+C	Peptidases and inhibitors	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Peptidases and Inhibitors - Streptomyces sp. 4F</h2>
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A<b>Aspartic peptidases</b>
B  Family A1: pepsin family
B  Family A2: retropepsin family
B  Family A5: thermopsin family
B  Family A8: signal peptidase II family
C    ASR50_10120 signal peptidase II	K03101 lspA; signal peptidase II [EC:3.4.23.36] 
B  Family A22: presenilin family
B  Family A24: type IV prepilin peptidase family
C    ASR50_20875 peptidase A24	K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] 
B  Family A25: gpr protease family
B  Family A26: omptin family
B  Family A28
B  Family A31: HybD endopeptidase family
B  Family A36
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A<b>Cysteine peptidases</b>
B  Family C1: papain family
B  Family C2: calpain family
B  Family C3: picornain family
B  Family C4: NIa protease family
B  Family C5
B  Family C9
B  Family C10: streptopain family
B  Family C11: clostripain family
B  Family C12: ubiquitin C-terminal hydrolase family
B  Family C13: legumain family
B  Family C14: caspase family
B  Family C15: pyroglutamyl peptidase I family
B  Family C16
B  Family C19: ubiquitin-specific protease family
B  Family C25: gingipain family
B  Family C26: gamma-glutamyl hydrolase family
C    ASR50_21875 guaA; GMP synthetase	K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] 
C    ASR50_07715 glutamine amidotransferase	K07010 K07010; putative glutamine amidotransferase 
B  Family C27
B  Family C30
B  Family C37
B  Family C39
B  Family C40
C    ASR50_10435 hypothetical protein	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
C    ASR50_18250 glycoside hydrolase	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
C    ASR50_20920 glycoside hydrolase	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
C    ASR50_24095 hypothetical protein	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
C    ASR50_10430 hypothetical protein	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
C    ASR50_21930 glycoside hydrolase	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
C    ASR50_21920 hypothetical protein	K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] 
B  Family C44
C    ASR50_17685 amidophosphoribosyltransferase	K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] 
C    ASR50_09885 glutamate synthase	K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13] 
C    ASR50_13555 glutamine amidotransferase	K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] 
C    ASR50_21620 glutamine amidotransferase	K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] 
C    ASR50_33065 asparagine synthetase B	K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 
C    ASR50_26910 asparagine synthetase B	K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 
B  Family C45
B  Family C46: hedgehog family
B  Family C47: staphopain family
B  Family C48: Ulp1 endopeptidase family
B  Family C50: separase family
B  Family C54: Aut2 peptidase family
B  Family C55: YopJ protease family
B  Family C56: PfpI endopeptidase family
C    ASR50_29240 glutamine amidotransferase	K05520 yhbO; deglycase [EC:3.5.1.124] 
B  Family C57: vaccinia virus I7 peptidase family
B  Family C58
B  Family C59
B  Family C60
C    ASR50_16665 hypothetical protein	K07284 srtA; sortase A [EC:3.4.22.70] 
B  Family C63
B  Family C64
B  Family C65
B  Family C67
B  Family C69
B  Family C70
B  Family C75
B  Family C76
B  Family C78
B  Family C79
B  Family C82
B  Family C83
B  Family C85
B  Family C86
B  Family C88
B  Family C89
B  Family C97
B  Family C98
B  Family C110
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A<b>Glutamic peptidases</b>
B  Family G1
B  Family G4
B  Family G5: prenyl protease 2 family
C    ASR50_13360 peptidase	K07052 K07052; CAAX protease family protein 
C    ASR50_24180 CAAX protease	K07052 K07052; CAAX protease family protein 
#
A<b>Metallo peptidases</b>
B  Family M1
C    ASR50_09850 aminopeptidase N	K01256 pepN; aminopeptidase N [EC:3.4.11.2] 
C    ASR50_12805 aminopeptidase N	K01256 pepN; aminopeptidase N [EC:3.4.11.2] 
C    ASR50_12765 aminopeptidase N	K01256 pepN; aminopeptidase N [EC:3.4.11.2] 
B  Family M2
B  Family M3
B  Family M4: thermolysin family
C    ASR50_11980 peptidase	K20273 zmpA; zinc metalloprotease ZmpA 
B  Family M5: mycolysin family
B  Family M6: immune inhibitor A family
C    ASR50_14130 protease	K09607 ina; immune inhibitor A [EC:3.4.24.-] 
B  Family M7: snapalysin family
C    ASR50_32995 peptidase	K01416 snpA; snapalysin [EC:3.4.24.77] 
C    ASR50_16485 ABC transporter substrate-binding protein	K01416 snpA; snapalysin [EC:3.4.24.77] 
C    ASR50_34020 metalloprotease	K01416 snpA; snapalysin [EC:3.4.24.77] 
B  Family M8: leishmanolysin family
B  Family M9
B  Family M10
B  Family M12: astacin/adamalysin family
B  Family M13: neprilysin family
B  Family M14: carboxypeptidase A family
B  Family M15: zinc D-Ala-D-Ala carboxypeptidase family
C    ASR50_03625 peptidase M15	K08640 E3.4.17.14; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] 
C    ASR50_06595 D-alanyl-D-alanine dipeptidase	K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] 
B  Family M16: pitrilysin family
B  Family M17: leucyl aminopeptidase family
C    ASR50_10620 aminopeptidase	K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1] 
B  Family M18
B  Family M19: membrane dipeptidase family
C    ASR50_19995 membrane dipeptidase	K01273 DPEP; membrane dipeptidase [EC:3.4.13.19] 
B  Family M20
C    ASR50_02295 2-dehydropantoate 2-reductase	K01295 cpg; glutamate carboxypeptidase [EC:3.4.17.11] 
C    ASR50_23335 succinyl-diaminopimelate desuccinylase	K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18] 
C    ASR50_05350 beta-Ala-His dipeptidase	K23980 tpdA; cysteinylglycine-S-conjugate dipeptidase [EC:3.4.13.23] 
B  Family M23
B  Family M24
C    ASR50_10985 methionine aminopeptidase	K01265 map; methionyl aminopeptidase [EC:3.4.11.18] 
C    ASR50_21545 methionine aminopeptidase	K01265 map; methionyl aminopeptidase [EC:3.4.11.18] 
C    ASR50_28785 methionine aminopeptidase	K01265 map; methionyl aminopeptidase [EC:3.4.11.18] 
C    ASR50_17175 Xaa-Pro aminopeptidase	K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] 
B  Family M26
B  Family M27
B  Family M28: aminopeptidase Y family
C    ASR50_23025 hydrolase	K19702 E3.4.11.24; aminopeptidase S [EC:3.4.11.24] 
B  Family M29: aminopeptidase T family
B  Family M32: carboxypeptidase Taq family
B  Family M34: anthrax lethal factor family
B  Family M35: deuterolysin family
B  Family M36: fungalysin family
B  Family M38: beta-aspartyl dipeptidase family
B  Family M41: FtsH endopeptidase family
C    ASR50_14885 cell division protein FtsH	K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] 
B  Family M42: glutamyl aminopeptidase family
B  Family M43: cytophagalysin family
B  Family M44
B  Family M48: Ste24 endopeptidase family
C    ASR50_21150 protease HtpX	K03799 htpX; heat shock protein HtpX [EC:3.4.24.-] 
B  Family M49: dipeptidyl-peptidase III family
B  Family M50: S2P protease family
B  Family M54
B  Family M55: DppA aminopeptidase family
C    ASR50_29120 peptide ABC transporter substrate-binding protein	K16203 dppA1; D-amino peptidase [EC:3.4.11.-] 
B  Family M56
C    ASR50_21000 hypothetical protein	K02172 blaR1; bla regulator protein blaR1 
B  Family M67
B  Family M72
B  Family M73
B  Family M74
B  Family M80
B  Family M82
C    ASR50_17800 hypothetical protein	K24131 prsW; protease PrsW [EC:3.4.-.-] 
B  Family M85
B  Family M88
B  Family M90
#
A<b>Asparagine peptide lyases</b>
B  Family N1
B  Family N8
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A<b>Mixed peptidases</b>
B  Family P1: DmpA aminopeptidase family
C    ASR50_02925 aminopeptidase	K01266 dmpA; D-aminopeptidase [EC:3.4.11.19] 
B  Family P2
#
A<b>Serine peptidases</b>
B  Family S1: chymotrypsin family
C    ASR50_17210 protease	K08372 pepD; putative serine protease PepD [EC:3.4.21.-] 
C    ASR50_23385 serine protease	K08372 pepD; putative serine protease PepD [EC:3.4.21.-] 
C    ASR50_18045 protease	K08372 pepD; putative serine protease PepD [EC:3.4.21.-] 
C    ASR50_08365 streptogrisin	K18545 sprB; streptogrisin B [EC:3.4.21.81] 
C    ASR50_03980 serine protease	K18546 sprC; streptogrisin C [EC:3.4.21.-] 
C    ASR50_33005 peptidase S1	K18546 sprC; streptogrisin C [EC:3.4.21.-] 
C    ASR50_08360 streptogrisin	K18547 sprD; streptogrisin D [EC:3.4.21.-] 
C    ASR50_32510 protease	K18547 sprD; streptogrisin D [EC:3.4.21.-] 
C    ASR50_32650 protease	K18547 sprD; streptogrisin D [EC:3.4.21.-] 
B  Family S3: togavirin family
B  Family S6
B  Family S7: flavivirin family
B  Family S8: subtilisin family
C    ASR50_01680 serine protease	K14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-] 
C    ASR50_25875 type VII secretion-associated serine protease mycosin	K14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-] 
B  Family S9: prolyl oligopeptidase family
C    ASR50_23220 peptidase S9	K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5] 
B  Family S10
B  Family S11: D-Ala-D-Ala carboxypeptidase A family
C    ASR50_04845 D-alanyl-D-alanine carboxypeptidase	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
C    ASR50_19135 D-alanyl-D-alanine carboxypeptidase	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
C    ASR50_16370 D-alanyl-D-alanine carboxypeptidase	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
C    ASR50_22195 D-alanyl-D-alanine carboxypeptidase	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
C    ASR50_32695 peptidase M15	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
B  Family S12: D-Ala-D-Ala carboxypeptidase B family
B  Family S13: D-Ala-D-Ala peptidase C family
C    ASR50_14905 D-alanyl-D-alanine carboxypeptidase	K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] 
B  Family S14: ClpP endopeptidase family
C    ASR50_04475 ATP-dependent Clp protease proteolytic subunit	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
C    ASR50_04480 ATP-dependent Clp protease proteolytic subunit	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
C    ASR50_05995 ATP-dependent Clp protease proteolytic subunit	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
C    ASR50_12645 clpP; ATP-dependent Clp protease proteolytic subunit	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
C    ASR50_12650 ATP-dependent Clp protease proteolytic subunit	K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 
B  Family S15
C    ASR50_30350 X-prolyl-dipeptidyl aminopeptidase	K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11] 
B  Family S16: lon protease family
C    ASR50_24050 Lon protease	K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53] 
C    ASR50_14190 hypothetical protein	K07177 K07177; Lon-like protease 
C    ASR50_23660 PDZ/DHR/GLGF domain-containing protein	K07177 K07177; Lon-like protease 
B  Family S21: assemblin family
B  Family S24: LexA family
C    ASR50_26230 LexA family transcriptional regulator	K01356 lexA; repressor LexA [EC:3.4.21.88] 
B  Family S26: signal peptidase I family
C    ASR50_25410 S26 family signal peptidase	K03100 lepB; signal peptidase I [EC:3.4.21.89] 
C    ASR50_25415 S26 family signal peptidase	K03100 lepB; signal peptidase I [EC:3.4.21.89] 
C    ASR50_25420 S26 family signal peptidase	K03100 lepB; signal peptidase I [EC:3.4.21.89] 
C    ASR50_25425 S26 family signal peptidase	K03100 lepB; signal peptidase I [EC:3.4.21.89] 
B  Family S28
B  Family S31
B  Family S32
B  Family S33
C    ASR50_09710 proline iminopeptidase	K01259 pip; proline iminopeptidase [EC:3.4.11.5] 
C    ASR50_28100 hypothetical protein	K01259 pip; proline iminopeptidase [EC:3.4.11.5] 
C    ASR50_03770 epoxide hydrolase	K27108 ephA_B; epoxide hydrolase A/B [EC:3.3.2.-] 
B  Family S41: C-terminal processing peptidase family
C    ASR50_14355 peptidase S41	K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102] 
C    ASR50_12300 peptidase S41	K08676 tri; tricorn protease [EC:3.4.21.-] 
C    ASR50_19440 peptidase S41	K08676 tri; tricorn protease [EC:3.4.21.-] 
B  Family S45
C    ASR50_17540 penicillin amidase	K01434 pac; penicillin G amidase [EC:3.5.1.11] 
C    ASR50_19365 penicillin amidase	K01434 pac; penicillin G amidase [EC:3.5.1.11] 
B  Family S49: protease IV family
B  Family S50
B  Family S51
C    ASR50_18310 peptidase S51	K05995 pepE; dipeptidase E [EC:3.4.13.21] 
C    ASR50_29345 peptidase S51 dipeptidase E	K05995 pepE; dipeptidase E [EC:3.4.13.21] 
B  Family S53
B  Family S54: Rhomboid family
C    ASR50_27455 rhomboid family intramembrane serine protease	K07059 K07059; rhomboid family protein 
C    ASR50_10450 rhomboid family intramembrane serine protease	K07059 K07059; rhomboid family protein 
B  Family S55: SpoIVB peptidase family
B  Family S62
B  Family S66
C    ASR50_29135 LD-carboxypeptidase	K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] 
C    ASR50_02370 peptidase S66 family protein	K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13] 
B  Family S77: phage prohead processing peptidase family
B  Family S78
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A<b>Threonine peptidases</b>
B  Family T1: proteasome family
C    ASR50_07850 proteasome subunit alpha	K03432 psmA; proteasome alpha subunit [EC:3.4.25.1] 
C    ASR50_07855 proteasome subunit beta	K03433 psmB; proteasome beta subunit [EC:3.4.25.1] 
B  Family T2
B  Family T3: gamma-glutamyltransferase family
C    ASR50_03300 transferase	K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] 
C    ASR50_28775 gamma-glutamyltransferase	K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] 
C    ASR50_28930 gamma-glutamyltransferase	K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13] 
#
A<b>Peptidases of unknown catalytic type</b>
B  Family U32
B  Family U62
C    ASR50_08790 peptidase C69	K03568 tldD; TldD protein 
#
A<b>Peptidase inhibitors</b>
B  Family I1: Kazal family
B  Family I2: Kunitz - BPTI family
B  Family I4: serpin family
B  Family I11: ecotin family
B  Family I17: WAP-type family
B  Family I25: cystatin family
B  Family I27: calpastatin family
B  Family I32: IAP family
B  Family I34: IA3 family
B  Family I35: timp family
B  Family I39: alpha2M family
B  Family I47: latexin family
B  Family I49: proSAAS family
B  Family I51: IC family
B  Family I57: staphostatin B family
B  Family I63
B  Family I80
B  Family I87
B  Family I93
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#<hr>
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#Last updated: December 13, 2023
#<br>Classification taken and modified from <a href="https://www.ebi.ac.uk/merops/">MEROPS</a>