+C Two-component system KO
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Two-Component System - Vibrio furnissii
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C vfu_A02812 phosphate regulon sensor kinase PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C vfu_A02813 Response regulator K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
C vfu_A00539 osmolarity sensor protein EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C vfu_A00538 osmolarity response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
C vfu_A00572 sensor protein CpxA K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C vfu_A00573 transcriptional regulator CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
C vfu_B00777 periplasmic sensor signal transduction histidine kinase K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C vfu_B00775 two-component response regulator K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C vfu_A00185 sensory histidine kinase in two-component regulatory system with CusR, senses copper ions K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
B QseC-QseB (quorum sensing)
C vfu_B00653 signal transduction histidine kinase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C vfu_B00654 DNA-binding response regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
B TorS-TorR (TMAO respiration)
C vfu_B00334 sensor protein TorS K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
C vfu_A01624 DNA-binding response regulator in two-component regulatory system with TorS K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
B ArcB-ArcA (anoxic redox control)
C vfu_A02903 sensor histidine kinase FexB K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C vfu_A02901 DNA-binding response regulator in two-component regulatory system with ArcB or CpxA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C vfu_A01709 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C vfu_A02440 Response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C vfu_A01759 transcriptional regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C vfu_B01444 two component transcriptional regulator, LuxR family K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
C vfu_B00309 nitrate/nitrite sensor protein NarQ K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C vfu_B00308 response regulator K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C vfu_A02667 sensor protein UhpB K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C vfu_A02666 response repressor in two-component regulatory system with UhpB K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
C vfu_A02457 sensor protein UhpB K20263 fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3]
C vfu_A02456 transcriptional regulator UhpA K20264 fusR; two-component system, NarL family, response regulator FusR
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C vfu_A00841 sensor histidine kinase/response regulator K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C vfu_A02143 transcriptional regulator, LuxR family K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C vfu_B00134 Sensory box sensor histidine kinase/response regulator VieS K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C vfu_B00670 PAS/PAC sensor hybrid histidine kinase K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C vfu_B00669 two component transcriptional regulator, LuxR family K07690 evgA; two-component system, NarL family, response regulator EvgA
C vfu_B00136 response regulator VbsA K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
C vfu_B00140 two component transcriptional regulator K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C vfu_A01758 Sensor histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
C vfu_B01443 sensor histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
C vfu_A02068 sensor kinase citA, hypothetical K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
C vfu_A02067 response regulator K02475 K02475; two-component system, CitB family, response regulator
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C vfu_A00992 hypothetical regulator of cell autolysis K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C vfu_A00991 response regulator K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C vfu_A00495 nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C vfu_A00494 nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C vfu_A02432 C4-dicarboxylate transport sensor protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C vfu_A02433 C4-dicarboxylate transport transcriptional regulatory protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C vfu_B00729 C4-dicarboxylate transport transcriptional regulatory protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C vfu_A01875 sensor histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C vfu_B00983 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C vfu_A01256 Chemotaxis protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C vfu_B00984 chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C vfu_A01795 hypothetical chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C vfu_A01254 chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C vfu_B00977 protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C vfu_A01257 protein-glutamate methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C vfu_A01326 chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C vfu_B00759 chemotaxis protein CheV, hypothetical K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C vfu_A01118 chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C vfu_A02065 chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
C vfu_B00358 sensor histidine kinase LuxQ K10909 luxQ; two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC:2.7.13.3 3.1.3.-]
C vfu_B00270 sensor histidine kinase/response regulator LuxN K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]
C vfu_A02580 phosphorelay protein K10911 luxU; two-component system, phosphorelay protein LuxU
C vfu_A02581 LuxO repressor protein K10912 luxO; two-component system, repressor protein LuxO
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
C vfu_A01446 hypothetical tetrathionate reductase complex: sensory transduction histidine kinase K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3]
C vfu_A01445 hypothetical tetrathionate reductase complex: response regulator K13041 ttrR; two-component system, LuxR family, response regulator TtrR
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C vfu_A01187 sensory box sensor histidine kinase K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C vfu_A01188 FlaM K10943 flrC; two-component system, response regulator FlrC
C vfu_A01403 acetoacetate metabolism regulatory protein AtoC K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C vfu_A01781 para-aminobenzoate synthase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C vfu_B00974 response regulator K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C vfu_A01559 hypothetical two-component response regulatory protein K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C vfu_A00916 sensory box sensor histidine kinase/response regulator K19694 chiS; two-component system, sensor histidine kinase ChiS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023