+F Repair protein KO
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DNA Repair and Recombination Proteins - Brevibacillus laterosporus
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D BRLA_c007770 methylated-DNA--protein-cysteine methyltransferase, constitutive K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E BRLA_c045170 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E BRLA_c007250 yfhQ; putative A/G-specific adenine glycosylase YfhQ K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E BRLA_c007530 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E BRLA_c037720 rad25; DNA repair helicase Rad25 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D BRLA_c034580 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c036830 mutT; mutator protein MutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c012290 nudE; adenosine nucleotide hydrolase NudE K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c040580 CTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c040720 diadenosine hexaphosphate hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c013130 NADH pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c022170 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c031330 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D BRLA_c032460 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D BRLA_c007770 methylated-DNA--protein-cysteine methyltransferase, constitutive K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D BRLA_c011850 methylphosphotriester-DNA--protein-cysteine S-methyltransferase K13530 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-]
D BRLA_c021920 methylphosphotriester-DNA--protein-cysteine S-methyltransferase K13530 adaA; AraC family transcriptional regulator, regulatory protein of adaptative response / methylphosphotriester-DNA alkyltransferase methyltransferase [EC:2.1.1.-]
D BRLA_c021930 methylated-DNA--protein-cysteine methyltransferase, inducible K13531 adaB; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E BRLA_c045170 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E BRLA_c021910 DNA-3-methyladenine glycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E BRLA_c007250 yfhQ; putative A/G-specific adenine glycosylase YfhQ K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E BRLA_c027760 DNA-3-methyladenine glycosylase 1 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E BRLA_c044920 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E BRLA_c009250 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E BRLA_c007530 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E BRLA_c014990 putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E BRLA_c035360 putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E BRLA_c012900 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E BRLA_c005100 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E BRLA_c009240 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E BRLA_c021970 uvrA_1; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E BRLA_c043380 uvrA_2; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E BRLA_c043390 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E BRLA_c011660 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E BRLA_c037540 yjcD; putative ATP-dependent DNA helicase YjcD K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c029150 superfamily I DNA/RNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c005090 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c027060 helicase IV K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c009240 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E BRLA_c005100 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F BRLA_c001690 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F BRLA_c001700 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F BRLA_c002060 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F BRLA_c044660 DNA-directed RNA polymerase K03048 rpoE; DNA-directed RNA polymerase subunit delta
F BRLA_c034230 DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F BRLA_c000770 transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E BRLA_c031770 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E BRLA_c011130 mutS2; endonuclease MutS2 K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E BRLA_c031760 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E BRLA_c016840 exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E BRLA_c016850 exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E BRLA_c009020 DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E BRLA_c032620 DNA polymerase III PolC-type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E BRLA_c000020 DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E BRLA_c013670 DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E BRLA_c000540 DNA polymerase III subunit tau K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E BRLA_c000410 DNA polymerase III subunit tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E BRLA_c005100 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E BRLA_c037540 yjcD; putative ATP-dependent DNA helicase YjcD K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c029150 superfamily I DNA/RNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c005090 pcrA; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c027060 helicase IV K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E BRLA_c031440 ssb_1; helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
E BRLA_c046430 ssb_2; helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E BRLA_c013040 ATP-dependent RecD-like DNA helicase K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E BRLA_c032150 recA; recombinase A K03553 recA; recombination protein RecA
E BRLA_c012770 ruvA; holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E BRLA_c012780 ruvB; holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E BRLA_c012760 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E BRLA_c034190 priA; replication restart DNA helicase PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E BRLA_c042390 sbcC; nuclease SbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E BRLA_c041080 yhaO; putative metallophosphoesterase YhaO K03547 sbcD; DNA repair protein SbcD/Mre11
E BRLA_c042400 sbcD; nuclease SbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E BRLA_c032150 recA; recombinase A K03553 recA; recombination protein RecA
E BRLA_c001470 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E BRLA_c000040 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E BRLA_c033920 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E BRLA_c033190 divergent AAA domain protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E BRLA_c012900 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E BRLA_c014240 recO; recombination protein O K03584 recO; DNA repair protein RecO (recombination protein O)
E BRLA_c000430 recR; recombination protein RecR K06187 recR; recombination protein RecR
E BRLA_c016920 recN; recombination protein N K03631 recN; DNA repair protein RecN (Recombination protein N)
E BRLA_c012770 ruvA; holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E BRLA_c012780 ruvB; holliday junction ATP-dependent DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E BRLA_c012760 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E BRLA_c042370 ATP-dependent helicase/nuclease subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E BRLA_c042380 ATP-dependent helicase/deoxyribonuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E BRLA_c042390 sbcC; nuclease SbcCD subunit C K03546 sbcC; DNA repair protein SbcC/Rad50
E BRLA_c041080 yhaO; putative metallophosphoesterase YhaO K03547 sbcD; DNA repair protein SbcD/Mre11
E BRLA_c042400 sbcD; nuclease SbcCD subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E BRLA_c033570 ykoV; putative DNA repair protein YkoV K10979 ku; DNA end-binding protein Ku
E BRLA_c033610 putative DNA ligase-like protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E BRLA_c033620 ykoU; putative ATP-dependent DNA ligase YkoU K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F BRLA_c000210 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F BRLA_c000060 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F BRLA_c033140 DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F BRLA_c012040 hup_1; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
F BRLA_c018880 hup_2; bacterial nucleoid DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F BRLA_c012900 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F BRLA_c014240 recO; recombination protein O K03584 recO; DNA repair protein RecO (recombination protein O)
F BRLA_c000430 recR; recombination protein RecR K06187 recR; recombination protein RecR
F BRLA_c005100 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F BRLA_c045510 recQ_2; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F BRLA_c018590 recQ_1; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F BRLA_c021970 uvrA_1; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F BRLA_c043380 uvrA_2; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F BRLA_c043390 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D BRLA_c013480 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D BRLA_c032150 recA; recombinase A K03553 recA; recombination protein RecA
D BRLA_c029420 LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D BRLA_c016920 recN; recombination protein N K03631 recN; DNA repair protein RecN (Recombination protein N)
D BRLA_c031440 ssb_1; helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
D BRLA_c046430 ssb_2; helix-destabilizing protein K03111 ssb; single-strand DNA-binding protein
D BRLA_c032140 recX; regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D BRLA_c019560 hypothetical protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D BRLA_c034580 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c036830 mutT; mutator protein MutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c012290 nudE; adenosine nucleotide hydrolase NudE K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c040580 CTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c040720 diadenosine hexaphosphate hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c013130 NADH pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c022170 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D BRLA_c031330 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D BRLA_c032460 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D BRLA_c016050 nrdZ; ribonucleoside-diphosphate reductase NrdZ K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D BRLA_c024310 ribonucleoside-diphosphate reductase subunit alpha 2 K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D BRLA_c024300 ribonucleoside-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D BRLA_c018100 ribonucleoside-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
D BRLA_c032530 nrnA_1; bifunctional oligoribonuclease and PAP phosphatase NrnA K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024