
E        111246786 serine/threonine-protein phosphatase 6 catalytic subunit-like	K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] 
E        111246942 serine/threonine-protein phosphatase 6 regulatory subunit 3-like	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        111248665 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like isoform X1	K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 
D      Ubiquitin ligases
E        111254037 E3 ubiquitin-protein ligase rnf8-like	K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
E        111245561 E3 ubiquitin-protein ligase HERC2-like isoform X1	K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] 
D      Others
E        111250024 telomerase Cajal body protein 1-like isoform X1	K23314 WRAP53; telomerase Cajal body protein 1 
E        111253958 uncharacterized protein LOC111253958 isoform X1	K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1 
E        111253615 WD repeat-containing protein 70-like isoform X1	K24752 WDR70; WD repeat-containing protein 70 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      111247667 DNA polymerase eta-like isoform X1	K03509 POLH; DNA polymerase eta [EC:2.7.7.7] 
D      111252512 uncharacterized protein LOC111252512 isoform X1	K03511 POLK; DNA polymerase kappa [EC:2.7.7.7] 
D      111250850 DNA repair protein REV1-like	K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] 
C    B-family DNA polymerases
C    A-family DNA polymerase
C    Rad6 epistasis group
D      111246563 ubiquitin-conjugating enzyme E2 A isoform X1	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      111254471 ubiquitin-conjugating enzyme E2 variant 2-like isoform X1	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      111244953 ubiquitin-conjugating enzyme E2 N	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
C    Other TLS factors
D      111255538 proliferating cell nuclear antigen-like	K04802 PCNA; proliferating cell nuclear antigen 
D      111244450 PCNA-interacting partner-like	K27412 PARPBP; PCNA-interacting partner 
D      111252866 sprT-like domain-containing protein Spartan isoform X1	K24051 SPRTN; SprT-like domain-contaning protein Spartan 
D      111250859 acidic repeat-containing protein-like	K26957 GCNA; germ cell nuclear acidic protein 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
D      111250491 cell cycle checkpoint control protein RAD9A-like	K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] 
D      111250112 checkpoint protein HUS1-like isoform X1	K10903 HUS1; HUS1 checkpoint protein 
D      111243288 uncharacterized protein LOC111243288	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    HRAD17(Rad24)-RFC complex
D      111245226 cell cycle checkpoint protein RAD17-like isoform X1	K06662 HRAD17; cell cycle checkpoint protein 
D      111246822 replication factor C subunit 4-like	K10755 RFC2_4; replication factor C subunit 2/4 
D      111255325 replication factor C subunit 2-like	K10755 RFC2_4; replication factor C subunit 2/4 
D      111253224 replication factor C subunit 5-like	K10756 RFC3_5; replication factor C subunit 3/5 
D      111249725 replication factor C subunit 3-like isoform X1	K10756 RFC3_5; replication factor C subunit 3/5 
C    Rad17-Mec3-Ddc1 complex
D      111243288 uncharacterized protein LOC111243288	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    FPC (fork protection complex)
D      111243424 protein timeless homolog isoform X1	K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 
D      111255029 uncharacterized protein LOC111255029 isoform X1	K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 
D      111249087 glutamic acid-rich protein-like	K25773 CLSPN; claspin 
C    Triple T complex
D      111251216 telomere length regulation protein TEL2 homolog	K11137 TELO2; telomere length regulation protein 
D      111245337 uncharacterized protein LOC111245337 isoform X1	K20403 TTI1; TELO2-interacting protein 1 
D      111251509 uncharacterized protein LOC111251509	K23115 TTI2; TELO2-interacting protein 2 
C    BAG6-UBL4A-GET4 complex
D      111243914 large proline-rich protein BAG6-like isoform X1	K23390 BAG6; large proline-rich protein BAG6 
D      111248394 ubiquitin-like protein 4A	K23388 UBL4; ubiquitin-like protein 4 
D      111255547 Golgi to ER traffic protein 4 homolog	K23387 GET4; golgi to ER traffic protein 4 
C    Other check point factors
D      111249578 serine/threonine-protein kinase ATR-like isoform X1	K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] 
D      111245313 uncharacterized protein LOC111245313 isoform X1	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      111251447 cellular tumor antigen p53-like	K04451 TP53; tumor protein p53 
D      111253280 serine/threonine-protein kinase grp-like	K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] 
D      111245511 M-phase inducer phosphatase 1-like	K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48] 
D      111244338 14-3-3 protein zeta/delta-like	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      111254609 14-3-3 protein zeta-like isoform X1	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      111251141 14-3-3 protein zeta-like	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      111252429 14-3-3 protein epsilon-like	K06630 YWHAE; 14-3-3 protein epsilon 
D      111247979 neuron navigator 3-like isoform X1	K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] 
D      111253089 wee1-like protein kinase 1-A	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      111250028 uncharacterized protein LOC111250028 isoform X1	K20780 MDC1; mediator of DNA damage checkpoint protein 1 
D      111250435 plastin-1-like	K17336 PLS3; plastin-3 
D      111247778 protein downstream neighbor of son homolog	K22422 DONSON; protein downstream neighbor of Son 
D      111249912 uncharacterized protein LOC111249912 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      111252513 vacuolar protein sorting-associated protein 4B-like isoform X1	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      111252985 vacuolar protein sorting-associated protein 4A-like	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      111246649 abscission/NoCut checkpoint regulator-like isoform X1	K24778 ZFYVE19; abscission/NoCut checkpoint regulator 
D      111249972 protein SDE2 homolog	K25059 SDE2; replication stress response regulator SDE2 
B  Other factors with a suspected DNA repair function
C    DNA polymerases
D      111248673 DNA polymerase theta-like isoform X1	K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] 
D      111252782 DNA polymerase V-like isoform X1	K02331 POL5; DNA polymerase phi [EC:2.7.7.7] 
D      111248135 DNA-directed primase/polymerase protein-like isoform X1	K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] 
C    Nucleases
D      111249405 uncharacterized protein LOC111249405	K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2] 
D      111247160 uncharacterized protein LOC111247160 isoform X1	K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 
C    Helicases
D      111251527 helicase POLQ-like	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
C    PSO4 complex
D      111252111 pre-mRNA-processing factor 19-like	K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] 
D      111243738 cell division cycle 5-like protein	K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 
D      111250048 pre-mRNA-splicing factor SPF27-like	K12861 BCAS2; pre-mRNA-splicing factor SPF27 
D      111242826 pleiotropic regulator 1-like	K12862 PLRG1; pleiotropic regulator 1 
C    Modulation of nucleotide pools
D      111247718 7,8-dihydro-8-oxoguanine triphosphatase-like	K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] 
D      111245848 8-oxo-dGDP phosphatase NUDT18-like	K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 
D      111250969 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      111252812 ribonucleoside-diphosphate reductase large subunit-like	K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] 
D      111247123 ribonucleoside-diphosphate reductase subunit M2 B-like	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
#
A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      111243174 methylated-DNA--protein-cysteine methyltransferase-like	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
C    BER (base exicision repair)
D      DNA glycosylases
E        111252021 DNA-3-methyladenine glycosylase-like	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
D      AP endonucleases
D      RecJ
D      DNA ligase
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      Molecular matchmaker
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
D      Other MMR factors
E        111245206 single-stranded DNA-binding protein, mitochondrial-like	K03111 ssb; single-strand DNA-binding protein 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
D      RecFOR pathway proteins
D      AddAB pathway proteins
D      Other HR factor
D      Archaeal homologous recombinant proteins
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
E        Facilitator
E        Supressor
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    Other SOS response factors
D      111245206 single-stranded DNA-binding protein, mitochondrial-like	K03111 ssb; single-strand DNA-binding protein 
B  Other factors with a suspected DNA repair function
C    DNA polymerase
C    DNA helicases
C    Modulation of nucleotide pools
D      111250969 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
C    Others
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#Last updated: March 29, 2024