+C Two-component system KO
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Two-Component System - Bacillus cereus F837/76
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C bcf_22980 Phosphate regulon sensor protein PhoR (SphS) K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C bcf_22985 Alkaline phosphatase synthesis transcriptional regulatory protein PhoP K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C bcf_03905 Osmosensitive K+ channel histidine kinase KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
C bcf_07475 Sensor histidine kinase ResE K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]
C bcf_07470 DNA-binding response regulator ResD family K07775 resD; two-component system, OmpR family, response regulator ResD
B VicK-VicR (cell wall metabolism)
C bcf_27435 Two-component sensor kinase SA14-24 like protein K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
C bcf_27440 Two-component response regulator SA14-24 like protein K07668 vicR; two-component system, OmpR family, response regulator VicR
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
C bcf_24250 Two-component sensor kinase YvcQ like protein K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]
C bcf_13030 sensor histidine kinase K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]
C bcf_13025 Two-component response regulator YvcP like protein K11634 yxdJ; two-component system, OmpR family, response regulator YxdJ
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
C bcf_02920 Two-component response regulator, malate K14983 ciaR; two-component system, OmpR family, response regulator CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
C bcf_25265 Two-component response regulator vanRB K18344 vanRB; two-component system, OmpR family, response regulator VanR
B VanS-VanR (VanE type vancomycin resistance)
C bcf_15990 Sensor histidine kinase VanS K18350 vanSC; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
C bcf_15995 Vancomycin response regulator VanR K18349 vanRC; two-component system, OmpR family, response regulator VanR
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
C bcf_11100 Two-component sensor kinase SA14-24 like protein K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C bcf_11095 DNA-binding response regulator K18941 arlR; two-component system, OmpR family, response regulator ArlR
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C bcf_09635 Two-component system response regulator QseB K02483 K02483; two-component system, OmpR family, response regulator
C bcf_22085 Two-component response regulator YvcP like protein K02483 K02483; two-component system, OmpR family, response regulator
C bcf_15900 Two-component response regulator colocalized with HrtAB transporter K02483 K02483; two-component system, OmpR family, response regulator
C bcf_24165 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C bcf_17855 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
C bcf_26875 sensor histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C bcf_26870 Two-component response regulator K07693 desR; two-component system, NarL family, response regulator DesR
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
C bcf_07280 Sensor histidine kinase LiaS K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C bcf_07285 Response regulator LiaR like protein K11618 liaR; two-component system, NarL family, response regulator LiaR
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
C bcf_05060 Nitrate/nitrite sensor protein K11623 ydfH; two-component system, NarL family, sensor histidine kinase YdfH [EC:2.7.13.3]
C bcf_05065 DNA-binding response regulator K11624 ydfI; two-component system, NarL family, response regulator YdfI
B SalK-SalR
C bcf_15580 SalK-like protein K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK
C bcf_15585 Transcriptional regulator DegU, LuxR family K14989 salR; two-component system, NarL family, secretion system response regulator SalR
B PprA–PprB (biofilm formation)
B Unclassified
C bcf_11350 Nitrate/nitrite sensor protein K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
C bcf_11355 DNA-binding response regulator, LuxR family K02479 K02479; two-component system, NarL family, response regulator
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
C bcf_15275 sporulation kinase K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C bcf_06785 Sporulation kinase B like protein K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C bcf_19920 Sporulation kinase B K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C bcf_06760 sensor histidine kinase KinD K13532 kinD; two-component system, sporulation sensor kinase D [EC:2.7.13.3]
C bcf_26790 Sporulation initiation phosphotransferase (Spo0F) K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F
C bcf_20735 Stage 0 sporulation two-component response regulator (Spo0A) K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
C bcf_04655 Two-component sensor histidine kinase, malate K11637 citS; two-component system, CitB family, sensor histidine kinase CitS [EC:2.7.13.3]
C bcf_04660 response regulator K11638 K11638; two-component system, CitB family, response regulator CitT
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
C bcf_02945 Two-component sensor histidine kinase, malate K11614 yufL; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3]
C bcf_02950 Two-component response regulator, malate K11615 malR; two-component system, CitB family, response regulator MalR
B Unclassified
C bcf_02880 Two-component sensor histidine kinase, malate K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
C bcf_02885 Two-component response regulator, malate K02475 K02475; two-component system, CitB family, response regulator
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ALytTR family
B LysS-LysR
C bcf_27325 Autolysis histidine kinase LytS K07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3]
C bcf_27320 Autolysis response regulator LytR K07705 lytT; two-component system, LytTR family, response regulator LytT
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
C bcf_14680 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
C bcf_14685 Response regulator of the competence regulon ComE K07707 agrA; two-component system, LytTR family, response regulator AgrA
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C bcf_08225 Signal transduction histidine kinase CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C bcf_05015 sensor histidine kinase/response regulator K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C bcf_08220 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C bcf_08355 Chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
C bcf_15370 Two-component sensor histidine kinase, controling glutamine utilization K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C bcf_08845 Two-component sensor histidine kinase, controling glutamine utilization K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C bcf_08850 Two-component response regulator, controling glutamine utilization K07719 glnL; two-component system, response regulator GlnL
C bcf_15365 Two-component response regulator, controling glutamine utilization K07719 glnL; two-component system, response regulator GlnL
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023