+F Repair protein KO
#
DNA Repair and Recombination Proteins - Drosophila sechellia
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 6621107 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 6608066 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 6616778 single-strand selective monofunctional uracil-DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 6619844 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 6618223 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 116803620 recombination repair protein 1 isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 6605851 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 6610397 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 6611343 translation initiation factor IF-2 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 6607565 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 6610932 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 6611694 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 6615524 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 6610043 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 6614723 proliferating cell nuclear antigen isoform X1 K04802 PCNA; proliferating cell nuclear antigen
E 6609505 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 6612418 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 116800177 DNA ligase 3-like K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
E 6606675 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 6613211 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 6619074 LOW QUALITY PROTEIN: aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 6606265 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 6617923 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 6620523 poly [ADP-ribose] polymerase isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 6619451 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
F 6607677 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 6610179 RING-box protein 1B K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 6615886 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 6608114 cullin-4A K10609 CUL4; cullin 4
F 6606575 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 6619875 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 6606436 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 6611208 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 6608582 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 6606308 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 6616497 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 6606411 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 6607789 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 6614475 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 6609247 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 6610179 RING-box protein 1B K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 6615886 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 6608114 cullin-4A K10609 CUL4; cullin 4
F 6606575 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 6621163 transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 6605165 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 6615322 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 6609129 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 6616609 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 6617345 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 6605796 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 6613425 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 6612428 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 6616512 cyclin-H K06634 CCNH; cyclin H
E 6608554 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 6607298 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 6618222 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 6619891 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 6612540 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 6609215 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 116802028 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 6611695 DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 6613913 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 6611346 cullin-3-A isoform X1 K03869 CUL3; cullin 3
E 6612648 cullin-5 K10612 CUL5; cullin 5
E 6609945 elongin-C K03872 ELOC; elongin-C
E 6619251 elongin-B K03873 ELOB; elongin-B
E 6607554 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 6608105 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 6611269 DNA mismatch repair protein spellchecker 1 K08735 MSH2; DNA mismatch repair protein MSH2
E 6605754 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 6608136 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 6609277 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 6605851 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 6610397 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 6611343 translation initiation factor IF-2 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 6607298 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 6618222 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 6619891 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 6613882 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 6610721 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 6614787 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 6612128 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 6611995 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 6610043 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 6614723 proliferating cell nuclear antigen isoform X1 K04802 PCNA; proliferating cell nuclear antigen
E 6614573 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 6617923 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 6612143 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 6615528 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 6605091 nibrin K10867 NBN; nibrin
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
E 6618448 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 6612143 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 6615528 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 6605091 nibrin K10867 NBN; nibrin
D BRCA complex
E 6612812 DNA repair protein Rad51 homolog K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 6612812 DNA repair protein Rad51 homolog K04482 RAD51; DNA repair protein RAD51
E 6617148 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 6606405 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 6613185 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 6613023 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 6606778 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116801092 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 6605676 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 6606778 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 6612288 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 6614698 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 6607298 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 6618222 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 6619891 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 6605346 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 6615128 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 6617559 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 6606496 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 6607703 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 6611424 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 6606093 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 6614212 MAGE-like protein 2 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
D Other HR factors
E 6606823 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 6615924 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 6611496 probable 26S proteasome complex subunit sem1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 6619402 uncharacterized protein LOC6619402 K10991 SWI5; DNA repair protein Swi5/Sae3
E 6613849 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 6610861 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 6615609 spatacsin K19026 SPG11; spatacsin
E 6606827 zinc finger FYVE domain-containing protein 26 homolog isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 6606289 nuA4 complex subunit EAF3 homolog K11339 MORF4L1; mortality factor 4-like protein 1
E 6618407 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 6613228 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 6620060 uncharacterized protein LOC6620060 K23112 BRAT1; BRCA1-associated ATM activator 1
E 6610716 RNA polymerase II degradation factor 1 isoform X3 K23456 CFAP410; cilla- and flagella-associated protein
E 6617603 cilia- and flagella-associated protein 410 isoform X2 K23456 CFAP410; cilla- and flagella-associated protein
E 6620972 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 6616038 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 6604767 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 6613768 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 6606831 ATP-dependent DNA helicase 2 subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 6611395 uncharacterized protein LOC6611395 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 6612143 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 6615528 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 6618438 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
D Other NHEJ factors
E 6619074 LOW QUALITY PROTEIN: aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 6606265 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 6607003 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 6614342 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E 6606778 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 6612288 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 6614698 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 6619215 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 6608259 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 6612812 DNA repair protein Rad51 homolog K04482 RAD51; DNA repair protein RAD51
E 6617148 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 6612679 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
C Other DSBR factors
D Protein phosphatase 6
E 6612269 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 6610994 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 6615120 probable E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 6613592 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 6615773 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 6616524 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 6607306 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 6610203 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 6608059 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 6613888 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 6610872 ubiquitin-conjugating enzyme E2 variant 1 isoform X2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 6611285 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 6618481 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 6610043 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 6614723 proliferating cell nuclear antigen isoform X1 K04802 PCNA; proliferating cell nuclear antigen
D 116802306 LOW QUALITY PROTEIN: sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 6620489 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 6616035 uncharacterized protein LOC6616035 isoform X2 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 6618355 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 6613870 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 6613115 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 6606367 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 6610721 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 6614787 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 6612128 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 6611995 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 6613115 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 6606569 protein timeless homolog isoform X2 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 6614575 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 6610768 claspin K25773 CLSPN; claspin
C Triple T complex
D 6607049 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 6616655 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 6613822 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 6617933 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 6606302 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 6614402 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 6614767 ovarian-specific serine/threonine-protein kinase Lok isoform X2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 6612683 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 6608463 14-3-3 protein zeta isoform X3 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 6616635 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 6614747 protein sickie isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 6611460 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 6616175 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 6618074 plastin-1 isoform X1 K17336 PLS3; plastin-3
D 116801796 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 6609231 KN motif and ankyrin repeat domain-containing protein 1 isoform X2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 6614802 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 6619983 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 6607670 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 6606617 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
C Nucleases
D 6613180 uncharacterized protein LOC6613180 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 116801012 uncharacterized protein LOC116801012 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 6604823 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 6609799 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 6610180 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 6621514 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
C Modulation of nucleotide pools
D 6606814 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 6612103 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 6611964 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 6608739 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 6608066 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 6616778 single-strand selective monofunctional uracil-DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 6618223 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 6616922 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 6616922 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 6612103 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024