KEGG ORTHOLOGY: K00501

ORTHOLOGY: K00501

Entry

K00501                      KO

Symbol

Name

tyrosine 3-monooxygenase [EC:1.14.16.2]

Pathway

map00350

Tyrosine metabolism

map00790

Folate biosynthesis

map00950

Isoquinoline alkaloid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04728

Dopaminergic synapse

map04917

Prolactin signaling pathway

map05012

Parkinson disease

map05030

Cocaine addiction

map05031

Amphetamine addiction

map05034

Alcoholism

Module

M00042

Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline

Reaction

R01815

L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

R07212

L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase(3-hydroxylating)

Disease

H02557

Dopa-responsive dystonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00501  TH; tyrosine 3-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K00501  TH; tyrosine 3-monooxygenase
  09156 Nervous system
   04728 Dopaminergic synapse
    K00501  TH; tyrosine 3-monooxygenase
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K00501  TH; tyrosine 3-monooxygenase
  09165 Substance dependence
   05030 Cocaine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05031 Amphetamine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05034 Alcoholism
    K00501  TH; tyrosine 3-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     K00501  TH; tyrosine 3-monooxygenase

Other DBs

GO:

0004511

Genes

HSA:

7054(TH)

PTR:	450955(TH)

PPS:	100967895(TH)

GGO:	101135345(TH)

PON:	100454349(TH)

NLE:	100591963(TH)

HMH:	116469148(TH)

MCC:	721137(TH)

MCF:	102134074(TH)

MTHB:

126935834

MNI:	105469782(TH)

CSAB:

103238895(TH)

CATY:

105577265(TH)

PANU:

100997633(TH)

TGE:	112606566(TH)

MLEU:

105545321(TH)

RRO:	104677105(TH)

RBB:	108539190(TH)

TFN:	117081144(TH)

PTEH:

111520620(TH)

CANG:

105503232(TH)

CJC:	100393454(TH)

SBQ:	101037795(TH)

CIMI:

108288724(TH)

CSYR:

103250431(TH)

MMUR:

105859820(TH)

LCAT:

123642916(TH)

PCOQ:

105816522(TH)

OGA:	100957987(TH)

MMU:

21823(Th)

MCAL:

110298803(Th)

MPAH:

110327669(Th)

RNO:

25085(Th)

MCOC:

116103251(Th)

ANU:	117721049(Th)

MUN:	110547270(Th)

MAUA:

101823328(Th)

PROB:

127228573(Th)

PLEU:

114694083(Th)

MORG:

121457807(Th)

MFOT:

126498125

AAMP:

119826306(Th)

NGI:	103738985(Th)

HGL:	101721615(Th)

CPOC:

100734150(Th)

CCAN:

109689795(Th)

DORD:

105989150(Th)

DSP:	122102061(Th)

NCAR:

124958984

MMMA:

107156899(Th)

TUP:	102482570(TH)

GVR:	103595280(TH)

CFA:	403444(TH)

CLUD:

112663223(TH)

VVP:	112924141(TH)

VLG:	121472267(TH)

NPO:	129503139(TH)

AML:	100483681(TH)

UMR:	103671121(TH)

UAH:	113243914(TH)

UAR:	123775491(TH)

ELK:

111149999

LLV:

125078776

MPUF:

101682802(TH)

MNP:	132016827(TH)

MLK:	131817620(TH)

NVS:	122914591(TH)

ORO:	101384343(TH)

EJU:	114220499(TH)

ZCA:	113914758(TH)

MLX:	118015655(TH)

NSU:	110576077(TH)

LWW:	102748225(TH)

FCA:	101090720(TH)

PYU:	121023849(TH)

PCOO:

112852062(TH)

PBG:	122484125(TH)

PVIV:

125146679(TH)

LRUF:

124527888

PTG:	102954972(TH)

PPAD:

109259420(TH)

PUC:

125911546

AJU:

106971078

HHV:	120226898(TH)

BTA:	280707(TH)

BOM:	102274970(TH)

BIU:	109554672(TH)

BBUB:

102395073(TH)

CHX:	102179849(TH)

OAS:	101120619(TH)

BTAX:

128068945(TH)

ODA:	120874169(TH)

CCAD:

122430977(TH)

MBEZ:

129548408(TH)

SSC:	110259705(TH)

CFR:	102508286(TH)

CBAI:

105070385(TH)

CDK:	105106406(TH)

VPC:	102544796(TH)

BACU:

103020745(TH)

BMUS:

118899690(TH)

LVE:	103086024(TH)

OOR:	101278256(TH)

DLE:	111184074(TH)

PCAD:

102996827(TH)

PSIU:

116757983(TH)

NASI:

112402332(TH)

ECB:	100146648(TH)

EAI:	106824091(TH)

MYD:	102756871(TH)

MMYO:

118659614(TH)

PKL:	118713980(TH)

EFUS:

103303267(TH)

MNA:	107539915(TH)

DRO:	112317145(TH)

SHON:

118988339(TH)

AJM:	119057534(TH)

PDIC:

114500037(TH)

PHAS:

123807340(TH)

MMF:	118628135(TH)

PPAM:

129068492(TH)

HAI:	109395916(TH)

RFQ:	117030018(TH)

PGIG:

120584600(TH)

PVP:	105299526(TH)

RAY:	107513264(TH)

MJV:	108402611(TH)

TOD:	119248786(TH)

SARA:

101541321(TH)

SETR:

126019057(TH)

TMU:

101347132

ETF:	101642018(TH)

DNM:

MDO:

GAS:

AFZ:

PCW:	110197189(TH) 110205577

OAA:	100075982 103167613(TH)

GGA:	395592(TH) 771761(THL)

PCOC:

116226760 116242979(TH)

MGP:	723977(TH)

CJO:	107314555(TH) 107314887

TPAI:

128073251 128086190(TH)

LMUT:

125694615 125694861(TH)

NMEL:

110398023 110401820(TH)

APLA:

101794316 101794610(TH)

ACYG:

106035805 106042638(TH)

CATA:

118244591(TH) 118254192

AFUL:

116486466 116490070(TH)

TGU:	100217613 100219119(TH)

LSR:	110468651(TH) 110473828

SCAN:

103819711 103826755(TH)

PMOA:

120501694 120511421(TH)

OTC:	121332934 121341537(TH)

PRUF:

121360967(TH) 121363538

GFR:	102039412 102044418(TH)

FAB:	101810723 101811971(TH)

OMA:	130248316 130253803(TH)

PHI:	102108161 102111024(TH)

PMAJ:

107204189 107205413(TH)

CCAE:

111930777(TH) 111931331

CCW:	104687428(TH) 104696496

CBRC:

103618194 103624929(TH)

ETL:	114056146 114059836(TH)

ZAB:	102071696 102072945(TH)

ACHL:

103802298(TH) 103804380

SVG:	106853603 106859792(TH)

MMEA:

130577050(TH)

HRT:	120752315 120754090(TH)

FPG:	101912036 101915572(TH)

FCH:	102049050 102055136(TH)

CLV:	102087146 102092212(TH) 110357291

EGZ:	104124906(TH) 104135597

NNI:	104010421(TH) 104013376

PCRI:

104027349 104029163

PLET:

104617694 104620102(TH)

EHS:	104503518 104516694(TH)

PCAO:

104041893 104046435

ACUN:

113481167(TH) 113488615

TALA:

104364913 104367985(TH)

PADL:

103920696(TH) 103924526

AFOR:

103906503 103906716(TH)

ACHC:

115351801(TH) 115352761

HALD:

104322627 104325057(TH)

HLE:	104829564(TH) 104831043

AGEN:

126047017 126048030

GCL:	127017019 127018134

CCRI:

104158076 104163520(TH)

CSTI:

104553490 104556074(TH)

CMAC:

104484559

MUI:	104533898 104541462

BREG:

104639472(TH) 104642948

FGA:	104069185(TH) 104069913

GSTE:

104251003 104259575

LDI:	104348112(TH) 104352213

MNB:	103768523(TH)

OHA:	104330119(TH) 104338293

NNT:	104404096 104404956

SHAB:

115605549 115607482(TH)

DPUB:

104296572 104305808(TH)

PGUU:

104467547 104472140

ACAR:

104520875(TH) 104523802

CPEA:

104394305(TH) 104396082

AVIT:

104277176 104279701(TH)

CVF:	104288616 104292588(TH)

RTD:	128906640 128908897(TH)

CUCA:

104058958 104068902(TH)

TEO:	104379610(TH) 104383676

BRHI:

104488945 104501461(TH)

AAM:	106488264 106497044(TH)

AROW:

112972432(TH)

NPD:	112945235(TH) 112946611

TGT:	104570707(TH) 104575507

DNE:	112978953(TH)

SCAM:

104143749(TH) 104147401

ASN:	102378400(TH) 102381461

AMJ:	102563069 102565540(TH)

CPOO:

109315934 109321480(TH)

GGN:	109296410 109299169(TH)

PSS:	102444955(TH) 102446096

CMY:	102935321(TH) 102941678

CCAY:

125627430 125638880(TH)

DCC:	119856605 119857224(TH)

CPIC:

101937054(TH) 101942670

TST:	117870626 117877299(TH)

CABI:

116819344(TH) 116819879

MRV:	120370067 120404504(TH)

ACS:	100561541(th) 100562555

ASAO:

132770987(TH) 132775713

PVT:	110076553(TH) 110084772

SUND:

121922073(TH) 121930910

PBI:	103048677 103061496(TH)

PMUR:

107289468 107294041(TH)

CTIG:

120305852 120311347(TH)

TSR:	106542491 106546997(TH)

PGUT:

117655512 117665229(TH)

APRI:

131188891(TH) 131202575

PTEX:

113438075 113440206(TH)

NSS:	113412546(TH) 113430512

VKO:	123021236(TH) 123028824

PMUA:

114599115(TH) 114605512

PRAF:

128416303(TH) 128422499

ZVI:	118089163(TH) 118091167

HCG:	128327450 128340985(TH)

GJA:	107108457(TH) 107119992

STOW:

125425715(TH) 125435334

EMC:	129324543(TH) 129335831

XLA:	100037248(th.S) 108710245(th2.L) 108713461(th.L)

XTR:	100488900(th) 100495856(th2)

NPR:	108789610 108791996(TH)

RTEM:

120917287(TH) 120932127

BBUF:

120980402(TH) 120987072

BGAR:

122920671(TH) 122925950

MUO:	115468008(TH) 115477798

GSH:	117351959(TH) 117363672

DRE:	30384(th) 414844(th2)

SRX:	107707537 107725618(pah) 107740562 107744916

SANH:

107664872 107675254(th) 107688572 107695848

SGH:	107553859(th) 107572878 107587609 107590157

CCAR:

109068217 109068347 109077513

CAUA:

113043589 113062808 113067107 113075326

CGIB:

127946712 127956588 128013814

PTET:

122330744(th) 122342852(th2)

LROH:

127156953(th) 127163859(th2)

OMC:	131534261(th) 131538892(th2)

PPRM:

120473330(th) 120477034(th2)

RKG:	130072230(th2) 130086004(th)

MAMB:

125244962(th2) 125247737(th)

CIDE:

127507221 127511004

MASI:

127435640 127436747 127437842

TROS:

130548155(th2) 130551496(th)

TDW:	130414100(th) 130420954(th2)

MANU:

129432206(th2) 129434402(th)

IPU:	108274586(th) 108279869(th2)

IFU:	128618514(th) 128623226(th2)

PHYP:

113529896(th) 113532096

SMEO:

124391871(th) 124401251(th2)

TFD:	113651566(th2) 113660155(th)

TVC:	132856839(th) 132859379(th2)

AMEX:

103023599(th) 103026162

CMAO:

118811537(th) 118812607(th2)

EEE:	113584590 113589509(th)

CHAR:

105900747(th) 105902612(th2)

TRU:	101078018(th) 446095

TFS:	130519131(th2) 130536698(th)

TNG:	GSTEN00019792G001 GSTEN00023797G001

LCO:	104920475(th) 104926293

NCC:	104945813 104966229(th)

TBEN:

117485068(th2) 117491252(th)

CGOB:

115009621(th) 115028288

PGEO:

117439143(th2) 117447500(th)

GACU:

117545933(th) 117552492(th2)

EMAC:

134879228(th2) 134880572(th)

ELY:	117249390(th2) 117261762(th)

EFO:	125882935(th2) 125888114(th)

PLEP:

121949711(th) 121961151(th2)

SLUC:

116038785(th) 116060201(th2)

ECRA:

117938735(th2) 117948912(th)

ESP:	116673350 116693998

PFLV:

114550010 114560170(th)

GAT:	120809587(th) 120818263(th2)

PPUG:

119196712(th) 119210571(th2)

AFB:	129108195(th) 129112337(th2)

CLUM:

117726085(th2) 117732290(th)

PSWI:

130195323(th) 130200514(th2)

MSAM:

119894432(th) 119917964(th2)

SCHU:

122871197(th2) 122875321(th)

CUD:	121505421(th2) 121515137(th)

ALAT:

119024333(th) 119032200(th2)

MZE:	101468237(th) 101477829

ONL:	100702996 100708687(th)

OAU:	116325448(th2) 116328933(th)

OLA:	101168664(th2) 101171548(th)

OML:	112152448(th) 112159073(th2)

CSAI:

133423792(th2) 133444693(th)

XMA:	102222085 102222392(th)

XCO:	114150851(th) 114160620

XHE:	116729483(th) 116737013

PRET:

103459397 103466160(th)

PFOR:

103140260 103144430(th)

PLAI:

106959916(th) 106960764

PMEI:

106905257(th) 106925437

GAF:	122826240(th2) 122834999(th)

PPRL:

129351518(th2) 129367031(th)

CVG:	107085478 107089460(th)

CTUL:

119781003(th2) 119796768(th)

GMU:	124879160(th) 124882783(th2)

NFU:	107386767 107389022(th)

KMR:	108233218(th2) 108237537(th)

ALIM:

106515667(th) 106530261

NWH:	119415586(th)

AOCE:

111582533(th) 111586653

MCEP:

125000310(th2) 125014315(th)

CSEM:

103380366 103382582

POV:	109638922(th) 109640773

SSEN:

122766054(th2) 122775716(th)

HHIP:

117757137(th2) 117763623(th)

HSP:	118101559(th2) 118109722(th)

SMAU:

118293287(th2) 118315918(th)

LCF:	108875328 108897565(th2)

SDU:	111224521 111228409(th)

SLAL:

111661851(th) 111664688

XGL:	120793270(th) 120799032(th2)

HCQ:	109530099 109530311(th)

SSCV:

125970525 125992294

SBIA:

133493389(th2) 133501919(th)

PEE:	133397075(th2) 133402871(th)

PTAO:

133471847(th2) 133478228(th)

BPEC:

110161487 110165894(th)

MALB:

109967816 109967893(th)

BSPL:

114857385(th) 114861698(th2)

SJO:	128353460(th2) 128359117(th)

SASA:

106560700(th) 106576278 106609447

STRU:

115197203(th) 115198942

OTW:	112214922 112218383(th)

OMY:	110490795(th) 110500050(th2)

OGO:	124014251 124040720(th)

ONE:	115133706 115134621(th)

OKI:	109867772(th) 109896376

OKE:	118365892 118392479 118396296(th)

SALP:

111961998(th) 111982828

SNH:	120049945 120066029(th)

CCLU:

121532008(th) 121549008 121579002 123484263

ELS:	105026610(th) 105030168

SFM:	108931392 108942201(th)

PKI:	111846560 111859412(th)

AANG:

118215238 118227840(th) 118232061(th2)

LOC:	102688831(th)

PSPA:

121294872 121319106(th2) 121330128

ARUT:

117415781(th2) 117432410 117435126

PSEX:

120523309(th) 120534263(th2)

LCM:	102350473 102363425

CMK:	103179919(th2) 103186002(th)

RTP:	109914089(th) 109914147(th2)

CPLA:

122557926(th) 122559408(th2)

HOC:	132824162(th) 132825033(th2)

LERI:

129705837(th) 129706325(th2)

PMRN:

LRJ:

BFO:

BBEL:

CIN:	493867(th)

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	100329060(TH)

DME:	Dmel_CG10118(ple)

DER:

6544948

DSE:

6611046

DSI:	Dsimw501_GD13115(Dsim_GD13115)

DYA:	Dyak_GE20472

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12682

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108379189 108380146

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ014156

CPII:

120412867

CNS:

116345444

BCOO:

119083661

AME:	408930(TyHyd)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	654918(Th)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100270767(Th)

BMAN:

114244521

MSEX:

115441153

DPL:	KGM_206781

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105380496(Th)

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103505706 103521760

CLEC:

HHAL:

NLU:

HVI:

MQU:	128994132 128994151

PHU:	Phum_PHUM501080

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_323742

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:	119165146 119184285

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129231642 129232636

SDM:	118183488 118190672

LPOL:

106462240

PMEO:

129601922

CEL:	CELE_B0432.5(cat-2)

CBR:	CBG_07026(Cbr-cat-2)

CRQ:	GCK72_007931

BMY:	BM_BM4930(Bma-cat-2)

LOA:	LOAG_02149

TSP:

Tsp_12013

HRO:	HELRODRAFT_66944

LGI:	LOTGIDRAFT_106041

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105337798 117691858

CVN:	111100427 111100428

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106153195 106158393

SMM:	Smp_007690

SHX:	MS3_00010321

OVI:	T265_08520

» show all

Reference

PMID:21176768

Authors

Daubner SC, Le T, Wang S

Title

Tyrosine hydroxylase and regulation of dopamine synthesis.

Journal

Arch Biochem Biophys 508:1-12 (2011)
DOI:10.1016/j.abb.2010.12.017

Reference

PMID:2887169

Authors

Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T

Title

Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.

Journal

Biochem Biophys Res Commun 146:971-5 (1987)
DOI:10.1016/0006-291x(87)90742-x

Sequence

[hsa:7054]

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