+C Two-component system KO
#
Two-Component System - Xenorhabdus nematophila AN6/1
%
!
AOmpR family
B PhoR-PhoB (phosphate starvation response)
C XNC2_0738 phoR; sensory histidine kinase in two-component regulatory system with PhoB, regulation of Pi uptake, senses Pi K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C XNC2_0737 phoB; response regulator in two-component regulatory system with PhoR (or CreC), regulation of Pi uptake (OmpR family) K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C XNC2_2608 phoQ; sensory histidine kinase in two-component regulatory system with PhoP, regulates gene expression at low [Mg+], senses Mg+ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C XNC2_2607 phoP; response regulator in two-component regulatory system with PhoQ, regulates gene expression at low [Mg+] (OmpR family) K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C XNC2_4289 EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C XNC2_4290 ompR; response regulator in two-component regulatory system with EnvZ, regulates ompF and ompC expression (OmpR family) K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
C XNC2_0112 cpxA; sensory histidine kinase in two-component regulatory system with CpxR, regulates genes involved in folding/degrading periplasmic proteins, senses changes in the cell envelope K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C XNC2_0111 cpxR; response regulator in two-component regulatory system with CpxA, regulates genes involved in folding/degrading periplasmic proteins (OmpR family) K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
C XNC2_2581 hypothetical protein K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C XNC2_2582 baeR; response regulator in two-component regulatory system with BaeS (OmpR family) K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C XNC2_1356 kdpD; sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C XNC2_1355 kdpE; response regulator in two-component regulatory system with KdpD, regulation of potassium translocation (OmpR family) K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
C XNC2_4018 arcB; hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C XNC2_0681 arcA; response regulator in two-component regulatory system with ArcB (or CpxA), regulates respiratory and fermentative metabolism (OmpR family) K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
C XNC2_3050 Two-component sensor kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C XNC2_3051 Transcriptional regulatory protein tctD K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
#
ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
C XNC2_2551 narP; response regulator in two-component regulatory system with NarQ (or NarX), regulates anaerobic respiratory gene expression K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C XNC2_1880 uhpB; sensory histidine kinase in two-component regulatory sytem with UhpA, regulates uhptT expression K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C XNC2_1886 uhpA; response regulator (activator) in two-component regulatory system wtih UhpB, regulates uhpT expression (LuxR/UhpA family) K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C XNC2_2749 rcsC; hybrid sensory histidine kinase in two-component regulatory system with RcsB and YojN, regulates capsule biosynthesis, cell division genes, OsmC expression K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C XNC2_2747 rcsD; putative sensory histidine kinase (phosphotransfer intermediate) associated with the RcsBC two-component regulatory system K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C XNC2_2748 rcsB; response regulator (positive) in two-component regulatory system with RcsC and YojN, regulates capsule biosynthesis, cell division genes, OsmC expression (LuxR/UhpA familiy) K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C XNC2_0868 Sensor protein BarA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C XNC2_2488 uvrY; putative regulator in two-component regulatory system with BarA (LuxR/UhpA familiy) K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
#
ASpo family
B KinABCDE-Spo0FA (sporulation control)
#
ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
#
ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C XNC2_0501 yehU; putative sensory kinase in two-component regulatory system K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C XNC2_0500 yehT; putative response regulator in two-component regulatory system K02477 K02477; two-component system, LytTR family, response regulator
#
ANtrC family
B GlnL-GlnG (nitrogen regulation)
C XNC2_4264 glnL; sensory kinase (soluble) in two-component regulatory system with GlnG, nitrogen regulation (nitrogen regulator II, NRII) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C XNC2_4265 glnG; response regulator in two-component regulatory system with GlnL, nitrogen regulation (EBP family) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C XNC2_3163 yfhK; putative sensory kinase in regulatory system K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C XNC2_3165 yfhA; putative response regulator in two-component regulatory system (EBP family) K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
#
ACheA family
B CheA-CheYBV (chemotaxis)
C XNC2_1577 cheA; chemotactic sensory histidine kinase (soluble) in two-component regulatory system with CheB and CheY, senses chemotactic signal K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C XNC2_1570 cheY; chemotactic response regulator in two-component regulatory system with CheA, transmits signals to FliM flagelllar motor component K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C XNC2_1571 cheB; chemotactic response regulator; methylesterase, in two-component regulatory system with CheA, regulates chemotactic response K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
#
ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
#
ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
#
ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
#
AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023