+F Repair protein KO
#
DNA Repair and Recombination Proteins - Zootermopsis nevadensis (dampwood termite)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 110833253 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 110828051 DNA oxidative demethylase ALKBH2-like isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 110826708 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 110840273 activating signal cointegrator 1 complex subunit 3-like isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 110829964 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 110831912 uncharacterized protein LOC110831912 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 110841309 probable DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 110841310 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 110832937 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 110834799 methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 110839907 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 110835729 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 110828723 DNA-(apurinic or apyrimidinic site) lyase-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 110834938 DNA-(apurinic or apyrimidinic site) lyase 2-like isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 110838407 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 110834496 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 110832871 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 110831436 LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 110840472 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 110828788 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 110832709 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 110837311 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 110827058 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 110828947 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 110832674 DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 110833550 uncharacterized protein LOC110833550 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 110838842 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 110835673 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 110829580 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 110834505 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 110826759 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 110832645 uncharacterized protein F21D5.5 isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 110833040 high mobility group protein B2-like K10802 HMGB1; high mobility group protein B1
E 110828244 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 110828240 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 110826833 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 110833508 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 110832453 RING-box protein 1A isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 110841214 LOW QUALITY PROTEIN: cullin-4A K10609 CUL4; cullin 4
F 110837897 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 110829047 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 110831776 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 110834145 DNA-directed RNA polymerase II subunit RPB3 isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 110827350 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 110834923 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 110832177 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 110827651 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 110828974 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 110827505 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 110832453 RING-box protein 1A isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 110841214 LOW QUALITY PROTEIN: cullin-4A K10609 CUL4; cullin 4
F 110837897 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 110829968 DNA excision repair protein ERCC-8-like K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 110837615 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 110830215 UV-stimulated scaffold protein A-like K23720 UVSSA; UV-stimulated scaffold protein A
F 110834123 transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 110837999 DNA excision repair protein haywire K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 110835521 TFIIH basal transcription factor complex helicase XPD subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 110830077 general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 110840592 general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 110826726 general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 110832778 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 110838088 cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 110838956 cyclin-H isoform X1 K06634 CCNH; cyclin H
E 110832376 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 110835820 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 110836080 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 110832858 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Other NER factors
E 110835101 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 110837252 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 110833523 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 110837468 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 110828947 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 110839373 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 110839934 cullin-3-A K03869 CUL3; cullin 3
E 110841467 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 110827097 elongin-C K03872 ELOC; elongin-C
E 110833978 elongin-B isoform X1 K03873 ELOB; elongin-B
E 110840493 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 110835332 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 110838930 DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 110836230 DNA mismatch repair protein Msh3-like isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 110831875 DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 110840510 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 110832217 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 110833225 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 110827319 uncharacterized protein LOC110827319 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 110838407 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 110834496 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 110832871 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 110835820 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 110836080 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 110832858 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 110829725 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 110827428 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 110827278 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 110831206 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 110841512 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 110837311 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 110833372 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 110833040 high mobility group protein B2-like K10802 HMGB1; high mobility group protein B1
E 110828947 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 110835870 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 110830606 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 110836742 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 110834688 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 110838645 BRCA1-associated RING domain protein 1-like isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 110831114 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 110840584 BRISC and BRCA1-A complex member 2-like isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 110835531 lys-63-specific deubiquitinase BRCC36-like isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 110839403 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 110836359 DNA topoisomerase 2-binding protein 1-B isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 110828509 uncharacterized protein LOC110828509 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 110830606 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 110836742 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 110834688 nibrin K10867 NBN; nibrin
D BRCA complex
E 110836322 uncharacterized protein LOC110836322 isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 110837880 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 110837880 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 110837696 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 110828050 DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 110831227 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 110833380 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 110827396 DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 110833208 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 110840524 uncharacterized protein LOC110840524 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 110838673 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 110835719 ATP-dependent DNA helicase Q1-like isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 110836313 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 110839240 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 110836313 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 110830832 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110833319 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110839628 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 110835820 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 110836080 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 110832858 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 110832746 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 110840658 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 110826617 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 110840721 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 110833050 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 110827193 AP-5 complex subunit beta-1-like isoform X1 K19022 AP5B1; AP-5 complex subunit beta-1
E 110832489 AP-5 complex subunit mu-1-like isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 110834039 AP-5 complex subunit zeta-1-like isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 110829758 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 110835806 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 110833274 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 110832084 E3 SUMO-protein ligase NSE2-like isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 110832519 non-structural maintenance of chromosomes element 3 homolog isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 110826871 melanoma-associated antigen D2-like K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 110840760 non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 110835608 uncharacterized protein LOC110835608 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 110829016 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 110839988 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 110833392 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 110839207 uncharacterized protein LOC110839207 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 110839532 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 110831371 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 110826792 spatacsin isoform X1 K19026 SPG11; spatacsin
E 110829239 uncharacterized protein LOC110829239 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 110838020 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 110836220 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 110835868 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 110838394 DNA repair-scaffolding protein-like K22806 SPIDR; DNA repair-scaffolding protein
E 110829974 BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 110837050 uncharacterized protein LOC110837050 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 110837929 zinc finger SWIM domain-containing protein 7-like isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 110837497 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 110834332 heat shock factor 2-binding protein-like isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 110836744 protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 110831642 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 110830322 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 110831579 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 110835367 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 110836224 DNA-dependent protein kinase catalytic subunit-like isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 110830606 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 110836742 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 110831443 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 110837903 uncharacterized protein LOC110837903 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 110840264 non-homologous end-joining factor 1-like isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 110832674 DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 110834505 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 110826759 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 110835878 protein artemis-like isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 110829803 tyrosyl-DNA phosphodiesterase 2-like isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 110831976 Fanconi anemia group A protein homolog isoform X1 K10888 FANCA; fanconi anemia group A protein
E 110840409 E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 110833543 centromere protein S-like isoform X1 K11511 APITD1; centromere protein S
E 110836675 centromere protein X-like K15360 STRA13; centromere protein X
D Bloom's syndrome complex (BTR)
E 110836313 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 110830832 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110833319 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110839628 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 110836484 Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 110839174 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 110836322 uncharacterized protein LOC110836322 isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 110839403 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 110837428 fanconi-associated nuclease 1-like isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 110837880 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 110837696 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 110829613 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 110830462 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 110831236 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 110834699 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 110832437 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 110828804 E3 ubiquitin-protein ligase rnf8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 110839608 E3 ubiquitin-protein ligase rnf8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 110830313 E3 ubiquitin-protein ligase RNF169-like K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 110831868 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 110839459 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 110828501 zinc finger CW-type PWWP domain protein 1-like K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 110835261 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
E 110835870 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 110835877 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 110836155 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 110829291 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 110826671 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 110831873 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 110833542 E3 ubiquitin-protein ligase RAD18-like isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 110833261 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 110835108 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 110837311 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 110828370 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 110830249 acidic repeat-containing protein-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 110828399 cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 110830652 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 110836478 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 110827609 cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 110827428 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 110827278 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 110831206 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 110841512 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 110836478 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 110831732 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 110835950 TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 110837875 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 110828803 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 110834210 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 110830659 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 110827297 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 110831919 serine/threonine-protein kinase ATR-like isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 110831099 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 110828242 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 110837933 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 110840805 serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 110839057 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 110833962 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 110829343 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 110841457 neuron navigator 3 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 110835658 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 110835158 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 110839960 plastin-2 isoform X1 K17336 PLS3; plastin-3
D 110833256 uncharacterized protein LOC110833256 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 110828709 protein downstream neighbor of son homolog isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 110828893 KN motif and ankyrin repeat domain-containing protein 2-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 110839885 vacuolar protein sorting-associated protein 4A-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 110831449 vacuolar protein sorting-associated protein 4B-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 110830174 vacuolar protein sorting-associated protein 4-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 110841519 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 110839612 vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 110831678 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
B Other factors with a suspected DNA repair function
C DNA polymerases
D 110827074 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 110832735 DNA polymerase V K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 110829048 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 110828923 three prime repair exonuclease 2 isoform X1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 110833241 DNA cross-link repair 1A protein-like isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 110828175 endonuclease V-like K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 110831486 uncharacterized protein LOC110831486 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 110832250 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 110829376 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 110830396 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 110841385 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 110831886 pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 110832773 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 110838996 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 110840292 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 110841396 ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 110833949 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 110833253 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 110829964 uracil-DNA glycosylase-like isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 110832937 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 110841309 probable DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 110841310 DNA-3-methyladenine glycosylase-like isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 110835729 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 110834297 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 110834297 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 110840292 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024