+F Repair protein KO
#
DNA Repair and Recombination Proteins - Strongylocentrotus purpuratus (purple sea urchin)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100889029 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 593121 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 592282 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 100888531 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 590527 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 754042 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 593941 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 586702 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 586471 integrator complex subunit 3 homolog isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 581391 uncharacterized protein LOC581391 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 764571 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 577235 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 586497 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 115928716 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 578658 methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 765066 methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 586897 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 105438678 N-glycosylase/DNA lyase-like K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 115920599 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 105441357 endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 105436686 endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 105446776 endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 588914 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 584564 DNA-(apurinic or apyrimidinic site) lyase isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 592745 DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 587280 DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 579199 DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100893055 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 577017 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 586784 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 100889220 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
F 115926799 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 589064 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 115921308 LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 592195 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 580013 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 763808 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 765052 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 115918456 LOW QUALITY PROTEIN: proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 757166 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 752989 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 582628 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 580530 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 581252 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 583910 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 592796 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 583036 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 580136 bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 586494 bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 373332 HMG1; high mobility group protein 1 homolog K10802 HMGB1; high mobility group protein B1
E 580054 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 752216 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 575677 formin-like protein 20 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 579954 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 763210 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 105437220 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 590750 protein mono-ADP-ribosyltransferase PARP4-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 577455 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 579780 uncharacterized protein LOC579780 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 581218 DNA repair protein complementing XP-C cells homolog isoform X2 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 578143 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
F 115918080 UV excision repair protein RAD23 homolog A-like K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 591601 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 115918507 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 592454 cullin-4A K10609 CUL4; cullin 4
F 588842 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100892716 DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
F 115924834 DNA damage-binding protein 2-like K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 583794 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 105446803 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 584422 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 575987 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 591189 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 578317 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 582938 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 752151 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 591688 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 583058 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 581204 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 591601 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 115918507 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 592454 cullin-4A K10609 CUL4; cullin 4
F 588842 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 577431 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 576112 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 582379 UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 115918980 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 584640 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 589434 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 105444553 general transcription and DNA repair factor IIH helicase subunit XPB-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 575323 LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 594243 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 589616 general transcription factor IIH subunit 2-like isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 586455 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 115926597 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 591457 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 577839 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 100894147 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 582289 cyclin-H K06634 CCNH; cyclin H
E 578782 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 757112 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 580037 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 752535 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
E 105446431 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
E 576263 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 105437552 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 586875 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 588601 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 587097 DNA repair protein complementing XP-G cells homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 585414 DNA repair protein complementing XP-G cells isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 752989 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 586369 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 590355 cullin-3-B K03869 CUL3; cullin 3
E 582593 cullin-5 K10612 CUL5; cullin 5
E 115918941 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 583564 elongin-C K03872 ELOC; elongin-C
E 115923029 elongin-C K03872 ELOC; elongin-C
E 753537 elongin-B K03873 ELOB; elongin-B
E 593051 transcription elongation factor B polypeptide 3 isoform X2 K15076 ELOA; elongin-A
E 580949 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 589363 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 756012 DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 593059 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 592483 PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 588545 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 581506 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 575007 DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
E 115929660 DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 100893055 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 577017 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 586784 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 100889220 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E 115926799 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 757112 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 580037 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 752535 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
E 105446431 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
E 576263 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 593379 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 582287 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 585743 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 115918535 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 576419 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 590824 LOW QUALITY PROTEIN: replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 764228 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 765052 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 115918456 LOW QUALITY PROTEIN: proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 762697 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 373332 HMG1; high mobility group protein 1 homolog K10802 HMGB1; high mobility group protein B1
E 752989 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 593392 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 583059 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 593604 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115921269 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 581691 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 578057 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 755086 LOW QUALITY PROTEIN: uncharacterized protein LOC755086 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105438132 uncharacterized protein LOC105438132 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 588646 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
E 115923889 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 755086 LOW QUALITY PROTEIN: uncharacterized protein LOC755086 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105438132 uncharacterized protein LOC105438132 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 588499 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 115918984 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 591774 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 574779 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 755086 LOW QUALITY PROTEIN: uncharacterized protein LOC755086 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105438132 uncharacterized protein LOC105438132 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 576476 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D BRCA1-C complex
E 755086 LOW QUALITY PROTEIN: uncharacterized protein LOC755086 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105438132 uncharacterized protein LOC105438132 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100893167 uncharacterized protein LOC100893167 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 583059 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 593604 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115921269 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 581691 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 578057 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 755086 LOW QUALITY PROTEIN: uncharacterized protein LOC755086 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105438132 uncharacterized protein LOC105438132 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 584780 uncharacterized protein LOC584780 K08775 BRCA2; breast cancer 2 susceptibility protein
E 583691 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 583691 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 593295 DNA repair protein RAD51 homolog 2 isoform X2 K10869 RAD51L1; RAD51-like protein 1
E 583093 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 582559 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 586282 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 583075 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 763443 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 579051 DNA repair and recombination protein rhm52 isoform X2 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 578476 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 585124 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 578074 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 115919144 helicase ARIP4-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 580512 DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 581689 ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 754123 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 575579 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 574701 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 590609 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 575579 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 591288 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 576753 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100893489 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 105443824 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 115928644 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
E 115928736 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 757112 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 580037 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 752535 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
E 105446431 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
E 576263 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 594644 serine/threonine-protein phosphatase 4 catalytic subunit isoform X2 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 576704 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 578003 serine/threonine-protein phosphatase 4 regulatory subunit 2-B K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 577660 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 576590 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 586201 AP-5 complex subunit beta-1 isoform X1 K19022 AP5B1; AP-5 complex subunit beta-1
E 577201 AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 752258 AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 592051 AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 581507 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100893240 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 584232 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 105443015 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 105443782 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100892588 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 100890292 EP300-interacting inhibitor of differentiation 3 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 100890260 uncharacterized protein LOC100890260 isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 100887999 uncharacterized protein LOC100887999 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
E 100893416 filaggrin K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 100889179 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 593371 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 575020 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 575952 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 100892049 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 581392 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 578194 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 100888713 structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 105437990 uncharacterized protein LOC105437990 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 589174 uncharacterized protein LOC589174 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 100891069 spatacsin isoform X1 K19026 SPG11; spatacsin
E 100893581 spatacsin K19026 SPG11; spatacsin
E 576553 zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 115919083 zinc finger FYVE domain-containing protein 26-like K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100892851 neurofilament medium polypeptide isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 585759 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 594252 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 575844 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 578665 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 592977 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 583384 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 585068 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 115920495 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100888301 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100889102 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 578480 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100892048 DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 100893417 uncharacterized protein LOC100893417 K23112 BRAT1; BRCA1-associated ATM activator 1
E 105446031 uncharacterized protein LOC105446031 K23112 BRAT1; BRCA1-associated ATM activator 1
E 576797 cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 763089 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 105439803 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 580415 uncharacterized protein LOC580415 K25771 SWSAP1; ATPase SWSAP1
E 115922506 BRCA2-interacting transcriptional repressor EMSY-like K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 594799 protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 591115 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 752321 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 752879 X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 764905 X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 583472 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 593186 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 576405 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
E 586799 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 583059 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 593604 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115921269 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 581691 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 582203 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 763163 DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 754820 non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 580054 DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 115923979 DNA nucleotidylexotransferase-like K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 591373 DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 582628 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 592796 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 583036 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 576456 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 764829 tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 100890804 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 583320 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 105447417 structural maintenance of chromosomes flexible hinge domain-containing protein 1-like K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 100891020 structural maintenance of chromosomes flexible hinge domain-containing protein 1-like K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 590026 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 105444851 structural maintenance of chromosomes flexible hinge domain-containing protein 1-like K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 105439373 structural maintenance of chromosomes flexible hinge domain-containing protein 1-like K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 115924981 structural maintenance of chromosomes flexible hinge domain-containing protein 1-like K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 115918961 protein PAXX-like K25772 PAXX; protein PAXX
E 578349 protein PAXX K25772 PAXX; protein PAXX
C FA (Fanconi anemia) pathway
D FA core complex
E 105439161 Fanconi anemia group A protein homolog K10888 FANCA; fanconi anemia group A protein
E 100893136 uncharacterized protein LOC100893136 K10889 FANCB; fanconi anemia group B protein
E 105441142 Fanconi anemia group C protein-like K10890 FANCC; fanconi anemia group C protein
E 105445051 uncharacterized protein LOC105445051 K10892 FANCE; fanconi anemia group E protein
E 105442300 uncharacterized protein LOC105442300 K10893 FANCF; fanconi anemia group F protein
E 105442869 uncharacterized protein LOC105442869 K10893 FANCF; fanconi anemia group F protein
E 581604 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 754616 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100890436 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 100889137 Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 115924682 transcription factor HES-4-like K06054 HES1; hairy and enhancer of split 1
E 752043 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 592057 transcription factor HES-4 K06054 HES1; hairy and enhancer of split 1
E 115926662 centromere protein S-like isoform X1 K11511 APITD1; centromere protein S
E 100893386 centromere protein X K15360 STRA13; centromere protein X
E 586901 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 575579 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 591288 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 576753 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100893489 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 105443824 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 115928644 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
E 115928736 recQ-mediated genome instability protein 2-like K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 755314 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 752867 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 755086 LOW QUALITY PROTEIN: uncharacterized protein LOC755086 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 105438132 uncharacterized protein LOC105438132 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 584780 uncharacterized protein LOC584780 K08775 BRCA2; breast cancer 2 susceptibility protein
E 576476 Fanconi anemia group J protein homolog K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 578527 fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 583691 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 583093 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 588739 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 576951 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 583324 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 586442 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 763822 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 575241 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 577202 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X2 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 583203 E3 ubiquitin-protein ligase RNF8 isoform X2 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100890567 uncharacterized protein LOC100890567 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 588717 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 594691 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 105437307 myb-like protein X K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 100894080 myb-like protein X K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 115917971 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
E 583554 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 593392 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 753975 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 580288 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 754579 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 592062 DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 580974 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 115919278 DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 105447382 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 105447057 DNA polymerase nu-like K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
D 115926866 DNA polymerase nu-like K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 762707 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 579478 E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 581625 helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 592030 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 753205 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 590968 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 765052 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 115918456 LOW QUALITY PROTEIN: proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 752321 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 762995 LOW QUALITY PROTEIN: sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 588195 acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
D 115922294 acidic repeat-containing protein-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100891745 cell cycle checkpoint control protein RAD9A K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 581750 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 589646 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 582037 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 582287 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 585743 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 115918535 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 576419 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 590824 LOW QUALITY PROTEIN: replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 764228 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 589646 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 579123 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 100890739 otolith matrix protein OMM-64 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 591154 claspin K25773 CLSPN; claspin
C Triple T complex
D 588739 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 100892948 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 763566 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 591081 TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 754825 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 586966 ubiquitin-like protein 4A-A K23388 UBL4; ubiquitin-like protein 4
D 581255 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 580976 serine/threonine-protein kinase atr K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 763088 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 762700 ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 105440179 serine-protein kinase ATM-like K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100889659 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 592974 Chk1; checkpoint kinase 1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 115921093 serine/threonine-protein kinase Chk1-like K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 589861 serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 115917991 serine/threonine-protein kinase Chk2-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 576121 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 575018 14-3-3-like protein 2 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 583263 14-3-3-like protein K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 581376 14-3-3 family protein artA isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 587482 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 373495 WEE1-like CDK tyrosine kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 755547 LOW QUALITY PROTEIN: wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 582503 mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 586505 plastin-3 K17336 PLS3; plastin-3
D 105445738 plastin-3 K17336 PLS3; plastin-3
D 580696 apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 577477 serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 583872 serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 593493 serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 591247 serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 588047 serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 592697 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 115918942 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 575146 KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 579676 suppressor protein of bem1/bed5 double mutants K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 579763 vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 115920163 vacuolar protein sorting-associated protein 4B-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 591968 abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 757154 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 583312 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 583345 myb-binding protein 1A-like protein isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 753259 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
D 581572 uncharacterized protein LOC581572 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 755651 uncharacterized protein LOC755651 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 753723 three prime repair exonuclease 2-like K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 592079 DNA cross-link repair 1A protein-like K15340 DCLRE1A; DNA cross-link repair 1A protein
D 115918083 DNA cross-link repair protein SNM1-like K15340 DCLRE1A; DNA cross-link repair 1A protein
D 582513 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 763923 exonuclease V isoform X1 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 589760 endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 576113 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 591443 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 578386 DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
D 115928802 DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 582924 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 115918835 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 583936 cell division cycle 5-like protein isoform X1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 576181 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 594479 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
D 756406 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 577580 nucleotide triphosphate diphosphatase NUDT15-like K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 587752 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 115918659 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 115924232 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100893273 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 574856 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115919171 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 581431 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 577596 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 594140 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100889029 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 593941 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 586702 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 764571 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 577235 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 581391 uncharacterized protein LOC581391 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 586497 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 115928716 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 588914 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100894038 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
F 115923630 probable Werner syndrome ATP-dependent helicase homolog 1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 762568 probable Werner syndrome ATP-dependent helicase homolog 1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 115921169 probable Werner syndrome ATP-dependent helicase homolog 1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 115926860 probable Werner syndrome ATP-dependent helicase homolog 1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 115927320 probable Werner syndrome ATP-dependent helicase homolog 1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 582073 probable Werner syndrome ATP-dependent helicase homolog 1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100894038 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 577580 nucleotide triphosphate diphosphatase NUDT15-like K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 574856 probable deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 115919171 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024