+F Repair protein KO
#
DNA Repair and Recombination Proteins - Mesotoga infera
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MESINF_2132 phr; Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MESINF_2112 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E MESINF_2423 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D MESINF_0460 Hydrolase, NUDIX family (modular protein) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MESINF_2585 NUDIX domain protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MESINF_1345 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MESINF_2132 phr; Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MESINF_2609 Phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MESINF_1426 tag; 3-methyl-adenine DNA glycosylase I, constitutive K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E MESINF_2423 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E MESINF_2313 nfo; putative endonuclease 4 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E MESINF_0319 nfi; Endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E MESINF_1799 Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E MESINF_0304 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E MESINF_2255 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E MESINF_2567 uvrA; ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC K03701 uvrA; excinuclease ABC subunit A
E MESINF_0149 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
E MESINF_2679 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E MESINF_0082 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MESINF_2255 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E MESINF_0304 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F MESINF_0291 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F MESINF_0515 DNA-directed RNA polymerase, beta subunit/140 kD subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F MESINF_0290 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F MESINF_0324 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F MESINF_0299 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F MESINF_2418 mfd; Transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E MESINF_0170 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E MESINF_1639 DNA mismatch repair protein MutS domain protein K07456 mutS2; DNA mismatch repair protein MutS2
E MESINF_0306 mutS; Endonuclease MutS2 K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E MESINF_2015 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E MESINF_0055 Exonuclease VII, large subunit-like protein K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E MESINF_0381 DNA-directed DNA polymerase K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E MESINF_1027 polC; DNA polymerase III PolC-type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E MESINF_0318 DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E MESINF_0254 Exonuclease, DNA polymerase III, epsilon subunit family K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MESINF_0272 Exonuclease, DNA polymerase III, epsilon subunit family K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MESINF_2552 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E MESINF_0304 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E MESINF_0082 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MESINF_2789 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E MESINF_1732 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
E MESINF_2413 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E MESINF_2613 ruvB; ATP-dependent DNA helicase, component of RuvABC resolvasome K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MESINF_1028 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E MESINF_1887 Replication restart DNA helicase PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E MESINF_2749 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E MESINF_2750 Metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E MESINF_1732 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
E MESINF_2531 radA; DNA repair protein RadA homolog K04485 radA; DNA repair protein RadA/Sms
E MESINF_2087 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E MESINF_1799 Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E MESINF_0228 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E MESINF_2413 ruvA; Holliday junction ATP-dependent DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E MESINF_2613 ruvB; ATP-dependent DNA helicase, component of RuvABC resolvasome K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MESINF_1028 ruvC; Crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E MESINF_1081 UvrD/REP helicase K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
D Other HR factor
E MESINF_1272 cas1; CRISPR-associated endonuclease Cas1 2 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E MESINF_2749 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E MESINF_2750 Metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F MESINF_2098 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F MESINF_2289 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F MESINF_2212 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F MESINF_2678 hup; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
F MESINF_1858 hup; DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F MESINF_1799 Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F MESINF_0304 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F MESINF_2567 uvrA; ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC K03701 uvrA; excinuclease ABC subunit A
F MESINF_0149 uvrB; excinulease of nucleotide excision repair, DNA damage recognition component K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D MESINF_1977 Nucleotidyltransferase/DNA polymerase involved in DNA repair K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D MESINF_1732 recA; DNA strand exchange and recombination protein with protease and nuclease activity K03553 recA; recombination protein RecA
D MESINF_2099 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D MESINF_0228 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D MESINF_2789 ssb; Single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D MESINF_1731 recX; Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D MESINF_0285 DNA polymerase IV (Family X)-like protein K02347 polX; DNA polymerase (family X)
C DNA helicases
D MESINF_1036 DinG; ATP-dependent helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D MESINF_2141 DEAD/DEAH box helicase domain protein (fragment) K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D MESINF_0460 Hydrolase, NUDIX family (modular protein) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MESINF_2585 NUDIX domain protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MESINF_1345 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
C Others
D MESINF_1807 Phosphoesterase RecJ domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024