+F Repair protein KO
#
DNA Repair and Recombination Proteins - Vulpes vulpes (red fox)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 112928803 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 112910483 ALKBH2; DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 112914443 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 112923182 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 112910498 UNG; LOW QUALITY PROTEIN: uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 112935129 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 112930670 TDG; G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 112909135 MPG; DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 112911277 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 112914785 MUTYH; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 112933691 MBD4; methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 112933671 OGG1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 112910111 NEIL1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 112926756 NEIL2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 112932862 NEIL3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 112909095 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 112914843 APEX1; DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 112912374 APEX2; DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 112931281 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 112911682 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 112928649 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 112924189 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 112911600 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 112921459 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 112923084 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 112916699 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 112930067 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 112931262 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 112916158 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 112931248 XRCC1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 112917995 LIG3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 112930197 TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 112927557 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 112934404 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 112931452 PNKP; bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 112925668 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 112918651 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 112915159 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 112923556 PARP1; poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 112918584 PARP4; poly [ADP-ribose] polymerase 4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 112910742 PARP3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 112914982 PARP2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 112914451 XPC; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 112908091 RAD23A; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 112922975 RAD23B; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 112912370 centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 112934005 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 112927492 CUL4A; cullin-4A K10609 CUL4; cullin 4
F 112934425 CUL4B; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 112911054 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 112924073 DDB2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 112924841 POLR2A; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 112923701 POLR2B; DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 112912793 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 112929650 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 112932713 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 112935475 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 112929126 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 112924357 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 112926268 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 112928543 POLR2I; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 112923954 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 112935797 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 112916960 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 112934005 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 112927492 CUL4A; cullin-4A K10609 CUL4; cullin 4
F 112934425 CUL4B; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 112911054 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 112935354 ERCC8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 112913160 ERCC6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 112920094 UVSSA; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 112908142 ELOF1; transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 112932697 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 112931257 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 112911569 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 112906917 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 112933823 GTF2H3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 112913577 GTF2H4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 112935134 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 112935878 CDK7; cyclin-dependent kinase 7 isoform X3 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 112915512 CCNH; LOW QUALITY PROTEIN: cyclin-H K06634 CCNH; cyclin H
E 112921362 MNAT1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 112933167 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 112931729 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 112923925 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 112910227 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Other NER factors
E 112930889 XPA; DNA repair protein complementing XP-A cells isoform X1 K10847 XPA; DNA-repair protein complementing XP-A cells
E 112931206 ERCC1; DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 112923338 ERCC4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 112927479 ERCC5; DNA repair protein complementing XP-G cells isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 112931262 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 112914369 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 112925537 CUL3; cullin-3 isoform X1 K03869 CUL3; cullin 3
E 112925956 CUL5; LOW QUALITY PROTEIN: cullin-5 K10612 CUL5; cullin 5
E 112930296 ELOC; elongin-C K03872 ELOC; elongin-C
E 112908995 ELOB; elongin-B K03873 ELOB; elongin-B
E 112930145 ELOA; elongin-A K15076 ELOA; elongin-A
E 112927547 UBAP2; ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 112918880 UBAP2L; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 112915229 MSH2; DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 112919583 MSH3; DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 112915230 MSH6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 112922936 PMS1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 112921667 MLH1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 112909998 PMS2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 112927286 MLH3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 112931281 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 112911682 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 112928649 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 112924189 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 112933167 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 112931729 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 112923925 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 112910227 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 112919329 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 112926297 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 112935749 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 112926201 LOW QUALITY PROTEIN: replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
E 112918670 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 112932911 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 112930067 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 112923521 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 112925668 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 112918651 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 112931262 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 112920011 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 112915765 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 112917079 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 112930896 NBN; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 112910801 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 112922456 BARD1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 112910801 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 112919685 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 112925695 UIMC1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 112913116 BABAM1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 112933000 BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 112918166 BRCC3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 112908355 LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 112910801 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 112917947 BRIP1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 112932500 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 112910801 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 112925728 RBBP8; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 112915765 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 112917079 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 112930896 NBN; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 112910801 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 112918664 BRCA2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 112908291 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 112919949 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 112919949 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 112927197 RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 112917927 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 112917992 RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 112916196 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 112930297 XRCC3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 112917413 RAD52; DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 112912513 LOW QUALITY PROTEIN: RAD52 motif-containing protein 1-like K10874 RDM1; RAD52 motif-containing protein 1
E 112912685 RDM1; LOW QUALITY PROTEIN: RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 112914769 RAD54L; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 112910820 RAD54L2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 112931140 RAD54B; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 112917227 RECQL; ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 112916106 WRN; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 112921453 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 112911115 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 112920796 RECQL5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 112921453 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 112907457 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 112924950 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 112911629 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 112933167 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 112931729 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 112923925 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 112910227 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 112929205 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 112925286 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 112932177 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 112909042 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 112915262 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 112919034 serine/threonine-protein phosphatase 4 regulatory subunit 3B-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 112907319 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 112907325 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 112924251 AP5B1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 112921398 AP5M1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 112930080 AP5S1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 112929318 AP5Z1; AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 112922115 SMC5; structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 112932098 SMC6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 112910730 FAM84A; protein FAM84A K22805 FAM84A; protein FAM84A
E 112929178 NSMCE1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 112915976 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 112922401 NSMCE3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 112915176 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 112916988 LOW QUALITY PROTEIN: non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 112929035 EID3; EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 112915488 SLF1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 112914918 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 112917857 EME1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 112909014 EME2; LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 112927208 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 112924243 MUS81; crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 112927817 SWI5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 112915799 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 112929339 SLX1A; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 112923260 SLX4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 112932118 GEN1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 112920022 SPG11; spatacsin K19026 SPG11; spatacsin
E 112927196 ZFYVE26; zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 112917375 RAD51AP1; RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 112922772 MORF4L1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 112928180 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 112925827 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 112910702 SPIDR; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 112915978 FAM84B; protein FAM84B K22810 FAM84B; protein FAM84B
E 112929311 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 112909531 CFAP410; protein C21orf2 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 112935624 HDGFL2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 112908153 SWSAP1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 112928631 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 112909522 HSF2BP; heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 112923169 MMS22L; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 112911171 TONSL; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 112922566 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 112930723 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 112934010 XRCC6; LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 112922451 XRCC5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 112929152 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 112915765 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 112917079 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 112927468 LIG4; DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 112915517 XRCC4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 112922536 NHEJ1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 112915159 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 112911693 POLM; DNA-directed DNA/RNA polymerase mu isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 112917661 DNTT; DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 112916158 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 112927557 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 112934404 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 112933106 DCLRE1C; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 112920496 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 112925259 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 112912659 LOW QUALITY PROTEIN: PWWP domain-containing protein MUM1L1-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 112912723 PWWP domain-containing protein MUM1L1-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 112932013 MUM1L1; PWWP domain-containing protein MUM1L1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 112911484 PWWP domain-containing protein MUM1L1-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 112935495 PWWP domain-containing protein MUM1 isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 112906905 PAXX; protein PAXX K25772 PAXX; protein PAXX
E 112908892 CYREN; cell cycle regulator of non-homologous end joining isoform X1 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 112909022 JMJD8; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 112930028 SHLD1; shieldin complex subunit 1 K26128 SHLD1; shieldin complex subunit 1
E 112925269 SHLD2; shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 112935675 shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 112924641 Fanconi anemia group A protein-like isoform X1 K10888 FANCA; fanconi anemia group A protein
E 112910548 FANCB; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 112908709 FANCC; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 112913924 FANCE; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 112930868 FANCG; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 112915267 FANCL; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 112921475 FANCM; Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 112928449 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X1 K10898 FAAP24; fanconi anemia-associated protein
E 112920678 FAAP100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 112925420 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 112929732 centromere protein S-like isoform X1 K11511 APITD1; centromere protein S
E 112920910 CENPX; centromere protein X isoform X1 K15360 STRA13; centromere protein X
E 112934543 UBE2T; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 112921453 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 112907457 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 112924950 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 112911629 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 112933672 FANCD2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 112921747 FANCI; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 112910801 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 112918664 BRCA2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 112917947 BRIP1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 112908291 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 112910162 FAN1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 112919949 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 112917927 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 112909072 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 112926075 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 112921643 WDR48; WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 112927877 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 112909323 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 112935848 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 112924163 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 112925618 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 112922905 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 112922385 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 112913950 RNF8; E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 112913532 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 112928737 RNF169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 112907079 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 112924854 WRAP53; telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 112911430 TPRN; taperin K24164 TPRN; taperin
E 112935679 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 112933503 WDR70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 112920011 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 112914023 POLH; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 112919274 POLI; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 112919752 POLK; DNA polymerase kappa isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 112915161 REV1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 112925183 REV3L; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 112920223 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 112910574 UBE2A; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 112917053 UBE2B; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 112933720 RAD18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 112932829 HLTF; helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 112919236 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 112926351 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 112929184 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 112931948 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 112921655 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112917985 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112917600 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112914910 UBE2N; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112932822 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112932868 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112928967 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112915544 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112913808 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112917147 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 112932306 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 112930067 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 112930723 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 112927340 SPRTN; sprT-like domain-containing protein Spartan isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 112907627 GCNA; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 112924186 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 112935251 RAD9B; cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 112911454 HUS1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 112908597 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 112906889 RAD17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 112926297 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 112935749 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 112926201 LOW QUALITY PROTEIN: replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 112918670 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 112932911 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 112908597 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 112922377 TIMELESS; protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 112928657 TIPIN; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 112914686 CLSPN; claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 112909072 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 112928144 TTI1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 112916112 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 112913594 BAG6; large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 112911467 UBL4A; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 112929286 GET4; Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 112934959 ATR; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 112912053 ATRIP; ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 112925961 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 112924853 TP53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 112920276 CHEK1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 112906959 CHEK2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 112912171 CDC25A; M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 112930081 CDC25B; M-phase inducer phosphatase 2 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 112921903 CDC25C; LOW QUALITY PROTEIN: M-phase inducer phosphatase 3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 112927727 YWHAQ; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 112916971 YWHAZ; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 112920076 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 112909830 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 112935798 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 112933041 YWHAE; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 112934712 NAV2; LOW QUALITY PROTEIN: neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 112907064 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 112927082 WEE1; wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 112924868 PER1; period circadian protein homolog 1 K21944 PER1; period circadian protein 1
D 112908777 PER2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 112924683 PER3; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 112913569 MDC1; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 112908438 PLS3; plastin-3 isoform X1 K17336 PLS3; plastin-3
D 112921805 AEN; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 112914964 PLK3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 112935619 PLK5; inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 112910267 NEK4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 112934153 NEK1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 112925580 NEK10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 112932538 NEK11; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 112909288 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 112908070 KANK2; KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112922131 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112926077 KANK4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112909691 KANK3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 112930618 CHMP4C; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 112919309 VPS4B; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 112929525 VPS4A; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 112919951 ZFYVE19; abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 112923560 SDE2; replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 112913480 POLQ; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 112924765 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 112934768 PRIMPOL; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 112912073 TREX1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 112911479 TREX2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 112916210 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 112916758 DCLRE1B; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 112908242 EXO5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 112920877 ENDOV; endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 112932593 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 112913179 ANKLE1; LOW QUALITY PROTEIN: ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 112919687 HELQ; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 112908690 ERCC6L2; DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 112911072 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 112914041 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 112916764 BCAS2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 112933424 PLRG1; pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 112933922 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 112929306 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 112926826 NUDT18; 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 112920043 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 112928709 RRM1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 112927720 RRM2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 112916984 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 112928803 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 112910498 UNG; LOW QUALITY PROTEIN: uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 112911277 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 112909135 MPG; DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 112914785 MUTYH; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 112909095 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 112907004 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 112907004 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 112933922 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 112920043 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024