+D
#
Transfer RNA Biogenesis
!
AEukaryotic type
B 5'processing factors
C Ribonucrease P
D K01164 POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
D K14522 POP3; ribonuclease P/MRP protein subunit POP3 [EC:3.1.26.5]
D K03538 POP4, RPP29; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D K14524 POP6; ribonuclease P/MRP protein subunit POP6 [EC:3.1.26.5]
D K14526 POP7, RPP2; ribonuclease P/MRP protein subunit POP7 [EC:3.1.26.5]
D K14528 POP8; ribonuclease P/MRP protein subunit POP8 [EC:3.1.26.5]
D K03539 RPP1, RPP30; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
D K03540 RPR2, RPP21; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
D K14529 RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
D K14527 RPP20, POP7; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
D K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D K14523 RPP38; ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
D K14530 RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
D K18213 PRORP; proteinaceous RNase P [EC:3.1.26.5]
D K14533 RPM2; ribonuclease P protein component, mitochondrial [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
D K01167 rnaSA; ribonuclease T1 [EC:4.6.1.24]
D K17710 PTCD1; pentatricopeptide repeat domain-containing protein 1
C CCA adding factors
D K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
D K15322 TSEN2; tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]
D K15323 TSEN34; tRNA-splicing endonuclease subunit Sen34 [EC:4.6.1.16]
D K15324 TSEN15; tRNA-splicing endonuclease subunit Sen15
D K15325 SEN15; tRNA-splicing endonuclease subunit Sen15, fungi type
D K15326 TSEN54; tRNA-splicing endonuclease subunit Sen54
C tRNA splicing ligase complex
D K14415 RTCB, rtcB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D K15432 ASW; ashwin
D K15433 CGI99, CLE7, RLLM1; RLL motif containing protein 1
D K15434 FAM98B; protein FAM98B
D K13177 DDX1; ATP-dependent RNA helicase DDX1 [EC:5.6.2.7]
D K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
D K10669 TRPT1, TPT1; 2'-phosphotransferase [EC:2.7.1.160]
D K20000 MATK; maturase K
D K15435 CPD1; 2',3'-cyclic-nucleotide 3'-phosphodiesterase [EC:3.1.4.37]
D K14679 TRL1; tRNA ligase [EC:6.5.1.3]
B tRNA transport factors
C tRNA export factors
D K07936 RAN; GTP-binding nuclear protein Ran
D K14288 XPOT; exportin-T
D K14290 XPO1, CRM1; exportin-1
D K14289 XPO5; exportin-5
D K03231 EEF1A; elongation factor 1-alpha
D K14547 UTP8; U3 small nucleolar RNA-associated protein 8
D K08876 SCYL1; SCY1-like protein 1
D K24887 GTPBP1; GTP-binding protein 1
C tRNA import factors
D K15436 TRPO3, MTR10; transportin-3
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D K14163 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]
D K01885 EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]
D K01881 PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]
D K01870 IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D K01869 LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]
D K01874 MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]
D K01886 QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D K01887 RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]
D K04567 KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D K22503 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]
D K01876 DARS2, aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]
D K15437 AIMP1, ARC1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D K15438 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2
D K15439 EEF1E1, AIMP3; eukaryotic translation elongation factor 1 epsilon-1
C Other AARSs
D K01872 AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]
D K01893 NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D K01880 GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14]
D K01868 TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]
D K01875 SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]
D K01883 CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D K01873 VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]
D K01892 HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]
D K01889 FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D K01890 FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D K01866 YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D K01867 WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D K07560 dtd, DTD; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D K09716 dtdA, GEK1; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D K07050 AARSD1, ALAX; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
C AARS associated factors
D K24278 ERDS; ergosteryl-3beta-O-L-aspartate synthase [EC:6.1.1.12 2.3.2.37]
D K24279 ERDH; ergosteryl-3beta-O-L-aspartate hydrolase [EC:3.1.1.121]
D K25102 TRNAU1AP; tRNA selenocysteine 1-associated protein 1
D K02503 HINT1_2, hinT, hit; histidine triad (HIT) family protein [EC:3.9.1.-]
D K12150 HINT3; adenosine 5'-monophosphoramidase HINT3 [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
D K15440 TAD1, ADAT1; tRNA-specific adenosine deaminase 1 [EC:3.5.4.34]
D K15441 TAD2, ADAT2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]
D K15442 TAD3, ADAT3; tRNA-specific adenosine deaminase 3
C Dihydorouridine synthases
D K05542 DUS1; tRNA-dihydrouridine synthase 1 [EC:1.3.1.88]
D K05543 DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]
D K05544 DUS3; tRNA-dihydrouridine synthase 3 [EC:1.3.1.89]
D K05545 DUS4; tRNA-dihydrouridine synthase 4 [EC:1.3.1.90]
C Methylthiotransferase
D K06168 CDK5RAP1, miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
D K15865 CDKAL1, mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]
C Methyltransferases
D K00555 TRMT1, trm1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D K15332 TRMT2A; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.-]
D K15331 TRMT2B, TRM2; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]
D K15333 TRM3, TARBP1; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]
D K15334 NCL1, TRM4; multisite-specific tRNA:(cytosine-C5)-methyltransferase [EC:2.1.1.202]
D K15335 NSUN2, TRM4; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203]
D K21969 NSUN3; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.-]
D K21971 NSUN6; methyltransferase NSUN6 [EC:2.1.1.-]
D K15429 TRM5, TRMT5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D K07442 TRM61, GCD14; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D K03256 TRM6, GCD10; tRNA (adenine58-N1)-methyltransferase non-catalytic subunit
D K14864 FTSJ1, TRM7; tRNA (cytidine32/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]
D K03439 trmB, METTL1, TRM8; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D K24974 METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2 [EC:2.1.1.-]
D K00599 METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1.-]
D K15444 TRM9; tRNA (uracil-5-)-methyltransferase TRM9 [EC:2.1.1.229]
D K10770 ALKBH8, TRM9; alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229]
D K15445 TRMT10, TRM10, RG9MTD; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D K15430 TRM11, TRMT11; tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]
D K15446 TRM13, CCDC76; tRNA:m4X modification enzyme [EC:2.1.1.225]
D K15447 TRM44, METTL19; tRNASer (uridine44-2'-O)-methyltransferase [EC:2.1.1.211]
D K15443 TRM82, WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit TRM82
D K28362 THUMPD3; tRNA (guanine(6/7)-N(2))-methyltransferase [EC:2.1.1.256 2.1.1.-]
D K15448 TRM112, TRMT112; multifunctional methyltransferase subunit TRM112
D K15336 TRDMT1, DNMT2; tRNA (cytosine38-C5)-methyltransferase [EC:2.1.1.204]
D K22900 TRMO, trmO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D K17053 ABP140; tRNAThr (cytosine32-N3)-methyltransferase [EC:2.1.1.268]
D K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D K07055 TRM12, TYW2; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]
D K15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]
D K15451 PPM2, LCMT2, TYW4; tRNA wybutosine-synthesizing protein 4 [EC:2.1.1.290 2.3.1.231]
D K18066 TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]
D K25191 BCDIN3D; RNA 5'-monophosphate methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D K06173 truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D K15452 PUS2; mitochondrial tRNA pseudouridine27/28 synthase [EC:5.4.99.44]
D K01855 PUS3, DEG1; tRNA pseudouridine38/39 synthase [EC:5.4.99.45]
D K03177 truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D K15453 PUS6; tRNA pseudouridine31 synthase [EC:5.4.99.42]
D K06176 truD, PUS7; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D K14655 RIB2, PUS8; tRNA pseudouridine32 synthase / 2,5-diamino-6-(5-phospho-D-ribitylamino)-pyrimidin-4(3H)-one deaminase [EC:5.4.99.28]
D K15454 PUS9; tRNA pseudouridine32 synthase [EC:5.4.99.28]
D K07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]
D K22538 RPUSD4; mitochondrial RNA pseudouridine synthase RPUSD4 [EC:5.4.99.-]
C Thiolation factors
D K21027 TRMU, SLM3; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]
D K14168 CTU1, NCS6; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D K14169 CTU2, NCS2; cytoplasmic tRNA 2-thiolation protein 2
D K04487 iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]
D K12161 URM1; ubiquitin related modifier 1
D K11996 MOCS3, UBA4; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C KEOPS/EKC complex
D K08851 TP53RK, PRPK, BUD32; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D K01409 OSGEP, KAE1, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D K15901 TPRKB, CGI121; EKC/KEOPS complex subunit TPRKB/CGI121
D K15902 LAGE3, PCC1; EKC/KEOPS complex subunit LAGE3/PCC1
D K15903 GON7, PCC2; EKC/KEOPS complex subunit GON7
C Elongator complex
D K11373 ELP1, IKI3, IKBKAP; elongator complex protein 1
D K11374 ELP2; elongator complex protein 2
D K07739 ELP3, KAT9; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]
D K11375 ELP4; elongator complex protein 4
D K11376 ELP5, IKI1; elongator complex protein 5
D K11377 ELP6; elongator complex protein 6
C Elongator related proteins
D K15455 DPH3, KTI11; diphthamide biosynthesis protein 3
D K15456 KTI12; protein KTI12
D K15462 KTI13, ATS1; protein ATS1
D K14758 HRR25; casein kinase I homolog HRR25 [EC:2.7.11.1]
D K15427 SIT4, PPH1; serine/threonine-protein phosphatase PP1-1 [EC:3.1.3.16]
D K15457 SAP155; SIT4-associating protein SAP155
D K15458 SAP185_190; SIT4-associating protein SAP185/190
C Other tRNA modification factors
D K07566 tsaC, rimN, SUA5, YRDC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D K00791 miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]
D K03650 mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]
D K03495 gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D K00777 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit [EC:2.4.2.64]
D K15407 QTRT2, QTRTD1; queuine tRNA-ribosyltransferase accessory subunit
D K15463 RIT1; tRNA A64-2'-O-ribosylphosphate transferase [EC:2.4.2.-]
D K01008 selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]
D K06963 TAN1, THUMPD1; tRNA acetyltransferase TAN1
D K10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]
D K00685 ATE1; arginyl-tRNA---protein transferase [EC:2.3.2.8]
D K24973 DALRD3; DALR anticodon-binding domain-containing protein 3
B tRNA degradation factors
C TRAMP complex
D K03514 PAPD5_7, TRF4; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D K12597 AIR1_2; protein AIR1/2
D K12598 MTR4, SKIV2L2; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
C Rapid tRNA decay (RTD) pathway factors
D K12618 XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
D K12619 XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D K01082 cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]
C Other tRNA degradation factors
D K16631 ANG, RNASE5; angiogenin [EC:3.1.27.-]
D K24459 SLFN13; schlafen family member 13 [EC:3.1.-.-]
D K24850 IFIT5; interferon-induced protein with tetratricopeptide repeats 5
#
AProkaryotic type
B 5'processing factors
C Ribonucrease P
D K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
D K01978 rnpB; RNase P catalytic RNA component
D K09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D K03683 rnt; ribonuclease T [EC:3.1.13.-]
D K00989 rph; ribonuclease PH [EC:2.7.7.56]
D K01169 rna; ribonuclease I (enterobacter ribonuclease) [EC:4.6.1.21]
D K01147 rnb; exoribonuclease II [EC:3.1.13.1]
D K03684 rnd; ribonuclease D [EC:3.1.13.5]
D K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
D K01167 rnaSA; ribonuclease T1 [EC:4.6.1.24]
C CCA adding factors
D K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D K07558 K07558, cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]
B tRNA spricing factors
C tRNA splicing endonucleases
D K01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]
C tRNA splicing ligases
D K14415 RTCB, rtcB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
D K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
D K07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]
B tRNA transport factors
C tRNA export factors
D K06020 ettA; energy-dependent translational throttle protein EttA
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D K01869 LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]
D K04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]
D K01881 PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D K01866 YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D K01867 WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D K01868 TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]
D K01870 IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D K04567 KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D K01872 AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]
D K01873 VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]
D K01874 MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]
D K01875 SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]
D K01876 DARS2, aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]
D K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D K14164 glyQS; glycyl-tRNA synthetase [EC:6.1.1.14]
D K01883 CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D K01884 cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]
D K01885 EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]
D K01886 QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D K01887 RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]
D K01889 FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D K01890 FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D K01892 HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]
D K01893 NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D K01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]
D K09759 aspC, aspS; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]
D K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D K11627 pylS; pyrrolysyl-tRNA synthetase [EC:6.1.1.26]
D K07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]
D K06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]
C Trans-editing factors
D K07560 dtd, DTD; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D K09716 dtdA, GEK1; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D K03976 ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]
D K19055 prdX, proX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]
D K07050 AARSD1, ALAX; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
D K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
D K16930 cdat8; tRNA(cytosine8) deaminase [EC:3.5.4.35]
C Dihydorouridine synthases
D K05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]
D K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
D K05541 dusC; tRNA-dihydrouridine synthase C [EC:1.-.-.-]
C Methylthiotransferases
D K06168 CDK5RAP1, miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
D K15865 CDKAL1, mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]
C Methyltransferases
D K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]
D K15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]
D K06219 smtA, cmoM; tRNA 5-carboxymethoxyuridine methyltransferase [EC:2.1.1.-]
D K02533 lasT; tRNA/rRNA methyltransferase [EC:2.1.1.-]
D K04094 trmFO, gid; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D K00557 trmA; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]
D K03439 trmB, METTL1, TRM8; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D K03650 mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]
D K03214 yfiF, trmG; RNA methyltransferase, TrmH family [EC:2.1.1.-]
D K00556 trmH; tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34]
D K15396 trmJ; tRNA (cytidine32/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]
D K06967 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217]
D K03216 trmL, cspR; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]
D K22900 TRMO, trmO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D K15460 yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]
D K16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]
D K22901 trm4; tRNA (cytosine40_48-C5)-methyltransferase [EC:2.1.1.-]
D K15566 trm10; tRNA (adenine9-N1/guanine9-N1)-methyltransferase [EC:2.1.1.218 2.1.1.221]
D K16318 trm14; tRNA (guanine6-N2)-methyltransferase [EC:2.1.1.256]
D K07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]
D K07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]
D K22446 K22446; tRNA (cytosine49-C5)-methyltransferase [EC:2.1.1.-]
D K03437 spoU; RNA methyltransferase, TrmH family
C Psudouridine synthases
D K06173 truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D K03177 truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D K06175 truC; tRNA pseudouridine65 synthase [EC:5.4.99.26]
D K06176 truD, PUS7; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D K06177 rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]
C Thiolation factors
D K00566 mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D K21947 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15]
D K14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA
D K04085 tusA, sirA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D K07237 tusB, dsrH; tRNA 2-thiouridine synthesizing protein B
D K07236 tusC, dsrF; tRNA 2-thiouridine synthesizing protein C
D K07235 tusD, dsrE; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]
D K11179 tusE, dsrC; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]
D K13628 iscA; iron-sulfur cluster assembly protein
D K04487 iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]
D K06980 ygfZ; tRNA-modifying protein YgfZ
C KEOPS/EKC complex
D K08851 TP53RK, PRPK, BUD32; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D K15904 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase / protein kinase Bud32 [EC:2.3.1.234 2.7.11.1]
D K01409 OSGEP, KAE1, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D K09119 cgi121; KEOPS complex subunit Cgi121
D K09741 pcc1; KEOPS complex subunit Pcc1
C Other tRNA modification factors
D K03495 gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D K00791 miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]
D K06169 miaE; tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase [EC:1.14.99.69]
D K15461 mnmC; tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein [EC:2.1.1.61 1.5.-.-]
D K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D K01737 queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D K06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D K09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]
D K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6]
D K01008 selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]
D K06917 selU, mnmH; tRNA 2-selenouridine synthase [EC:2.9.1.3]
D K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D K18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]
D K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D K06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]
D K04075 tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D K15780 tilS-hprT; bifunctional protein TilS/HprT [EC:6.3.4.19 2.4.2.8]
D K06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]
D K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D K07566 tsaC, rimN, SUA5, YRDC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
D K22132 tcdA; tRNA threonylcarbamoyladenosine dehydratase
D K27343 tmcAL; tRNAmet cytidine acetate ligase [EC:6.3.1.22]
B tRNA degradation factors
C K12573 rnr, vacB; ribonuclease R [EC:3.1.13.1]
C K00962 pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C K12579 ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]
C K18828 mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: September 26, 2025