+F Repair protein
#
DNA Repair and Recombination Proteins
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D K00567 ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D K10860 ALKBH3, DEPC1; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D K01669 phr, PHR1; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E K03648 UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]
E K10861 UDG2, CCNO; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E K10773 NTHL1, nth; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F K02328 POLD2; DNA polymerase delta subunit 2
F K03504 POLD3; DNA polymerase delta subunit 3
F K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E K04802 PCNA; proliferating cell nuclear antigen
E K04799 FEN1, RAD2; flap endonuclease-1 [EC:3.1.-.-]
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E K10803 XRCC1; DNA-repair protein XRCC1
E K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E K08075 E3.1.3.32; polynucleotide 3'-phosphatase [EC:3.1.3.32]
E K10802 HMGB1; high mobility group protein B1
E K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
E K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F K10838 XPC; xeroderma pigmentosum group C-complementing protein
F K10839 RAD23, HR23; UV excision repair protein RAD23
F K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F K03868 RBX1, ROC1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F K10609 CUL4; cullin 4
F K10610 DDB1; DNA damage-binding protein 1
F K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
F K15082 RAD7; DNA repair protein RAD7
F K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F K03006 RPB1, POLR2A; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F K03010 RPB2, POLR2B; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F K03011 RPB3, POLR2C; DNA-directed RNA polymerase II subunit RPB3
F K03012 RPB4, POLR2D; DNA-directed RNA polymerase II subunit RPB4
F K03013 RPABC1, RPB5, POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F K03014 RPABC2, RPB6, POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F K03015 RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7
F K03016 RPABC3, RPB8, POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F K03017 RPB9, POLR2I; DNA-directed RNA polymerase II subunit RPB9
F K03007 RPABC5, RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F K03008 RPB11, POLR2J; DNA-directed RNA polymerase II subunit RPB11
F K03009 RPABC4, RPB12, POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F K03868 RBX1, ROC1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F K10609 CUL4; cullin 4
F K10610 DDB1; DNA damage-binding protein 1
F K10570 ERCC8, CKN1, CSA; DNA excision repair protein ERCC-8
E Other TCR factor
F K10841 ERCC6, CSB, RAD26; DNA excision repair protein ERCC-6
F K23720 UVSSA; UV-stimulated scaffold protein A
F K25829 ELOF1, ELF1; transcription elongation factor 1
D TFIIH complex
E K10843 ERCC3, XPB; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E K10844 ERCC2, XPD; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E K03141 TFIIH1, GTF2H1, TFB1; transcription initiation factor TFIIH subunit 1
E K03142 TFIIH2, GTF2H2, SSL1; transcription initiation factor TFIIH subunit 2
E K03143 TFIIH3, GTF2H3, TFB4; transcription initiation factor TFIIH subunit 3
E K03144 TFIIH4, GTF2H4, TFB2; transcription initiation factor TFIIH subunit 4
E K10845 TTDA, GTF2H5, TFB5; TFIIH basal transcription factor complex TTD-A subunit
E K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E K06634 CCNH; cyclin H
E K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E K07466 RFA1, RPA1, rpa; replication factor A1
E K10739 RFA2, RPA2; replication factor A2
E K10740 RPA3; replication factor A3
E K10741 RPA4; replication factor A4
D Other NER factors
E K10847 XPA; DNA-repair protein complementing XP-A cells
E K10849 ERCC1; DNA excision repair protein ERCC-1
E K10848 ERCC4, XPF; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E K10846 ERCC5, XPG, RAD2; DNA excision repair protein ERCC-5
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E K15075 MET18, MMS19; DNA repair/transcription protein MET18/MMS19
E K27967 CCDC117; coiled-coil domain-containing protein 117
E K24730 CIAO1, CIA1; cytosolic iron-sulfur protein assembly protein CIAO1
E K26403 CIAO2, CIA2, FAM96; cytosolic iron-sulfur assembly component 2
E K03869 CUL3; cullin 3
E K10612 CUL5; cullin 5
E K03872 ELOC, TCEB1; elongin-C
E K03873 ELOB, TCEB2; elongin-B
E K15076 ELOA, TCEB3; elongin-A
E K15077 ELA1; elongin-A
E K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E K08735 MSH2; DNA mismatch repair protein MSH2
E K08736 MSH3; DNA mismatch repair protein MSH3
E K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E K10864 PMS1; DNA mismatch repair protein PMS1
E K08734 MLH1; DNA mismatch repair protein MLH1
E K10858 PMS2; DNA mismatch repair protein PMS2
E K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E K02328 POLD2; DNA polymerase delta subunit 2
E K03504 POLD3; DNA polymerase delta subunit 3
E K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E K07466 RFA1, RPA1, rpa; replication factor A1
E K10739 RFA2, RPA2; replication factor A2
E K10740 RPA3; replication factor A3
E K10741 RPA4; replication factor A4
D RFC (replication factor C)
E K10754 RFC1; replication factor C subunit 1
E K10755 RFC2_4; replication factor C subunit 2/4
E K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E K04802 PCNA; proliferating cell nuclear antigen
E K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E K10802 HMGB1; high mobility group protein B1
E K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E K24755 WDR76, CMR1; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E K10865 MRE11; double-strand break repair protein MRE11
E K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E K10867 NBN, NBS1; nibrin
E K10868 XRS2; DNA repair protein XRS2
D BRCA1-core complex
E K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E K20774 FAM175A, ABRA1; BRCA1-A complex subunit Abraxas
E K20775 UIMC1, RAP80; BRCA1-A complex subunit RAP80
E K20776 BABAM, NBA1, MERIT40; BRISC and BRCA1-A complex member 1
E K12173 BRE, BRCC45; BRCA1-A complex subunit BRE
E K11864 BRCC3, BRCC36; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E K15362 BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:5.6.2.3]
E K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E K20773 RBBP8, CTIP; DNA endonuclease RBBP8 [EC:3.1.-.-]
E K10865 MRE11; double-strand break repair protein MRE11
E K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E K10867 NBN, NBS1; nibrin
D BRCA complex
E K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
E K10897 PALB2, FANCN; partner and localizer of BRCA2
E K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E K04482 RAD51; DNA repair protein RAD51
E K10869 RAD51L1, RAD51B; RAD51-like protein 1
E K10870 RAD51L2, RAD51C; RAD51-like protein 2
E K10871 RAD51L3, RAD51D; RAD51-like protein 3
E K10879 XRCC2; DNA-repair protein XRCC2
E K10880 XRCC3; DNA-repair protein XRCC3
E K10957 RAD55; DNA repair protein RAD55
E K10958 RAD57; DNA repair protein RAD57
D Rad52 family proteins
E K10873 RAD52; DNA repair and recombination protein RAD52
E K10874 RDM1, RAD52B; RAD52 motif-containing protein 1
E K26556 RAD52-1; DNA repair RAD52-like protein 1, mitochondrial
E K26558 RAD52-2; DNA repair RAD52-like protein 2, chloroplastic
E K10959 RAD59; DNA repair protein RAD59
D Rad54 family proteins
E K10875 RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E K10900 WRN, RECQL2; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]
E K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]
E K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E K10990 RMI1, BRAP75; RecQ-mediated genome instability protein 1
E K15364 NCE4, RMI1; RecQ-mediated genome instability protein 1
E K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E K07466 RFA1, RPA1, rpa; replication factor A1
E K10739 RFA2, RPA2; replication factor A2
E K10740 RPA3; replication factor A3
E K10741 RPA4; replication factor A4
D Protein phosphatase 4
E K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E K17491 SMEK, PPP4R3; protein phosphatase 4 regulatory subunit 3
E K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E K19022 AP5B1; AP-5 complex subunit beta-1
E K19023 AP5M1, MUDENG; AP-5 complex subunit mu-1
E K19024 AP5S1; AP-5 complex subunit sigma-1
E K19025 AP5Z1, SPG48; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E K22803 SMC5; structural maintenance of chromosomes protein 5
E K22804 SMC6; structural maintenance of chromosomes protein 6
E K22805 FAM84A, NSE1; protein FAM84A
E K22817 NSMCE1, NSE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E K22756 NSMCE2, NSE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E K22823 NSMCE3, NSE3; non-structural maintenance of chromosomes element 3
E K22825 NSMCE4, NSE4; non-structural maintenance of chromosomes element 4
E K22826 EID3, NSMCE4B; EP300-interacting inhibitor of differentiation 3
E K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E K10882 EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]
E K10883 EME2; crossover junction endonuclease EME2
E K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E K10881 SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
E K10991 SWI5, SAE3; DNA repair protein Swi5/Sae3
E K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E K10484 BTBD12, SLX4; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E K15079 SLX4; structure-specific endonuclease subunit SLX4
E K15338 GEN1, YEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E K19026 SPG11; spatacsin
E K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E K20778 RAD51AP1; RAD51-associated protein 1
E K11339 MORF4L1, MRG15, EAF3; mortality factor 4-like protein 1
E K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E K22806 SPIDR; DNA repair-scaffolding protein
E K22810 FAM84B; protein FAM84B
E K23112 BRAT1; BRCA1-associated ATM activator 1
E K23456 CFAP410, C21ORF2; cilla- and flagella-associated protein
E K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E K25770 ZSWIM7, SWS1; zinc finger SWIM domain-containing protein 7
E K25771 SWSAP1; ATPase SWSAP1
E K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E K25791 HSF2BP; heat shock factor 2-binding protein
E K26125 MMS22L; protein MMS22-like
E K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E K27412 PARPBP; PCNA-interacting partner
E K27803 HROB; homologous recombination OB-fold protein
E K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
E K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
E K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E K26559 WHY1; single-stranded DNA-binding protein WHY1
E K26561 WHY2; single-stranded DNA-binding protein WHY2
E K26560 WHY3; single-stranded DNA-binding protein WHY3
E K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
E K15080 SAW1; single-strand annealing weakened protein 1
E K26124 RTT101, CUL8; cullin 8
E K26122 MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
E K26123 MMS1; E3 ubiquitin-protein ligase linker protein MMS1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E K10884 XRCC6, KU70, G22P1; ATP-dependent DNA helicase 2 subunit 1
E K10885 XRCC5, KU80, G22P2; ATP-dependent DNA helicase 2 subunit 2
E K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E K10865 MRE11; double-strand break repair protein MRE11
E K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E K10868 XRS2; DNA repair protein XRS2
D DNA Ligase 4 complex
E K10777 LIG4, DNL4; DNA ligase 4 [EC:6.5.1.1]
E K10886 XRCC4; DNA-repair protein XRCC4
E K10980 NHEJ1, XLF; non-homologous end-joining factor 1
E K10982 LIF1; ligase-interacting factor 1
E K10983 NEJ1, LIF2; non-homologous end-joining protein 1
D X-family DNA polymerases
E K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E K10981 POL4; DNA polymerase IV [EC:2.7.7.7]
D Other NHEJ factors
E K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E K10887 DCLRE1C, ARTEMIS, SCIDA; DNA cross-link repair 1C protein [EC:3.1.-.-]
E K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E K23386 PWWP3, MUM1; PWWP domain-containing DNA repair factor 3
E K25772 PAXX; protein PAXX
E K26155 CYREN, MRI; cell cycle regulator of non-homologous end joining
E K25792 JMJD8; jumonji domain-containing protein 8
E K26128 SHLD1; shieldin complex subunit 1
E K26129 SHLD2; shieldin complex subunit 2
E K26130 SHLD3; shieldin complex subunit 3
E K27845 BEND4; BEN domain-containing protein 4
C FA (Fanconi anemia) pathway
D FA core complex
E K10888 FANCA; fanconi anemia group A protein
E K10889 FANCB; fanconi anemia group B protein
E K10890 FANCC; fanconi anemia group C protein
E K10892 FANCE; fanconi anemia group E protein
E K10893 FANCF; fanconi anemia group F protein
E K10894 FANCG; fanconi anemia group G protein
E K10606 FANCL, PHF9; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E K10896 FANCM; fanconi anemia group M protein
E K10898 FAAP24; fanconi anemia-associated protein
E K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E K06054 HES1; hairy and enhancer of split 1
E K11511 APITD1, CENPS, MHF1; centromere protein S
E K15360 STRA13, CENPX, MHF2; centromere protein X
E K13960 UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]
E K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E K10990 RMI1, BRAP75; RecQ-mediated genome instability protein 1
E K15364 NCE4, RMI1; RecQ-mediated genome instability protein 1
E K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E K10891 FANCD2; fanconi anemia group D2 protein
E K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E K08775 BRCA2, FANCD1; breast cancer 2 susceptibility protein
E K15362 BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:5.6.2.3]
E K10897 PALB2, FANCN; partner and localizer of BRCA2
D Other FA pathway factors
E K15363 FAN1, MTMR15; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E K04482 RAD51; DNA repair protein RAD51
E K10870 RAD51L2, RAD51C; RAD51-like protein 2
E K11137 TELO2, TEL2; telomere length regulation protein
E K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E K15361 WDR48, UAF1; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E K15499 PPP6R1, SAPS1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E K15500 PPP6R2, SAPS2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E K15501 PPP6R3, SAPS3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E K23314 WRAP53, TCAB1; telomerase Cajal body protein 1
E K24164 TPRN; taperin
E K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E K24752 WDR70; WD repeat-containing protein 70
E K24755 WDR76, CMR1; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D K02350 REV3L, POLZ; DNA polymerase zeta [EC:2.7.7.7]
D K03508 POLZ2, rev7; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D K10573 UBE2A, UBC2, RAD6A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D K10574 UBE2B, RAD6B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D K15711 SMARCA3, HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D K10580 UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D K04802 PCNA; proliferating cell nuclear antigen
D K27412 PARPBP; PCNA-interacting partner
D K24051 SPRTN; SprT-like domain-contaning protein Spartan
D K26957 GCNA, ACRC; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D K10903 HUS1; HUS1 checkpoint protein
D K10996 HUS1B; checkpoint protein HUS1B
D K02830 HRAD1, RAD17; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D K06662 HRAD17, RAD24; cell cycle checkpoint protein
D K10755 RFC2_4; replication factor C subunit 2/4
D K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D K02830 HRAD1, RAD17; cell cycle checkpoint protein [EC:3.1.11.2]
D K02544 MEC3; G2-specific checkpoint protein
D K06663 DDC1; DNA damage checkpoint protein
C FPC (fork protection complex)
D K10997 TIMELESS, TOF1, SWI1; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D K10998 TIPIN, CSM3, SWI3; replication fork protection complex subunit TIPIN/Csm3/Swi3
D K25773 CLSPN; claspin
D K11272 MRC1; mediator of replication checkpoint protein 1
C Triple T complex
D K11137 TELO2, TEL2; telomere length regulation protein
D K20403 TTI1; TELO2-interacting protein 1
D K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D K23390 BAG6; large proline-rich protein BAG6
D K23388 UBL4; ubiquitin-like protein 4
D K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D K10905 ATRIP; ATR interacting protein
D K04728 ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
D K04451 TP53, P53; tumor protein p53
D K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D K02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
D K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D K16198 YWHAG_H; 14-3-3 protein gamma/eta
D K06630 YWHAE; 14-3-3 protein epsilon
D K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D K02831 RAD53; ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
D K21944 PER1; period circadian protein 1
D K02633 PER2; period circadian protein 2
D K21945 PER3; period circadian protein 3
D K06661 RAD9; DNA repair protein RAD9
D K20780 MDC1; mediator of DNA damage checkpoint protein 1
D K02543 MEC1; cell cycle checkpoint protein MEC1
D K15081 AMN1; antagonist of mitotic exit network protein 1
D K17336 PLS3; plastin-3
D K18340 AEN, ISG20L1; apoptosis-enhancing nuclease [EC:3.1.-.-]
D K08862 PLK3, CNK; polo-like kinase 3 [EC:2.7.11.21]
D K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D K03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
D K24663 NDD1; nuclear division defective protein 1
D K24664 FKH; forkhead protein FKH
D K22422 DONSON; protein downstream neighbor of Son
D K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D K23389 KLLN; killin
D K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D K24782 CHMP4C, SNF7, VPS32C; charged multivesicular body protein 4C
D K12196 VPS4; vacuolar protein-sorting-associated protein 4
D K24778 ZFYVE19, ANCHR; abscission/NoCut checkpoint regulator
D K25059 SDE2; replication stress response regulator SDE2
D K24770 DSE1, ALT2, EMB2757; protein decreased size exclusion limit 1
B Other factors with a suspected DNA repair function
C DNA polymerases
D K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D K02331 POL5, MYBBP1A; DNA polymerase phi [EC:2.7.7.7]
D K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D K15340 DCLRE1A, SNM1A, PSO2; DNA cross-link repair 1A protein
D K15341 DCLRE1B, SNM1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D K17815 EXO5; exonuclease V [EC:3.1.-.-]
D K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D K21411 ANKLE1, LEM3; ankyrin repeat and LEM domain-containing protein 1
D K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
D K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D K10599 PRPF19, PRP19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D K12860 CDC5L, CDC5, CEF1; pre-mRNA-splicing factor CDC5/CEF1
D K12861 BCAS2; pre-mRNA-splicing factor SPF27
D K12862 PLRG1, PRL1, PRP46; pleiotropic regulator 1
C Modulation of nucleotide pools
D K03574 mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D K17816 NUDT1, MTH1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D K17817 NUDT18, MTH3; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D K01520 dut, DUT; dUTP diphosphatase [EC:3.6.1.23]
D K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D K00567 ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D K13530 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-]
D K13531 adaB; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D K01669 phr, PHR1; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]
D K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E K03648 UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]
E K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E K10563 mutM, fpg; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E K10773 NTHL1, nth; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E K01142 xthA, xth; exodeoxyribonuclease III [EC:3.1.11.2]
E K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E K05982 nfi; deoxyribonuclease V [EC:3.1.21.7]
E K09120 dU; endonuclease dU
D RecJ
E K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E K03701 uvrA; excinuclease ABC subunit A
E K03702 uvrB; excinuclease ABC subunit B
E K03703 uvrC; excinuclease ABC subunit C
E K05984 cho; excinuclease Cho [EC:3.1.25.-]
E K03657 uvrD, pcrA; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E K02335 polA; DNA polymerase I [EC:2.7.7.7]
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F K13797 rpoBC; DNA-directed RNA polymerase subunit beta-beta' [EC:2.7.7.6]
F K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F K03048 rpoE; DNA-directed RNA polymerase subunit delta
F K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E K03555 mutS; DNA mismatch repair protein MutS
E K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E K01141 sbcB, exoI; exodeoxyribonuclease I [EC:3.1.11.1]
E K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E K14159 rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7]
E K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E K03657 uvrD, pcrA; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E K03111 ssb; single-strand DNA-binding protein
E K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E K03553 recA; recombination protein RecA
E K03550 ruvA; holliday junction DNA helicase RuvA
E K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E K02686 priB; primosomal replication protein N
E K04067 priC; primosomal replication protein N''
E K02317 dnaT; DNA replication protein DnaT
E K01141 sbcB, exoI; exodeoxyribonuclease I [EC:3.1.11.1]
E K03546 sbcC, rad50; DNA repair protein SbcC/Rad50
E K03547 sbcD, mre11; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E K03553 recA; recombination protein RecA
E K04485 radA, sms; DNA repair protein RadA/Sms
E K03629 recF; DNA replication and repair protein RecF
E K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E K03584 recO; DNA repair protein RecO (recombination protein O)
E K06187 recR; recombination protein RecR
E K03631 recN; DNA repair protein RecN (Recombination protein N)
E K03700 recU; recombination protein U
E K03554 rdgC; recombination associated protein RdgC
E K03550 ruvA; holliday junction DNA helicase RuvA
E K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E K15342 cas1; CRISP-associated protein Cas1
E K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E K04483 radA; DNA repair protein RadA
E K04484 radB; DNA repair protein RadB
E K03552 hjr, hjc, hje; holliday junction resolvase [EC:3.1.21.10]
E K03546 sbcC, rad50; DNA repair protein SbcC/Rad50
E K03547 sbcD, mre11; DNA repair protein SbcD/Mre11
E K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
E K25510 nurA; DNA double-strand break repair nuclease NurA [EC:3.1.-.-]
E K03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E K10979 ku; DNA end-binding protein Ku
E K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F K05787 hupA; DNA-binding protein HU-alpha
F K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F K07455 recT; recombination protein RecT
F K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F K03584 recO; DNA repair protein RecO (recombination protein O)
F K06187 recR; recombination protein RecR
F K01972 E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F K04764 ihfA, himA; integration host factor subunit alpha
F K05788 ihfB, himD; integration host factor subunit beta
E Supressor
F K01141 sbcB, exoI; exodeoxyribonuclease I [EC:3.1.11.1]
F K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F K03701 uvrA; excinuclease ABC subunit A
F K03702 uvrB; excinuclease ABC subunit B
F K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D K03502 umuC; DNA polymerase V
D K03503 umuD; DNA polymerase V [EC:3.4.21.-]
D K04479 dbh; DNA polymerase IV (archaeal DinB-like DNA polymerase) [EC:2.7.7.7]
C Other SOS response factors
D K03553 recA; recombination protein RecA
D K01356 lexA; repressor LexA [EC:3.4.21.88]
D K03631 recN; DNA repair protein RecN (Recombination protein N)
D K02336 polB; DNA polymerase II [EC:2.7.7.7]
D K14160 imuA; protein ImuA
D K14161 imuB; protein ImuB
D K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D K03111 ssb; single-strand DNA-binding protein
D K14623 dinD; DNA-damage-inducible protein D
D K12149 dinI; DNA-damage-inducible protein I
D K03565 recX; regulatory protein
D K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D K24089 rpnD; recombination-promoting nuclease RpnD [EC:3.1.21.-]
D K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
D K02347 polX, dpx; DNA polymerase (family X)
C DNA helicases
D K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D K03658 helD; DNA helicase IV [EC:5.6.2.4]
D K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D K03574 mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D K01520 dut, DUT; dUTP diphosphatase [EC:3.6.1.23]
D K00525 E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D K00526 E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
D K22585 nreA; DNA repair protein NreA
D K28130 cc1; DNA binding protein, CC1 family
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 5, 2025