+D Protein
#
Membrane Trafficking
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
D K15290 SYT1; synaptotagmin-1
D K19902 SYT2; synaptotagmin-2
D K19903 SYT3; synaptotagmin-3
D K19904 SYT4; synaptotagmin-4
D K19905 SYT5; synaptotagmin-5
D K19906 SYT6; synaptotagmin-6
D K19907 SYT7; synaptotagmin-7
D K19908 SYT8; synaptotagmin-8
D K19909 SYT9; synaptotagmin-9
D K19910 SYT10; synaptotagmin-10
D K19911 SYT11; synaptotagmin-11
D K19912 SYT12; synaptotagmin-12
D K19913 SYT13; synaptotagmin-13
D K19328 SYT14_16; synaptotagmin-14/16
D K19914 SYT15; synaptotagmin-15
D K19915 SYT17; synaptotagmin-17
D K17598 SYTL; synaptotagmin-like protein
D K28063 ESYT, TCB, SYT; extended synaptotagmin
C Septins
D K16942 SEPT2; septin 2
D K16943 SEPT4; septin 4
D K04557 SEPT5, PNUTL1, CDCREL1; septin 5
D K16944 SEPT7, CDC3; septin 7
C DOC-2 proteins
D K19916 DOC2A; double C2-like domain-containing protein alpha
D K19917 DOC2B; double C2-like domain-containing protein beta
D K19918 DOC2G; double C2-like domain-containing protein gamma
C Acrosomal exocytosis proteins
D K01317 ACR; acrosin [EC:3.4.21.10]
D K07966 B4GALT1; beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
D K19919 CRISP1_2_3; cysteine-rich secretory protein 1/2/3
D K19920 EQTN; equatorin
D K05193 GLRA1; glycine receptor alpha-1
D K05196 GLRB; glycine receptor beta
D K08671 PCSK4; proprotein convertase subtilisin/kexin type 4 [EC:3.4.21.-]
D K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
D K19921 PKDREJ; polycystic kidney disease and receptor for egg jelly-related protein
D K15291 RIMS1, RIM1; regulating synaptic membrane exocytosis protein 1
D K15297 RIMS2, RIM2; regulating synaptic membrane exocytosis protein 2
D K15298 RIMS3, RIM3; regulating synaptic membrane exocytosis protein 3
D K15299 RIMS4, RIM4; regulating synaptic membrane exocytosis protein 4
D K19922 TSPOAP1, BZRAP1, RIMBP1; peripheral-type benzodiazepine receptor-associated protein 1
D K26225 RIMBP3; RIMS-binding protein 3
D K06257 SDC1, CD138; syndecan 1
D K19923 SPESP1; sperm equatorial segment protein 1
D K19924 SPINK13; serine protease inhibitor Kazal-type 13
D K19925 TNP2; nuclear transition protein 2
D K12013 TRIM36; tripartite motif-containing protein 36 [EC:2.3.2.27]
D K19926 ZP1; zona pellucida sperm-binding protein 1
D K19927 ZP2; zona pellucida sperm-binding protein 2
D K19928 ZP3; zona pellucida sperm-binding protein 3
C Phospholipases
D K14621 PLB1, PLB; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]
D K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
D K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D K05860 PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
D K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
D K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
D K05861 PLCZ; phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
D K19006 PLCH; phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]
D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D K16860 PLD3_4; phospholipase D3/4 [EC:3.1.4.4]
C Kinases and associated proteins
D K02090 CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]
D K11716 CDK5R1; cyclin-dependent kinase 5 activator 1
D K19929 CDK5R2; cyclin-dependent kinase 5 activator 2
D K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D K08844 LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]
D K05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
D K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D K19930 SRCIN1, SNIP; SRC kinase signaling inhibitor 1
D K05705 YES1; tyrosine-protein kinase Yes [EC:2.7.10.2]
D K05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
D K21442 ANKRD54; ankyrin repeat domain-containing protein 54
D K08891 FGR, SRC2; tyrosine-protein kinase Fgr [EC:2.7.10.2]
D K08893 HCK; hemopoietic cell kinase [EC:2.7.10.2]
D K17511 YRK; proto-oncogene tyrosine-protein kinase YRK [EC:2.7.10.2]
D K06103 CASK; calcium/calmodulin-dependent serine protein kinase [EC:2.7.11.1]
D K21952 CASKIN, ANKS5; CASK-interacting protein
D K08796 BRSK; BR serine/threonine kinase [EC:2.7.11.1]
D K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D K08838 STK24_25_MST4; serine/threonine-protein kinase 24/25/MST4 [EC:2.7.11.1]
D K00940 ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]
D K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D K04531 APBA1, X11; amyloid beta A4 precursor protein-binding family A member 1
D K04528 SNCA; alpha-synuclein
D K04647 HAP1; huntingtin-associated protein 1
D K19931 LIN7; protein lin-7
D K19932 NCS1; neuronal calcium sensor
D K07377 NRXN; neurexin
D K07378 NLGN; neuroligin
D K16882 PCLO; protein piccolo
D K27927 BSN; protein bassoon
D K17093 ANXA4; annexin A4
D K19933 CADPS; calcium-dependent secretion activator
D K05170 IL1RAPL, IL1R8_9; interleukin 1 receptor accessory protein-like
D K19934 SDF4; calcium-binding protein
D K19935 SYCN; syncollin
D K10649 TRIM9_67; tripartite motif-containing protein 9/67
D K19936 VSNL1; visinin-like protein 1
D K23531 CABP1_2_4_5; calcium-binding protein 1/2/4/5
D K23864 PNKD; paroxysmal nonkinesiogenic dyskinesia protein
B Small GTPases and associated proteins
C Rab GTPases
D K07882 RAB3A; Ras-related protein Rab-3A
D K06108 RAB3B; Ras-related protein Rab-3B
D K07883 RAB3C; Ras-related protein Rab-3C
D K07884 RAB3D; Ras-related protein Rab-3D
D K07901 RAB8A, MEL; Ras-related protein Rab-8A
D K07902 RAB8B; Ras-related protein Rab-8B
D K07903 RAB10; Ras-related protein Rab-10
D K07907 RAB12; Ras-related protein Rab-12
D K07913 RAB26; Ras-related protein Rab-26
D K07885 RAB27A; Ras-related protein Rab-27A
D K07886 RAB27B; Ras-related protein Rab-27B
D K07914 RAB37; Ras-related protein Rab-37
C Rab associated proteins
D K16779 RAB3IP, RABIN8; Rab-3A-interacting protein
D K18270 RAB3GAP1; Rab3 GTPase-activating protein catalytic subunit
D K19937 RAB3GAP2; Rab3 GTPase-activating protein non-catalytic subunit
D K19938 RPH3A; rabphilin-3A
D K19939 RPH3AL; Rab effector Noc2
D K05699 ACTN1_4; actinin alpha 1/4
D K21073 ACTN2_3; actinin alpha 2/3
D K02183 CALM; calmodulin
D K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D K19941 SYN; synapsin
D K17598 SYTL; synaptotagmin-like protein
D K15292 STXBP1, MUNC18-1; syntaxin-binding protein 1
D K08518 STXBP5, SRO7_77; syntaxin-binding protein 5
D K08509 SNAP29; synaptosomal-associated protein 29
D K15291 RIMS1, RIM1; regulating synaptic membrane exocytosis protein 1
D K15297 RIMS2, RIM2; regulating synaptic membrane exocytosis protein 2
D K26226 PPFIA; liprin-alpha
D K27096 PPFIBP; liprin-beta
D K19952 RABIF, MSS4, DSS4; guanine nucleotide exchange factor
D K19942 GAS8, DRC4; dynein regulatory complex subunit 4
D K19943 ZWINT; ZW10 interactor
D K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D K18341 TBC1D1; TBC1 domain family member 1
D K17902 TBC1D4, AS160; TBC1 domain family member 4
D K19953 GRTP1, TBC1D6, MSB3_4; TBC1 domain family member 6
D K19951 TBC1D8_9; TBC1 domain family member 8/9
D K19944 TBC1D10; TBC1 domain family member 10
D K19945 TBC1D17; TBC1 domain family member 17
D K24798 TBC1D21; TBC1 domain family member 21
D K24800 TBC1D30; TBC1 domain family member 30
D K19946 OPTN, FIP2; optineurin
D K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225]
D K19948 MICALL1; MICAL-like protein 1
D K21068 MICALL2, JRAB; MICAL-like protein 2
D K25572 EHBP1; EH domain-binding protein 1
D K25573 EHBP1L1; EH domain-binding protein 1-like protein 1
D K13342 PEX5, PXR1; peroxin-5
D K19949 OTOF; otoferlin
D K06094 LLGL; lethal(2) giant larvae protein
D K23460 CHM, CHML; Rab proteins geranylgeranyltransferase component A
D K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D K22235 MLPH; melanophilin
D K22236 EXPH5; exophilin-5
D K22237 MYRIP; Rab effector MyRIP
D K24155 DMXL, DMX, RAV1; rabconnectin-3a
D K26162 MADD; MAP kinase-activating death domain protein
C Rho GTPases
D K04393 CDC42; cell division control protein 42
D K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D K07857 RHOC; Ras homolog gene family, member C
D K07872 RHOF, RIF; Ras homolog gene family, member F
D K07864 RHOJ, TCL; Ras homolog gene family, member J
D K07194 RHOQ, TC10; Ras homolog gene family, member Q
D K07865 RHOU, WRCH1; Ras homolog gene family, member U
D K07866 RHOV, WRCH2; Ras homolog gene family, member V
C Other small GTPases and associated proteins
D K02833 HRAS; GTPase HRas
D K07828 NRAS; GTPase NRas
D K25778 ZDHHC9; palmitoyltransferase ZDHHC9 [EC:2.3.1.225]
D K25777 GOLGA7, GCP16; golgin subfamily A member 7
B Tethering complex
C Exocyst complex
D K19983 EXOC1, SEC3; exocyst complex component 1
D K17637 EXOC2, SEC5; exocyst complex component 2
D K06110 EXOC3, SEC6; exocyst complex component 3
D K06111 EXOC4, SEC8; exocyst complex component 4
D K19984 EXOC5, SEC10; exocyst complex component 5
D K19985 EXOC6, SEC15; exocyst complex component 6
D K07195 EXOC7, EXO70; exocyst complex component 7
D K19986 EXOC8, SEC84; exocyst complex component 8
C Exocyst complex assembly proteins
D K19987 EXOC3L1; exocyst complex component 3-like protein
D K19988 EXOC3L2; exocyst complex component 3-like protein 2
D K19989 TNFAIP2, EXOC3L3; tumor necrosis factor alpha-induced protein 2
D K06491 NCAM, CD56; neural cell adhesion molecule
D K07834 RALA; Ras-related protein Ral-A
D K07835 RALB; Ras-related protein Ral-B
D K25768 RALGAPA; Ral GTPase-activating protein subunit alpha
D K25769 RALGAPB; Ral GTPase-activating protein subunit beta
D K10881 SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
D K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D K19877 CHS5; chitin biosynthesis protein CHS5
D K19880 CHS6, BCH2; Chs5-Arf1p-binding protein CHS6/BCH2
D K19881 BUD7, BCH1; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D K19990 CHGA; chromogranin-A
D K19991 CHGB; chromogranin-B
D K16072 ERC1, CAST2, ELKS; ELKS/RAB6-interacting/CAST family member 1
D K19878 ERC2, CAST; ELKS/RAB6-interacting/CAST family member 2
D K04592 ADGRL1, LPHN1; adhesion G protein-coupled receptor L1
D K19992 MSO1; protein MSO1
D K12481 RBSN, ZFYVE20; rabenosyn-5
D K19993 PLEK; pleckstrin
D K19994 PRAM1; PML-RARA-regulated adapter molecule 1
D K19995 SCAMP; secretory carrier-associated membrane protein
D K19996 SFH5; phosphatidylinositol transfer protein SFH5
D K14737 STEAP1; metalloreductase STEAP1 [EC:1.16.1.-]
D K14738 STEAP2; metalloreductase STEAP2 [EC:1.16.1.-]
D K10142 STEAP3, TSAP6; metalloreductase STEAP3 [EC:1.16.1.-]
D K19876 STEAP4; metalloreductase STEAP4 [EC:1.16.1.-]
D K12036 TRIM72; tripartite motif-containing protein 72
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D K04560 STX1A; syntaxin 1A
D K08486 STX1B_2_3; syntaxin 1B/2/3
D K13502 STX4; syntaxin 4
D K08487 STX11; syntaxin 11
C Stx-Endo
D K08488 STX7; syntaxin 7
D K21155 VAM3; syntaxin VAM3
D K13813 STX12, STX13; syntaxin 12/13
D K13814 TSNARE1; t-SNARE domain-containing protein 1
C Stx-TGN / EE
D K08489 STX16; syntaxin 16
C Stx-cisGolgi
D K08490 STX5; syntaxin 5
C Stx-sER
D K08491 STX17; syntaxin 17
C Stx-rER
D K08492 STX18; syntaxin 18
B SNAP-25[N] (Qb)
C Vti1
D K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
D K08494 NSPN; novel plant SNARE
C Gos1 (Gos28)
D K08495 GOSR1, GOS1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D K08496 GOSR2, BOS1; golgi SNAP receptor complex member 2
C Sec20
D K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
D K08498 STX6; syntaxin 6
D K08499 TLG1; member of the syntaxin family of t-SNAREs
D K08500 SYP6; syntaxin of plants SYP6
C STX8
D K08501 STX8; syntaxin 8
D K08502 VAM7; regulator of vacuolar morphogenesis
D K08503 SYP5; syntaxin of plants SYP5
C STX10
D K23937 STX10; syntaxin 10
C Bet1
D K08504 BET1; blocked early in transport 1
C Sft1
D K08505 SFT1; protein transport protein SFT1
C Syp7
D K08506 SYP7; syntaxin of plants SYP7
C Use1
D K08507 USE1; unconventional SNARE in the endoplasmic reticulum protein 1
B SNAP-25 (Qb,c)
C SNAP-23
D K08508 SNAP23; synaptosomal-associated protein 23
C SNAP-25
D K18211 SNAP25; synaptosomal-associated protein 25
D K19950 SEC9; protein transport protein SEC9
C SNAP-29
D K08509 SNAP29; synaptosomal-associated protein 29
C SNAP-47
D K18212 SNAP47; synaptosomal-associated protein 47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D K08510 VAMP1; vesicle-associated membrane protein 1
D K13504 VAMP2; vesicle-associated membrane protein 2
D K13505 VAMP3; vesicle-associated membrane protein 3
D K08513 VAMP4; vesicle-associated membrane protein 4
D K08514 VAMP5; vesicle-associated membrane protein 5
D K08515 VAMP7; vesicle-associated membrane protein 7
D K08512 VAMP8; vesicle-associated membrane protein 8
D K08564 NYV1; vacuolar v-SNARE NYV1
C Ykt6
D K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D K08518 STXBP5, SRO7_77; syntaxin-binding protein 5
D K08519 STXBP6; syntaxin-binding protein 6
C Putative SNAREs
D K08520 SEC22A_C; SEC22 vesicle trafficking protein A/C
B SNARE associated proteins
C Syntaxin-binding proteins
D K15292 STXBP1, MUNC18-1; syntaxin-binding protein 1
D K15300 STXBP2, MUNC18-2; syntaxin-binding protein 2
D K15301 STXBP3, MUNC18-3; syntaxin-binding protein 3
D K15293 UNC13A_B_C, MUNC13; protein unc-13 A/B/C
D K19728 UNC13D, MUNC13; protein unc-13 D
D K19998 SCFD1, SLY1; sec1 family domain-containing protein 1
D K19999 LGI3; leucine-rich repeat LGI family member 3
D K15294 CPLX1_2; complexin-1/2
D K15295 CPLX3_4; complexin-3/4
D K26808 TXLN; taxilin
D K28598 SNPH; syntaphilin
D K28599 SYBU; syntabulin
C Palmitoyltransferases
D K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D K20029 ZDHHC3_7_25; palmitoyltransferase ZDHHC3/7/25 [EC:2.3.1.225]
D K20003 ZDHHC4, SWF1; palmitoyltransferase ZDHHC4 [EC:2.3.1.225]
D K20032 ZDHHC13_17, HIP14; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D K20002 SNAPIN, BLOC1S7; SNARE-associated protein Snapin
D K20004 TMEM27; collectrin
D K06027 NSF, SEC18; vesicle-fusing ATPase [EC:3.6.4.6]
D K15296 NAPA, SNAPA, SEC17; alpha-soluble NSF attachment protein
D K26120 NAPB, SNAPB; beta-soluble NSF attachment protein
D K21198 NAPG, SNAPG; gamma-soluble NSF attachment protein
D K14971 NCOA6, ASC2; nuclear receptor coactivator 6
D K20041 GAP43; neuromodulin
D K11828 DLG4, PSD95; discs large protein 4
D K17919 SNX4; sorting nexin-4
D K21996 SNX41_42; sorting nexin-41/42
D K15620 GOLPH3, GPP34; golgi phosphoprotein 3
D K23282 PLEKHM1; pleckstrin homology domain-containing family M member 1
D K22990 TOR1; torsin-1
D K23283 RUSC1, NESCA; RUN and SH3 domain-containing protein 1
D K13525 VCP, CDC48; transitional endoplasmic reticulum ATPase
D K14012 NSFL1C, UBX1, SHP1; UBX domain-containing protein 1
D K24347 UBXN2B; UBX domain-containing protein 2B
D K28145 SYP; synaptophysin
D K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D K04644 CLTA, LCA; clathrin light chain A
D K04645 CLTB, LCB; clathrin light chain B
D K04646 CLTC; clathrin heavy chain
C Dynamin
D K01528 DNM1_3; dynamin 1/3 [EC:3.6.5.5]
D K23484 DNM2; dynamin 2 [EC:3.6.5.5]
D K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D K27686 DL1; phragmoplastin DRP1 [EC:3.6.5.-]
C AP-2 complex
D K11824 AP2A; AP-2 complex subunit alpha
D K11825 AP2B1; AP-2 complex subunit beta-1
D K11826 AP2M1; AP-2 complex subunit mu-1
D K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D K20042 FCHO; F-BAR domain only protein
D K12471 EPN; epsin
D K12472 EPS15; epidermal growth factor receptor substrate 15
D K12470 SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
D K20043 SNAP91, AP180, CALM; clathrin coat assembly protein AP180
D K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D K20045 ITSN; intersectin
D K12562 AMPH; amphiphysin
D K17923 SNX9_18_33; sorting nexin-9/18/33
D K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D K20048 END3; actin cytoskeleton-regulatory complex protein END3
D K09526 DNAJC6; DnaJ homolog subfamily C member 6
D K08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]
D K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D K26598 HSPA2; heat shock 70kDa protein 2
C Low-density lipoprotein receptor (LDLR) family proteins
D K12473 LDLR; low-density lipoprotein receptor
D K04550 LRP1, CD91; low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)
D K20049 LRP1B; low-density lipoprotein receptor-related protein 1B
D K06233 LRP2; low density lipoprotein-related protein 2
D K20050 LRP3_10_12; low-density lipoprotein receptor-related protein 3/10/12
D K20051 LRP4, MEGF7; low-density lipoprotein receptor-related protein 4
D K03068 LRP5_6; low density lipoprotein receptor-related protein 5/6
D K20052 LRP8, APOER2; low-density lipoprotein receptor-related protein 8
D K20053 VLDLR; very low-density lipoprotein receptor
C LDLR adaptor proteins
D K12474 LDLRAP1, ARH; low density lipoprotein receptor adapter protein 1
D K20054 DAB1; disabled homolog 1
D K12475 DAB2; disabled homolog 2
D K06057 NUMBL; numb
D K04529 APBB1, FE65; amyloid beta A4 precursor protein-binding family B member 1
D K04531 APBA1, X11; amyloid beta A4 precursor protein-binding family A member 1
D K20055 APBA2, X11L; amyloid beta A4 precursor protein-binding family A member 2
D K04434 MAPK8IP1, JIP1; mitogen-activated protein kinase 8 interacting protein 1
D K04435 MAPK8IP2, JIP2; mitogen-activated protein kinase 8 interacting protein 2
D K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D K11828 DLG4, PSD95; discs large protein 4
D K20056 GIPC, SEMCAP; PDZ domain-containing protein GIPC
D K20057 SYNJ2BP, OMP25; synaptojanin-2-binding protein
D K20058 ITGB1BP1; integrin beta-1-binding protein 1
D K16513 NOS1AP, CAPON; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
C GPCR adaptor proteins
D K04439 ARRB; beta-arrestin
D K20059 LDB19, ART1; arrestin-related trafficking adapter 1
D K20060 ECM21, CSR2, ART2_8; arrestin-related trafficking adapter 2/8
D K20061 ALY1_2, ART3_6; arrestin-related trafficking adapter 3/6
D K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D K20063 RIM8, ART9; arrestin-related trafficking adapter 9
C Receptor tyrosine kinase (RTK) adaptor proteins
D K04364 GRB2; growth factor receptor-bound protein 2
D K20064 GRB10; growth factor receptor-bound protein 10
D K24156 GFRAL; GDNF family receptor alpha-like
C Inositol 5-phosphatases
D K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D K20279 SYNJ; synaptojanin [EC:3.1.3.36]
D K15909 SHIP2, INPPL1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
C Kinases
D K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D K17541 SCYL2; SCY1-like protein 2
D K08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
C Ubiquitin E3 ligases
D K04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]
D K22517 CBLB; E3 ubiquitin-protein ligase CBL-B [EC:2.3.2.27]
D K22518 CBLC; E3 ubiquitin-protein ligase CBL-C [EC:2.3.2.27]
D K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
D K10591 NEDD4, RSP5; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
D K13305 NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
D K05632 ITCH, AIP4; E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]
D K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
D K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
D K11981 RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
D K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
D K05633 WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]
D K10637 MYLIP, MIR; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
C Others
D K04559 HIP1; huntingtin interacting protein 1
D K20040 HIP1R, SLA2; huntingtin-interacting protein 1-related protein
D K06106 CTTN, EMS1; cortactin
D K08054 CANX; calnexin
D K11247 SH3GL; endophilin-A
D K11248 SH3GLB1; endophilin-B1
D K21269 SH3GLB2; endophilin-B2
D K15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1
D K20065 SGIP1; SH3-containing GRB2-like protein 3-interacting protein 1
D K20066 SH3BP4; SH3 domain-binding protein 4
D K20067 STON; stonin
D K20068 REPS; RalBP1-associated Eps domain-containing protein
D K20069 NECAP1_2; adaptin ear-binding coat-associated protein 1/2
D K20031 ZDHHC6; palmitoyltransferase ZDHHC6 [EC:2.3.1.225]
D K21437 ANKRD13; ankyrin repeat domain-containing protein 13
D K21953 SHKBP1; SH3KBP1-binding protein 1
D K22936 CNPY1_2; protein canopy 1/2
D K23532 WDFY2; WD repeat and FYVE domain-containing protein 2
D K23878 AAGAB; alpha- and gamma-adaptin-binding protein p34
D K24177 SERINC4; serine incorporator 4
D K25655 SERINC5; serine incorporator 5
D K24402 MXRA8; matrix remodeling-associated protein 8
D K24403 KIAA0319, AAVR; dyslexia-associated protein KIAA0319
D K25217 LMBR1; limb region 1 protein
D K12469 EHD2; EH domain-containing protein 2
D K25572 EHBP1; EH domain-binding protein 1
D K26150 UNC93B; MFS transporter, NAG-T family, unc-93 homolog B
D K26401 TOM1, TOM1L1_2; target of Myb membrane trafficking protein 1 and related proteins
D K15493 CALY; neuron-specific vesicular protein calcyon
D K27410 CCDC32; coiled-coil domain-containing protein 32
D K27870 TGOLN; trans-Golgi network integral membrane protein
D K27926 RFTN; raftlin
D K28033 MAL; myelin and lymphocyte protein
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D K06278 CAV1; caveolin 1
D K12958 CAV2; caveolin 2
D K12959 CAV3; caveolin 3
D K01528 DNM1_3; dynamin 1/3 [EC:3.6.5.5]
D K23484 DNM2; dynamin 2 [EC:3.6.5.5]
D K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
D K20045 ITSN; intersectin
D K20070 MLC1; membrane protein MLC1
D K19387 CAVIN1, PTRF; caveolae-associated protein 1
D K27813 CAVIN2, SDPR; caveolae-associated protein 2
D K27814 CAVIN3; caveolae-associated protein 3
D K27815 CAVIN4, MURC; caveolae-associated protein 4
C Flotillin-dependent endocytosis
D K07192 FLOT, floT; flotillin
D K05703 FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
C GRAF1-dependent endocytosis
D K20071 ARHGAP26, GRAF; Rho GTPase-activating protein 26
D K04393 CDC42; cell division control protein 42
D K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D K07941 ARF6; ADP-ribosylation factor 6
D K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
C RhoA-dependent endocytosis
D K04513 RHOA; Ras homolog gene family, member A
D K01528 DNM1_3; dynamin 1/3 [EC:3.6.5.5]
D K23484 DNM2; dynamin 2 [EC:3.6.5.5]
D K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D K23533 LINGO, LRRN6; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
B Phagocytosis
C Fc receptors
D K06513 FCAR, CD89; CD89 antigen
D K06498 FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
D K06472 FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
D K12560 FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
D K16824 FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
D K06463 FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
D K24019 FCGRT; IgG receptor FcRn large subunit p51
C Integrins (complement receptors)
D K04011 CR1, CD35; complement component (3b/4b) receptor 1
D K06461 ITGAM, CD11b; integrin alpha M
D K06487 ITGAV, CD51; integrin alpha V
D K05719 ITGB1, CD29; integrin beta 1
D K06464 ITGB2, CD18; integrin beta 2
D K06493 ITGB3, CD61; integrin beta 3
D K06588 ITGB5; integrin beta 5
C Opsonins
D K06856 IGH; immunoglobulin heavy chain
D K03990 C3; complement component 3
D K16857 THBS1; thrombospondin 1
D K04659 THBS2S; thrombospondin 2/3/4/5
D K10066 COLEC11; collectin sub-family member 11
D K10062 COLEC12; collectin sub-family member 12
D K03991 MBL; mannose-binding lectin
D K10067 SFTPA; pulmonary surfactant-associated protein A
D K10068 SFTPD, SFTP4; pulmonary surfactant-associated protein D
D K03986 C1QA; complement C1q subcomponent subunit A
D K03987 C1QB; complement C1q subcomponent subunit B
D K03988 C1QG; complement C1q subcomponent subunit C
D K01330 C1R; complement component 1, r subcomponent [EC:3.4.21.41]
D K01331 C1S; complement component 1, s subcomponent [EC:3.4.21.42]
D K23284 C1QL; C1q-related factor
C Toll-like receptors
D K10159 TLR2, CD282; toll-like receptor 2
D K10160 TLR4, CD284; toll-like receptor 4
D K10169 TLR6, CD286; toll-like receptor 6
C C-lectin receptors
D K06560 MRC, CD206, CD280; mannose receptor, C type
D K06563 CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
D K10074 CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A
C Scavenger receptors
D K06558 MSR1, CD204; macrophage scavenger receptor 1
D K13884 MARCO; macrophage receptor with collagenous structure
D K08763 OLR1; oxidised low-density lipoprotein receptor 1
D K13885 SCARB1; scavenger receptor class B, member 1
D K24318 SCARF1; scavenger receptor class F member 1
D K06259 CD36; CD36 antigen
C Coronins
D K13882 CORO1A; coronin-1A
C Others
D K10356 MYO1; myosin I
D K20732 GPNMB; transmembrane glycoprotein NMB
D K23285 GULP1, CED6; PTB domain-containing engulfment adapter protein 1
D K04596 ADGRB1, BAI1; adhesion G protein-coupled receptor B1
D K24068 MEGF10_11; multiple epidermal growth factor-like domains protein 10/11
B Macropinocytosis
C Ras GTPases
D K02833 HRAS; GTPase HRas
D K07827 KRAS, KRAS2; GTPase KRas
D K07828 NRAS; GTPase NRas
D K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D K04393 CDC42; cell division control protein 42
C Kinases
D K05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]
D K00914 PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D K00921 PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D K05858 PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
D K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
D K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
D K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D K05860 PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
D K19006 PLCH; phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]
C Sorting nexins
D K17917 SNX1_2; sorting nexin-1/2
D K17920 SNX5_6_32; sorting nexin-5/6/32
D K17923 SNX9_18_33; sorting nexin-9/18/33
C Others
D K13744 ARHGEF26, SGEF; Rho guanine nucleotide exchange factor 26
D K04496 CTBP; C-terminal binding protein [EC:1.1.1.428]
D K20072 SWAP70; switch-associated protein 70
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D K12562 AMPH; amphiphysin
D K20119 BIN2; bridging integrator 2
D K20120 BIN3; bridging integrator 3
D K11247 SH3GL; endophilin-A
D K11248 SH3GLB1; endophilin-B1
C F-BAR proteins
D K07196 TRIP10, CIP4; thyroid hormone receptor interactor 10
D K20121 FNBP1; formin-binding protein 1
D K20042 FCHO; F-BAR domain only protein
D K07526 SRGAP; SLIT-ROBO Rho GTPase activating protein
D K20122 ARHGAP4; Rho GTPase-activating protein 4
D K20123 PACSIN; protein kinase C and casein kinase substrate in neurons protein
D K12804 PSTPIP1; proline-serine-threonine phosphatase interacting protein 1
D K20124 PSTPIP2; proline-serine-threonine phosphatase interacting protein 2
D K20125 FCHSD; F-BAR and double SH3 domains protein
D K08889 FER, TYK3; tyrosine-protein kinase Fer [EC:2.7.10.2]
D K07527 FES, FPS; tyrosine-protein kinase Fes/Fps [EC:2.7.10.2]
D K20126 NOSTRIN; nostrin
D K18618 GAS7; growth arrest-specific protein 7
D K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
D K05627 BAIAP2, IRSP53; BAI1-associated protein 2
D K20127 BAIAP2L1, IRTKS; BAI1-associated protein 2-like protein 1
D K23645 BAIAP2L2; BAI1-associated protein 2-like protein 2
D K20128 MTSS1; metastasis suppressor protein 1
B Rab GTPases and associated proteins
C Rab GTPases
D K07887 RAB5A; Ras-related protein Rab-5A
D K07888 RAB5B; Ras-related protein Rab-5B
D K07889 RAB5C; Ras-related protein Rab-5C
C Rab associated proteins
D K20129 ANKFY1; rabankyrin-5
D K12480 RABEP1; Rab GTPase-binding effector protein 1
D K20130 RABEP2; Rab GTPase-binding effector protein 2
D K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D K12478 EEA1; early endosome antigen 1
D K12481 RBSN, ZFYVE20; rabenosyn-5
D K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D K03084 SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
D K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
D K21289 PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
D K00914 PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
D K08333 PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D K21290 PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
D K12479 VPS45; vacuolar protein sorting-associated protein 45
D K08733 APPL1, DIP13A; DCC-interacting protein 13 alpha
D K20132 APPL2, DIP13B; DCC-interacting protein 13 beta
D K20133 USP6NL; USP6 N-terminal-like protein
D K20134 TBC1D3; TBC1 domain family member 3
D K04533 HD; huntingtin
D K20135 F8A; factor VIII intron 22 protein
D K04166 AGTR1; angiotensin II receptor type 1
D K20027 ZDHHC1_11; palmitoyltransferase ZDHHC1/11 [EC:2.3.1.225]
D K17638 RIN1; Ras and Rab interactor 1
D K23687 RIN2_3; Ras and Rab interactor 2/3
D K27566 GAPVD1; GTPase-activating protein and VPS9 domain-containing protein 1
B Arf GTPases and associated proteins
C Arf GTPases
D K07937 ARF1_2; ADP-ribosylation factor 1/2
D K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D K12489 ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
D K18439 ARAP1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
D K18440 ARAP2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
D K12490 ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
D K12486 SMAP; stromal membrane-associated protein
D K05737 GIT1; G protein-coupled receptor kinase interactor 1
D K12487 GIT2; G protein-coupled receptor kinase interactor 2
D K12494 PSD; PH and SEC7 domain-containing protein
D K12495 IQSEC; IQ motif and SEC7 domain-containing protein
D K18441 CYTH; cytohesin
D K21841 TBC1D24; TBC1 domain family member 24
D K23538 ELMOD; ELMO domain-containing protein
B Others
C Fucosyltransferase
D K00718 FUT1_2; galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]
C EFR3-PI4KIII alpha complex and associated proteins
D K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D K21842 EFR3; protein EFR3
D K21843 TTC7; tetratricopeptide repeat protein 7
D K21844 FAM126; protein FAM126
D K21845 YPP1; cargo-transport protein YPP1
D K21846 TMEM150; transmembrane protein 150
C Insulin-like growth factor-binding proteins
D K23578 IGFBP1; insulin-like growth factor-binding protein 1
D K23575 IGFBP2; insulin-like growth factor-binding protein 2
D K10138 IGFBP3; insulin-like growth factor-binding protein 3
D K23576 IGFBP4; insulin-like growth factor-binding protein 4
D K23577 IGFBP5; insulin-like growth factor-binding protein 5
D K23579 IGFBP6; insulin-like growth factor-binding protein 6
D K23580 IGFBP7; insulin-like growth factor-binding protein 7
D K06827 CTGF, CCN2, IGFBP8; connective tissue growth factor (insulin-like growth factor-binding protein 8)
D K23571 NOV, CCN3, IGFBP9; insulin-like growth factor-binding protein 9
D K06829 CYR61, CCN1, IGFBP10; insulin-like growth factor-binding protein 10
D K24197 IGFBPL1; insulin-like growth factor-binding protein-like 1
D K22471 CCN4, WISP1; CCN family member 4
D K23089 CCN5, WISP2; CCN family member 5
D K23090 CCN6, WISP3; CCN family member 6
C Others
D K20733 MSLN; mesothelin
D K25442 NCOA7; nuclear receptor coactivator 7
D K27083 SORC3; VPS10 domain-containing receptor SorCS3
D K27816 FIBCD1; fibrinogen C domain-containing protein 1
D K28019 WDP; protein windpipe
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D K07887 RAB5A; Ras-related protein Rab-5A
D K07888 RAB5B; Ras-related protein Rab-5B
D K07889 RAB5C; Ras-related protein Rab-5C
D K07897 RAB7A; Ras-related protein Rab-7A
D K07898 RAB7B; Ras-related protein Rab-7B
D K07907 RAB12; Ras-related protein Rab-12
D K07890 RAB21; Ras-related protein Rab-21
C Retromer subcomplex
D K18468 VPS35; vacuolar protein sorting-associated protein 35
D K18467 VPS29; vacuolar protein sorting-associated protein 29
D K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
D K26419 AKTIP, FTS; AKT-interacting protein
D K16612 HOOK1; protein HOOK1
D K16611 HOOK2; protein HOOK2
D K16536 HOOK3; protein HOOK3
D K26420 FHIP1, FAM160A; FHF complex subunit HOOK interacting protein 1
D K26421 FHIP2, FAM160B; FHF complex subunit HOOK interacting protein 2
C FERRY complex
D K17544 TBCK; TBC domain-containing protein kinase-like protein
D K17562 PPP1R21, CCDC128, KLRAQ1; protein phosphatase 1 regulatory subunit 21
D K28020 FERRY3; Ferry endosomal RAB5 effector complex subunit 3
D K28021 CRYZL1, FERRY4; quinone oxidoreductase-like protein 1
D K28022 GATD1, FERRY5; glutamine amidotransferase-like class 1 domain-containing protein 1
C Rab associated proteins
D K13883 RILP; Rab-interacting lysosomal protein
D K20173 RILPL1; RILP-like protein 1
D K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D K00914 PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D K20162 DENND3; DENN domain-containing protein 3
D K20165 TBC1D2; TBC1 domain family member 2A
D K18469 TBC1D5; TBC1 domain family member 5
D K20168 TBC1D15; TBC1 domain family member 15
D K20174 OSBPL1_2, ORP1_2; oxysterol-binding protein-related protein 1/2
D K20175 ANKRD27; ankyrin repeat domain-containing protein 27
D K23460 CHM, CHML; Rab proteins geranylgeranyltransferase component A
D K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D K20176 SGSM3, MAP; small G protein signaling modulator 3
D K21954 FYCO1; FYVE and coiled-coil domain-containing protein 1
D K15620 GOLPH3, GPP34; golgi phosphoprotein 3
D K26227 ALS2CL; ALS2 C-terminal-like protein
D K26496 RAB5IF; GEL complex subunit OPTI
D K26676 NSG1; neuronal vesicle trafficking-associated protein 1
D K26677 NSG2; neuronal vesicle trafficking-associated protein 2
D K15493 CALY; neuron-specific vesicular protein calcyon
D K07856 RHOB; Ras homolog gene family, member B
D K28414 DENND10; DENN domain-containing protein 10
D K20284 RABGAP1, GAPCENA; Rab GTPase-activating protein 1
B Arf GTPases and associated proteins
C Arf GTPases
D K07955 ARL8; ADP-ribosylation factor-like protein 8
C BLOC-one-related complex (BORC)
D K20185 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1
D K16750 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2
D K20002 SNAPIN, BLOC1S7; SNARE-associated protein Snapin
D K20818 KXD1, BORCS4; KxDL motif-containing protein 1
D K20819 BORCS5, LOH12CR1; BLOC-1 related complex subunit 5
D K20820 BORCS6; BLOC-1 related complex subunit 6
D K20821 BORCS7; BLOC-1 related complex subunit 7
D K20822 MEF2BNB, BORCS8; BLOC-1 related complex subunit 8
C N-acetyl transferase complex C (NatC)
D K00670 NAA30, MAK3; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D K20823 NAA35, MAK10; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
D K15348 PLEKHM2, SKIP; pleckstrin homology domain-containing family M member 2
D K24776 RUFY3; RUN and FYVE domain-containing protein 3
D K28542 RUFY4; RUN and FYVE domain-containing protein 4
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D K12182 HGS, HRS, VPS27; hepatocyte growth factor-regulated tyrosine kinase substrate
D K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D K12183 TSG101, STP22, VPS23; ESCRT-I complex subunit TSG101
D K12184 VPS28; ESCRT-I complex subunit VPS28
D K12185 VPS37; ESCRT-I complex subunit VPS37
D K12186 FAM125; ESCRT-I complex subunit MVB12
D K12187 MVB12; ESCRT-I complex subunit MVB12
D K24629 UBAP1; ubiquitin-associated protein 1
C ESCRT-II complex
D K12188 SNF8, EAP30; ESCRT-II complex subunit VPS22
D K12189 VPS25, EAP20; ESCRT-II complex subunit VPS25
D K12190 VPS36, EAP45; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D K12197 CHMP1, VPS46, DID2; charged multivesicular body protein 1
D K12191 CHMP2A; charged multivesicular body protein 2A
D K12192 CHMP2B; charged multivesicular body protein 2B
D K12193 VPS24, CHMP3; charged multivesicular body protein 3
D K12194 CHMP4A_B, SNF7, VPS32A_B; charged multivesicular body protein 4A/B
D K24782 CHMP4C, SNF7, VPS32C; charged multivesicular body protein 4C
D K12198 CHMP5, VPS60; charged multivesicular body protein 5
D K12195 CHMP6, VPS20; charged multivesicular body protein 6
D K15053 CHMP7; charged multivesicular body protein 7
D K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D K12199 VTA1, LIP5; vacuolar protein sorting-associated protein VTA1
D K12200 PDCD6IP, ALIX, RIM20; programmed cell death 6-interacting protein
D K26228 ARRDC1; arrestin domain-containing protein 1
D K26229 ARRDC2_3; arrestin domain-containing protein 2/3
D K26230 ARRDC4; arrestin domain-containing protein 4
D K26401 TOM1, TOM1L1_2; target of Myb membrane trafficking protein 1 and related proteins
D K28543 UBAP1L; ubiquitin-associated protein 1-like
B Tethering complex
C CORVET complex
D K20177 VPS3, TGFBRAP1; vacuolar protein sorting-associated protein 3
D K20178 VPS8; vacuolar protein sorting-associated protein 8
D K20179 VPS11, PEP5; vacuolar protein sorting-associated protein 11
D K20180 VPS16; vacuolar protein sorting-associated protein 16
D K20181 VPS18, PEP3; vacuolar protein sorting-associated protein 18
D K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D K20179 VPS11, PEP5; vacuolar protein sorting-associated protein 11
D K20180 VPS16; vacuolar protein sorting-associated protein 16
D K20181 VPS18, PEP3; vacuolar protein sorting-associated protein 18
D K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D K20183 VPS39, VAM6; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D K24155 DMXL, DMX, RAV1; rabconnectin-3a
D K24738 WDR7; rabconnectin-3b
C RAVE complex
D K24155 DMXL, DMX, RAV1; rabconnectin-3a
D K25485 RAV2; regulator of V-ATPase in vacuolar membrane protein 2
D K03094 SKP1, CBF3D; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D K12396 AP3D; AP-3 complex subunit delta
D K12397 AP3B; AP-3 complex subunit beta
D K12398 AP3M; AP-3 complex subunit mu
D K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
D K20185 BLOC1S1; biogenesis of lysosome-related organelles complex 1 subunit 1
D K16750 BLOC1S2; biogenesis of lysosome-related organelles complex 1 subunit 2
D K20186 BLOC1S3; biogenesis of lysosome-related organelles complex 1 subunit 3
D K08366 BLOC1S4, CNO; biogenesis of lysosome-related organelles complex 1 subunit 4
D K20187 BLOC1S5; biogenesis of lysosome-related organelles complex 1 subunit 5
D K20188 BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6
D K20002 SNAPIN, BLOC1S7; SNARE-associated protein Snapin
D K20189 DTNBP1, BLOC1S8; dysbindin
C BLOC-1 complex (yeast)
D K22238 BLI1; biogenesis of lysosome-related organelles complex 1 subunit BLI1
D K22239 BLS1; biogenesis of lysosome-related organelles complex 1 subunit BLS1
D K22240 CNL1; biogenesis of lysosome-related organelles complex 1 subunit CNL1
D K22241 SNN1; biogenesis of lysosome-related organelles complex 1 subunit SNN1
D K22242 VAB2; biogenesis of lysosome-related organelles complex 1 subunit VAB2
D K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
C BLOC-2 complex
D K20190 HPS3; Hermansky-Pudlak syndrome 3 protein
D K20191 HPS5; Hermansky-Pudlak syndrome 5 protein
D K20192 HPS6; Hermansky-Pudlak syndrome 6 protein
C BLOC-3 complex
D K20193 HPS1; Hermansky-Pudlak syndrome 1 protein
D K20194 HPS4; Hermansky-Pudlak syndrome 4 protein
C Ferlins
D K18261 DYSF; dysferlin
D K22125 MYOF; myoferlin
C Lysosomal membrane proteins
D K28023 MFSD1; MFS transporter, Pht family, lysosomal dipeptide transporter
D K28024 GLMP; glycosylated lysosomal membrane protein
D K05656 ABCB9, TAPL; ATP-binding cassette, subfamily B (MDR/TAP), member 9
D K06528 LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
D K06562 LAMP3, CD208; lysosomal-associated membrane protein 3
D K06501 CD68, LAMP4; CD68 antigen
D K28774 LAMP5; lysosome-associated membrane glycoprotein 5
D K13783 SLC37A1_2; MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2
D K28025 ATRAID; all-trans retinoic acid-induced differentiation factor
D K05016 CLCN7; chloride channel 7
D K23863 OSTM1; osteopetrosis-associated transmembrane protein 1 (chloride channel 7 beta subunit)
D K05678 ABCD4, PXMP1L; ATP-binding cassette, subfamily D (ALD), member 4 [EC:7.6.2.8]
D K14617 LMBRD1; LMBR1 domain-containing protein 1
D K13526 ATP13A2; cation-transporting P-type ATPase 13A2 [EC:7.2.2.-]
D K28775 TASL; TLR adapter interacting with SLC15A4 on the lysosome
C Others
D K20195 MON1; vacuolar fusion protein MON1
D K27045 CCZ1; vacuolar fusion protein CCZ1, animal type
D K21156 CCZ1; vacuolar fusion protein CCZ1, fungi type
D K24763 RMC1; regulator of MON1-CCZ1 complex
D K11839 USP8, UBP5; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D K11866 STAMBP, AMSH; STAM-binding protein [EC:3.4.19.12]
D K26237 TMEM9B; transmembrane protein 9B
D K25048 TMEM106B; transmembrane protein 106B
D K20656 TMEM189; plasmanylethanolamine desaturase [EC:1.14.19.77]
D K21955 DRAM1; DNA damage-regulated autophagy modulator protein 1
D K21956 DRAM2; DNA damage-regulated autophagy modulator protein 2
D K22937 LYST, CHS1; lysosomal-trafficking regulator
D K23286 NEBL1_2; neurobeachin-like protein 1/2
D K23281 VPS33B; vacuolar protein sorting-associated protein 33B
D K23287 VIPAS39, VPS16B; VPS33B-interacting protein in polarity and apical restriction
D K23343 CCDC22; coiled-coil domain-containing protein 22
D K23879 GRN; progranulin
D K23949 SAMD9, SAMD9L; sterile alpha motif domain-contaning protein 9
D K24176 SERINC2; serine incorporator 2
D K24181 LRBA; lipopolysaccharide-responsive and beige-like anchor protein
D K24260 WDR11; WD repeat-containing protein 11
D K24760 WDR91; WD repeat-containing protein 91
D K24780 ZFYVE28, LST2; lateral signaling target protein 2
D K26111 SIDT1; SID1 transmembrane family member 1
D K27083 SORC3; VPS10 domain-containing receptor SorCS3
D K28049 CLVS; clavesin
D K28056 RHPN2; rhophilin-2
D K28212 LEPROT, VPS55; OB-RGRP/VPS55 family protein
D K23481 VPS1; vacuolar protein sorting-associated protein 1
D K24781 BPH1; beige protein homolog 1
D K28440 VAC7; vacuolar segregation protein 7
D K28441 TAG1; protein TAG1
D K28544 SSH4, EAR1; SSH4 family protein
D K28545 RCR; protein RCR
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D K07879 RAB4A, RAB4; Ras-related protein Rab-4A
D K07880 RAB4B; Ras-related protein Rab-4B
D K07903 RAB10; Ras-related protein Rab-10
D K07904 RAB11A; Ras-related protein Rab-11A
D K07905 RAB11B; Ras-related protein Rab-11B
D K06109 RAB13; Ras-related protein Rab-13
D K07881 RAB14; Ras-related protein Rab-14
D K07908 RAB15; Ras-related protein Rab-15
D K07909 RAB17; Ras-related protein Rab-17
D K07891 RAB22; Ras-related protein Rab-22
D K06234 RAB23; Ras-related protein Rab-23
D K07906 RAB25; Ras-related protein Rab-25
D K07876 RAB35, RAB1C; Ras-related protein Rab-35
C Rab4 associated proteins
D K12480 RABEP1; Rab GTPase-binding effector protein 1
D K12481 RBSN, ZFYVE20; rabenosyn-5
D K12482 RUFY1_2, RABIP4; RUN and FYVE domain-containing protein 1/2
D K13738 CD2AP; CD2-associated protein
D K16526 AKAP10; A-kinase anchor protein 10
D K17919 SNX4; sorting nexin-4
D K10416 DYNC1LI, DNCLI; dynein cytoplasmic 1 light intermediate chain
D K24183 NBEA; neurobeachin
D K24185 KIF21; kinesin family member 21
D K24797 TBC1D16; TBC1 domain family member 16
D K27567 GRIPAP1; GRIP1-associated protein 1
C Rab11 associated proteins
D K12484 RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5
D K12485 RAB11FIP3_4; Rab11 family-interacting protein 3/4
D K20241 WDR44, RAB11BP; WD repeat-containing protein 44
D K14004 SEC13; protein transport protein SEC13
D K19985 EXOC6, SEC15; exocyst complex component 6
D K20242 EVI5; ecotropic viral integration site 5 protein
D K24795 TBC1D12; TBC1 domain family member 12
D K20167 TBC1D14; TBC1 domain family member 14
D K15620 GOLPH3, GPP34; golgi phosphoprotein 3
D K23539 UNC119; protein unc-119
D K24313 SH3TC; SH3 domain and tetratricopeptide repeat-containing protein
D K23739 SH3BP5; SH3-domain binding protein 5
D K26154 RELCH; RAB11-binding protein RELCH
C Other Rab GTPase associated proteins
D K12478 EEA1; early endosome antigen 1
D K12483 EHD1; EH domain-containing protein 1
D K12476 EHD3; EH domain-containing protein 3
D K12477 EHD4; EH domain-containing protein 4
D K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D K13758 PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
D K20243 REP15; Rab15 effector protein
D K19947 MICAL; F-actin monooxygenase [EC:1.14.13.225]
D K19948 MICALL1; MICAL-like protein 1
D K21068 MICALL2, JRAB; MICAL-like protein 2
D K25572 EHBP1; EH domain-binding protein 1
D K25573 EHBP1L1; EH domain-binding protein 1-like protein 1
D K19946 OPTN, FIP2; optineurin
D K18341 TBC1D1; TBC1 domain family member 1
D K20166 TBC1D2B; TBC1 domain family member 2B
D K17902 TBC1D4, AS160; TBC1 domain family member 4
D K20396 TBC1D7; TBC1 domain family member 7
D K24796 TBC1D13; TBC1 domain family member 13
D K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D K04482 RAD51; DNA repair protein RAD51
D K23551 FSCN1; fascin 1
D K12489 ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
D K20160 DENND1; DENN domain-containing protein 1
D K20163 DENND4; DENN domain-containing protein 4
D K28416 DENND6; DENN domain-containing protein 6
D K22126 FER1L5; fer-1-like protein 5
D K22127 FER1L6; fer-1-like protein 6
D K20284 RABGAP1, GAPCENA; Rab GTPase-activating protein 1
B Others
C Glutamate receptor-interacting proteins (GRIPs)
D K20251 GRIP; glutamate receptor-interacting protein
C GRIP associated proteins
D K20030 ZDHHC5_8; palmitoyltransferase ZDHHC5/8 [EC:2.3.1.225]
C EARP complex
D K20296 ANG2, VPS51; vacuolar protein sorting-associated protein 51
D K20298 VPS52; vacuolar protein sorting-associated protein 52
D K20299 VPS53; vacuolar protein sorting-associated protein 53
D K23288 VPS50; syndetin
C WASH complex
D K18461 WASH1; WAS protein family homolog 1
D K18462 FAM21; WASH complex subunit FAM21
D K18463 CCDC53; WASH complex subunit CCDC53
D K18464 RTSC, SPG8; WASH complex subunit strumpellin
D K18465 MRT43, SWIP; WASH complex subunit 7
D K10364 CAPZA; F-actin-capping protein subunit alpha
D K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D K25730 VPS26C; vacuolar protein sorting-associated protein 26C
D K18467 VPS29; vacuolar protein sorting-associated protein 29
D K25731 VPS35L; VPS35 endosomal protein-sorting factor-like
C Others
D K23289 EIPR1, TSSC1; EARP and GARP complex-interacting protein 1
D K17924 SNX10_11; sorting nexin-10/11
D K17936 SNX27; sorting nexin-27
D K22938 SDCCAG3, ENTR1; serologically defined colon cancer antigen 3
D K21440 ANKRD50; ankyrin repeat domain-containing protein 50
D K23791 PHETA; sesquipedalian
D K23950 MAGEL2; MAGE-like protein 2
D K24964 BLTP1, CSF1; Bridge-like lipid transfer protein family member 1
D K28442 TMEM170A; transmembrane protein 170A
D K25112 TMX2; thioredoxin-related transmembrane protein 2
D K26497 TMEM230; transmembrane protein 230
D K27081 SORC1; VPS10 domain-containing receptor SorCS1
D K27082 SORC2; VPS10 domain-containing receptor SorCS2
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
D K07893 RAB6A_C_D; Ras-related protein Rab-6A/C/D [EC:3.6.5.2]
D K07894 RAB6B; Ras-related protein Rab-6B [EC:3.6.5.2]
D K07899 RAB9A, RAB9; Ras-related protein Rab-9A
D K07900 RAB9B; Ras-related protein Rab-9B
C Rab associated proteins
D K18739 BICD; protein bicaudal D
D K20161 DENND2; DENN domain-containing protein 2
D K20164 DENND5; DENN domain-containing protein 5
D K16072 ERC1, CAST2, ELKS; ELKS/RAB6-interacting/CAST family member 1
D K19878 ERC2, CAST; ELKS/RAB6-interacting/CAST family member 2
D K20281 GCC1; GRIP and coiled-coil domain-containing protein 1
D K20282 GCC2; GRIP and coiled-coil domain-containing protein 2
D K16731 GOLGA1; golgin subfamily A member 1
D K20283 GOLGA4; golgin subfamily A member 4
D K15620 GOLPH3, GPP34; golgi phosphoprotein 3
D K19748 GORAB, SCYL1BP1; RAB6-interacting golgin
D K10402 KIF20; kinesin family member 20
D K17387 KIF23; kinesin family member 23
D K19951 TBC1D8_9; TBC1 domain family member 8/9
D K22555 TBC1D23; TBC1 domain family member 23
D K20284 RABGAP1, GAPCENA; Rab GTPase-activating protein 1
D K20285 RABEPK; Rab9 effector protein with kelch motifs
D K20286 TMF1; TATA element modulatory factor
D K20287 PLIN3; perilipin-3
D K10419 DYNLRB, DNCL2; dynein light chain roadblock-type
D K04648 DCTN1; dynactin 1
D K01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
D K21847 SGSM1, RUTBC2; small G protein signaling modulator 1
D K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
D K19526 VPS13B; vacuolar protein sorting-associated protein 13B
D K19527 VPS13D; vacuolar protein sorting-associated protein 13D
D K28453 BLTP3A, SHIP164B, UHRF1BP1; bridge-like lipid transfer protein family member 3A
D K28454 BLTP3B, SHIP164A, UHRF1BP1L; bridge-like lipid transfer protein family member 3B
B Arf GTPases and associated proteins
C Arf GTPases
D K07937 ARF1_2; ADP-ribosylation factor 1/2
D K07938 ARF3; ADP-ribosylation factor 3
D K07939 ARF4; ADP-ribosylation factor 4
D K07940 ARF5; ADP-ribosylation factor 5
D K07942 ARL1; ADP-ribosylation factor-like protein 1
D K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D K12491 AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11
D K17848 AGAP2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
D K18439 ARAP1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
D K18440 ARAP2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
D K12486 SMAP; stromal membrane-associated protein
D K05737 GIT1; G protein-coupled receptor kinase interactor 1
D K12487 GIT2; G protein-coupled receptor kinase interactor 2
D K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
D K18442 ARFGEF, BIG; brefeldin A-inhibited guanine nucleotide-exchange protein
D K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
D K18441 CYTH; cytohesin
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D K20288 COG1; conserved oligomeric Golgi complex subunit 1
D K20289 COG2; conserved oligomeric Golgi complex subunit 2
D K20290 COG3, SEC34; conserved oligomeric Golgi complex subunit 3
D K20291 COG4, COD1; conserved oligomeric Golgi complex subunit 4
D K20292 COG5; conserved oligomeric Golgi complex subunit 5
D K20293 COG6, COD2; conserved oligomeric Golgi complex subunit 6
D K20294 COG7; conserved oligomeric Golgi complex subunit 7
D K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D K20296 ANG2, VPS51; vacuolar protein sorting-associated protein 51
D K20297 VPS51; vacuolar protein sorting-associated protein 51
D K20298 VPS52; vacuolar protein sorting-associated protein 52
D K20299 VPS53; vacuolar protein sorting-associated protein 53
D K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D K20300 TRAPPC1, BET5; trafficking protein particle complex subunit 1
D K20301 TRAPPC2, TRS20; trafficking protein particle complex subunit 2
D K20302 TRAPPC3, BET3; trafficking protein particle complex subunit 3
D K20303 TRAPPC4, TRS23; trafficking protein particle complex subunit 4
D K20280 TRAPPC5, TRS31; trafficking protein particle complex subunit 5
D K20304 TRAPPC6, TRS33; trafficking protein particle complex subunit 6
D K20305 TRAPPC8, TRS85; trafficking protein particle complex subunit 8
D K20306 TRAPPC9, TRS120; trafficking protein particle complex subunit 9
D K20307 TRAPPC10, TRS130; trafficking protein particle complex subunit 10
D K20308 TRAPPC11; trafficking protein particle complex subunit 11
D K20309 TRAPPC12; trafficking protein particle complex subunit 12
D K20310 TRAPPC13; trafficking protein particle complex subunit 13
D K20311 TRS65; trafficking protein particle complex II-specific subunit 65
D K20312 TCA17; TRAPP-associated protein TCA17
B Others
C AP-1 complex
D K12391 AP1G1; AP-1 complex subunit gamma-1
D K12392 AP1B1; AP-1 complex subunit beta-1
D K12393 AP1M; AP-1 complex subunit mu
D K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
D K12395 AP1S3; AP-1 complex subunit sigma-3
D K28417 AP1AR; AP-1 complex-associated regulatory protein
C AP-3 complex
D K12396 AP3D; AP-3 complex subunit delta
D K12397 AP3B; AP-3 complex subunit beta
D K12398 AP3M; AP-3 complex subunit mu
D K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
D K12400 AP4E1; AP-4 complex subunit epsilon-1
D K12401 AP4B1; AP-4 complex subunit beta-1
D K12402 AP4M1; AP-4 complex subunit mu-1
D K12403 AP4S1; AP-4 complex subunit sigma-1
D K27312 TEPSIN; AP-4 complex accessory subunit Tepsin
C GGA
D K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D K25218 AFTPH; aftiphilin
D K24814 HEATR5, LAA1; HEAT repeat-containing protein 5
D K25219 SYNRG; synergin gamma
C Others
D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D K00921 PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D K20313 PLEKHA3, FAPP1; pleckstrin homology domain-containing family A member 3
D K08051 PLEKHA8, FAPP2; pleckstrin homology domain containing family A member 8
D K20314 ARFIP; arfaptin
D K20315 ARHGAP21_23; Rho GTPase-activating protein 21/23
D K01349 FURIN, PCSK3; furin [EC:3.4.21.75]
D K20316 SCOC; short coiled-coil protein
D K20317 SPAG9, JIP4; c-Jun-amino-terminal kinase-interacting protein 4
D K20318 SYS1; protein SYS1
D K10362 MYO18; myosin XVIII
D K23290 PACS1; phosphofurin acidic cluster sorting protein 1
D K23540 GOLIM4; golgi integral membrane protein 4
D K28026 TMEM87; transmembrane protein 87
D K23541 TMEM165, GDT1; Ca2+/H+ antiporter, TMEM165/GDT1 family
D K23542 TMEM199; TMEM199 family protein
D K23543 CCDC115; coiled-coil domain-containing protein 115
D K23544 SERINC1; serine incorporator 1
D K25661 SERINC3; serine incorporator 3
D K17918 SNX3_12; sorting nexin-3/12
D K17922 SNX8, MVP1; sorting nexin-8
D K26678 MON2; protein MON2
D K26679 ATP9A; phospholipid-transporting ATPase IIA [EC:7.6.2.1]
D K26680 DOP1, DOPEY; protein dopey
D K27258 WLS; protein wntless
D K28435 TMEM181; transmembrane protein 181
D K24181 LRBA; lipopolysaccharide-responsive and beige-like anchor protein
D K24404 KIAA0319L; dyslexia-associated protein KIAA0319-like protein
D K24498 SORL1; sortilin-related receptor
D K27083 SORC3; VPS10 domain-containing receptor SorCS3
D K24721 CLINT1, EPN4; clathrin interactor 1
D K15493 CALY; neuron-specific vesicular protein calcyon
D K26747 LYSET, TMEM251; lysosomal enzyme trafficking factor
D K27870 TGOLN; trans-Golgi network integral membrane protein
D K27894 HID1; protein HID1
D K28326 FAM177; protein FAM177
D K26750 TVP15; golgi apparatus membrane protein TVP15
D K26751 TVP18; golgi apparatus membrane protein TVP18
D K26752 TVP23; golgi apparatus membrane protein TVP23
D K26753 TVP38; golgi apparatus membrane protein TVP38
D K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D K14004 SEC13; protein transport protein SEC13
D K14005 SEC31; protein transport protein SEC31
D K14006 SEC23; protein transport protein SEC23
D K14007 SEC24; protein transport protein SEC24
D K14003 PREB, SEC12; prolactin regulatory element-binding protein
D K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D K20300 TRAPPC1, BET5; trafficking protein particle complex subunit 1
D K20301 TRAPPC2, TRS20; trafficking protein particle complex subunit 2
D K20302 TRAPPC3, BET3; trafficking protein particle complex subunit 3
D K20303 TRAPPC4, TRS23; trafficking protein particle complex subunit 4
D K20280 TRAPPC5, TRS31; trafficking protein particle complex subunit 5
D K20304 TRAPPC6, TRS33; trafficking protein particle complex subunit 6
C p24 family proteins
D K20346 TMED4_9_11; p24 family protein alpha
D K20347 TMED2, EMP24; p24 family protein beta-1
D K20348 TMED1; p24 family protein gamma-1
D K14825 TMED5, ERP2, ERP4; p24 family protein gamma-2
D K20349 TMED7; p24 family protein gamma-3
D K20350 TMED3; p24 family protein gamma-4
D K20351 TMED6; p24 family protein gamma-5
D K20352 TMED10, ERV25; p24 family protein delta-1
C PDI family proteins
D K09580 PDIA1, P4HB; protein disulfide-isomerase A1 [EC:5.3.4.1]
D K09581 PDIA2; protein disulfide-isomerase A2 [EC:5.3.4.1]
D K08056 PDIA3, GRP58; protein disulfide-isomerase A3 [EC:5.3.4.1]
D K09582 PDIA4, ERP72; protein disulfide-isomerase A4 [EC:5.3.4.1]
D K09583 PDIA5; protein disulfide-isomerase A5 [EC:5.3.4.1]
D K09584 PDIA6, TXNDC7; protein disulfide-isomerase A6 [EC:5.3.4.1]
D K20354 PDILT; protein disulfide-isomerase-like protein of the testis
D K20355 ERP27; endoplasmic reticulum protein 27
D K09586 ERP29; endoplasmic reticulum protein 29
D K17264 ERP44, TXNDC4; endoplasmic reticulum resident protein 44
D K13984 TXNDC5, ERP46; thioredoxin domain-containing protein 5 [EC:5.3.4.1]
D K05360 TXNDC12; protein-disulfide reductase (glutathione) [EC:1.8.4.2]
D K26746 TMX1_4; thioredoxin-related transmembrane protein 1/4
D K09585 TMX3, TXNDC10; protein disulfide-isomerase [EC:5.3.4.1]
D K20356 AGR2; anterior gradient protein 2
D K20357 AGR3; anterior gradient protein 3
D K09530 DNAJC10; DnaJ homolog subfamily C member 10 [EC:1.8.4.-]
C Rab GTPases
D K07874 RAB1A; Ras-related protein Rab-1A
D K07875 RAB1B; Ras-related protein Rab-1B
D K07877 RAB2A; Ras-related protein Rab-2A
D K07878 RAB2B; Ras-related protein Rab-2B
C Rab associated proteins
D K04351 RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
D K20358 GOLGA2; golgin subfamily A member 2
D K20359 RABAC1, PRAF1; PRA1 family protein 1
D K13504 VAMP2; vesicle-associated membrane protein 2
D K18341 TBC1D1; TBC1 domain family member 1
D K17902 TBC1D4, AS160; TBC1 domain family member 4
D K20372 TBC1D20, GYP8; TBC1 domain family member 20
D K20360 TBC1D22, GYP1; TBC1 domain family member 2
D K23368 TRIP11; thyroid receptor-interacting protein 11
D K20362 YIF1; protein transport protein YIF1
D K22939 IER3IP1, YOS1; immediate early response 3-interacting protein 1
D K23291 RUSC2; iporin
D K27568 BLZF1; golgin-45
D K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D K10080 LMAN1, ERGIC53; lectin, mannose-binding 1
D K20364 MCFD2; multiple coagulation factor deficiency protein 2
D K10082 LMAN2, VIP36; lectin, mannose-binding 2
D K01230 MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D K20365 ERGIC1; endoplasmic reticulum-Golgi intermediate compartment protein 1
D K20366 ERGIC2, ERV41; endoplasmic reticulum-Golgi intermediate compartment protein 2
D K20367 ERGIC3, ERV46; endoplasmic reticulum-Golgi intermediate compartment protein 3
D K20368 CNIH, ERV14; protein cornichon
D K20369 ERV29, SURF4; ER-derived vesicles protein
D K09490 HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]
D K09501 SERPINH1, HSP47; serpin peptidase inhibitor, clade H, member 1
D K05717 FN1; fibronectin 1
D K11140 ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]
D K20371 NUCB; nucleobindin
B Retrieval pathways
C Coat protein complex I (COP-I)
D K05236 COPA, RET1; coatomer subunit alpha
D K17301 COPB1, SEC26; coatomer subunit beta
D K17302 COPB2, SEC27; coatomer subunit beta'
D K17267 COPG; coatomer subunit gamma
D K20471 COPD, ARCN1, RET2; coatomer subunit delta
D K17268 COPE; coatomer subunit epsilon
D K20472 COPZ, RET3; coatomer subunit zeta
C NRZ (DSL1) complex
D K20473 NBAS; neuroblastoma-amplified sequence
D K20474 RINT1, TIP20; RAD50-interacting protein 1
D K11578 ZW10, DSL1; protein transport protein DSL1/ZW10
D K20475 SEC39, DSL3; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D K22384 GET1, WRB; tail-anchored protein insertion receptor
D K22386 GET2; GET complex subunit GET2
D K01551 arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D K23387 GET4; golgi to ER traffic protein 4
D K23388 UBL4; ubiquitin-like protein 4
C Rab GTPases
D K07893 RAB6A_C_D; Ras-related protein Rab-6A/C/D [EC:3.6.5.2]
D K07919 RAB33A; Ras-related protein Rab-33A
D K07920 RAB33B; Ras-related protein Rab-33B
C Rab associated proteins
D K20476 RIC1; RAB6A-GEF complex partner protein 1
D K20477 RGP1; RAB6A-GEF complex partner protein 2
D K20478 GOLGB1; golgin subfamily B member 1
D K10949 KDELR; ER lumen protein retaining receptor
D K12481 RBSN, ZFYVE20; rabenosyn-5
D K20360 TBC1D22, GYP1; TBC1 domain family member 2
D K23368 TRIP11; thyroid receptor-interacting protein 11
B Others
C Oxysterol-binding proteins
D K20456 OSBP; oxysterol-binding protein 1
D K20462 OSBP2, ORP4; oxysterol-binding protein 2
D K20174 OSBPL1_2, ORP1_2; oxysterol-binding protein-related protein 1/2
D K20463 OSBPL3_6_7, ORP3_6_7; oxysterol-binding protein-related protein 3/6/7
D K20464 OSBPL5, ORP5; oxysterol-binding protein-related protein 5
D K22285 OSBPL8, ORP8; oxysterol-binding protein-related protein 8
D K20465 OSBPL9_10_11, ORP9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
D K13360 FXYD1, PLM; FXYD domain-containing ion transport regulator 1
D K13364 FXYD7; FXYD domain-containing ion transport regulator 7
C YIPF proteins
D K22940 YIPF1_2; protein YIPF1/2
D K22941 YIPF3, KLIP1; protein YIPF3
D K22942 YIPF4; protein YIPF4
D K20363 YIPF5_7, YIP1; protein YIPF5/7
D K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D K23562 EMC1; ER membrane protein complex subunit 1
D K23563 EMC2, TTC35; ER membrane protein complex subunit 2
D K23564 EMC3, TMEM111; ER membrane protein complex subunit 3
D K23565 EMC4, TMEM85; ER membrane protein complex subunit 4
D K23566 MMGT1, EMG5; membrane magnesium transporter 1
D K23567 EMC6, TMEM93; ER membrane protein complex subunit 6
D K23568 EMC7; ER membrane protein complex subunit 7
D K23569 EMC8_9; ER membrane protein complex subunit 8/9
D K23570 EMC10; ER membrane protein complex subunit 10
C SEC61 complex
D K10956 SEC61A; protein transport protein SEC61 subunit alpha
D K09481 SEC61B, SBH2; protein transport protein SEC61 subunit beta
D K07342 SEC61G, SSS1, secE; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
D K13249 SSR1; translocon-associated protein subunit alpha
D K13250 SSR2; translocon-associated protein subunit beta
D K13251 SSR3; translocon-associated protein subunit gamma
D K04571 SSR4; translocon-associated protein subunit delta
C Multi-pass translocon (MPT) complex
D K21891 TMCO1; calcium load-activated calcium channel
D K26496 RAB5IF; GEL complex subunit OPTI
D K24962 CCDC47; PAT complex subunit CCDC47
D K24963 WDR83OS; PAT complex subunit Asterix
D K26498 TMEM147; BOS complex subunit TMEM147
D K26499 NCLN; BOS complex subunit NCLN
D K26500 NOMO1_2_3; BOS complex subunit NOMO
C Post-GPI attachment to proteins factors (PGAP)
D K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D K23552 PGAP2; post-GPI attachment to proteins factor 2
D K23553 PGAP3, PER1; post-GPI attachment to proteins factor 3
D K26235 PGAP4, TMEM246; post-GPI attachment to proteins factor 4
D K23362 MPPE1, PGAP5, CDC1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D K19998 SCFD1, SLY1; sec1 family domain-containing protein 1
D K19934 SDF4; calcium-binding protein
D K20479 WHAMM; WASP homolog-associated protein with actin, membranes and microtubules
D K19872 FKTN; fukutin [EC:2.7.8.-]
D K19873 FKRP; fukutin-related protein [EC:2.7.8.-]
D K21957 FAM20A; pseudokinase FAM20A
D K20825 FAM20B; glycosaminoglycan xylosylkinase [EC:2.7.1.-]
D K21958 FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1]
D K19874 SEPN1; selenoprotein N
D K20392 PRAF2; PRA1 family protein 2
D K20393 ARL6IP5, PRAF3; PRA1 family protein 3
D K24864 ARL6IP1; ADP-ribosylation factor-like protein 6-interacting protein 1
D K20724 TMEM33; transmembrane protein 33
D K20721 RTN1; reticulon-1
D K20722 RTN2; reticulon-2
D K20723 RTN3; reticulon-3
D K20720 RTN4; reticulon-4
D K23554 GRAMD4; GRAM domain-containing protein 4
D K23555 LMF1; lipase maturation factor 1
D K06096 VAPA; vesicle-associated membrane protein-associated protein A
D K21413 ANKS1; ankyrin repeat and SAM domain-containing protein 1
D K21414 ANKS4B, HARP; ankyrin repeat and SAM domain-containing protein 4B
D K21848 ARV1; lipid intermediate transporter
D K21849 KEG1; beta-1,6-glucan synthesis-associated protein KEG1
D K21850 KRE6; beta-glucan synthesis-associated protein KRE6
D K15620 GOLPH3, GPP34; golgi phosphoprotein 3
D K22128 PIEZO1_2, FAM38; piezo-type mechanosensitive ion channel component 1/2
D K22556 MANF, ARMET; mesencephalic astrocyte-derived neurotrophic factor
D K22697 SAMD8; ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.48 3.1.4.62]
D K17339 ATL; atlastin [EC:3.6.5.-]
D K13254 SPAST; spastin [EC:5.6.1.1]
D K23292 LNPK; endoplasmic reticulum junction formation protein lunapark
D K12360 CLN8; ceroid-lipofuscinosis neuronal protein 8
D K23951 DYM; dymeclin
D K24069 PITPNM; membrane-associated phosphatidylinositol transfer protein
D K24996 STEEP1; STING ER exit protein
D K25381 FRRS1L; DOMON domain-contaning protein FRRS1L
D K25789 JAGN; protein jagunal
D K26681 INSIG; insulin-induced protein
D K26682 SCAP; sterol regulatory element-binding protein cleavage-activating protein
D K07197 SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1
D K09107 SREBP2, SREBF2; sterol regulatory element-binding transcription factor 2
D K28167 SPRING1; SREBP regulating gene protein
D K26683 GOLT1, GOT1; vesicle transport protein GOT1
D K27761 GIMAP4; GTPase IMAP family member 4
D K28402 FAM8A1; protein FAM8A1
D K28439 TMEM39; transmembrane protein 39
D K28681 PVA, VAP27; plant VAMP family protein
D K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D K21357 ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
D K08331 ATG13; autophagy-related protein 13
D K17589 RB1CC1; RB1-inducible coiled-coil protein 1
D K19730 ATG101; autophagy-related protein 101
C Atg1 complex
D K08269 ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D K08331 ATG13; autophagy-related protein 13
D K08329 ATG17; autophagy-related protein 17
D K21143 ATG29; autophagy-related protein 29
D K21144 ATG31; autophagy-related protein 31
C PI3K complex
D K00914 PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D K08333 PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D K17889 ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
D K08335 ATG14; autophagy-related protein 14
D K08334 BECN, VPS30, ATG6; beclin
D K21246 NRBF2; nuclear receptor-binding factor 2
D K21145 ATG38; autophagy-related protein 38
C ATG9 transmembrane protein
D K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D K17908 WIPI1_2, ATG18; autophagy-related protein 18
D K17906 ATG2; autophagy-related protein 2
C Atg12 conjugation proteins
D K08336 ATG12; ubiquitin-like protein ATG12
D K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D K17888 ATG10L, ATG10; ubiquitin-like-conjugating enzyme ATG10
D K08338 ATG10; ubiquitin-like-conjugating enzyme ATG10
D K08339 ATG5; autophagy-related protein 5
D K17890 ATG16L1; autophagy-related protein 16-1
D K20868 ATG16L2; autophagy-related protein 16-2
D K08340 ATG16; autophagy-related protein 16
C Atg8 conjugation proteins
D K08341 GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
D K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
D K23880 RETREG; reticulophagy regulator
D K24181 LRBA; lipopolysaccharide-responsive and beige-like anchor protein
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D K01268 LAP4; aminopeptidase I [EC:3.4.11.22]
D K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
D K21997 ATG19_34; autophagy-related protein 19/34
C Scaffold protein
D K08330 ATG11; autophagy-related protein 11
C Other Cvt associated proteins
D K21996 SNX41_42; sorting nexin-41/42
D K17919 SNX4; sorting nexin-4
D K17900 ATG15, AUT5; lipase ATG15 [EC:3.1.1.3]
D K17909 ATG23; autophagy-related protein 23
D K21141 ATG27; autophagy-related protein 27
D K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
D K14381 SQSTM1; sequestosome 1
D K15464 BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
D K15465 BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
D K17984 ATG32; autophagy-related protein 32
C Scaffold proteins
D K08330 ATG11; autophagy-related protein 11
C PINK1-Parkin associated proteins
D K05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]
D K04556 PARK2; parkin [EC:2.3.2.31]
D K06030 MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
D K11981 RNF41, NRDP1; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
D K19513 CLEC16A; protein CLEC16A
D K21347 TAX1BP1; Tax1-binding protein 1
D K19946 OPTN, FIP2; optineurin
D K17987 NBR1; next to BRCA1 gene 1 protein
D K17985 AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
C Other mitophagy associated proteins
D K00844 HK; hexokinase [EC:2.7.1.1]
D K09558 BAG4; BCL2-associated athanogene 4
D K22255 ATPIF1; ATPase inhibitor, mitochondrial
D K04678 SMURF; E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
D K07197 SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1
D K10260 FBXW7, SEL10; F-box and WD-40 domain protein 7
D K22256 SIAH3; seven in absentia homolog 3
D K21343 USP15; ubiquitin carboxyl-terminal hydrolase 15 [EC:3.4.19.12]
D K11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]
D K17771 TOM7; mitochondrial import receptor subunit TOM7
D K22257 SPATA18; mitochondria-eating protein
D K17986 FUNDC1; FUN14 domain-containing protein 1
D K24308 FUNDC2; FUN14 domain-containing protein 2
D K10435 MAP1LC; microtubule-associated protein 1 light chain
D K19717 ATG33; autophagy-related protein 33
B Pexophagy
C Selective cargos
D K13336 PEX3; peroxin-3
D K13343 PEX14; peroxin-14
C Cargo receptors
D K14381 SQSTM1; sequestosome 1
D K22258 ATG36; autophagy-related protein 36
D K22259 ATG30; autophagy-related protein 30
C Other pexophagy associated proteins
D K17987 NBR1; next to BRCA1 gene 1 protein
D K09095 HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
D K27288 ACBD4_5; acyl-CoA-binding domain-containing protein 4/5
D K13338 PEX1; peroxin-1
D K13339 PEX6, PXAAA1; peroxin-6
D K22260 PEX15; peroxin-15
B Aggrephagy
C Cargo receptors
D K14381 SQSTM1; sequestosome 1
D K17987 NBR1; next to BRCA1 gene 1 protein
D K22261 SEPA1; protein sepa-1
C Scaffold proteins
D K22262 WDFY3, ALFY; WD repeat and FYVE domain-containing protein 3
D K22263 EPG2; ectopic P granules protein 2
C Other aggrephagy associated proteins
D K13525 VCP, CDC48; transitional endoplasmic reticulum ATPase
D K04556 PARK2; parkin [EC:2.3.2.31]
D K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
D K09561 STUB1, CHIP; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]
D K09557 BAG3; BCL2-associated athanogene 3
D K08879 HSPB8; heat shock protein beta-8
B Xenophagy
C Cargo receptors
D K14381 SQSTM1; sequestosome 1
D K21348 CALCOCO2, NDP52; calcium-binding and coiled-coil domain-containing protein 2
D K19946 OPTN, FIP2; optineurin
D K17987 NBR1; next to BRCA1 gene 1 protein
D K21347 TAX1BP1; Tax1-binding protein 1
C Other xenophagy associated proteins
D K05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]
D K07902 RAB8B; Ras-related protein Rab-8B
D K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
D K04556 PARK2; parkin [EC:2.3.2.31]
D K12654 STING1, TMEM173, MITA; stimulator of interferon genes protein
D K06832 LGALS8; galectin-8
B ER-phagy
C ER-phagy recepters
D K23880 RETREG; reticulophagy regulator
D K28115 CCPG1; cell cycle progression protein 1
D K28116 CDK5RAP3; CDK5 regulatory subunit-associated protein 3
D K14381 SQSTM1; sequestosome 1
D K20723 RTN3; reticulon-3
D K12275 SEC62; translocation protein SEC62
D K17339 ATL; atlastin [EC:3.6.5.-]
D K28117 TEX264; testis-expressed protein 264
D K25828 CALCOCO1; calcium-binding and coiled-coil domain-containing protein 1
D K28118 ATG40; autophagy-related protein 40
D K28119 ATG39; autophagy-related protein 39
C Other ER-phagy associated proteins
D K08054 CANX; calnexin
D K23344 DDRGK1; DDRGK domain-containing protein 1
D K22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]
D K12003 TRIM13; tripartite motif-containing protein 13 [EC:2.3.2.27]
D K17278 PGRMC1_2; membrane-associated progesterone receptor component
D K06096 VAPA; vesicle-associated membrane protein-associated protein A
D K10707 VAPB, ALS8; vesicle-associated membrane protein-associated protein B
C ER stress-related proteins
D K09490 HSPA5, BIP; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]
D K09487 HSP90B, TRA1; heat shock protein 90kDa beta
D K09027 XBP1; X box-binding protein 1
D K03237 EIF2S1; translation initiation factor 2 subunit 1
D K22188 CLCC1; chloride channel CLIC-like protein 1
D K28120 PIGBOS1; protein PIGBOS1
B Chaperone mediated autophagy (CMA)
C Selective cargos
D K01623 ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]
D K17091 ANXA1; annexin A1
D K17092 ANXA2; annexin A2
D K17093 ANXA4; annexin A4
D K17094 ANXA6; annexin A6
D K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D K04379 FOS; proto-oncogene protein c-fos
D K17277 EPS8; epidermal growth factor receptor kinase substrate 8
D K00134 GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D K13823 HBB; hemoglobin subunit beta
D K04734 NFKBIA; NF-kappa-B inhibitor alpha
D K09262 MEF2D; MADS-box transcription enhancer factor 2D
D K03910 A2M; alpha-2-macroglobulin
D K15608 PAX2; paired box protein 2
D K01834 PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D K00873 PK, pyk; pyruvate kinase [EC:2.7.1.40]
D K17901 RCAN1, MCIP1; calcipressin-1
D K01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]
D K04380 MAPT, TAU; microtubule-associated protein tau
D K04523 UBQLN, DSK2; ubiquilin
C Cargo receptors
D K06528 LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
C Chaperones
D K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D K26598 HSPA2; heat shock 70kDa protein 2
D K04079 HSP90A, htpG; molecular chaperone HtpG
C Co-chaperones
D K09555 BAG1; BCL2-associated athanogene 1
D K09560 ST13; suppressor of tumorigenicity protein 13
D K09502 DNAJA1; DnaJ homolog subfamily A member 1
C Other CMA associated proteins
D K05640 GFAP; glial fibrillary acidic protein
D K03231 EEF1A; elongation factor 1-alpha
D K13289 CTSA, CPY; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
D K26112 SIDT2; SID1 transmembrane family member 2
D K06528 LAMP1_2, CD107; lysosomal-associated membrane protein 1/2
C Micronucleophagy
D K22264 NVJ1; nucleus-vacuole junction protein 1
D K08332 VAC8; vacuolar protein 8
C Midbophagy
D K16456 CEP55; centrosomal protein CEP55
D K17987 NBR1; next to BRCA1 gene 1 protein
D K14381 SQSTM1; sequestosome 1
C Glycophagy
D K22267 STBD1; starch-binding domain-containing protein 1
C TRIM-directed selective autophagy
D K12803 MEFV; pyrin
D K01370 CASP1; caspase 1 [EC:3.4.22.36]
D K12798 NLRP1, CARD7; NACHT, LRR and PYD domains-containing protein 1
D K12800 NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
D K10651 TRIM21, SSA1; tripartite motif-containing protein 21 [EC:2.3.2.27]
D K05411 IRF3; interferon regulatory factor 3
C ER-mitochondria tethering complex
D K10707 VAPB, ALS8; vesicle-associated membrane protein-associated protein B
D K23293 RMDN3, PTPIP51; regulator of microtubule dynamics protein 3
D K23294 PACS2; phosphofurin acidic cluster sorting protein 2
D K06030 MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D K07203 MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D K08266 MLST8, GBL; target of rapamycin complex subunit LST8
D K20402 DEPTOR; DEP domain-containing mTOR-interacting protein
D K07204 RAPTOR; regulatory associated protein of mTOR
D K16184 AKT1S1, PRAS40; proline-rich AKT1 substrate 1
D K25579 TCO89; target of rapamycin complex 1 subunit TCO89
C mTORC2 complex
D K07203 MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D K08266 MLST8, GBL; target of rapamycin complex subunit LST8
D K20402 DEPTOR; DEP domain-containing mTOR-interacting protein
D K20410 MAPKAP1, SIN1, AVO1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D K08267 RICTOR; rapamycin-insensitive companion of mTOR
D K20411 PRR5, PROTOR; proline-rich protein 5
D K25576 AVO2; target of rapamycin complex 2 subunit AVO2
D K25577 BIT61_2; target of rapamycin complex 2 subunit BIT61/BIT2
C SEACIT/GATOR1 complex
D K20404 DEPDC5, SEA1; SEA/GATOR complex protein SEA1/DEPDC5
D K20405 NPRL2, NPR2; nitrogen permease regulator 2
D K20406 NPRL3, NPR3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D K20408 WDR24, SEA2; SEA/GATOR complex protein SEA2/WDR24
D K20409 WDR59, SEA3; SEA/GATOR complex protein SEA3/WDR59
D K20407 MIOS, MIO, SEA4; SEA/GATOR complex protein SEA4/MIOS
D K14299 SEH1; nucleoporin SEH1
D K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
D K23295 KPTN; KICSTOR complex protein kaptin
D K23296 ITFG2; KICSTOR complex protein ITFG2
D K23297 C12ORF66; KICSTOR complex protein C12orf66
D K23298 SZT2; KICSTOR complex protein SZT2
C Rab GTPases
D K07874 RAB1A; Ras-related protein Rab-1A
D K07875 RAB1B; Ras-related protein Rab-1B
D K07901 RAB8A, MEL; Ras-related protein Rab-8A
D K07925 RAB39B; Ras-related protein Rab-39B
C Rab associated proteins
D K23609 C9ORF72; guanine nucleotide exchange protein C9orf72
D K23610 WDR41; WD repeat-containing protein 41
D K23611 SMCR8; guanine nucleotide exchange protein SMCR8
C Others
D K07198 PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
D K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D K17606 IGBP1, TAP42; immunoglobulin-binding protein 1
D K17988 TECPR1; tectonin beta-propeller repeat-containing protein 1
D K17603 ZFYVE1; zinc finger FYVE domain-containing protein 1
D K22265 NLRP4; NACHT, LRR and PYD domains-containing protein 4
D K22266 NLRP10; NACHT, LRR and PYD domains-containing protein 10
D K21249 UVRAG; UV radiation resistance-associated gene protein
D K25948 RUBCNL; protein associated with UVRAG as autophagy enhancer
D K19330 RUBCN; run domain Beclin-1 interacting and cysteine-rich containing protein
D K06902 UMF1; MFS transporter, UMF1 family
D K14209 SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter)
D K06819 NRP2; neuropilin 2
D K23299 WDFY1; WD repeat and FYVE domain-containing protein 1
D K24777 WDFY4; WD repeat and FYVE domain-containing protein 4
D K22991 WDR45, WIPI4, WIPI3; WD repeat-containing protein 45
D K23881 TECPR2; tectonin beta-propeller repeat-containing protein 2
D K23882 CISD2; CDGSH iron-sulfur domain-containing protein 2
D K23883 EPG5; ectopic P granules protein 5
D K23884 WAC; WW domain-containing adapter protein with coiled-coil
D K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
D K24045 JMY; junction-mediating and -regulatory protein
D K24928 TTC5; tetratricopeptide repeat protein 5
D K25663 FEZ1; fasciculation and elongation protein zeta-1
D K25668 FEZ2; fasciculation and elongation protein zeta-2
D K25949 CCDC50; coiled-coil domain-containing protein 50
D K26231 GPRASP1; G-protein coupled receptor-associated sorting protein 1
D K26232 DDIT4L, CHRB; DNA damage-inducible transcript 4-like protein
D K27309 TMEM59; transmembrane protein 59
D K28394 TMEM74; transmembrane protein 74
D K24550 BCAS3; breast carcinoma-amplified sequence 3
D K27411 PHAF1; phagosome assembly factor 1
D K27476 PHF23; PHD finger protein 23
D K27569 EVA1; protein eva-1
D K27570 DAP; death-associated protein 1
D K27762 GIMAP6; GTPase IMAP family member 6
#
AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
D K08008 NOX1, MOX1; NADPH oxidase 1
D K21421 NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
D K21422 NOX3, MOX2; NADPH oxidase 3 [EC:1.6.3.-]
D K21424 NOX5; NADPH oxidase 5 [EC:1.6.3.-]
D K13411 DUOX, THOX; dual oxidase [EC:1.6.3.1 1.11.1.-]
C Nox associated proteins
D K08009 CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
D K08011 NCF1, P47PHOX; neutrophil cytosolic factor 1
D K08010 NCF2, P67PHOX; neutrophil cytosolic factor 2
D K08012 NCF4, P40PHOX; neutrophil cytosolic factor 4
D K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
D K21432 NOXA1; NADPH oxidase activator 1
D K17934 NOXO1, SNX28; NADPH oxidase organizer 1
D K17233 DUOXA1; dual oxidase maturation factor 1
D K17232 DUOXA2; dual oxidase maturation factor 2
D K24032 SH3PXD2; SH3 and PX domain-containing protein 2
B Actin-binding proteins
C Myosins
D K10356 MYO1; myosin I
D K10357 MYO5; myosin V
D K10358 MYO6; myosin VI
D K10359 MYO7A, USH1B; myosin VIIa
D K21868 MYO7B; myosin VIIb
D K10362 MYO18; myosin XVIII
C Arp2/3 complex
D K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D K17260 ACTR2, ARP2; actin-related protein 2
D K18584 ACTR3, ARP3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D K05747 WAS; Wiskott-Aldrich syndrome protein
D K23612 WASL; neural Wiskott-Aldrich syndrome protein
D K19475 WIPF; WAS/WASL-interacting protein
D K20479 WHAMM; WASP homolog-associated protein with actin, membranes and microtubules
D K20493 LRRC16, CARMIL; leucine-rich repeat-containing protein 16
D K06106 CTTN, EMS1; cortactin
D K20520 DBNL, ABP1; drebrin-like protein
D K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D K12562 AMPH; amphiphysin
D K12470 SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
D K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D K20521 BBC1, MTI1; myosin tail region-interacting protein MTI1
D K20522 LSB1_2; LAS seventeen-binding protein 1/2
D K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D K20524 LSB5; LAS seventeen-binding protein 5
D K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D K05759 PFN; profilin
D K05765 CFL; cofilin
D K17261 CAP1_2, SRV2; adenylyl cyclase-associated protein
D K10396 KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
D K19875 MYOT; myotilin
D K12567 TTN; titin [EC:2.7.11.1]
D K21433 ANKRD1; ankyrin repeat domain-containing protein 1
D K21434 ANKRD2; ankyrin repeat domain-containing protein 2
D K21438 ANKRD23; ankyrin repeat domain-containing protein 23
D K19879 TCAP; telethonin
D K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
D K06568 MUC1, CD227; mucin-1
D K22017 MUC4; mucin-4
D K22018 MUC3_12_17; mucin-3/12/17
D K17298 MUC13; mucin-13
D K22019 MUC15; mucin-15
D K16145 MUC16, CA125; mucin-16
D K22021 MUC20; mucin-20
D K22022 MUC21; mucin-21
D K24296 MUC22; mucin-22
C Secretory mucins
D K10955 MUC2; mucin-2
D K13908 MUC5; mucin-5
D K22023 MUC6_19; mucin-6/19
D K13909 MUC7, MG2; mucin-7
B MARVEL domain-containing proteins
C K28038 CKLF; chemokine-like factor
C K28039 CMTM1; CKLF-like MARVEL transmembrane domain-containing protein 1
C K28040 CMTM2; CKLF-like MARVEL transmembrane domain-containing protein 2
C K28041 CMTM3; CKLF-like MARVEL transmembrane domain-containing protein 3
C K28042 CMTM4; CKLF-like MARVEL transmembrane domain-containing protein 4
C K28043 CMTM5; CKLF-like MARVEL transmembrane domain-containing protein 5
C K28044 CMTM6; CKLF-like MARVEL transmembrane domain-containing protein 6
C K28045 CMTM7; CKLF-like MARVEL transmembrane domain-containing protein 7
C K28046 CMTM8; CKLF-like MARVEL transmembrane domain-containing protein 8
C K28036 MAL2; protein MAL2
C K28037 MALL; MAL-like protein
C K28047 PLLP; plasmolipin
C K28048 PLP2; proteolipid protein 2
B Specific organelles associated proteins
C Melanosome
D K07918 RAB32; Ras-related protein Rab-32
D K07923 RAB38; Ras-related protein Rab-38
D K20175 ANKRD27; ankyrin repeat domain-containing protein 27
D K21851 SGSM2, RUTBC1; small G protein signaling modulator 2
C Auto phagosome
D K07912 RAB24; Ras-related protein Rab-24
D K07919 RAB33A; Ras-related protein Rab-33A
D K07920 RAB33B; Ras-related protein Rab-33B
D K24799 TBC1D25; TBC1 domain family member 25
D K17890 ATG16L1; autophagy-related protein 16-1
D K20868 ATG16L2; autophagy-related protein 16-2
C Lipid droplets
D K07910 RAB18; Ras-related protein Rab-18
D K21407 APMAP; adipocyte plasma membrane-associated protein
D K27760 GIMAP2; GTPase IMAP family member 2
D K27773 GIMAP7; GTPase IMAP family member 7
D K19365 BSCL2; seipin
D K28099 FITM1; fat storage-inducing transmembrane protein 1
D K28100 FITM2; fat storage-inducing transmembrane protein 2 [EC:3.6.1.-]
D K28352 C18ORF32; UPF0729 protein C18orf32
C Mitochondrion
D K07918 RAB32; Ras-related protein Rab-32
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D K08878 BCR1, BCR; breakpoint cluster region protein [EC:2.7.11.1]
D K20629 ABR; active breakpoint cluster region-related protein
D K18470 ARHGAP1, CDC42GAP; Rho GTPase-activating protein 1
D K20630 CHN1_2, ARHGAP2_3; chimaerin
D K20122 ARHGAP4; Rho GTPase-activating protein 4
D K13709 ARHGAP5; Rho GTPase-activating protein 5
D K20631 ARHGAP6; Rho GTPase-activating protein 6
D K20632 DLC; deleted in liver cancer protein
D K20633 ARHGAP8, BPGAP1; Rho GTPase-activating protein 8
D K20634 ARHGAP9; Rho GTPase-activating protein 9
D K13736 ARHGAP10; Rho GTPase-activating protein 10
D K20635 ARHGAP11; Rho GTPase-activating protein 11
D K20636 ARHGAP12_27; Rho GTPase-activating protein 12/27
D K07526 SRGAP; SLIT-ROBO Rho GTPase activating protein
D K20637 ARHGAP15; Rho GTPase-activating protein 15
D K20638 ARHGAP17, RICH1; Rho GTPase-activating protein 17
D K20639 ARHGAP18_28_40; Rho GTPase-activating protein 18/28/40
D K20640 ARHGAP19; Rho GTPase-activating protein 19
D K20641 ARHGAP20; Rho GTPase-activating protein 20
D K20315 ARHGAP21_23; Rho GTPase-activating protein 21/23
D K20642 ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25
D K20071 ARHGAP26, GRAF; Rho GTPase-activating protein 26
D K20644 ARHGAP29; Rho GTPase-activating protein 29
D K20645 ARHGAP30; Rho GTPase-activating protein 30
D K20646 ARHGAP31, CDGAP; Rho GTPase-activating protein 31
D K20647 ARHGAP32; Rho GTPase-activating protein 32
D K17933 ARHGAP33, SNX26; Rho GTPase-activating protein 33
D K05732 ARHGAP35, GRLF1; glucocorticoid receptor DNA-binding factor 1
D K20648 ARHGAP36; Rho GTPase-activating protein 36
D K20649 ARHGAP39; Rho GTPase-activating protein 39
D K20650 OPHN1, ARHGAP41; oligophrenin-1
D K20651 ARHGAP42, GRAF3; Rho GTPase-activating protein 42
D K20652 SH3BP1, ARHGAP43; SH3-domain binding protein 1
D K21067 ARHGAP44, RICH2; Rho GTPase-activating protein 44
D K26415 ARHGAP45; Rho GTPase-activating protein 45
D K20653 GMIP, ARHGAP46; GEM interacting protein
D K20654 TAGAP, ARHGAP47; T-cell activation Rho GTPase-activating protein
D K20655 SYDE; Rho GTPase-activating protein SYDE
D K20643 RGD1; Rho GTPase-activating protein RGD1
D K18439 ARAP1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
D K18440 ARAP2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
D K12490 ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
D K16733 RACGAP1, Tum; Rac GTPase-activating protein 1
D K08773 RALBP1; RalA-binding protein 1
D K10360 MYO9; myosin IX
D K24353 UBXN11; UBX domain-containing protein 11
C Rho guanine nucleotide exchange factors (GEFs)
D K12330 ARHGEF1; Rho guanine nucleotide exchange factor 1
D K12791 ARHGEF2, GEF-H1; Rho guanine nucleotide exchange factor 2
D K20683 ARHGEF3_8; Rho guanine nucleotide exchange factor 3/8
D K05769 ARHGEF4_29, ASEF1_2; Rho guanine nucleotide exchange factor 4/29
D K20684 ARHGEF5; Rho guanine nucleotide exchange factor 5
D K05729 ARHGEF6, PIXA; Rho guanine nucleotide exchange factor 6
D K13710 ARHGEF7, PIXB; Rho guanine nucleotide exchange factor 7
D K20686 ARHGEF9; Rho guanine nucleotide exchange factor 9
D K16727 ARHGEF10; Rho guanine nucleotide exchange factor 10
D K12331 ARHGEF11; Rho guanine nucleotide exchange factor 11
D K07532 ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
D K16529 ARHGEF13; A-kinase anchor protein 13
D K20685 MCF2, ARHGEF14_21_22; guanine nucleotide exchange factor MCF2
D K20687 ARHGEF15; Rho guanine nucleotide exchange factor 15
D K20688 ARHGEF16; Rho guanine nucleotide exchange factor 16
D K20689 ARHGEF17; Rho guanine nucleotide exchange factor 17
D K21066 ARHGEF18; A-kinase anchor protein 18
D K20691 ARHGEF19, WGEF; Rho guanine nucleotide exchange factor 19
D K08810 TRIO; triple functional domain protein [EC:2.7.11.1]
D K15048 KALRN; kalirin [EC:2.7.11.1]
D K20690 ARHGEF25; Rho guanine nucleotide exchange factor 25
D K13744 ARHGEF26, SGEF; Rho guanine nucleotide exchange factor 26
D K07525 NGEF, EPHEXIN, ARHGEF27; neuronal guanine nucleotide exchange factor
D K21072 ARHGEF28; A-kinase anchor protein 28
D K17531 OBSCN, ARHGEF30; obscurin-RhoGEF [EC:2.7.11.1]
D K20704 ECT2, ARHGEF31; protein ECT2
D K20705 DNMBP, ARHGEF36, TUBA; dynamin-binding protein
D K20710 ARHGEF37; Rho guanine nucleotide exchange factor 37
D K20711 ARHGEF38; Rho guanine nucleotide exchange factor 38
D K23798 ARHGEF39; Rho guanine nucleotide exchange factor 39
D K24316 ARHGEF40; Rho guanine nucleotide exchange factor 40
D K20045 ITSN; intersectin
D K13708 DOCK1; dedicator of cytokinesis protein 1
D K12367 DOCK2; dedicator of cytokinesis protein 2
D K05727 DOCK3; dedicator of cytokinesis protein 3
D K17697 DOCK4; dedicator of cytokinesis protein 4
D K17707 DOCK5; dedicator of cytokinesis protein 5
D K21852 DOCK6_7_8; dedicator of cytokinesis protein 6/7/8
D K21853 DOCK9_10_11; dedicator of cytokinesis protein 9/10/11
D K27817 RAP1GDS1; Rap1 GTPase-GDP dissociation stimulator 1
D K27818 RIC8; synembryn
D K28415 DENND11; DENN domain-containing protein 11
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: January 14, 2026