+F Repair protein KO
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DNA Repair and Recombination Proteins - Pelagibacterium halotolerans
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D KKY_1293 deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E KKY_1628 DNA-3-methyladenine glycosylase II K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E KKY_525 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E KKY_3355 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D KKY_2913 5-methyl-dCTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D KKY_576 MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D KKY_2976 mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) / thiamin-phosphate pyrophosphorylase-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D KKY_3427 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D KKY_3109 ADA regulatory protein / methylated-DNA--protein-cysteine methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D KKY_3357 ADA regulatory protein / methylated-DNA--protein-cysteine methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D KKY_1293 deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E KKY_2392 uracil-DNA glycosylase-associated domain / uracil-DNA glycosylase, putative family 6 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E KKY_1098 uracil-DNA glycosylase, family 5 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E KKY_537 uracil-DNA glycosylase, family 4 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E KKY_2994 HhH-GPD base excision DNA repair family protein, probable 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E KKY_1628 DNA-3-methyladenine glycosylase II K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E KKY_525 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E KKY_449 DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E KKY_3422 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E KKY_3355 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E KKY_1484 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E KKY_3317 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E KKY_1164 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E KKY_1985 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E KKY_3719 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E KKY_1459 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E KKY_3846 excinuclease ABC subunit A paralog of unknown function K03701 uvrA; excinuclease ABC subunit A
E KKY_2150 excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E KKY_2161 excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E KKY_1970 ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E KKY_3629 Superfamily I DNA and RNA helicases-like protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E KKY_3719 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E KKY_1985 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F KKY_1680 DNA-directed RNA polymerase beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F KKY_1679 DNA-directed RNA polymerase beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F KKY_1647 DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F KKY_1100 DNA-directed RNA polymerase omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F KKY_1405 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E KKY_3392 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E KKY_476 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E KKY_480 exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E KKY_592 exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E KKY_1335 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E KKY_3419 DNA polymerase III beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E KKY_1032 DNA polymerase III chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E KKY_3323 DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E KKY_1424 DNA polymerase III delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E KKY_3335 DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E KKY_49 DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E KKY_1985 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E KKY_1970 ATP-dependent DNA helicase UvrD/PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E KKY_3629 Superfamily I DNA and RNA helicases-like protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E KKY_1458 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E KKY_2838 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E KKY_1845 RecA protein K03553 recA; recombination protein RecA
E KKY_2458 holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E KKY_2456 holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E KKY_2459 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E KKY_3182 helicase PriA essential for oriC/DnaA-independent DNA replication K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E KKY_1845 RecA protein K03553 recA; recombination protein RecA
E KKY_1004 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E KKY_3417 DNA recombination and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E KKY_1403 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E KKY_1164 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E KKY_1107 DNA recombination and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E KKY_51 recombination protein RecR K06187 recR; recombination protein RecR
E KKY_1986 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E KKY_2458 holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E KKY_2456 holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E KKY_2459 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E KKY_3501 ATP-dependent nuclease subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E KKY_613 ATPase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E KKY_1734 hypothetical protein K10979 ku; DNA end-binding protein Ku
E KKY_1733 ATP-dependent DNA ligase clustered with Ku protein, LigD K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F KKY_1449 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F KKY_3416 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F KKY_1736 DNA topoisomerase IB (poxvirus type) K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F KKY_1606 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F KKY_1503 DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F KKY_1164 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F KKY_1107 DNA recombination and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F KKY_51 recombination protein RecR K06187 recR; recombination protein RecR
F KKY_1985 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F KKY_447 transcriptional regulatory protein flbD K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F KKY_1135 integration host factor alpha subunit K04764 ihfA; integration host factor subunit alpha
F KKY_3485 Integration host factor beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F KKY_205 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F KKY_1459 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F KKY_3846 excinuclease ABC subunit A paralog of unknown function K03701 uvrA; excinuclease ABC subunit A
F KKY_2150 excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D KKY_1613 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D KKY_1845 RecA protein K03553 recA; recombination protein RecA
D KKY_1352 SOS-response repressor and protease LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D KKY_1986 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D KKY_3145 hypothetical protein related to DNA replication/repair K14160 imuA; protein ImuA
D KKY_3144 DNA polymerase-like protein K14161 imuB; protein ImuB
D KKY_3143 DNA polymerase III alpha subunit K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D KKY_1458 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D KKY_2838 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D KKY_375 helicase domain protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D KKY_2913 5-methyl-dCTP pyrophosphohydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D KKY_576 MutT/nudix family protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D KKY_2976 mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) / thiamin-phosphate pyrophosphorylase-like protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D KKY_3427 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D KKY_1558 ribonucleotide reductase of class II (coenzyme B12-dependent) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024