KEGG   DRUG: D00293Help
Entry
D00293                      Drug                                   

Name
Diazepam (JP16/USP/INN);
Diastat (TN);
Valium (TN)
Product
  Generic
DIAZEPAM (A-S Medication Solutions LLC), DIAZEPAM (A-S Medication Solutions LLC), DIAZEPAM (A-S Medication Solutions LLC), DIAZEPAM (A-S Medication Solutions LLC), DIAZEPAM (Aidarex Pharmaceuticals LLC), DIAZEPAM (American Health Packaging), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Aphena Pharma Solutions - Tennessee), DIAZEPAM (Apotheca), DIAZEPAM (Atlantic Biologicals Corps), DIAZEPAM (Blenheim Pharmacal), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Bryant Ranch Prepack), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Cardinal Health), DIAZEPAM (Contract Pharmacy Services-PA), DIAZEPAM (DIRECT RX), DIAZEPAM (Dispensing Solutions), DIAZEPAM (Dispensing Solutions), DIAZEPAM (Dispensing Solutions), DIAZEPAM (General Injectables and Vaccines), DIAZEPAM (General Injectables and Vaccines), DIAZEPAM (Hospira), DIAZEPAM (Hospira), DIAZEPAM (Hospira), DIAZEPAM (Hospira), DIAZEPAM (Hospira), DIAZEPAM (IVAX Pharmaceuticals), DIAZEPAM (KAISER FOUNDATION HOSPITALS), DIAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DIAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DIAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), DIAZEPAM (Lannett Company), DIAZEPAM (Major Pharmaceuticals), DIAZEPAM (McKesson Contract Packaging), DIAZEPAM (McKesson Packaging Services Business Unit of McKesson Corporation), DIAZEPAM (Mylan Institutional), DIAZEPAM (Mylan Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (PD-Rx Pharmaceuticals), DIAZEPAM (Physicians Total Care), DIAZEPAM (Physicians Total Care), DIAZEPAM (Precision Dose), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Preferred Pharmaceuticals), DIAZEPAM (Qualitest Pharmaceuticals), DIAZEPAM (REMEDYREPACK), DIAZEPAM (Rebel Distributors Corp), DIAZEPAM (Rebel Distributors Corp.), DIAZEPAM (RedPharm Drug), DIAZEPAM (STAT RX USA LLC), DIAZEPAM (STAT Rx USA LLC), DIAZEPAM (TYA Pharmaceuticals), DIAZEPAM (TYA Pharmaceuticals), DIAZEPAM (Teva Pharmaceuticals USA), DIAZEPAM (Unit Dose Services), DIAZEPAM (Unit Dose Services), DIAZEPAM (Watson Laboratories), DIAZEPAM INTENSOL (Roxane Laboratories)
Formula
C16H13ClN2O
Exact mass
284.0716
Mol weight
284.7402
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C18 [HSA:1562], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Anxiolytics
Hypnotics
Anticonvulsants
Benzodiazepine family
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA01 Diazepam
      D00293  Diazepam (JP16/USP/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Diazepam
    D00293  Diazepam (JP16/USP/INN)
 Anxiolytics
  Benzodiazepines
   Diazepam
    D00293  Diazepam (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00293  Diazepam (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Diazepam
      D00293  Diazepam (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C18
   Diazepam
    D00293  Diazepam (JP16/USP/INN)
  CYP2C19
   Diazepam
    D00293  Diazepam (JP16/USP/INN)
  CYP3A4
   Diazepam
    D00293  Diazepam (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00293  Diazepam
  D00293  Diazepam tablets
BRITE hierarchy
Other DBs
CAS: 
439-14-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        20
            1   C2y C    17.4934  -14.8494
            2   C8y C    16.6513  -13.7398
            3   C8y C    16.9865  -12.3830
            4   N1y N    18.2475  -11.8049
            5   N2x N    18.8992  -14.8746
            6   C5x C    19.5011  -12.4272
            7   C1x C    19.7876  -13.7959
            8   C8x C    15.9794  -11.4146
            9   C8x C    14.6374  -11.8027
            10  C8y C    14.3022  -13.1595
            11  C8x C    15.3093  -14.1276
            12  O5x O    20.5452  -11.4928
            13  X   Cl   12.9374  -13.5539
            14  C8y C    16.8589  -16.0991
            15  C8x C    15.4573  -16.0991
            16  C1a C    18.2692  -10.4300
            17  C8x C    14.7573  -17.3116
            18  C8x C    15.4573  -18.5240
            19  C8x C    16.8589  -18.5240
            20  C8x C    17.5589  -17.3116
BOND        22
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17    4  16 1
            18   15  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   14  20 2

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