Orcinus orca (killer whale): 101278256
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Entry
101278256 CDS
T05247
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00350
Tyrosine metabolism
oor00790
Folate biosynthesis
oor01100
Metabolic pathways
oor04728
Dopaminergic synapse
oor04917
Prolactin signaling pathway
oor05012
Parkinson disease
oor05030
Cocaine addiction
oor05031
Amphetamine addiction
oor05034
Alcoholism
Module
oor_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
101278256 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
101278256 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
101278256 (TH)
09156 Nervous system
04728 Dopaminergic synapse
101278256 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
101278256 (TH)
09165 Substance dependence
05030 Cocaine addiction
101278256 (TH)
05031 Amphetamine addiction
101278256 (TH)
05034 Alcoholism
101278256 (TH)
Enzymes [BR:
oor01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
101278256 (TH)
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Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
101278256
NCBI-ProteinID:
XP_004278116
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Position
8:complement(1585675..1592792)
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AA seq
496 aa
AA seq
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MPTPNAASPQAKGFRRAVSELDAKQAEAIMSPRFVGRRQSLIQDARNERQKAEAAAAAAA
TAAAAAEPGEALGGRAGKAALNLLFTLRATKPPALSRAVKVFETFEAQIHHLETRPAQKP
QAGGPHLEYFVRCEVPSAALPTLLSSLRRVAEDVRGAGENKVLWFPRKVSELDKCHHLVT
KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKQGDPIPHVEYTAEETATWKEIYTTLRG
LYATHACREHLEAFELLEHFCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLA
SLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDE
EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEGPEIRAFDPDAAAVQP
YQDQTYQPVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRALDG
VRDELHALTHALSAIS
NT seq
1491 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccaacgctgcctcgccgcaggccaagggcttccgcagggccgtctccgag
ctggacgccaagcaggccgaggccatcatgtccccacgcttcgtcgggaggcggcagagc
ctcatccaggatgcccgcaacgagcgacagaaggcggaggccgccgccgccgccgccgcc
accgccgctgcagccgcggagccgggcgaggccctggggggacgggccgggaaggccgcg
ctgaatctcctcttcaccctgcgggccaccaagccccctgcgctgtcccgggctgtgaag
gtgttcgagacatttgaagcccaaatccaccacctggagacccggcccgcccagaagcca
caggcagggggcccgcacctggagtacttcgtgcgctgtgaggtacccagcgccgccctg
cccaccctgctcagctcccttcgccgcgtggctgaagatgtgcggggcgctggggagaac
aaggtcctctggttcccaaggaaagtttctgagctggacaagtgtcaccacctggtcacc
aagtttgaccctgacctggacttggaccatccgggcttctccgaccaggtgtaccgccag
cgcaggaagctgattgctgagatcgccttccagtacaagcaaggcgaccctattccccac
gtggagtacacggccgaggagactgccacctggaaggagatctacaccacgctgcggggc
ctctacgccacccacgcgtgccgggaacacctggaggctttcgagctgctggagcacttc
tgcgggtaccgggaggacagcatcccccagctggaggacgtctcccgcttcctgaaggag
cggaccggcttccagctgcggcccgtggccggcctgctgtccgcccgggacttcctggcc
agcctggccttccgcgtgttccagtgcacccagtacatccgccacgcctcctcacccatg
cactcccccgagccggactgctgccacgagctgctggggcacgtgcccatgctggccgac
cggaccttcgcccagttctcccaggacatcggcctcgcatccctgggggcatcggacgaa
gaaattgagaagctgtccacgctgtactggttcaccgtggagtttgggctgtgcaaacag
aacggcgaggtgaaggcctacggagcggggctgctgtcctcctatggggagctcctgcat
tccctgtctgaggggcccgagatccgggccttcgaccccgacgcagcggccgtgcagccc
taccaggaccagacttatcaacctgtctacttcgtgtctgagagtttcagcgacgccaag
gacaaactcaggagctatgcctcccgcatccagcgccccttctccgtgaagttcgaccca
tacacgctggccatcgatgtgctggacagcccccacgccatccgacgcgccctggatggt
gtccgggacgagctgcacgccctcacccacgccctgagcgccatcagctag
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