KEGG   ORTHOLOGY: K08845
Entry
K08845                      KO                                     
Symbol
ARAF, ARAF1
Name
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04068  FoxO signaling pathway
map04270  Vascular smooth muscle contraction
map04650  Natural killer cell mediated cytotoxicity
map04720  Long-term potentiation
map04726  Serotonergic synapse
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04928  Parathyroid hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05034  Alcoholism
map05160  Hepatitis C
map05161  Hepatitis B
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05208 Chemical carcinogenesis - reactive oxygen species
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05161 Hepatitis B
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Genes
HSA: 369(ARAF)
PTR: 100614256(ARAF)
PPS: 100990590(ARAF)
GGO: 101134493(ARAF)
PON: 100431871(ARAF)
NLE: 100595311(ARAF)
HMH: 116811640(ARAF)
MCC: 707169(ARAF)
MCF: 101925249(ARAF)
MTHB: 126945567
MNI: 105463916(ARAF)
CSAB: 103231895(ARAF)
CATY: 105590503(ARAF)
PANU: 101019640(ARAF)
TGE: 112616121(ARAF)
MLEU: 105541693(ARAF)
RRO: 104664593(ARAF)
RBB: 108530908(ARAF)
TFN: 117078298(ARAF)
PTEH: 111536410(ARAF)
CANG: 105509473(ARAF)
CJC: 100387961(ARAF)
SBQ: 101043605(ARAF)
CIMI: 108295532(ARAF)
CSYR: 103270865(ARAF)
MMUR: 105862190(ARAF)
LCAT: 123628637(ARAF)
PCOQ: 105816815(ARAF)
OGA: 100947929(ARAF)
MMU: 11836(Araf)
MCAL: 110287540(Araf)
MPAH: 110314283(Araf)
RNO: 64363(Araf)
MCOC: 116073820(Araf)
ANU: 117694504(Araf)
MUN: 110541705(Araf)
CGE: 100751432(Araf)
MAUA: 101826679(Araf)
PLEU: 114703900(Araf)
MFOT: 126496069
AAMP: 119805132(Araf)
NGI: 103741627(Araf)
HGL: 101723157(Araf)
CPOC: 100727629(Araf)
CCAN: 109696670(Araf)
DORD: 106000303(Araf)
DSP: 122098764(Araf)
PLOP: 125343344(Araf)
NCAR: 124971762
MMMA: 107144326(Araf)
OCU: 100340437
OPI: 101529871(ARAF)
TUP: 102493239(ARAF)
GVR: 103594183(ARAF)
CFA: 491857(ARAF)
CLUD: 112673245(ARAF)
VVP: 112907269(ARAF)
VLG: 121483180(ARAF)
NPO: 129518309(ARAF)
AML: 100475955(ARAF)
UMR: 103664348(ARAF)
UAH: 113265980(ARAF)
UAR: 123786515(ARAF)
ELK: 111150582
LLV: 125091395
MPUF: 101687799(ARAF)
MNP: 132007524(ARAF)
MLK: 131821130(ARAF)
NVS: 122897579(ARAF)
ORO: 101372839(ARAF)
EJU: 114216801(ARAF)
ZCA: 113930205(ARAF)
MLX: 118009801(ARAF)
NSU: 110571460(ARAF)
LWW: 102736249(ARAF)
FCA: 101089839(ARAF)
PYU: 121026094(ARAF)
PCOO: 112870575(ARAF)
PBG: 122477714(ARAF)
PVIV: 125157334(ARAF)
LRUF: 124509491
PTG: 102956086(ARAF)
PPAD: 109248156(ARAF)
PUC: 125931647
AJU: 106972677
HHV: 120219872(ARAF)
BTA: 540421(ARAF)
BOM: 102285079(ARAF)
BIU: 109555027(ARAF)
BBUB: 102392863(ARAF)
BBIS: 104999018
CHX: 102169370(ARAF)
OAS: 100305131(ARAF)
BTAX: 128070468(ARAF)
ODA: 120882071(ARAF)
CCAD: 122434589(ARAF)
MBEZ: 129564326(ARAF)
SSC: 397601(ARAF)
CFR: 102506774(ARAF)
CBAI: 105079376(ARAF)
CDK: 105102848(ARAF)
VPC: 102529339(ARAF)
BACU: 103020975(ARAF)
BMUS: 118888277(ARAF)
LVE: 103090018(ARAF)
OOR: 101271966(ARAF)
DLE: 111165554(ARAF)
PCAD: 102974274(ARAF)
PSIU: 116747370(ARAF)
NASI: 112402589(ARAF)
ECB: 100061212(ARAF)
EAI: 106847984(ARAF)
MYB: 102241454(ARAF)
MYD: 102755690(ARAF)
MMYO: 118653778(ARAF)
MLF: 102420799(ARAF)
PKL: 118731760(ARAF)
EFUS: 103296401(ARAF)
MNA: 107541381(ARAF)
DRO: 112322484(ARAF)
SHON: 118998301(ARAF)
AJM: 119060144(ARAF)
PDIC: 114504860(ARAF)
PHAS: 123832643(ARAF)
MMF: 118635666(ARAF)
PPAM: 129065223(ARAF)
HAI: 109376563(ARAF)
RFQ: 117022263(ARAF)
PALE: 102877877(ARAF)
PGIG: 120605533(ARAF)
PVP: 105305459(ARAF)
RAY: 107509353(ARAF)
MJV: 108398550(ARAF)
TOD: 119246187(ARAF)
SARA: 101554406(ARAF)
SETR: 125999333(ARAF)
LAV: 100671404(ARAF)
TMU: 101351589
ETF: 101648298(ARAF)
DNM: 101419167(ARAF)
MDO: 100017615(ARAF)
GAS: 123253593(ARAF)
SHR: 100913901(ARAF)
AFZ: 127543183
PCW: 110201017(ARAF)
OAA: 100084423(ARAF)
CCAY: 125628410(ARAF)
DCC: 119847238(ARAF)
CPIC: 101949192(ARAF)
CABI: 116817290
MRV: 120388490(ARAF)
ACS: 100562070(araf)
ASAO: 132767633(ARAF)
PVT: 110081172(ARAF)
SUND: 121923177(ARAF)
PBI: 103066155(ARAF)
PMUR: 107297295(ARAF)
CTIG: 120306657(ARAF)
TSR: 106553001
PGUT: 117675400(ARAF)
APRI: 131191616(ARAF)
PTEX: 113443282(ARAF)
NSS: 113417793(ARAF)
VKO: 123024016(ARAF)
PMUA: 114587447(ARAF)
PRAF: 128404741(ARAF)
ZVI: 118097605(ARAF)
HCG: 128344467(ARAF)
GJA: 107119310(ARAF) 107120717
STOW: 125429274(ARAF)
EMC: 129346271(ARAF)
XLA: 398892(araf.L) 399056(araf.S)
XTR: 100495479(araf)
NPR: 108801347(ARAF)
RTEM: 120913987(ARAF)
BBUF: 120978227(ARAF) 121005800
BGAR: 122922903 122946066(ARAF)
MUO: 115463424(ARAF)
GSH: 117350098(ARAF)
DRE: 403063(araf)
SRX: 107709867 107750175
SANH: 107672764 107673380
SGH: 107592338 107595004
CCAR: 109065600 109092279
CAUA: 113049421 113091344
CGIB: 127957206 128010014
PTET: 122345507(araf)
LROH: 127165632(araf)
OMC: 131541667(araf)
PPRM: 120470201(araf)
MAMB: 125266490(araf)
CIDE: 127512955
MASI: 127428261 127436698
TROS: 130565845(araf)
TDW: 130418981(araf)
MANU: 129440088(araf)
IPU: 108255753(araf)
IFU: 128625606(araf)
PHYP: 113542410
SMEO: 124380566(araf)
TFD: 113639392(araf)
TVC: 132855403(araf)
AMEX: 103043654(araf)
CMAO: 118827772(araf)
EEE: 113588109(araf)
CHAR: 105890001(araf)
TRU: 654307(araf)
TFS: 130526499(araf)
TNG: GSTEN00020048G001
LCO: 104930864
NCC: 104953267
TBEN: 117473092(araf)
PGEO: 117452438
GACU: 117541187(araf)
EMAC: 134873719(araf)
ELY: 117252832(araf)
EFO: 125890244(araf)
PLEP: 121943992(araf)
SLUC: 116050444(araf)
ECRA: 117944848(araf)
ESP: 116689928(araf)
PFLV: 114555276(araf)
GAT: 120830450(araf)
PPUG: 119224747(araf)
AFB: 129101790(araf)
CLUM: 117735957(araf)
PSWI: 130196479(araf)
MSAM: 119891482(araf)
SCHU: 122876305(araf)
CUD: 121509700(araf)
ALAT: 119019813(araf)
MZE: 101471760
ONL: 100698373
OAU: 116316356(araf)
OLA: 101159594(araf)
OML: 112137697(araf)
CSAI: 133450793(araf)
XMA: 102235904
XCO: 114154407
XHE: 116729539
PRET: 103469576
PFOR: 103141909(araf)
PLAI: 106956161(araf)
PMEI: 106930520
GAF: 122827739(araf)
PPRL: 129351582(araf)
CVG: 107104990
CTUL: 119775797(araf)
GMU: 124878222(araf)
NFU: 107393473(araf)
KMR: 108249882(araf)
ALIM: 106533959(araf)
NWH: 119412941(araf)
AOCE: 111568015
MCEP: 125012267(araF)
CSEM: 103397124 103397571
POV: 109633665
SSEN: 122769858(araf)
HHIP: 117767832(araf)
HSP: 118114645(araf)
SMAU: 118314403(araf)
LCF: 108878154
SDU: 111227828
SLAL: 111647945
XGL: 120805159(araf)
HCQ: 109510536
SSCV: 125994756
SBIA: 133499160(araf)
PEE: 133400428(araf)
PTAO: 133474590(araf)
BPEC: 110162179
MALB: 109959639
BSPL: 114845646(araf)
SJO: 128364280(araf)
SASA: 106580530 106585138
STRU: 115164256 115200393
OTW: 112248687(araf) 112265332
OMY: 110525904(araf) 110536286
OGO: 124034135(araf) 124036513
ONE: 115111809 115140270
OKI: 109882485 109896112
OKE: 118358512 118393428(araf)
SALP: 111957871 111973909
SNH: 120041600(araf) 120063367
CCLU: 121530684 121585055(araf)
ELS: 105014388(araf)
SFM: 108931249(araf)
PKI: 111844715(araf)
AANG: 118208073(araf)
LOC: 102687735
PSPA: 121305491 121329240(araf)
ARUT: 117401630(araf) 117967710
PSEX: 120542924(araf)
LCM: 102351967
HOC: 132814149
TPRE: 106652672
DFR: 124498302
XEN: 124459479
 » show all
Reference
PMID:8020955
  Authors
Lee JE, Beck TW, Brennscheidt U, DeGennaro LJ, Rapp UR
  Title
The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1).
  Journal
Genomics 20:43-55 (1994)
DOI:10.1006/geno.1994.1125
  Sequence
[hsa:369]
Reference
PMID:20674547
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)
DOI:10.1016/j.bbrc.2010.07.092
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