+F Repair protein KO
#
DNA Repair and Recombination Proteins - Xiphias gladius (swordfish)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 120796490 mgmt; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 120804685 alkbh2; DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 120793747 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 120783761 ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 120799015 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 120804684 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 120805164 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 120792658 tdg.2; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 120793792 tdg.1; thymine DNA glycosylase, tandem duplicate 1 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 120788059 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 120783049 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 120791200 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 120803891 mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 120803691 ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 120793168 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 120785501 neil3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 120799939 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 120804033 apex1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 120794056 si:ch211-141o9.10; probable endonuclease 4 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 120804331 apex2; DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 120806492 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 120805294 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 120799075 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 120799761 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 120805060 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 120795553 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 120790092 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 120790934 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 120805813 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 120798522 zgc:110269; probable flap endonuclease 1 homolog isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 120789802 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 120799359 lig1; LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 120805089 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 120784694 xrcc1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 120802374 lig3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 120796509 tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 120800216 aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 120800838 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 120792538 bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 120802163 hmgb1a; high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 120792406 hmgb1b; high mobility group protein B1b K10802 HMGB1; high mobility group protein B1
E 120800637 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 120789344 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 120798684 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 120801237 parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 120783259 parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 120804525 xpc; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 120790872 rad23ab; RAD23 homolog A, nucleotide excision repair protein b isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 120805636 rad23aa; RAD23 homolog A, nucleotide excision repair protein a K10839 RAD23; UV excision repair protein RAD23
F 120806805 rad23b; UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 120785538 cetn2; caltractin K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 120783375 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 120784968 cul4b; cullin-4B K10609 CUL4; cullin 4
F 120794300 cul4a; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 120786538 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 120793553 ddb2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 120797709 polr2a; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 120785292 polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 120792759 polr2c; DNA-directed RNA polymerase II subunit RPB3 isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 120791547 polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 120790973 polr2eb; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 120784475 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 120785622 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 120790740 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 120791556 polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 120790614 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 120782985 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 120786767 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 120783375 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 120784968 cul4b; cullin-4B K10609 CUL4; cullin 4
F 120794300 cul4a; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 120786538 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 120805187 ercc8; DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 120796776 ercc6; DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 120785192 uvssa; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 120800818 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 120788086 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 120793466 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 120791822 ercc2; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 120793547 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 120805533 gtf2h2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 120805398 gtf2h3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 120786305 gtf2h4; general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 120789122 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 120804721 cdk7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 120805100 ccnh; cyclin-H K06634 CCNH; cyclin H
E 120795164 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 120802763 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 120792103 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 120785990 replication protein A 32 kDa subunit-like isoform X1 K10739 RFA2; replication factor A2
E 120783879 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 120785957 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 120799646 xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 120801148 ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 120794757 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 120794470 ercc5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 120799359 lig1; LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 120794784 mms19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 120792313 cul3b; cullin-3b K03869 CUL3; cullin 3
E 120799398 cullin-3-like K03869 CUL3; cullin 3
E 120803011 cul5b; cullin-5 isoform X1 K10612 CUL5; cullin 5
E 120791811 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 120789572 eloca; elongin C paralog a K03872 ELOC; elongin-C
E 120787150 elob; elongin-B isoform X1 K03873 ELOB; elongin-B
E 120794286 elongin-B-like isoform X1 K03873 ELOB; elongin-B
E 120796055 eloal; elongin A, like isoform X1 K15076 ELOA; elongin-A
E 120805315 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 120786202 ubap2l; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 120807346 ubap2a; ubiquitin-associated protein 2a isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 120794634 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 120805552 msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 120796186 msh6; DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 120801425 pms1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 120796817 mlh1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 120794154 pms2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 120795807 mlh3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 120806492 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 120805294 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 120799075 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 120799761 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 120802763 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 120792103 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 120785990 replication protein A 32 kDa subunit-like isoform X1 K10739 RFA2; replication factor A2
E 120783879 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 120785957 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 120800030 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 120803389 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 120790368 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 120802757 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 120805144 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 120805813 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 120796630 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 120802163 hmgb1a; high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 120792406 hmgb1b; high mobility group protein B1b K10802 HMGB1; high mobility group protein B1
E 120799359 lig1; LOW QUALITY PROTEIN: DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 120805210 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 120791726 mre11a; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 120802966 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 120784770 nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 120794600 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 120801192 bard1; BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 120794600 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 120806037 abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 120802690 uimc1; neurofilament heavy polypeptide isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 120790825 babam1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 120795044 babam2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 120805930 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 120794600 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 120791865 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 120790079 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 120794600 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 120790147 rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 120791726 mre11a; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 120802966 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 120784770 nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 120794600 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 120791707 brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 120799965 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 120788703 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 120788703 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 120788697 rad51b; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 120804404 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 120802377 rad51d; DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 120788916 xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 120793149 rad52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 120805258 rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 120791352 rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 120803621 helicase ARIP4-like isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 120807150 rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 120784178 rad54b; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 120799060 recql; ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 120793501 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 120786775 recql4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 120788078 recql5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 120793501 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 120788215 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 120805659 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 120804932 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 120786211 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 120802763 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 120792103 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 120785990 replication protein A 32 kDa subunit-like isoform X1 K10739 RFA2; replication factor A2
E 120783879 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 120785957 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 120785530 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 120807560 ppp4r1l; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 120803833 serine/threonine-protein phosphatase 4 regulatory subunit 2-like K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 120783319 ppp4r2b; serine/threonine-protein phosphatase 4 regulatory subunit 2-B K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 120796531 serine/threonine-protein phosphatase 4 regulatory subunit 3-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 120788968 smek1; serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 120789056 ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 120783128 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 120795161 ap5m1; AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 120795285 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 120785423 ap5z1; LOW QUALITY PROTEIN: AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 120804336 smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 120789409 si:dkey-119f1.1; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 120795214 smc6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 120788653 lratd1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 120800351 nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 120783701 nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 120804229 ndnl2; necdin-like 2 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 120796300 nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 120805832 slf1; SMC5-SMC6 complex localization factor protein 1 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 120796655 slf2; SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 120794604 eme1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 120795823 exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 120797067 mus81; crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 120806421 swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 120796131 sfr1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 120797355 slx1b; structure-specific endonuclease subunit SLX1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 120799875 slx4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 120789445 flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 120793087 spg11; spatacsin K19026 SPG11; spatacsin
E 120795185 zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 120801204 rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 120794752 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 120793571 morf4l1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 120804145 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 120796368 fignl1; fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 120799319 spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 120784825 protein LRATD2-like K22810 FAM84B; protein FAM84B
E 120786891 lratd2a; protein LRATD2a K22810 FAM84B; protein FAM84B
E 120800156 brat1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 120799107 cfap410; cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 120791373 hdgfl2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 120802570 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 120806186 swsap1; ATPase SWSAP1 isoform X1 K25771 SWSAP1; ATPase SWSAP1
E 120802582 emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 120798051 heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 120784662 mms22l; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 120795778 tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 120785479 bod1l1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 120800323 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 120794372 xrcc6; X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 120801290 xrcc5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 120789644 prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 120791726 mre11a; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 120802966 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 120798289 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 120805235 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 120806747 xrcc4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 120798160 nhej1; non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 120800637 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 120806548 polm; DNA-directed DNA/RNA polymerase mu isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 120796576 dntt; DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 120805089 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 120800216 aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 120800838 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 120799355 dclre1c; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 120786080 tdp2b; tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 120789968 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 120795052 si:dkey-127k13.1; PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 120804806 paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 120793320 si:ch211-127m7.2; uncharacterized protein si:ch211-127m7.2 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 120806918 jmjd8; jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 120796114 shld2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 120805839 zgc:101664; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 120793205 Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 120801096 fancb; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 120805810 fancc; Fanconi anemia group C protein isoform X1 K10890 FANCC; fanconi anemia group C protein
E 120803870 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 120793569 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 120804864 fancg; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 120796229 fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 120795295 fancm; Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 120793448 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 120794438 faap100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 120791319 her6; hairy-related 6 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 120803357 her9; hairy-related 9 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 120799161 transcription factor HES-1-B-like K06054 HES1; hairy and enhancer of split 1
E 120782912 cenps; centromere protein S K11511 APITD1; centromere protein S
E 120786169 cenpx; centromere protein X K15360 STRA13; centromere protein X
E 120803514 ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 120793501 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 120788215 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 120805659 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 120804932 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 120786211 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 120783341 fancd2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 120787272 fanci; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 120794600 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 120791707 brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 120791865 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 120799965 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 120793206 fan1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 120788703 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 120804404 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 120794824 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 120790687 usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 120798553 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 120805579 serine/threonine-protein phosphatase 6 catalytic subunit isoform X1 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 120806408 serine/threonine-protein phosphatase 6 catalytic subunit-like isoform X1 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 120793810 ppp6r2b; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 120800222 ppp6r2a; serine/threonine-protein phosphatase 6 regulatory subunit 2a isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 120792948 ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 120784804 ankrd28b; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 120786263 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 120801277 ankrd44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 120804248 ankrd52a; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 120807184 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 120789394 rnf8; E3 ubiquitin-protein ligase rnf8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 120792279 rnf168; E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 120791641 rnf169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 120791178 herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 120797553 wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 120805968 tprn; taperin K24164 TPRN; taperin
E 120806125 WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 120805210 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 120796944 polh; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 120804999 poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 120805797 polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 120801446 rev1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 120789076 rev3l; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 120797717 poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 120785186 ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 120801495 ube2al; ubiquitin conjugating enzyme E2 A, like isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 120803047 ube2b; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 120806947 rad18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 120795155 hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 120804465 ubiquitin-conjugating enzyme E2 variant 1-like isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 120799464 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 120783097 ubiquitin-conjugating enzyme E2 variant 1-like isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 120802378 ube2nb; ubiquitin-conjugating enzyme E2Nb K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 120793793 ube2na; ubiquitin-conjugating enzyme E2Na K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 120805813 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 120800323 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 120788894 sprtn; DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 120785349 gcna; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 120785262 rad9a; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 120804820 rad9b; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 120789905 hus1; checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 120806334 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 120805039 rad17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 120803389 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 120790368 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 120802757 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 120805144 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 120806334 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 120806910 timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 120797544 tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 120786835 claspin K25773 CLSPN; claspin
C Triple T complex
D 120794824 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 120803839 tti1; TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 120805840 tti2; TELO2-interacting protein 2 isoform X1 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 120786371 bag6l; large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 120783861 bag6; large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 120805226 ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 120794530 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 120795290 atr; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 120783467 ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 120792134 atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 120797533 tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 120802605 chek1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 120787503 chek2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 120795284 cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 120786203 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 120804520 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 120795373 ywhaqb; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 120807301 ywhaba; 14-3-3 protein beta/alpha-A K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 120784186 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 120803118 ywhag1; 14-3-3 protein gamma-1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 120791919 ywhag2; 14-3-3 protein gamma-B K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 120802438 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 120791861 ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 120788620 nav2a; neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 120793699 wee2; wee1-like protein kinase 2 isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 120793828 wee1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 120797071 per1b; period circadian protein homolog 1b isoform X1 K21944 PER1; period circadian protein 1
D 120791715 LOW QUALITY PROTEIN: period circadian protein homolog 2-like K02633 PER2; period circadian protein 2
D 120799452 per2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 120782967 per3; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 120784047 mdc1; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 120802707 pls3; plastin-3 K17336 PLS3; plastin-3
D 120785420 plastin-3-like K17336 PLS3; plastin-3
D 120793834 isg20; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 120799271 plk3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 120790913 nek1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 120801466 serine/threonine-protein kinase Nek5-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 120807302 nek4; serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 120783816 nek10; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 120783911 nek11; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 120797933 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 120785892 kank2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 120804706 kank1a; KN motif and ankyrin repeat domain-containing protein 1a isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 120799496 KN motif and ankyrin repeat domain-containing protein 4-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 120806117 kank1b; KN motif and ankyrin repeat domain-containing protein 1b isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 120790568 kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 120790646 kank4; uncharacterized protein kank4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 120789937 chmp4c; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 120799358 vps4b; vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 120793656 vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 120790493 vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 120795259 zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 120799736 sde2; replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 120799846 polq; DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 120802798 mybbp1a; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 120799690 primpol; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 120793894 dclre1a; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 120804478 dclre1b; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 120800777 endonuclease V-like isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 120798031 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 120791174 ankle1; ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 120806033 helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 120805584 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 120785848 prpf19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 120796792 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 120803359 bcas2; pre-mRNA-splicing factor SPF27 isoform X1 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 120800048 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 120804726 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 120805394 nudt18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 120788058 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 120802700 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 120792386 ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 120786219 rrm2b; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 120788707 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 120789441 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 120796490 mgmt; methylated-DNA--protein-cysteine methyltransferase isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 120799015 CPD photolyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 120804684 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 120783049 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 120788059 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 120791200 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 120799939 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 120803165 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 120803165 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 120788058 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024