Two-Component System

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 OmpR family
   PhoR-PhoB (phosphate starvation response)
   SenX3-RegX3 (phosphate starvation response)
   PhoQ-PhoP (magnesium transport)
   EnvZ-OmpR (osmotic stress response)
   RstB-RstA
   CpxA-CpxR (envelope stress response)
   CssS-CssR (secretion stress response)
   CreC-CreB (phosphate regulation)
   BaeS-BaeR (envelope stress response)
   BasS-BasR (antimicrobial peptide resistance)
   CusS-CusR (copper tolerance)
   QseC-QseB (quorum sensing)
   KdpD-KdpE (potassium transport)
   TorS-TorR (TMAO respiration)
   ArcB-ArcA (anoxic redox control)
   TctE-TctD (tricarboxylic acid transport)
     K07649  tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
     K07774  tctD; two-component system, OmpR family, response regulator TctD
   ResE-ResD (aerobic and anaerobic respiration)
   VicK-VicR (cell wall metabolism)
   MprB-MprA (maintenance of persistent infection)
   MtrB-MtrA (osmotic stress response)
   PrrB-PrrA (intracellular multiplication)
   TrcS-TrcR
   NrsS-NrsR (nickel tolerance)
   ManS-ManR (manganese homeostasis)
   NblS-NblR (photosynthesis)
   SasA-RpaAB (circadian timing mediating)
   SaeS-SaeR (staphylococcal virulence regulation)
   BceS-BceR (bacitracin transport)
   BraS-BraR (bacitracin transport)
   GraS-GraR (cationic antimicrobial peptide transport)
   YxdK-YxdJ (antimicrobial peptide response)
   ChvG-ChvI (acidity sensing)
   CiaH-CiaR
   ParS-ParR (polymyxin-adaptive resistance)
   AdeS-AdeR
   VanS-VanR (VanB type vancomycin resistance)
   VanS-VanR (VanE type vancomycin resistance)
   VanS-VanR (actinomycete type vancomycin resistance)
   ArlS-ArlR (virulence regulation)
   Ihk-Irr (virulence regulation)
   PfeS-PfeR (enterobactin-dependent iron acquisition)
   NisK-NisR (lantibiotic biosynthesis)
   Unclassified
     K21603  ftcR; two-component system, OmpR family, flagellar system response regulator FtcR
     K02484  K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
     K02483  K02483; two-component system, OmpR family, response regulator
 
 NarL family
 
 Spo family
 
 CitB family
 
 LytTR family
 
 NtrC family
 
 CheA family
   CheA-CheYBV (chemotaxis)
   ChpA-ChpB/PilGH (chemosensory)
     K06596  chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
     K02657  pilG; twitching motility two-component system response regulator PilG
     K02658  pilH; twitching motility two-component system response regulator PilH
     K06597  chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
   PixL-PixGH (positive phototaxis)
   WspE-WspRF (chemosensory)
   Cph1-Rcp1 (light response)
 
 Cell cycle family
 
 Lux family
 
 LuxR family
 
 Other families
   FlrB-FlrC (polar flagellar synthesis)
   AauS-AauR (acidic amino acids utilization)
   SLN1-YPD1-SSK1/SKN7 (osmosensing)
     K11231  SLN1; osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3]
     K19690  CHK1; osomolarity two-component system, sensor histidine kinase CHK1 [EC:2.7.13.3]
     K19691  NIK1, TCSC; osomolarity two-component system, sensor histidine kinase NIK1 [EC:2.7.13.3]
     K19692  TCSA; osomolarity two-component system, sensor histidine kinase TcsA [EC:2.7.13.3]
     K11232  YPD1; osomolarity two-component system, phosphorelay intermediate protein YPD1
     K11233  SSK1; osomolarity two-component system, response regulator SSK1
     K15859  SKN7; osomolarity two-component system, response regulator SKN7
   RpfC-RpfG (cell-to-cell signaling)
   GlnK-GlnL (glutamine utilization)
   HspS-HspR (hexose phosphates uptake)
   YesM-YesN
   CikA
   RegB-RegA (redox response)
   FitF-FitH (insecticidal toxin regulation)
   PhcS-PhcRQ
   SagS-HptB-HsbR (swarming activity and biofilm formation)
   PdtaS-PdtaR
   NasS-NasT
   Unclassified

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Last updated: October 8, 2024