+D Messenger RNA Biogenesis
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Prokaryotic Defense System
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ACRISPR-Cas system
B Universal Cas proteins
C K15342 cas1; CRISP-associated protein Cas1
C K09951 cas2; CRISPR-associated protein Cas2
B Type I CRISPR-Cas system
C Type I signiture cas proteins
D K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
D K07475 cas3; CRISPR-associated endonuclease Cas3-HD [EC:3.1.-.-]
C Subtype I-A factors
D K19085 csa1; CRISPR-associated protein Csa1
D K19074 csa2; CRISPR-associated protein Csa2
D K07725 csa3; CRISPR-associated protein Csa3
D K19086 csa4, cas8a2; CRISPR-associated protein Csa4
D K19087 csa5; CRISPR-associated protein Csa5
D K19088 cst1, cas8a; CRISPR-associated protein Cst1
D K19075 cst2, cas7; CRISPR-associated protein Cst2
D K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D K19089 cas5a_b_c; CRISPR-associated protein Cas5a/b/c
D K19090 cas5t; CRISPR-associated protein Cas5t
D K19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]
C Subtype I-B factors
D K19114 csh1; CRISPR-associated protein Csh1
D K19115 csh2; CRISPR-associated protein Csh2
D K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D K19116 cas5h; CRISPR-associated protein Cas5h
C Subtype I-C factors
D K19117 csd1, cas8c; CRISPR-associated protein Csd1
D K19118 csd2, cas7; CRISPR-associated protein Csd2
D K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D K19119 cas5d; CRISPR-associated protein Cas5d
C Subtype I-D factors
D K19120 csc1; CRISPR-associated protein Csc1
D K19121 csc2; CRISPR-associated protein Csc2
D K19122 csc3; CRISPR-associated protein Csc3
D K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D K19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]
C Subtype I-E factors
D K19123 casA, cse1; CRISPR system Cascade subunit CasA
D K19046 casB, cse2; CRISPR system Cascade subunit CasB
D K19124 casC, cse4; CRISPR system Cascade subunit CasC
D K19125 casD, cse5; CRISPR system Cascade subunit CasD
D K19126 casE, cse3; CRISPR system Cascade subunit CasE
C Subtype I-F factors
D K19127 csy1; CRISPR-associated protein Csy1
D K19128 csy2; CRISPR-associated protein Csy2
D K19129 csy3; CRISPR-associated protein Csy3
D K19130 csy4, cas6f; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-]
C Subtype I-U factors
D K19131 csb1; CRISPR-associated protein Csb1
D K19132 csb2; CRISPR-associated protein Csb2
D K19133 csb3; CRISPR-associated protein Csb3
D K19134 csx10; CRISPR-associated protein Csx10
D K19135 csx14; CRISPR-associated protein Csx14
D K19136 csx17; CRISPR-associated protein Csx17
B Type II CRISPR-Cas system
C Type II signiture cas proteins
D K09952 csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]
C Subtype II-A factors
D K19137 csn2; CRISPR-associated protein Csn2
C Subtype II-B factors
D K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
B Type III CRISPR-Cas system
C Type III signiture cas proteins
D K07016 csm1, cas10; CRISPR-associated protein Csm1
C Subtype III-A factors
D K19138 csm2; CRISPR-associated protein Csm2
D K09002 csm3; CRISPR-associated protein Csm3
D K19139 csm4; CRISPR-associated protein Csm4
D K19140 csm5; CRISPR-associated protein Csm5
C Subtype III-B factors
D K07061 cmr1; CRISPR-associated protein Cmr1
D K19076 cmr2, cas10; CRISPR-associated protein Cmr2
D K09127 cmr3; CRISPR-associated protein Cmr3
D K09000 cmr4; CRISPR-associated protein Cmr4
D K19141 cmr5; CRISPR-associated protein Cmr5
D K19142 cmr6; CRISPR-associated protein Cmr6
C Subtype III-U factors
D K19143 csx1; CRISPR-associated protein Csx1
D K19144 csx3; CRISPR-associated protein Csx3
D K19145 csx16; CRISPR-associated protein Csx16
D K19146 csaX; CRISPR-associated protein CsaX
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ARestriction and modification system (R-M system)
B Type I R-M system
C K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
C K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
C K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
B Type II R-M system
C Restriction endonucleases
D K01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]
C DNA methyltransferases
D K06223 dam; DNA adenine methylase [EC:2.1.1.72]
D K13581 ccrM; modification methylase [EC:2.1.1.72]
D K07317 K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D K07318 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D K07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]
D K00558 DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D K00590 E2.1.1.113; site-specific DNA-methyltransferase (cytosine-N4-specific) [EC:2.1.1.113]
D K24451 zim; modification methylase
B Type III R-M system
C K01156 res; type III restriction enzyme [EC:3.1.21.5]
C K07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
B Type IV R-M system
C K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
C K07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]
C K19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC
C K07448 mrr; restriction system protein
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AToxin-antitoxin system (TA system)
B Type I TA system
C Hok-Sok
D K18920 hokA; protein HokA
D K18921 hokB; protein HokB
D K18919 hokC_D; protein HokC/D
D K18922 hokE; protein HokE
D K18870 sokB; sRNA antisense regulator of MokB and HokB protein
D K18871 sokC; sRNA antisense regulator of MokC and HokC protein
C SymE-SymR
D K19048 symE; toxic protein SymE
D K18524 symR; sRNA antisense regulator of SymE protein
C Ldr-Rdl
D K18862 ldrA_B_C_D; small toxic polypeptide LdrA/B/C/D
D K18863 rdlA_B_C_D; sRNA antisense regulator of LdrA/B/C/D protein
C TisB-IstR
D K19148 tisB; small toxic protein TisB
D K18526 istR; sRNA antisense regulator of TisB protein
C Ibs-Sib
D K19149 ibsA; small toxic protein IbsA
D K19150 ibsB; small toxic protein IbsB
D K19151 ibsC; small toxic protein IbsC
D K19152 ibsD; small toxic protein IbsD
D K19153 ibsE; small toxic protein IbsE
D K18864 sibA; sRNA antisense regulator of IbsA protein
D K18865 sibB; sRNA antisense regulator of IbsB protein
D K18867 sibC; sRNA antisense regulator of IbsC protein
D K18868 sibD; sRNA antisense regulator of IbsD protein
D K18869 sibE; sRNA antisense regulator of IbsE protein
C ShoB-OhsC
D K19154 shoB; small toxic protein ShoB
D K18872 ohsC; sRNA antisense regulator of ShoB protein
C RalR-RalA
D K19779 ralR; endodeoxyribonuclease RalR [EC:3.1.-.-]
D K19780 ralA, rcbA; antisense regulator of RalR protein
B Type II TA system
C MazF-MazE
D K07171 mazF, ndoA, chpA; mRNA interferase MazF [EC:3.1.-.-]
D K07172 mazE, chpAI; antitoxin MazE
D K26981 mazE1; antitoxin MazE1
D K26982 mazE2; antitoxin MazE2
D K26983 mazE3; antitoxin MazE3
D K26984 mazE4; antitoxin MazE4
D K26985 mazE5; antitoxin MazE5
D K26986 mazE6; antitoxin MazE6
D K26987 mazE7; antitoxin MazE7
D K26988 mazE8; antitoxin MazE8
D K26989 mazE9; antitoxin MazE9
D K07723 ndoAI; CopG family transcriptional regulator / antitoxin EndoAI
C ChpB-ChpS
D K18841 chpB, chpBK; mRNA interferase ChpB [EC:3.1.-.-]
D K18842 chpS, chpBI; antitoxin ChpS
C YhaV-PrlF
D K19155 yhaV; toxin YhaV [EC:3.1.-.-]
D K19156 prlF, sohA; antitoxin PrlF
C RelE/StbE-RelB/StbD
D K06218 relE, stbE; mRNA interferase RelE/StbE
D K18918 relB; RHH-type transcriptional regulator, rel operon repressor / antitoxin RelB
D K18923 stbD; antitoxin StbD
C YafQ-dinJ
D K19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]
D K07473 dinJ; DNA-damage-inducible protein J
C YoeB-YefM
D K19158 yoeB; toxin YoeB [EC:3.1.-.-]
D K19159 yefM; antitoxin YefM
C HipA-HipB
D K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]
D K15773 hipB; HTH-type transcriptional regulator / antitoxin HipB
C HicA-HicB
D K07339 hicA; mRNA interferase HicA [EC:3.1.-.-]
D K18843 hicB; antitoxin HicB
C YafO-YafN
D K19160 yafO; mRNA interferase YafO [EC:3.1.-.-]
D K19161 yafN; antitoxin YafN
C Hha-TomB
D K05839 hha; haemolysin expression modulating protein
D K19162 tomB; hha toxicity modulator TomB
C PspC-PspB
D K03973 pspC; phage shock protein C
D K03970 pspB; phage shock protein B
C CcdB-CcdA
D K19163 ccdB; toxin CcdB
D K19164 ccdA; antitoxin CcdA
C ParE-ParD
D K19092 parE1_3_4; toxin ParE1/3/4
D K19093 parE2; toxin ParE2
D K07746 parD1_3_4; antitoxin ParD1/3/4
D K19094 parD2; antitoxin ParD2
C Doc-Phd
D K07341 doc; death on curing protein
D K19165 phd; antitoxin Phd
C HigB-HigA
D K19166 higB; mRNA interferase HigB [EC:3.1.-.-]
D K07334 higB-1; toxin HigB-1
D K18831 higA; HTH-type transcriptional regulator / antitoxin HigA
D K21498 higA-1; antitoxin HigA-1
C MqsR-MqsA
D K13651 mqsR; motility quorum-sensing regulator / GCU-specific mRNA interferase toxin
D K13655 mqsA; HTH-type transcriptional regulator / antitoxin MqsA
C VapC-VapB
D K18828 mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]
D K18829 mvpT, vapB; antitoxin VapB
D K19686 vapC; ribonuclease VapC [EC:3.1.-.-]
D K19687 vapB; antitoxin VapB
C PezT-PezA
D K16214 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]
D K18830 pezA; HTH-type transcriptional regulator / antitoxin PezA
C YobL-YobK
D K21487 yobL; toxin YobL [EC:3.1.-.-]
D K21488 yobK; antitoxin YobK
C YokI-YokJ
D K21489 yokI; toxin YokI [EC:3.1.-.-]
D K21490 yokJ; antitoxin YokJ
C YqcG-YqcF
D K21491 yqcG; toxin YqcG [EC:3.1.-.-]
D K21492 yqcF; antitoxin YqcF
C YxiD-YxxD
D K21493 yxiD; toxin YxiD [EC:3.1.-.-]
D K21494 yxxD; antitoxin YxxD
C FitB-FitA
D K07062 fitB; toxin FitB [EC:3.1.-.-]
D K21495 fitA; antitoxin FitA
C BC_0920-BC_0921
D K21496 BC_0920; toxin [EC:3.1.-.-]
D K21497 BC_0921; antitoxin
C Type II TA system related factors
D K19334 tabA; biofilm protein TabA
D K13650 mcbA; MqsR-controlled colanic acid and biofilm protein A
D K12148 bssS; biofilm regulator BssS
D K19688 bssR; biofilm regulator BssR
D K12151 bhsA; multiple stress resistance protein BhsA
D K03531 ftsZ; cell division protein FtsZ
D K03569 mreB; rod shape-determining protein MreB and related proteins
D K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D K01885 EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]
D K07060 nob1; endoribonuclease Nob1 [EC:3.1.-.-]
B Type III TA system
C AbiQ system
D K19167 abiQ; protein AbiQ
B Type IV TA system
C YeeV-YeeU
D K18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins
D K18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins
C CptA-CptB
D K19168 cptA; toxin CptA
D K09159 cptB; antitoxin CptB
B Type V TA system
C GhoT-GhoS
D K18839 ghoT; toxin GhoT
D K18840 ghoS; antitoxin GhoS
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ADNA phosphothiolation system
B Sulfur modification proteins
C K04487 iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]
C K19169 dndB; DNA sulfur modification protein DndB
C K19170 dndC; DNA sulfur modification protein DndC
C K19171 dndD; DNA sulfur modification protein DndD
C K19172 dndE; DNA sulfur modification protein DndE
B DNA phosphorothioation-dependent restriction proteins
C K19173 dptF; DNA phosphorothioation-dependent restriction protein DptF
C K19174 dptG; DNA phosphorothioation-dependent restriction protein DptG
C K19175 dptH; DNA phosphorothioation-dependent restriction protein DptH
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 7, 2023