+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Streptomyces aquilus

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2] C Bacterial type B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E EJC51_03330 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K14667 whiEIII; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] E EJC51_03325 ketosynthase chain-length factor K14668 whiEIV; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] E EJC51_03320 acyl carrier protein K14669 whiEV; minimal PKS acyl carrier protein E EJC51_03315 polyketide cyclase K14670 whiEVI; aromatase E EJC51_03310 TcmI family type II polyketide cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E EJC51_31355 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E EJC51_31360 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E EJC51_31365 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E EJC51_31370 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] E EJC51_31375 cyclase K05554 actVII; aromatase [EC:4.2.1.-] D Nonaketide PKS E EJC51_31355 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E EJC51_31360 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E EJC51_31365 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E EJC51_31370 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] E EJC51_31350 TcmI family type II polyketide cyclase K15926 jadI; cyclase D Decaketide PKS E EJC51_31355 beta-ketoacyl-[acyl-carrier-protein] synthase family protein K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E EJC51_31360 ketosynthase chain-length factor K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E EJC51_31365 acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein E EJC51_31370 SDR family NAD(P)-dependent oxidoreductase K12420 actIII; ketoreductase [EC:1.1.1.-] B Type III PKS C Plant type C Fungal type C Bacterial type D EJC51_23015 type III polyketide synthase K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246] D EJC51_08470 type III polyketide synthase K19580 rppA; 1,3,6,8-tetrahydroxynaphthalene synthase [EC:2.3.1.233] D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D EJC51_23040 MbtH family protein K05375 mbtH; MbtH protein D EJC51_45205 MbtH family protein K05375 mbtH; MbtH protein D EJC51_07350 MbtH family protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase D EJC51_04130 2 K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Bacillibactin synthetase D EJC51_04130 2 K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase D EJC51_04130 2 K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Myxochelin synthetase D EJC51_04130 2 K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase D EJC51_04130 2 K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71] # APolyketide tailoring proteins B Hydrolase B Ketoreductase B Oxygenase C EJC51_22545 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C EJC51_36380 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C EJC51_05885 epoxide hydrolase K21159 sgcF; epoxide hydrolase C EJC51_02625 epoxide hydrolase K21159 sgcF; epoxide hydrolase C EJC51_23005 enoyl-CoA hydratase/isomerase family protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C EJC51_03335 cupin domain-containing protein K14673 whiEII; putative monooxygenase C EJC51_03355 monooxygenase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C EJC51_03305 methyltransferase K14251 oxyF; C-methyltransferase [EC:2.1.1.-] B Glycosyltransferase B Halogenase C EJC51_07485 FAD-dependent oxidoreductase K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-] B beta-Branched incorporating proteins B Others C EJC51_31075 hypothetical protein K14628 actVI2; enoyl reductase C EJC51_15160 flavin reductase K21185 sgcE6; flavin reductase # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase C EJC51_30950 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] C EJC51_40985 glycosyltransferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase C EJC51_23020 PLP-dependent aminotransferase family protein K16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103] B Others C EJC51_23010 enoyl-CoA hydratase/isomerase family protein K16425 dpgB; isomerase DpgB C EJC51_23005 enoyl-CoA hydratase/isomerase family protein K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80] C EJC51_23000 enoyl-CoA hydratase K16426 dpgD; dehydration protein DpgD ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: July 4, 2022