+E Replication protein
#
DNA Replication Proteins
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D K02603 ORC1; origin recognition complex subunit 1
D K02604 ORC2; origin recognition complex subunit 2
D K02605 ORC3; origin recognition complex subunit 3
D K02606 ORC4; origin recognition complex subunit 4
D K02607 ORC5; origin recognition complex subunit 5
D K02608 ORC6; origin recognition complex subunit 6
D K10727 CDT1; chromatin licensing and DNA replication factor 1
D K02213 CDC6; cell division control protein 6
D K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D K02212 MCM4, CDC54; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D K02209 MCM5, CDC46; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D K02210 MCM7, CDC47; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D K06627 CCNA; cyclin-A
D K06626 CCNE; G1/S-specific cyclin-E1
D K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D K06629 DBF4, ASK; protein DBF4
D K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D K10732 GINS1, PSF1; GINS complex subunit 1
D K10733 GINS2, PSF2; GINS complex subunit 2
D K10734 GINS3; GINS complex subunit 3
D K10735 GINS4, SLD5; GINS complex subunit 4
C Other initiation factors
D K03507 DPB11; DNA replication regulator DPB11
D K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D K10729 SLD2; DNA replication regulator SLD2
D K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D K10731 SLD3; DNA replication regulator SLD3
D K06628 CDC45; cell division control protein 45
D K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D K10736 MCM10; minichromosome maintenance protein 10
D K28390 MCMBP; minichromosome maintenance complex-binding protein
D K15254 HELB; DNA helicase B [EC:5.6.2.3]
D K24274 FAM111A; protein FAM111A
D K26052 CINP; cyclin-dependent kinase 2-interacting protein
D K26116 MTBP; Mdm2-binding protein
D K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D K02321 POLA2; DNA polymerase alpha subunit B
D K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D K02328 POLD2; DNA polymerase delta subunit 2
D K03504 POLD3; DNA polymerase delta subunit 3
D K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D K07466 RFA1, RPA1, rpa; replication factor A1
D K10739 RFA2, RPA2; replication factor A2
D K10740 RPA3; replication factor A3
D K10741 RPA4; replication factor A4
C RFC (replication factor C)
D K10754 RFC1; replication factor C subunit 1
D K10755 RFC2_4; replication factor C subunit 2/4
D K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D K03469 rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]
D K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D K10744 RNASEH2B; ribonuclease H2 subunit B
D K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D K04802 PCNA; proliferating cell nuclear antigen
D K28763 PCLAF; PCNA-associated factor
D K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D K04799 FEN1, RAD2; flap endonuclease-1 [EC:3.1.-.-]
D K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D K00558 DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D K10749 GMNN; geminin
D K26119 MCIDAS; multicilin
D K05868 CCNB1; G2/mitotic-specific cyclin-B1
D K21770 CCNB2; G2/mitotic-specific cyclin-B2
D K21771 CCNB3; G2/mitotic-specific cyclin-B3
D K21777 CCNB; G2/mitotic-specific cyclin-B, other
D K02087 CDK1, CDC2; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E K11109 POT1; protection of telomeres protein 1
E K11110 TERF1, TRF1; telomeric repeat-binding factor 1
E K11111 TERF2, TRF2; telomeric repeat-binding factor 2
E K11112 TINF2, TIN2; TERF1-interacting nuclear factor 2
E K11113 TERF2IP, RAP1; telomeric repeat-binding factor 2-interacting protein 1
E K11114 ACD, TPP1; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E K23311 CTC1; CST complex subunit CTC1
E K23312 STN1; CST complex subunit STN1
E K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
E K11115 CDC13; cell division control protein 13
E K11117 STN1; protein STN1
E K11116 TEN1; telomere length regulation protein
D RIF proteins
E K11118 RIF1; RAP1-interacting factor 1
E K11119 RIF2; RAP1-interacting factor 2
D SIR proteins
E K11120 SIR1; regulatory protein SIR1
E K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E K11122 SIR3; regulatory protein SIR3
E K11123 SIR4; regulatory protein SIR4
D K09426 RAP1; Myb-like DNA-binding protein RAP1
C Telomerase complex (animals)
D K11124 SMG6, EST1A; protein SMG6 [EC:3.1.-.-]
D K11125 SMG5, EST1B; protein SMG5
D K11126 TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
D K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E K11128 GAR1, NOLA1; H/ACA ribonucleoprotein complex subunit 1
E K11129 NHP2, NOLA2; H/ACA ribonucleoprotein complex subunit 2
E K11130 NOP10, NOLA3; H/ACA ribonucleoprotein complex subunit 3
E K11131 DKC1, NOLA4, CBF5; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D K11132 EST1; telomere elongation protein [EC:2.7.7.-]
D K11126 TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
D K11133 EST3; telomere replication protein
D Sm core complex
E K11086 SNRPB, SMB; small nuclear ribonucleoprotein B and B'
E K11087 SNRPD1, SMD1; small nuclear ribonucleoprotein D1
E K11096 SNRPD2, SMD2; small nuclear ribonucleoprotein D2
E K11088 SNRPD3, SMD3; small nuclear ribonucleoprotein D3
E K11097 SNRPE, SME; small nuclear ribonucleoprotein E
E K11098 SNRPF, SMF; small nuclear ribonucleoprotein F
E K11099 SNRPG, SMG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D K11134 ELG1; telomere length regulation protein
D K10755 RFC2_4; replication factor C subunit 2/4
D K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D K10865 MRE11; double-strand break repair protein MRE11
D K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D K10867 NBN, NBS1; nibrin
C Other termination factors
D K04728 ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
D K10900 WRN, RECQL2; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]
D K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D K10848 ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
D K10799 TNKS; tankyrase [EC:2.4.2.30]
D K11135 PINX1; Pin2-interacting protein X1
D K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D K11137 TELO2, TEL2; telomere length regulation protein
D K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D K11138 RIF1; telomere-associated protein RIF1
D K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D K21772 PURA; transcriptional activator protein Pur-alpha
D K21800 PURG; purine-rich element-binding protein gamma
D K23314 WRAP53, TCAB1; telomerase Cajal body protein 1
D K25059 SDE2; replication stress response regulator SDE2
D K25186 RTF2; replication termination factor 2
D K22485 TBF1; protein TBF1
D K28506 GBP2, HRB1; serine/arginine (SR)-type shuttling mRNA binding protein
D K28514 TCG1; single-stranded TG1-3 DNA-binding protein
B DNA Topoisomerases
C K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
#
AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D K05787 hupA; DNA-binding protein HU-alpha
D K03530 hupB; DNA-binding protein HU-beta
D K04764 ihfA, himA; integration host factor subunit alpha
D K05788 ihfB, himD; integration host factor subunit beta
D K02313 dnaA; chromosomal replication initiator protein
D K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D K02315 dnaC; DNA replication protein DnaC
D K02316 dnaG; DNA primase [EC:2.7.7.101]
D K03346 dnaB; replication initiation and membrane attachment protein
D K11144 dnaI; primosomal protein DnaI
D K18996 repC; replication initiation protein RepC
D K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
D K10725 cdc6A; archaeal cell division control protein 6
D K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3]
D K02683 priS, pri1, priA; DNA primase small subunit [EC:2.7.7.102]
D K18882 priL, pri2, priB; DNA primase large subunit
D K09723 ginS; DNA replication factor GINS
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
E K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E K14159 rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
E K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D RNase H
E K03469 rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]
E K14159 rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
E K22316 rhnA-cobC; ribonuclease H / adenosylcobalamin/alpha-ribazole phosphatase [EC:3.1.26.4 3.1.3.73]
E K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
E K03471 rnhC; ribonuclease HIII [EC:3.1.26.4]
D Other elongation factors
E K02335 polA; DNA polymerase I [EC:2.7.7.7]
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
E K23786 exoA; 5'-3' exonuclease [EC:3.1.11.-]
C Elongation factors (archaeal)
D B-family DNA polymerases
E K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7]
D D-family DNA polymerases
E K02322 polC; DNA polymerase II large subunit [EC:2.7.7.7]
E K02323 polB; DNA polymerase II small subunit [EC:2.7.7.7]
D RNase H
E K03469 rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]
E K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D RFC (replication factor C)
E K04800 rfcL; replication factor C large subunit
E K04801 rfcS; replication factor C small subunit
D Other elongation factors
E K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E K04799 FEN1, RAD2; flap endonuclease-1 [EC:3.1.-.-]
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
D K10748 tus, tau; DNA replication terminus site-binding protein
C DNA methylation enzymes
D K06223 dam; DNA adenine methylase [EC:2.1.1.72]
C Prevention of re-replication factors
D K03645 seqA; negative modulator of initiation of replication
D K10763 hda; DnaA-homolog protein
B DNA Topoisomerases
C K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
C K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
C K03166 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2]
C K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
C K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
C K03169 topB; DNA topoisomerase III [EC:5.6.2.1]
C K03170 topG, rgy; reverse gyrase [EC:5.6.2.2 5.6.2.-]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 25, 2025