KEGG   Microcebus murinus (gray mouse lemur): 105862190
Entry
105862190         CDS       T07238                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur01521  EGFR tyrosine kinase inhibitor resistance
mmur01522  Endocrine resistance
mmur04010  MAPK signaling pathway
mmur04012  ErbB signaling pathway
mmur04068  FoxO signaling pathway
mmur04270  Vascular smooth muscle contraction
mmur04650  Natural killer cell mediated cytotoxicity
mmur04720  Long-term potentiation
mmur04726  Serotonergic synapse
mmur04730  Long-term depression
mmur04810  Regulation of actin cytoskeleton
mmur04910  Insulin signaling pathway
mmur04914  Progesterone-mediated oocyte maturation
mmur04928  Parathyroid hormone synthesis, secretion and action
mmur05010  Alzheimer disease
mmur05022  Pathways of neurodegeneration - multiple diseases
mmur05034  Alcoholism
mmur05160  Hepatitis C
mmur05161  Hepatitis B
mmur05200  Pathways in cancer
mmur05205  Proteoglycans in cancer
mmur05208  Chemical carcinogenesis - reactive oxygen species
mmur05210  Colorectal cancer
mmur05211  Renal cell carcinoma
mmur05212  Pancreatic cancer
mmur05213  Endometrial cancer
mmur05214  Glioma
mmur05215  Prostate cancer
mmur05218  Melanoma
mmur05219  Bladder cancer
mmur05220  Chronic myeloid leukemia
mmur05221  Acute myeloid leukemia
mmur05223  Non-small cell lung cancer
mmur05224  Breast cancer
mmur05225  Hepatocellular carcinoma
mmur05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105862190 (ARAF)
   04012 ErbB signaling pathway
    105862190 (ARAF)
   04068 FoxO signaling pathway
    105862190 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105862190 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    105862190 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105862190 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    105862190 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    105862190 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105862190 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    105862190 (ARAF)
   04720 Long-term potentiation
    105862190 (ARAF)
   04730 Long-term depression
    105862190 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105862190 (ARAF)
   05205 Proteoglycans in cancer
    105862190 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    105862190 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105862190 (ARAF)
   05212 Pancreatic cancer
    105862190 (ARAF)
   05225 Hepatocellular carcinoma
    105862190 (ARAF)
   05226 Gastric cancer
    105862190 (ARAF)
   05214 Glioma
    105862190 (ARAF)
   05221 Acute myeloid leukemia
    105862190 (ARAF)
   05220 Chronic myeloid leukemia
    105862190 (ARAF)
   05218 Melanoma
    105862190 (ARAF)
   05211 Renal cell carcinoma
    105862190 (ARAF)
   05219 Bladder cancer
    105862190 (ARAF)
   05215 Prostate cancer
    105862190 (ARAF)
   05213 Endometrial cancer
    105862190 (ARAF)
   05224 Breast cancer
    105862190 (ARAF)
   05223 Non-small cell lung cancer
    105862190 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    105862190 (ARAF)
   05160 Hepatitis C
    105862190 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105862190 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    105862190 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    105862190 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105862190 (ARAF)
   01522 Endocrine resistance
    105862190 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmur01001]
    105862190 (ARAF)
Enzymes [BR:mmur01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     105862190 (ARAF)
Protein kinases [BR:mmur01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   105862190 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo C1_2
Other DBs
NCBI-GeneID: 105862190
NCBI-ProteinID: XP_012603793
Ensembl: ENSMICG00000016177
UniProt: A0A8B7F7J0
LinkDB
Position
X:136927297..136939031
AA seq 612 aa
MEPPRGSPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFQVRKTFFSLAFCDFCLKFL
FNGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGGSRQHEAPSNHPLNEP
LTPQGPSLSPVSPCTQHCDPKHFPFPAPANVPLQRIRSTSTPNVHMVSTTAPMDSSLIQL
TAQSFSTDAAGSKGGSDGAPRGSPSPVSVSSGRKSPHSKSPSEQRERKSLADEKKKVKNL
GYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNE
MQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTA
QGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMA
AEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKI
SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADEL
PACLLSAARLVP
NT seq 1839 nt   +upstreamnt  +downstreamnt
atggagccaccaaggggctcccctgccaatggggctgagccgtcccgggcagtgggcaca
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggatggcatgagt
gtctatgactctctagacaaggccctcaaggtgcggggtctcaatcaagattgctgcgtg
gtctaccgactcatcaaggggagaaagacagtcactgcctgggacacggccattgccccc
ctggatggcgaggaactcattgtcgaggtccttgaagacgtcccactgaccatgcacaat
tttcaggtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctg
ttcaatggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaag
gtccccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccag
gatttgtccggagggtccagacagcatgaggctccctcgaaccaccccttgaatgagccg
ctaacccctcagggtcccagcctttcccccgtcagcccctgcacccagcactgtgacccg
aagcacttccccttccctgccccagccaacgtccccctccagcgcatccgctccacatcc
actcccaacgtccatatggtcagcaccacagcccccatggactccagcctcatccagctc
actgcccagagtttcagcactgatgctgctggtagtaaaggtggcagtgatggagccccc
cgggggagccccagcccagtcagtgtgtcctcggggaggaagtccccacattctaagtcg
ccatcggagcagcgggaacggaagtccttagctgatgagaagaagaaagtgaagaacctg
gggtaccgggactcaggctattactgggaggtgccacccagtgaggtgcagctgctgaag
aggatcgggacaggctcgtttggcaccgtttttcgagggcggtggcatggtgatgtggcc
gtgaaggtgctcaaggtagcccagcccacagctgagcaggcccaggccttcaagaacgag
atgcaggttctcaggaagacacgacacgtcaacatcttgctgtttatgggcttcatgacc
cggccggggtttgccatcatcacacagtggtgtgagggctccagcctctaccaccacctg
cacgtggctgatacacgcttcgacatggtccagctcatcgacgtggctcggcagactgcc
cagggcatggactaccttcatgccaagaacatcatccaccgagatctcaagtctaacaac
atcttcttacacgaggggctcactgtgaagatcggtgactttggcctggccacggtgaag
acgcggtggagtggggcacagcccttggaacagccctcaggttccgtgctatggatggcc
gctgaggtgatccgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcc
tatggggttgtgctctatgagctcatgacgggctcactgccttacagccacattggcagt
cgtgaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatc
tccagcaactgccccaaggccatgcggcgcctgctatctgactgcctcaagttccagcgg
gaggagcgacccctcttcccccagatcctggccacaattgagctgctgcaacggtcactt
cccaagattgagcggagtgcctcggaaccctccttgcaccgcacccaggctgatgagttg
cctgcctgcctactcagtgcagcccgccttgtgccttag

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