| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
|
map04934
|
|
Cushing syndrome |
... of corticotroph adenoma. Germline mutations in MEN1 (encoding menin), AIP (encoding aryl-hydrocarbo... |
...9093 (AHR) K17767 (AIP) K06622 (CDKN2C) K14970 (MEN1) K14964 (ASH2), K14961 (RBBP5), K14963 (WDR5), ... |
CUSHING SYNDROME PLCβ L-type IP3 q/11 T-type Calcium signaling pathway Mitochondria CREB cAMP AMP P... |
|
map05010
|
|
Alzheimer disease |
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... |
... cation) C14818 (Fe2+) K06170 (PSENEN) K04505 (PSEN1), K04522 (PSEN2) K06171 (NCSTN) K06172 (APH1) K... |
...emory Anterograde Cargo XBP1 ER chaperons ERAD PSEN1 GSK-3β XBP1 CHOP CHOP Proteasome 20S 19S 26S pr... |
|
map03410
|
|
Base excision repair |
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small ... |
K10771 (APEX1) K04799 (FEN1) K10747 (LIG1) K10776 (LIG3) K01972 (E6.5.1.2), K10747 (LIG1) K02324 (PO... |
APEX Fen1 Lig1 Lig3 Lig Polε Polδ Polβ Polβ Polβ Polβ PCNA PCNA PCNA DpoI DpoI DpoI APEX Nfo Xth MUT... |
|
map03030
|
|
DNA replication |
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DN... |
K10747 (LIG1) K04799 (FEN1) K10742 (DNA2) K10743 (RNASEH2A) K10744 (RNASEH2B) K10755 (RFC2_4) K10745... |
Lig1 Fen1 Dna2 RNaseH2A RNaseH2B RFC2/4 RNaseH2C RFC3/5 PCNA RPA3 Mcm5 SSB DnaG DNA REPLICATION γ &... |
|
map05022
|
|
Pathways of neurodegeneration - multiple diseases |
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... |
...(MAP2K1), K04369 (MAP2K2) K04371 (ERK) K04505 (PSEN1) K05853 (ATP2A) K04505 (PSEN1), K04522 (PSEN2) ... |
... complications Raf MEK ERK1/2 Reduction in LTP PSEN1 SERCA PSEN (Oligomeric) (Oligomeric) ABAD CypD ... |
|
map04361
|
|
Axon regeneration |
Many mature central nervous system (CNS) neurons in non-mammals, such as C. elegans, Drosophila, and... |
...FOSLN) K02599 (NOTCH1) K06704 (ADAM10) K04505 (PSEN1) K04505 (PSEN1) K06839 (SLIT2) K06754 (ROBO2) K... |
AXON REGENERATION DAF-16 DAF-2 mTOR DAF-18 Insulin signaling pathway mTOR signaling pathway EGL-19 ... |
|
map00909
|
|
Sesquiterpenoid and triterpenoid biosynthesis |
Sesquiterpenoids (C15 terpenoids) are a group of terpenoids consisting of three isoprene units. They... |
...(PSM), K21928 (TTS2), 5.4.99.40, R06471 K15823 (PEN1), 4.2.1.124, R09700 K15816 (LUP1), 4.2.1.128, R... |
Albaflavenone Terpenoid backbone biosynthesis Farnesyl-PP (S,E)-Nerolidol (E,E)-α-Farnesene (E,E)-β... |
|
map01110
|
|
Biosynthesis of secondary metabolites |
|
...PS4), K12928 (K12928), 5.5.1.14, R06312 K15823 (PEN1), 4.2.1.124, R09700 K13032 (PH), K01188 (E3.2.1... |
Starch and sucrose metabolism Benzoxazinoid biosynthesis Indole diterpene alkaloid biosynthesis Phos... |
|
map03450
|
|
Non-homologous end-joining |
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ... |
...5 (XRCC5) K10886 (XRCC4) K10884 (XRCC6) K04799 (FEN1) K10980 (NHEJ1) K10982 (LIF1) |
Lig4 Nej1 Polλ Dnl4 TdT Polμ Artemis Pol4 Lig NON-HOMOLOGOUS END-JOINING Mre11 Rad50 DNAPKcs XRS2 K... |
|
map04310
|
|
Wnt signaling pathway |
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as ce... |
...085 (APC) K02105 (CTNNB1) K04345 (PKA) K04505 (PSEN1) K03083 (GSK3B) K03069 (FRAT1), K03096 (FRAT2) ... |
p53 signaling pathway Adherens junction SMAD3 TGF-β signaling pathway Cell cycle WNT SIGNALING PAT... |
|
map04330
|
|
Notch signaling pathway |
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essent... |
...r domain) K06171 (NCSTN) K06172 (APH1) K04505 (PSEN1), K04522 (PSEN2) K06067 (HDAC1_2) K06066 (CIR) ... |
NCSTN APH-1 PSEN MAPK signaling pathway HDAC CIR Gro/TLE CtBP Hairless SMRT PreTα Hes1/5 CSL SKIP HA... |
|
map04722
|
|
Neurotrophin signaling pathway |
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cel... |
...09 (IKBKB) K02161 (BCL2) K02183 (CALM) K04505 (PSEN1), K04522 (PSEN2) K02580 (NFKB1), K04735 (RELA) ... |
Plasticity Cell survival TrkA TrkB TrkC Apoptosis BDNF NT4 NT3 Cellular differentiation PI3K PLCγ D... |
|
map05165
|
|
Human papillomavirus infection |
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cuta... |
...996 (NOTCH4) K21807 (E6) K12236 (NFX1) K04505 (PSEN1) K05948 (FNG) K05414 (IFNA), K05415 (IFNB) K051... |
PIP 4EBPs S6K1/2 mTOR Rheb TSC2 TSC1 AKT PI3K p53 signaling pathway HUMAN PAPILLOMAVIRUS INFECTION... |
|
map05202
|
|
Transcriptional misregulation in cancer |
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged ... |
...725 (PTK2) K03176 (NTRK1) K02583 (NGFR) K14970 (MEN1) K06624 (CDKN1B) K09186 (MLL1) K02211 (CDK9), K... |
TRANSCRIPTIONAL MISREGULATION IN CANCER Ewing's sarcoma Clear-cell sarcoma Desmoplastic small ro... |