+F Repair protein KO
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DNA Repair and Recombination Proteins - Varroa jacobsoni
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111263173 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 111271503 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 111263432 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111267380 N-glycosylase/DNA lyase-like K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 111268356 uncharacterized protein LOC111268356 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 111273632 DNA-(apurinic or apyrimidinic site) lyase 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 111270861 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 111261587 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F 111266697 DNA polymerase epsilon catalytic subunit A-like isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 111267118 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 111260336 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 111270450 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 111269688 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 111271971 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 111268406 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 111268016 uncharacterized protein LOC111268016 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 111266979 DNA ligase 3-like isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 111272196 tyrosyl-DNA phosphodiesterase 1-like isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 111265003 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111267008 uncharacterized protein LOC111267008 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111265958 uncharacterized protein F21D5.5-like isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 111261156 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 111263161 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 111260632 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 111272687 uncharacterized protein LOC111272687 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 111267200 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
F 111272096 caltractin-like isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 111266216 RING-box protein 1-like isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111267494 cullin-4B-like K10609 CUL4; cullin 4
F 111273762 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 111269507 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 111270656 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 111265116 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 111269298 DNA-directed RNA polymerase II subunit RPB4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111272633 DNA-directed RNA polymerases I, II, and III subunit RPABC1-like K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 111259886 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 111271467 DNA-directed RNA polymerase II subunit RPB7-like isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 111273077 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 111263466 DNA-directed RNA polymerase II subunit RPB9-like K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 111258735 DNA-directed RNA polymerase II subunit RPB11-like isoform X1 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 111266216 RING-box protein 1-like isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111267494 cullin-4B-like K10609 CUL4; cullin 4
F 111273762 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 111267730 DNA excision repair protein ERCC-8-like K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 111268207 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 111267601 UV-stimulated scaffold protein A-like K23720 UVSSA; UV-stimulated scaffold protein A
F 111259450 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 111260331 DNA excision repair protein haywire-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 111270433 TFIIH basal transcription factor complex helicase XPD subunit-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 111259512 general transcription factor IIH subunit 1-like K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 111262647 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 111260781 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 111271441 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 111260023 cyclin-dependent kinase 7-like K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 111267927 cyclin-H-like K06634 CCNH; cyclin H
E 111273263 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 111263210 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 111272059 replication protein A 32 kDa subunit-A-like isoform X1 K10739 RFA2; replication factor A2
E 111263989 uncharacterized protein LOC111263989 isoform X1 K10740 RPA3; replication factor A3
D Other NER factors
E 111264857 DNA repair protein complementing XP-A cells-like K10847 XPA; DNA-repair protein complementing XP-A cells
E 111262195 DNA excision repair protein ERCC-1-like isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 111258717 DNA repair endonuclease XPF-like K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 111266153 DNA repair protein complementing XP-G cells homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 111268406 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 111263884 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 111272929 cullin-3-like isoform X1 K03869 CUL3; cullin 3
E 111265637 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 111266070 elongin-C K03872 ELOC; elongin-C
E 111265275 elongin-B-like K03873 ELOB; elongin-B
E 111271179 transcription elongation factor B polypeptide 3-like isoform X1 K15076 ELOA; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 111265491 DNA mismatch repair protein Msh2-like isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 111259884 DNA mismatch repair protein Msh6-like isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 111264396 DNA mismatch repair protein MLH1-like isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 111260709 mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
E 111263425 uncharacterized protein LOC111263425 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 111270861 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 111261587 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E 111263210 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 111272059 replication protein A 32 kDa subunit-A-like isoform X1 K10739 RFA2; replication factor A2
E 111263989 uncharacterized protein LOC111263989 isoform X1 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 111265416 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
E 111262039 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 111271150 replication factor C subunit 4-like isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 111268481 replication factor C subunit 5-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 111260816 replication factor C subunit 3-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 111269688 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 111270908 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 111261156 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 111268406 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 111265608 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 111263227 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 111259831 BRCA1-associated RING domain protein 1-like isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
E 111269982 uncharacterized protein LOC111269982 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 111258653 BRISC complex subunit Abraxas 2-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 111264568 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 111272722 lys-63-specific deubiquitinase BRCC36-like isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 111271554 Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 111264203 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 111265608 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 111263227 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 111266126 DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 111266126 DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 111266689 DNA repair protein RAD51 homolog 4-like K10871 RAD51L3; RAD51-like protein 3
E 111266162 DNA repair protein XRCC2-like isoform X1 K10879 XRCC2; DNA-repair protein XRCC2
E 111261659 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 111266579 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 111273974 helicase ARIP4-like isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 111261315 putative ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 111262383 putative ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 111259405 Werner syndrome ATP-dependent helicase-like isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 111273019 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111271328 uncharacterized protein LOC111271328 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 111266250 ATP-dependent DNA helicase Q5-like isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 111273019 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111259134 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111269938 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111273459 uncharacterized protein LOC111273459 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 111263210 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 111272059 replication protein A 32 kDa subunit-A-like isoform X1 K10739 RFA2; replication factor A2
E 111263989 uncharacterized protein LOC111263989 isoform X1 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 111269924 serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111268103 serine/threonine-protein phosphatase 4 catalytic subunit-like K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111271022 uncharacterized protein LOC111271022 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 111273167 serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111271497 serine/threonine-protein phosphatase 4 regulatory subunit 3-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 111271333 structural maintenance of chromosomes protein 5-like isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 111259179 structural maintenance of chromosomes protein 6-like isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 111262277 uncharacterized protein LOC111262277 isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 111266276 uncharacterized protein LOC111266276 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 111269443 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 111266204 non-structural maintenance of chromosome element 4-like isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 111261183 uncharacterized protein LOC111261183 isoform X1 K10883 EME2; crossover junction endonuclease EME2
E 111270175 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 111261288 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 111265261 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 111260264 uncharacterized protein LOC111260264 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 111260326 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 111263347 structure-specific endonuclease subunit slx1-like isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 111262365 uncharacterized protein LOC111262365 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 111259822 spatacsin-like isoform X1 K19026 SPG11; spatacsin
E 111261153 uncharacterized protein LOC111261153 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 111264368 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111273094 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111267457 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 111268954 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 111267291 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 111270378 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 111263378 ATP-dependent DNA helicase 2 subunit 1-like isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 111268071 uncharacterized protein LOC111268071 isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 111265608 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 111263227 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
E 111265003 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111267008 uncharacterized protein LOC111267008 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111268153 protein artemis-like isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 111262434 tyrosyl-DNA phosphodiesterase 2-like isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 111272797 uncharacterized protein LOC111272797 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
C FA (Fanconi anemia) pathway
D FA core complex
E 111261302 uncharacterized protein LOC111261302 isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 111260001 uncharacterized protein LOC111260001 isoform X1 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 111269929 protein hairy-like K06054 HES1; hairy and enhancer of split 1
E 111264899 centromere protein S-like isoform X1 K11511 APITD1; centromere protein S
E 111270812 centromere protein X-like K15360 STRA13; centromere protein X
E 111270810 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 111273019 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111259134 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111269938 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111273459 uncharacterized protein LOC111273459 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 111271705 Fanconi anemia group D2 protein-like isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 111263256 uncharacterized protein LOC111263256 isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 111271554 Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 111272248 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 111266126 DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 111274014 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 111260243 WD repeat-containing protein 48-like K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 111264868 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111261143 serine/threonine-protein phosphatase 6 regulatory subunit 3-like K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 111266141 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 111259548 E3 ubiquitin-protein ligase rnf8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 111263816 E3 ubiquitin-protein ligase HERC2-like K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 111272964 telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
E 111261799 uncharacterized protein LOC111261799 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 111267603 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 111264142 DNA polymerase eta-like isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 111271260 uncharacterized protein LOC111271260 isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 111266567 DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D 111259034 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111273647 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111269164 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 111269688 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 111270378 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
D 111267525 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 111262716 acidic repeat-containing protein-like isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 111263346 cell cycle checkpoint control protein RAD9A-like K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 111263374 checkpoint protein HUS1-like isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 111264981 uncharacterized protein LOC111264981 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 111265835 cell cycle checkpoint protein RAD17-like isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 111262039 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 111271150 replication factor C subunit 4-like isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 111268481 replication factor C subunit 5-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 111260816 replication factor C subunit 3-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 111264981 uncharacterized protein LOC111264981 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 111260152 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 111273683 uncharacterized protein LOC111273683 isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 111265093 glutamic acid-rich protein-like K25773 CLSPN; claspin
C Triple T complex
D 111274014 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 111263696 uncharacterized protein LOC111263696 isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 111266391 uncharacterized protein LOC111266391 isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 111260878 large proline-rich protein BAG6-like K23390 BAG6; large proline-rich protein BAG6
D 111271428 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 111261996 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 111268316 serine/threonine-protein kinase ATR-like isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 111270379 uncharacterized protein LOC111270379 isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 111269297 cellular tumor antigen p53-like isoform X1 K04451 TP53; tumor protein p53
D 111259065 serine/threonine-protein kinase grp-like K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 111260799 M-phase inducer phosphatase 1-like K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 111259331 14-3-3 protein zeta-like isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111260328 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111263305 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111269528 14-3-3 protein epsilon-like isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 111261312 neuron navigator 3-like isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 111260557 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111269362 uncharacterized protein LOC111269362 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 111259911 plastin-1-like K17336 PLS3; plastin-3
D 111261322 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 111261544 uncharacterized protein LOC111261544 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111272496 uncharacterized protein LOC111272496 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111269958 uncharacterized protein LOC111269958 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111271261 vacuolar protein sorting-associated protein 4B-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111262830 vacuolar protein sorting-associated protein 4A-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111266714 abscission/NoCut checkpoint regulator-like isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 111271565 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 111262867 DNA polymerase theta-like K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 111263051 DNA polymerase V-like isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 111267590 DNA-directed primase/polymerase protein-like isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 111271764 uncharacterized protein LOC111271764 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 111273810 uncharacterized protein LOC111273810 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 111265553 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 111266289 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 111271126 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 111273188 pre-mRNA-splicing factor SPF27-like K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 111258731 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 111270435 7,8-dihydro-8-oxoguanine triphosphatase-like isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 111258620 8-oxo-dGDP phosphatase NUDT18-like isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 111263437 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 111265451 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111265112 ribonucleoside-diphosphate reductase subunit M2 B-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111263173 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 111263432 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 111259586 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F 111273277 LOW QUALITY PROTEIN: uncharacterized protein LOC111273277 K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F 111273398 uncharacterized protein LOC111273398 K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F 111273383 LOW QUALITY PROTEIN: uncharacterized protein LOC111273383 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 111259586 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 111263437 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024