+F Repair protein KO
#
DNA Repair and Recombination Proteins - Zygosaccharomyces rouxii
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D ZYRO0A09900g methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D ZYRO0A13530g uncharacterized protein K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D ZYRO0G22418g uncharacterized protein K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E ZYRO0D13178g uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ZYRO0B14146g 8-oxoguanine glycosylase OGG1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E ZYRO0D05566g uncharacterized protein K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E ZYRO0G02838g DNA-(apurinic or apyrimidinic site) lyase APN1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E ZYRO0C13222g DNA-(apurinic or apyrimidinic site) lyase APN2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F ZYRO0A07524g DNA-directed DNA polymerase delta POL3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F ZYRO0F01738g DNA-directed DNA polymerase delta subunit POL31 K02328 POLD2; DNA polymerase delta subunit 2
F ZYRO0E02948g DNA polymerase delta subunit POL32 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F ZYRO0F16412g DNA polymerase epsilon catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F ZYRO0D01166g DNA polymerase epsilon noncatalytic subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F ZYRO0D06864g DNA polymerase epsilon noncatalytic subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F ZYRO0G20878g uncharacterized protein K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E ZYRO0C15730g proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E ZYRO0G02860g multifunctional nuclease RAD27 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E ZYRO0F11572g DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E ZYRO0E01914g tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E ZYRO0F11924g DNA 5'-adenosine monophosphate hydrolase K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E ZYRO0A07744g polynucleotide 3'-phosphatase K08075 E3.1.3.32; polynucleotide 3'-phosphatase [EC:3.1.3.32]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F ZYRO0B11572g uncharacterized protein K10838 XPC; xeroderma pigmentosum group C-complementing protein
F ZYRO0F05192g uncharacterized protein K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F ZYRO0C03058g SCF ubiquitin ligase complex subunit HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E NER4 complex
F ZYRO0C09548g UV-damaged DNA-binding protein RAD7 K15082 RAD7; DNA repair protein RAD7
F ZYRO0C16544g DNA repair protein RAD16 K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F ZYRO0F05918g DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F ZYRO0D11770g DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F ZYRO0D15796g DNA-directed RNA polymerase II core subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F ZYRO0D02992g DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F ZYRO0B06006g DNA-directed RNA polymerase core subunit RPB5 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F ZYRO0D00880g DNA-directed RNA polymerase core subunit RPO26 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F ZYRO0D11726g DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F ZYRO0F06644g DNA-directed RNA polymerase core subunit RPB8 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F ZYRO0G08800g DNA-directed RNA polymerase II core subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F ZYRO0F06226g DNA-directed RNA polymerase core subunit RPB10 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F ZYRO0C07502g DNA-directed RNA polymerase II core subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F ZYRO0G05038g DNA-directed RNA polymerase core subunit RPC10 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F ZYRO0C03058g SCF ubiquitin ligase complex subunit HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F ZYRO0A03234g uncharacterized protein K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F ZYRO0E03190g DNA-dependent ATPase RAD26 K10841 ERCC6; DNA excision repair protein ERCC-6
F ZYRO0G16170g uncharacterized protein K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E ZYRO0G14630g TFIIH/NER complex ATPase/helicase subunit SSL2 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E ZYRO0B11836g TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E ZYRO0C14212g TFIIH/NER complex subunit TFB1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E ZYRO0A11176g TFIIH/NER complex subunit SSL1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E ZYRO0C16016g TFIIH/NER complex subunit TFB4 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E ZYRO0F11088g TFIIH/NER complex subunit TFB2 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E ZYRO0B11242g TFIIH complex subunit TFB5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E ZYRO0A07062g TFIIH complex serine/threonine-protein kinase subunit KIN28 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E ZYRO0F13046g TFIIH complex kinase subunit CCL1 K06634 CCNH; cyclin H
E ZYRO0D13882g TFIIH/NER complex subunit TFB3 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E ZYRO0G10428g replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
E ZYRO0C02948g uncharacterized protein K10739 RFA2; replication factor A2
D Other NER factors
E ZYRO0C05522g DNA repair protein RAD14 K10847 XPA; DNA-repair protein complementing XP-A cells
E ZYRO0A00550g DNA repair protein RAD10 K10849 ERCC1; DNA excision repair protein ERCC-1
E ZYRO0A02860g ssDNA endodeoxyribonuclease RAD1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E ZYRO0D07788g ssDNA endodeoxyribonuclease RAD2 K10846 ERCC5; DNA excision repair protein ERCC-5
E ZYRO0F11572g DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E ZYRO0A01298g uncharacterized protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
E ZYRO0C11242g iron-sulfur cluster assembly protein CIA1 K24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1
E ZYRO0G06248g iron-sulfur cluster assembly protein CIA2 K26403 CIAO2; cytosolic iron-sulfur assembly component 2
E ZYRO0G10934g cullin CUL3 K03869 CUL3; cullin 3
E ZYRO0F08360g elongin C K03872 ELOC; elongin-C
E ZYRO0F15444g elongin A K15077 ELA1; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E ZYRO0B06160g mismatch repair ATPase MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E ZYRO0D17490g mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
E ZYRO0B11792g mismatch repair ATPase MSH6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E ZYRO0A08800g mismatch repair protein MLH2 K10864 PMS1; DNA mismatch repair protein PMS1
E ZYRO0A07282g mismatch repair ATPase MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E ZYRO0C15180g ATP-binding mismatch repair protein K10858 PMS2; DNA mismatch repair protein PMS2
E ZYRO0F07634g mismatch repair protein MLH3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E ZYRO0A07524g DNA-directed DNA polymerase delta POL3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E ZYRO0F01738g DNA-directed DNA polymerase delta subunit POL31 K02328 POLD2; DNA polymerase delta subunit 2
E ZYRO0E02948g DNA polymerase delta subunit POL32 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E ZYRO0G10428g replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
E ZYRO0C02948g uncharacterized protein K10739 RFA2; replication factor A2
D RFC (replication factor C)
E ZYRO0F06446g replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E ZYRO0B06248g replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E ZYRO0G02002g replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E ZYRO0C02090g replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E ZYRO0F12914g replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E ZYRO0C15730g proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E ZYRO0C11110g uncharacterized protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E ZYRO0F11572g DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E ZYRO0F11374g uncharacterized protein K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E ZYRO0A05918g MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
E ZYRO0F16038g MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E ZYRO0F10054g uncharacterized protein K10868 XRS2; DNA repair protein XRS2
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E ZYRO0A05918g MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
E ZYRO0F16038g MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E ZYRO0B03190g recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E ZYRO0B03190g recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
E ZYRO0G14872g uncharacterized protein K10957 RAD55; DNA repair protein RAD55
E ZYRO0A04708g uncharacterized protein K10958 RAD57; DNA repair protein RAD57
D Rad52 family proteins
E ZYRO0D13772g recombinase RAD52 K10873 RAD52; DNA repair and recombination protein RAD52
E ZYRO0B12166g uncharacterized protein K10959 RAD59; DNA repair protein RAD59
D Rad54 family proteins
E ZYRO0F04906g DNA-dependent ATPase RAD54 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E ZYRO0G12474g DNA-dependent ATPase RDH54 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E ZYRO0E08250g ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E ZYRO0E08250g ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E ZYRO0C04642g DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E ZYRO0A02816g uncharacterized protein K15364 NCE4; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E ZYRO0G10428g replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
E ZYRO0C02948g uncharacterized protein K10739 RFA2; replication factor A2
D Protein phosphatase 4
E ZYRO0G14850g phosphoprotein phosphatase PP4 catalytic subunit PPH3 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E ZYRO0C10252g uncharacterized protein K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E ZYRO0G01584g DNA repair ATPase SMC5 K22803 SMC5; structural maintenance of chromosomes protein 5
E ZYRO0B12122g DNA repair protein SMC6 K22804 SMC6; structural maintenance of chromosomes protein 6
E ZYRO0A11110g Smc5-Smc6 complex subunit NSE1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E ZYRO0E03498g SUMO ligase MMS21 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E ZYRO0G16522g Smc5-Smc6 complex subunit NSE3 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E ZYRO0A07304g Smc5-Smc6 complex subunit NSE4 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E ZYRO0D13244g Smc5-Smc6 complex subunit NSE5 K28409 NSE5; non-structural maintenance of chromosome element 5
E ZYRO0E08866g Smc5-Smc6 complex subunit KRE29 K28410 KRE29; DNA repair protein KRE29
D Other HR factors
E ZYRO0C15928g uncharacterized protein K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E ZYRO0D11066g uncharacterized protein K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E ZYRO0F09878g proteasome regulatory particle lid subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E ZYRO0D10450g uncharacterized protein K10991 SWI5; DNA repair protein Swi5/Sae3
E ZYRO0F11044g uncharacterized protein K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E ZYRO0E01804g endonuclease K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E ZYRO0F10516g uncharacterized protein K15079 SLX4; structure-specific endonuclease subunit SLX4
E ZYRO0E08932g crossover junction endodeoxyribonuclease K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E ZYRO0E02398g uncharacterized protein K11339 MORF4L1; mortality factor 4-like protein 1
E ZYRO0D03938g uncharacterized protein K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E ZYRO0D16346g uncharacterized protein K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E ZYRO0G05456g metalloendopeptidase WSS1 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E ZYRO0G03938g 3'-5' DNA helicase K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
E ZYRO0D05126g DNA-binding protein SAW1 K15080 SAW1; single-strand annealing weakened protein 1
E ZYRO0B09020g cullin RTT101 K26124 RTT101; cullin 8
E ZYRO0G10890g uncharacterized protein K26122 MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
E ZYRO0D01496g uncharacterized protein K26123 MMS1; E3 ubiquitin-protein ligase linker protein MMS1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E ZYRO0C14850g ATP-dependent DNA helicase YKU70 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E ZYRO0G02486g ATP-dependent DNA helicase YKU80 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E ZYRO0A05918g MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
E ZYRO0F16038g MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E ZYRO0F10054g uncharacterized protein K10868 XRS2; DNA repair protein XRS2
D DNA Ligase 4 complex
E ZYRO0C07854g DNA ligase (ATP) DNL4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E ZYRO0G08118g uncharacterized protein K10982 LIF1; ligase-interacting factor 1
E ZYRO0C06930g uncharacterized protein K10983 NEJ1; non-homologous end-joining protein 1
D X-family DNA polymerases
E ZYRO0E04048g DNA-directed DNA polymerase IV K10981 POL4; DNA polymerase IV [EC:2.7.7.7]
D Other NHEJ factors
E ZYRO0F11924g DNA 5'-adenosine monophosphate hydrolase K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E ZYRO0E08250g ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E ZYRO0C04642g DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E ZYRO0A02816g uncharacterized protein K15364 NCE4; RecQ-mediated genome instability protein 1
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E ZYRO0B03190g recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
E ZYRO0C12694g uncharacterized protein K11137 TELO2; telomere length regulation protein
E ZYRO0B05984g uncharacterized protein K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E ZYRO0C09878g uncharacterized protein K23314 WRAP53; telomerase Cajal body protein 1
E ZYRO0F11374g uncharacterized protein K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D ZYRO0D12452g DNA-directed DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D ZYRO0D04664g deoxycytidyl transferase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D ZYRO0F07766g DNA-directed DNA polymerase K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D ZYRO0C15202g uncharacterized protein K03508 POLZ2; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D ZYRO0C04950g E2 ubiquitin-conjugating protein RAD6 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D ZYRO0D08404g E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D ZYRO0A08932g DNA helicase RAD5 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D ZYRO0G08228g E2 ubiquitin-conjugating protein MMS2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D ZYRO0B11682g E2 ubiquitin-conjugating protein UBC13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D ZYRO0C15730g proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
D ZYRO0C00616g uncharacterized protein K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D ZYRO0B11880g uncharacterized protein K06662 HRAD17; cell cycle checkpoint protein
D ZYRO0B06248g replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D ZYRO0G02002g replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D ZYRO0C02090g replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D ZYRO0F12914g replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D ZYRO0C00616g uncharacterized protein K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
D ZYRO0D14674g uncharacterized protein K02544 MEC3; G2-specific checkpoint protein
D ZYRO0G08492g uncharacterized protein K06663 DDC1; DNA damage checkpoint protein
C FPC (fork protection complex)
D ZYRO0F16742g uncharacterized protein K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D ZYRO0F00638g uncharacterized protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D ZYRO0F18480g chromatin-modulating protein MRC1 K11272 MRC1; mediator of replication checkpoint protein 1
C Triple T complex
D ZYRO0C12694g uncharacterized protein K11137 TELO2; telomere length regulation protein
D ZYRO0B02222g uncharacterized protein K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D ZYRO0C06886g uncharacterized protein K23387 GET4; golgi to ER traffic protein 4
C SOSS complex
C Other check point factors
D ZYRO0B03982g DNA-binding protein kinase TEL1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D ZYRO0B09196g serine/threonine protein kinase CHK1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D ZYRO0A07546g serine/threonine protein kinase DUN1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D ZYRO0F01056g uncharacterized protein K02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
D ZYRO0B11990g 14-3-3 family protein BMH1 K06630 YWHAE; 14-3-3 protein epsilon
D ZYRO0F07370g serine/threonine/tyrosine protein kinase RAD53 K02831 RAD53; ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
D ZYRO0A09438g chromatin-binding protein RAD9 K06661 RAD9; DNA repair protein RAD9
D ZYRO0C17270g protein kinase MEC1 K02543 MEC1; cell cycle checkpoint protein MEC1
D ZYRO0F08712g uncharacterized protein K15081 AMN1; antagonist of mitotic exit network protein 1
D ZYRO0C12078g tyrosine protein kinase SWE1 K03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
D ZYRO0C00528g uncharacterized protein K24663 NDD1; nuclear division defective protein 1
D ZYRO0A01254g forkhead family transcription factor FKH1 K24664 FKH; forkhead protein FKH
D ZYRO0D01210g AAA family ATPase VPS4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
D ZYRO0F00440g DNA-directed DNA polymerase K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D ZYRO0A08514g DNA cross-link repair protein PSO2 K15340 DCLRE1A; DNA cross-link repair 1A protein
D ZYRO0F08910g uncharacterized protein K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D ZYRO0G07898g E3 ubiquitin-protein ligase PRP19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D ZYRO0F09526g uncharacterized protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D ZYRO0F07282g mRNA splicing protein PRP46 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D ZYRO0D15356g bifunctional dITP/dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D ZYRO0C08514g uncharacterized protein K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D ZYRO0F10956g uncharacterized protein K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D ZYRO0G14388g ribonucleotide-diphosphate reductase subunit RNR2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D ZYRO0A09900g methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D ZYRO0A13530g uncharacterized protein K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D ZYRO0G22418g uncharacterized protein K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E ZYRO0D13178g uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E ZYRO0G06886g DNA-3-methyladenine glycosylase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E ZYRO0D05566g uncharacterized protein K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E ZYRO0G15224g DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E ZYRO0G15224g DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D ZYRO0D15356g bifunctional dITP/dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 23, 2026